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TDMS Study 05028-01 Pathology Tables

NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 08:33:42




       Facility:  TSI Mason Research

       Chemical CAS #:  67-72-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X  X  X  X     X  X        X           X      |             
      Neoplastic Nodule                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
      Ventricle Left, Schwannoma Malignant |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X              X           X     X     X  X  X  X           X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X     X                 X           X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                                                  |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                      X   |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        | X              X     X                 X                    X            |             
      Cervix, Leukemia Mononuclear         |                                                       X                  |             
      Cervix, Endometrium, Sarcoma Stromal |             X                                                            |             
      Endometrium, Adenocarcinoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinosarcoma, Metastatic, Zymbal's |                                                                          |             
          Gland                            |                                                          X               |             
      Mediastinal, Leukemia Mononuclear    |                            X              X           X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
      Renal, Leukemia Mononuclear          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X  X  X  X     X           X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X  X  X  X     X  X        X           X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X  X  X  X     X  X        X           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  I  M  M  M  +  M  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                            X              X           X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |          X                       X                    X  X     X     X  X|             
      Fibroadenoma, Multiple               |    X              X           X        X                          X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |       X                                                                  |             
      Subcutaneous Tissue, Fibroma         |                                                       X                  |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Leukemia Mononuclear       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +     +  +     +     +  +  M        +     +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Leukemia Mononuclear                 |                         X  X  X     X     X           X           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Conjunctiva, Squamous Cell Carcinoma |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                          +               |             
      Carcinoma                            |                               X                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X  X  X  X     X  X        X           X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X  X              X           X  X              X  X|         19 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +                       +           +  +   |   7        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
      Schwannoma Malignant                 |    X                                                                     |          1 |
      Ventricle Left, Schwannoma Malignant |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                            X   |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  M  M  +  +  +  +  +  M  +|  38        |
      Adenoma                              |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               | X  X  X     X        X  X  X     X  X           X        X  X  X  X     X|         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |          X     X           X                                   X     X   |          9 |
      C-Cell, Carcinoma                    |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Adenoma                              | X     X                                                                  |          3 |
      Carcinoma                            |                   X                                                      |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cystadenoma                          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  48        |
      Polyp Stromal                        |    X                 X           X           X        X                  |         10 |
      Cervix, Leukemia Mononuclear         |                                                                          |          1 |
      Cervix, Endometrium, Sarcoma Stromal |                                                                          |          1 |
      Endometrium, Adenocarcinoma          |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X              X   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinosarcoma, Metastatic, Zymbal's |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                    X  X              X   |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                       X              X   |          3 |
      Renal, Leukemia Mononuclear          |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                         X              X           X  X              X   |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X              X  X  X              X           X  X              X  X|         19 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X  X              X           X  X              X  X|         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                         X                             X                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Fibroadenoma                         | X           X           X        X  X     X     X                 X  X  X|         17 |
      Fibroadenoma, Multiple               |       X  X                 X  X              X              X            |         11 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Leukemia Mononuclear       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  M  +  +  +     +  +           +  M           +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +     +  +           +  +           +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          2 |
      Leukemia Mononuclear                 |                      X  X              X           X  X              X  X|         14 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                               +  +     +     +         |   6        |
      Conjunctiva, Squamous Cell Carcinoma |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X              X   |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Transitional Epithelium, Papilloma   | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X              X  X  X              X           X  X              X  X|         19 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +     +  +           +  +        +     +     +  +  +  +|             
      Carcinoma, Metastatic, Adrenal Gland |             X                                                            |             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |    X                    X                                               X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +           +                 +              +              +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +                             +                             +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
      Squamous Cell Papilloma              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +           +                 +                             +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +                             +           +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +                             +           +  +  +           +|             
      Carcinoma                            |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +                             +           +  +  +           +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +                             +              +              +|             
      Carcinoma                            |                                                          X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |    X     X     X     X     X     X           X           X        X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                                               X                 X   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +                 +           M                             +|             
      Carcinoma                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +              +              +                             +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +  +              +     +  +     +  +  +        +        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                                          X        X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +        +                    +        +     +              +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +                             +                             +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +                             +              +              +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +           +                 +  +                          +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |    X                    X                    X                          X|             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  +           +                 +                             +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +     +     +     +  +     +  +              +     +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |       X           X  X     X     X     X  X     X  X              X      |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +              +              +                             +|             
      Keratoacanthoma                      |                                           X                              |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +                             +                             +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +     +        +  +  +  +  +  +  +           +|             
      Carcinoma, Metastatic, Adrenal Gland |             X                                                            |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +                             +                             +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +        +                       +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +                             +                             +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |    X                    X                    X                          X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                      +  +  M           +  +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +              +  +     +  +  +  +  +  +  +  +        +  +  +|  32        |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                 X                        |          1 |
      Leukemia Mononuclear                 | X     X  X                 X              X     X  X  X                  |         11 |
      Neoplastic Nodule                    |                                     X  X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +                    +                    +                  |   5        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                      +  +  +           +  +|  12        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +                                      +  +  +           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                                      +  +  +           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +                                      +  +  +           +  +|  10        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                                      +  +  +           +  +|  11        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +                                      +  +  +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +                                      +  +  +           +  +|  15        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                            X                     |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +                                      +  +  +           +  +|  15        |
      Leukemia Mononuclear                 |       X                                            X                     |          2 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                                      +  +  +           +  +|  11        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +  M|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
      Pars Distalis, Adenoma               |    X  X     X  X  X           X  X  X     X     X                 X      |         20 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      | X                       X     X                                X         |          7 |
      Follicular Cell, Adenoma             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                    +  +  +  +        +  +|  10        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +              +                       +  +  +  +        +  +|  14        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +  +           +     +        +     +  +  +  +  +     +  +  +|  25        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
      Polyp Stromal                        |                X                 X        X              X  X            |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                             +        +  +  +           +  +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +              +     +                 +  +  +        +  +  +|  17        |
      Mediastinal, Leukemia Mononuclear    |       X                    X                       X                     |          3 |
      Pancreatic, Leukemia Mononuclear     |       X                    X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +                                      +  +  M        +  +  +|  10        |
      Leukemia Mononuclear                 |                                                    X  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +              +                       +  +  +           +  +|  12        |
      Leukemia Mononuclear                 |                            X                       X  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +           +  +     +        +  +  +  +  +  +           +  +|  23        |
      Leukemia Monocytic                   |          X                                                               |          1 |
      Leukemia Mononuclear                 | X     X                    X              X     X  X  X                  |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +              +                       +  +  +           M  +|  11        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           M  +  +              +  +  +  +        +  +  +     +  +  +  +|  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma                       |                                                                   X      |          1 |
      Fibroadenoma                         | X              X  X                                      X     X     X  X|         17 |
      Fibroadenoma, Multiple               |                                  X  X     X                       X      |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +                 +                    +  +  +           +  +|  12        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                               X                                      X   |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                      +  +  +           +  +|  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +     +     +  +  +  +              +  +  +  +           +  +|  29        |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                    X                    X  X  X                  |          6 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                      +     +           +  +|   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                      +  +  +           +  +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                               +     +                  |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +        +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                    X                       X                     |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +           +                          +  +  +           +  +|  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Monocytic                   |          X                                                               |          1 |
      Leukemia Mononuclear                 | X     X  X                 X              X     X  X  X                  |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X  X           X     X              X           X      |             
      Neoplastic Nodule                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                                 |             
      Palate, Squamous Cell Papilloma      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                X         |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X        X              X  X              X     X  X        X         |             
      Pars Distalis, Carcinoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X     X                  |             
      Follicular Cell, Carcinoma           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  M  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
      Polyp Stromal                        |          X                                      X        X               |             
      Endometrium, Adenocarcinoma          |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                      X                                                   |             
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X  X                 X                          X      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X     X  X                 X              X           X      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X              X     X              X           X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  M  M  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |       X  X              X     X  X     X  X  X        X           X     X|             
      Fibroadenoma, Multiple               |    X           X                                   X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +     +              +  +  +        +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +     +              +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                        X                                 |             
      Leukemia Mononuclear                 |          X  X     X  X                                            X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X  X           X     X              X           X      |             
      Lymphoma Malignant Lymphocytic       |                      X           X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                             X        X  X  X                  |         14 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +     +                                   +   |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma                              |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  +  I  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |    X           X     X     X                             X     X  X      |         16 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |    X     X        X                                         X            |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Carcinoma           |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +|  39        |
      Adenoma                              |                               X                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyoma                            | X                                                                        |          1 |
      Polyp Stromal                        | X                                      X                                 |          5 |
      Endometrium, Adenocarcinoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  I  +  +|  43        |
      Leukemia Mononuclear                 |          X                             X        X  X  X                  |         10 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X                                      X  X  X                  |         11 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X                       X        X  X  X                  |         14 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |          X                                      X                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Fibroadenoma                         |       X        X        X        X        X  X  X        X     X         |         20 |
      Fibroadenoma, Multiple               |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +        +  +  +  +  +  M  M  +        +  +     M     M  +  +  M   |  30        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +        +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          1 |
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                             X        X  X  X                  |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                    +  +                 +|   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   1        |
      Adenocarcinoma                       |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X                       X        X  X  X                  |         15 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |                      X     X                 X        X        X        X|             
      Neoplastic Nodule                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                 X                        |             
      Pheochromocytoma Benign              |             X  X                       X     X        X  X        X  X   |             
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X     X  X  X  X  X           X  X           X     X  X  X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X              X     X  X                              |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X        X  X  X           X     X  X        X  X  X  X  X        X  X   |             
      Interstitial Cell, Adenoma           |    X              X  X                 X                    X           X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X        X        X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                       X        X        X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                 X        X        X        X|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  M  +  +  M  +  M  M  M  +  +  +  M  M  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         | X                                                                        |             
      Fibroadenoma, Multiple               |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |    X                                                                     |             
      Keratoacanthoma                      |       X                                X                       X         |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                          X               |             
      Subcutaneous Tissue, Fibroma         |                                                                      X   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Lipoma                               |                            X                                             |             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Cranial Nerve, Schwannoma Malignant  |          X                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X              X                              |             
      Leukemia Mononuclear                 |                                              X        X        X        X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                    +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +  +                                             |             
      Carcinoma                            |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |       X                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                 X        X        X        X|             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyosarcoma                       |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                       X                  |          1 |
      Leukemia Mononuclear                 |       X  X              X           X  X                 X  X            |         13 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   1        |
      Mesothelioma NOS                     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma NOS                     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Schwannoma Malignant                 |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                 X                       X                              |         11 |
      Bilateral, Pheochromocytoma Benign   |                               X     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               | X                 X  X           X  X     X     X           X  X         |         24 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |             X                                                     X      |          6 |
      C-Cell, Carcinoma                    |                                     X     X           X                  |          3 |
      Follicular Cell, Carcinoma           |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Mesothelioma NOS                     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Mesothelioma NOS                     |                                                             X            |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X     X  X  X           X  X  X  X  X  X  X        X  X  X  X  X  X   |         32 |
      Interstitial Cell, Adenoma           |       X           X  X  X                          X                     |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                                                     X            |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Leukemia Mononuclear    |                         X                                X               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M|  45        |
      Leukemia Mononuclear                 |       X  X                             X                    X            |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X              X              X                 X  X            |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |       X  X              X           X  X                 X  X            |         13 |
      Mesothelioma NOS                     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |          X              X              X                    X            |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  M  M  +  M  M  +  +  +  M|  33        |
      Adenocarcinoma                       |                                  X                                       |          1 |
      Fibroadenoma                         |          X                                X           X        X  X      |          6 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                              X     X           X         |          6 |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |    X        X        X                             X        X            |          6 |
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +  +                                +            |   4        |
      Lipoma                               |                                                                          |          1 |
      Mesothelioma NOS                     |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |          X                                                               |          1 |
      Cranial Nerve, Schwannoma Malignant  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            I                                             |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X  X                                                                  |          4 |
      Leukemia Mononuclear                 |       X  X              X              X                 X  X            |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                       +              +               |   5        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X              X           X  X                 X  X            |         13 |
      Mesothelioma NOS                     |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +              +           M  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  +  +              +           A  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  M              +           +  +              +              +|             
      Mesothelioma NOS                     |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    M  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +           +  +           A  +              +              +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +     +  +     +     +     +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |                      X        X     X           X  X                 X   |             
      Neoplastic Nodule                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +  +                                   +|             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +     +     +     +  +              +           +  +|             
      Adenoma                              |                                  X                                       |             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                                                                         X|             
      Acinus, Adenoma                      |                X                                                     X   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                       +                  |             
      Palate, Squamous Cell Papilloma      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +           +  +  +        +  +              +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +           +  +  +        +  +              +     +        +|             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +           +  +  +        +  +              +     +        +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +              +        +  +  +              +     +        +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                  X                             X         |             
      Pheochromocytoma Benign              | X        X     X  X  X        X                    X  X     X     X  X   |             
      Bilateral, Pheochromocytoma Benign   |                         X           X        X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +     +     +     +  +              +           +  +|             
      Adenoma                              |             X                                                        X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X        X     X  X              X  X  X                 X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      | X                    X     X                       X  X              X   |             
      C-Cell, Carcinoma                    |    X                                                                     |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +              +           +  +              +              +|             
      Mesothelioma Malignant               |                                                                          |             
      Mesothelioma NOS                     |                                                                         X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +              +     +     +  +        +     +              +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +     +        +  +  +     +  +           +  +              +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                                                                         X|             
      Bilateral, Interstitial Cell, Adenoma| X        X        X  X     X  X  X  X     X  X  X  X  X     X  X  X  X   |             
      Interstitial Cell, Adenoma           |    X                                                                    X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +        +  +  +  +  +  +  +        +     +  +        +  +|             
      Mediastinal, Leukemia Mononuclear    |                               X  X  X                                    |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +        +  +           +  +              +  +        +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +              +     +     +  +              +              +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +     +  +  +  +  +  +     +  +     +     +     +  +|             
      Leukemia Mononuclear                 |                      X        X  X  X           X  X                 X   |             
      Mesothelioma NOS                     |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +              M           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  M  +  +     +     +           +  +           +  +              +|             
      Fibroadenoma                         |                X     X                                X                  |             
      Lipoma                               |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +              +     +     +  +              +           +  +|             
      Basal Cell Adenoma                   |                                  X                                       |             
      Keratoacanthoma                      |                                           X                          X   |             
      Squamous Cell Papilloma              |    X                                                                     |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                             X                              |             
      Subcutaneous Tissue, Lipoma          |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           M                              |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +              +           +  +              +              +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +              +  +     +  +  +              +              +|             
      Leukemia Mononuclear                 |                               X     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +              +           +  +              +              +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +              +           +  +              +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
      Adenoma                              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  A  +  +              +           A  +              +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X        X  X  X           X  X                 X   |             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                      +  +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                         +  +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                         +  +           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                         +  +           +  +|  13        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                         +  +              +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +              +              +           +  +              +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +              +                          +  +              +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +              +              +           A  +              +|  14        |
      Leiomyosarcoma                       |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             M              +                          +  +              +|  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +  +  +           +        +        +  +  +           +  +|  31        |
      Fibrosarcoma, Metastatic, Skin       |                X                                                         |          1 |
      Leukemia Mononuclear                 |             X        X                    X           X  X           X  X|         13 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   5        |
      Mesothelioma Malignant               |          X                                                               |          2 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +                                         +  A              +|  18        |
      Adenoma                              |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                         X|          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                         +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +           +                             +  +     +     +  +|  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +           +                             +  +           +  +|  18        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +           +                             +  +     +     +  +|  19        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   2        |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                                         +  +              +|  15        |
      Leukemia Mononuclear                 |                                                          X              X|          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  45        |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              | X     X  X              X                    X  X           X  X         |         19 |
      Bilateral, Pheochromocytoma Benign   |    X              X           X                                      X   |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +                                         +  A              +|  17        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|  40        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      Pars Distalis, Adenoma               |       X              X     X     X        X  X        X     X  X  X  X   |         22 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      C-Cell, Adenoma                      |    X              X                                X                     |          9 |
      C-Cell, Carcinoma                    |       X                                                                  |          2 |
      Follicular Cell, Adenoma             |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +                                         +  +              +|  14        |
      Mesothelioma Malignant               |          X                                                               |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                    +                    +  +        +     +|  17        |
      Adenoma                              |                                  X                                X      |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                                            +  +           +|  13        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        +  +     +  +  +                 +  +        +     +|  23        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|  46        |
      Mesothelioma Malignant               |          X                                                               |          2 |
      Mesothelioma NOS                     |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X     X     X        X|         36 |
      Interstitial Cell, Adenoma           | X                                         X           X                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                                         +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +        +  +  +     +  +  +        +  +  +  +        +  +  +|  31        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |             X                                         X  X               |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +        +              +  +        +  +  +  +           +  +|  23        |
      Leukemia Mononuclear                 |             X                                         X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +           +                             +  +              +|  15        |
      Leukemia Mononuclear                 |             X                                         X  X              X|          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +                 +           +     +     +  +        +  +  +|  28        |
      Leukemia Mononuclear                 |             X                             X           X  X        X  X  X|         14 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M           M                          +  M  +           +  +|  11        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             M                    +           +  +     M  M  +        +  +|  16        |
      Fibroadenoma                         |                                  X           X  X                        |          6 |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +     +        +                    +  +  +              +|  21        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      | X        X     X                                                         |          5 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |                      X                                                   |          1 |
      Subcutaneous Tissue, Fibroma         |                               X                    X                    X|          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |          3 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                         +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +  +                                                            |   2        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Mesothelioma Malignant               |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                         +  +              +|  13        |
      Leukemia Mononuclear                 |                                                       X  X               |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   1        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +           +        +  +     +     +  +  +  +     +  +  +  +|  24        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                             X           X  X        X      |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                         +  +              +|  13        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                         +  +              +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +              +                    +|   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   2        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                         X  X               |          3 |
      Renal Tubule, Adenoma                |          X                                                           X   |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             A                                   +     A  +              +|  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                    X           X  X        X  X  X|         15 |
      Mesothelioma Malignant               |          X                                                               |          2 |
      Mesothelioma NOS                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                               X                                          |             
      Mesothelioma NOS                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |             X     X                          X     X           X        X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +              +               |             
      Mesothelioma NOS                     |                                           X                              |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                      +   |             
      Palate, Squamous Cell Papilloma      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                               X                                          |             
      Pheochromocytoma Complex             |                                                 X                        |             
      Pheochromocytoma Benign              |    X     X     X  X              X                          X            |             
      Bilateral, Pheochromocytoma Benign   | X                          X                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X        X  X                    X           X        X  X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                    X                                                   |             
      Follicular Cell, Carcinoma           |                         X                                      X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Carcinoma                            |                                                                         X|             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                           X           X                  |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X|             
      Interstitial Cell, Adenoma           |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |             X                                                            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X                                X                    X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X                          X     X           X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X                          X     X           X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  M  +  +  M  +  +  M  M  +  +  M  +  M  M  M  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |       X           X                                                      |             
      Squamous Cell Carcinoma              |                                        X                                 |             
      Subcutaneous Tissue, Fibroma         |                         X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Mesothelioma NOS                     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |             X     X                                X           X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       M                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Adenoma                |                               X              X                           |             
      Renal Tubule, Carcinoma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma NOS                     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X                          X     X           X        X|             
      Mesothelioma NOS                     |                                           X           X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  46        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  47        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                    X                     |          1 |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |         11 |
      Neoplastic Nodule                    |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +        +        M           +                  |   5        |
      Mesothelioma NOS                     |                         X                                                |          2 |
      Sarcoma                              |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                 X                    X               |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Complex             |                                                    X                     |          2 |
      Pheochromocytoma Benign              | X     X     X  X  X                       X        X  X           X      |         15 |
      Bilateral, Pheochromocytoma Benign   |                      X                                         X         |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                        X     X                           |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M|  43        |
      Adenoma                              |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               | X        X     X           X                       X           X  X  X   |         16 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |    X        X                                                        X   |          5 |
      Follicular Cell, Carcinoma           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma NOS                     |       X                 X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |       X                                                                  |          2 |
      Carcinoma                            |                                                                          |          1 |
      Bilateral, Adenoma                   |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma NOS                     |       X                 X     X                                          |          5 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X  X  X        X      |         42 |
      Interstitial Cell, Adenoma           |          X                                                  X            |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Leukemia Mononuclear    |                   X                                   X                  |          3 |
      Pancreatic, Leukemia Mononuclear     |                   X                 X                    X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  44        |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  I  +  +  +  +|  43        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Thymoma Benign                       | X  X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  +  M  M  M  M  M  M  +  M  +  +  +  M  M  +  +  M  +|  23        |
      Adenocarcinoma                       |                      X                                                   |          1 |
      Fibroadenoma                         |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      | X                                               X                 X      |          5 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                               X                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |    X                                               X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
      Mesothelioma NOS                     |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |             X                                                            |          2 |
      Carcinoma, Metastatic, Kidney        |             X                                                            |          1 |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +              +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05028-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:42  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                     X                    X               |          2 |
      Renal Tubule, Adenoma                |                      X                                                   |          3 |
      Renal Tubule, Carcinoma              |             X              X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
      Mesothelioma NOS                     |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X     X                 X                 X  X               |         11 |
      Mesothelioma NOS                     |       X                 X     X                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
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                                  ----------              END OF REPORT             ----------                                      
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