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TDMS Study 05028-01 Pathology Tables

NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 08:33:49




       Facility:  TSI Mason Research

       Chemical CAS #:  67-72-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 3  4                          2     3           2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       4                       2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     | X  X     X  X  X  X  X           X              X           X  X  X      |             
      Fatty Change                         |                         4  2        2           2     2  3  1     2      |             
      Granuloma                            |                                                                      2  3|             
      Hepatodiaphragmatic Nodule           |                X                                                         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      | 2        2     2           2                       1        2            |             
      Bile Duct, Hyperplasia               |    2  2  1     2              2     2  2     2     2              2      |             
      Periductular, Inflammation, Chronic  |                                                                          |             
      Perivascular, Inflammation, Chronic  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                 +                                             |             
      Fat, Necrosis                        |          4                 4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Acinus, Atrophy                      |                                  2  1  2           2                     |             
      Acinus, Hyperplasia, Focal           |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell, Focal       | 3                                                                        |             
      Inflammation, Chronic                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2     2     3  1     3     4  2  1  2  2  3  2  1           2     2  3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Cytoplasmic Alteration, Focal        |          2                                                     2  4      |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         1              4                       3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2              4                                      4         |             
      Pars Distalis, Cyst                  | X  X  X  X     X  X  X     X  X        X     X  X        X  X            |             
      Pars Distalis, Hyperplasia, Focal    |                   2           2  3                       2               |             
      Pars Intermedia, Cyst                |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      Infiltration Cellular, Histiocyte    |                                                                      4   |             
      Pigmentation                         |                                                                      3   |             
      C-Cell, Hyperplasia                  | 3  2           3                             4  4  2     2  2     4     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |          4           4                                                   |             
      Atrophy                              |                                                       3                  |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                               1                                          |             
      Inflammation, Chronic                |                      3                          1  3        4  2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |          X     X                                   3                 X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                              4                           |             
      Exudate                              |                                                                          |             
      Thrombosis                           |                X                             X  X                        |             
      Endometrium, Cyst                    |          X                                                  X            |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3  4           2  4                    2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lumbar, Congestion                   |                                  3                                       |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                  2                                       |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       | 2                                                                        |             
      Mediastinal, Congestion              |                                                                      3   |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                            3                                             |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Congestion                    | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Congestion                           |                                                 3  4                     |             
      Infiltration Cellular, Plasma Cell   |       2           2  3  3  2  4  3  2  2     3     3     4  2        4  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                          3               |             
      Pigmentation, Hemosiderin            |                   2                             2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                                               2  2     3     2     2  2|             
      Necrosis, Focal                      |                         4                                                |             
      Pigmentation, Hemosiderin            |                                                    2                 4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  I  M  M  M  +  M  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 4  3                     |             
      Galactocele                          |    X                    X        X     X                          X  X  X|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
      Hydrocephalus                        |                                                    2                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +     +  +     +     +  +  M        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|             
                                           | 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +     +     +  +  +  +     +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            | 3                                                                        |             
      Hemorrhage, Focal                    |                                                                          |             
      Pigmentation, Focal, Hemosiderin     |                         2                                                |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |             2                                                            |             
      Alveolar Epithelium, Metaplasia      |                                  3                                       |             
      Peribronchial, Inflammation, Chronic | 2  2  2  2     2  2  1           2     2     1  2  2        2  2     3  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                       2     1     1        3     3|             
      Metaplasia, Squamous                 | 2  2  2     2  2  2  2  2     1  2  2  2     2  2  2        3     2  2  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                3         |             
      Retina, Degeneration                 |                                                                3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |                                                                          |             
      Mineralization                       | 1           1  2  2     1     1     1                          2         |             
      Nephropathy                          | 2  2           1           2     1     2     2  1  2                 1  1|             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                      3   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    2                             2                             2         |      8  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  3                             2         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                            3                                             |      1  3.0|
      Basophilic Focus                     |    X  X  X  X  X  X        X  X  X           X  X        X     X  X      |     26     |
      Fatty Change                         | 2        2  1  2     3  3        2        2        2        2        3   |     19  2.2|
      Granuloma                            |                                                                          |      2  2.5|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      2     |
      Mixed Cell Focus                     |                                           X                              |      1     |
      Necrosis, Focal                      | 1  3     2     1           2  2     2                       2  2  2      |     16  1.9|
      Bile Duct, Hyperplasia               |    2  1  2  2  2  2           2        3     2           3              3|     21  2.0|
      Periductular, Inflammation, Chronic  |                                                          2               |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                  2              1                        |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +                       +           +  +   |   7        |
      Fat, Necrosis                        |          4                    4                                   4  4   |      6  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Focal         |                                                                   2      |      1  2.0|
      Acinus, Atrophy                      | 2  3  1                       2        2                                 |      9  1.9|
      Acinus, Hyperplasia, Focal           |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Basal Cell, Focal       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization, Focal                |                      2                                                   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2        1     2  3              1  2     1  2        2     2     2      |     28  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                4     3                             2           2         |      7  2.7|
      Hypertrophy                          |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 2  4                                                                     |      5  2.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  M  M  +  +  +  +  +  M  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                      3   |      4  3.3|
      Pars Distalis, Cyst                  |    X     X     X  X  X        X  X     X     X     X              X      |     25     |
      Pars Distalis, Hyperplasia, Focal    |          3                                                               |      5  2.4|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |             2  3     4           3           4  3     3     3     1      |     19  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Abscess                              |                4                                                         |      3  4.0|
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                      X   |      1     |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1     2  1                          2                             3  2|     11  2.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    1                                                                     |      1  1.0|
      Cyst                                 |                X                                      X           X      |      7  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           | 4        4                                   4        3                  |      5  3.8|
      Exudate                              |                         3  X                                             |      2  3.0|
      Thrombosis                           |                                                                          |      3     |
      Endometrium, Cyst                    |                                                                          |      2     |
      Endometrium, Hyperplasia             |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2        3  3  2              2  2                                 |     11  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumbar, Congestion                   |                                                                          |      1  3.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Mediastinal, Congestion              |          2                                                               |      2  2.5|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                     3                                    |      1  3.0|
      Renal, Congestion                    |          3                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  4.0|
      Congestion                           |          3                                                              3|      4  3.3|
      Infiltration Cellular, Plasma Cell   | 3  3  2  2  2  3              2  3     2     2  3              3  2      |     28  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                               2                                   1      |      2  1.5|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |          3                                                               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2     3        4  3           2     3        2  2        2        2      |     17  2.4|
      Necrosis, Focal                      |                                                                      4   |      2  4.0|
      Pigmentation, Hemosiderin            |                                           2     3        2               |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Ectasia                              |                            4                                             |      3  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                            X                                         X  X|     10     |
      Hypertrophy                          |          2           2                                            3      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                          2               |      2  2.0|
      Pigmentation, Hemosiderin            |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  M  +  +  +     +  +           +  M           +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +     +  +           +  +           +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           2              2               |      2  2.0|
      Granuloma                            |                                     3                                    |      2  3.0|
      Hemorrhage, Focal                    |                                                       3                  |      1  3.0|
      Pigmentation, Focal, Hemosiderin     |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia      |                                                                   3      |      2  3.0|
      Peribronchial, Inflammation, Chronic | 2  2  2  2  2     1        2  2  1        2  2                 1  2      |     29  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 2           2  1                 2        2  2  3  1     2     1         |     16  1.9|
      Metaplasia, Squamous                 | 2  2  2  2  2     2  2  2  1  2  2  2  2     2  3           2  2  2  2  4|     39  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                               +  +     +     +         |   6        |
      Cataract                             | 3                                                                        |      2  3.0|
      Retina, Degeneration                 | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3|            |
                                           | 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |                            3                                             |      1  3.0|
      Mineralization                       |       2  2           1        1        1     1                           |     14  1.4|
      Nephropathy                          | 2  2  1  1  1           1        2              2  1           3        3|     22  1.6|
      Renal Tubule, Pigmentation           |                      2                                               3   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +                             +                             +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +                             +                             +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +     +  +           +  +        +     +     +  +  +  +|             
      Basophilic Focus                     | 1                                      1  X        X              X  X  X|             
      Basophilic Focus, Multiple           |          X                                                               |             
      Cytoplasmic Alteration               |                                        2                                 |             
      Fatty Change                         |                         1                                2     1  4  2  2|             
      Granuloma                            |                                                                3        2|             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X        X                       X     X               |             
      Necrosis, Focal                      |                                           2                          3   |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                         2                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Accessory Spleen                     |                                                                          |             
      Hemorrhage                           |                                                                      3   |             
      Fat, Inflammation                    |                                                                          |             
      Fat, Necrosis                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +           +                 +              +              +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Acinus, Atrophy                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +                             +                             +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +                             +                             +|             
      Acanthosis                           | 3                                                                        |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +           +                 +                             +|             
      Cardiomyopathy                       |             2                             1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +                             +           +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +                             +           +  +  +           +|             
      Atrophy                              |             4                                                            |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +                             +           +  +  +           +|             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +                             +              +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | X     X              X  X           X  X  X     X              X         |             
      Pars Distalis, Hyperplasia, Focal    | 2                             3  3           2  2                    3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     3        3           1  3     1  2                 2     1         |             
      Follicle, Cyst                       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +                 +           M                             +|             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +              +              +                             +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +  +              +     +  +     +  +  +        +        +     +|             
      Dilatation                           |                            4     4  3           3                        |             
      Inflammation, Acute, Focal           |                                                                          |             
      Thrombosis                           |                                              X                           |             
      Cervix, Hypertrophy                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +        +                    +        +     +              +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                           3                              |             
      Mediastinal, Congestion              |                                                    2                     |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Congestion                    |                      3                                                   |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +                             +                             +|             
      Congestion                           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +                             +              +              +|             
      Pigmentation, Hemosiderin            |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +           +                 +  +                          +|             
      Hematopoietic Cell Proliferation     |                                           4                              |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            | 2        3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  +           +                 +                             +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +     +     +     +  +     +  +              +     +|             
      Galactocele                          |       X        X  X  X     X              X     X                 X      |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +              +              +                             +|             
      Subcutaneous Tissue, Abscess         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +                             +                             +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +                             +                             +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +     +        +  +  +  +  +  +  +           +|             
      Congestion                           |       2              2     2                 1  2  2  1  3  2           2|             
      Granuloma                            |                                  4                                       |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                             4            |             
      Alveolar Epithelium, Metaplasia      |                                                             3            |             
      Alveolus, Atypia Cellular            |                                                                          |             
      Peribronchial, Inflammation, Chronic |                                           2     2     2  2  2           2|             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +                             +                             +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +                             +                             +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +        +                       +      |             
      Lens, Mineralization, Focal          |                                                                   2      |             
      Posterior Chamber, Hemorrhage        |                                  3                                       |             
      Retina, Degeneration                 |                                  3                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .08 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |       1  1  1  1  1  1     1     1     1  1     1  1  1        1        2|             
      Nephropathy                          | 1  1  1  2  1  3  2  2  1  2  1  1  1  1     1  2  2  2  2  2  1  2     2|             
      Renal Tubule, Hyperplasia            |                                                 1                        |             
      Renal Tubule, Pigmentation           |                                           1                              |             
      Renal Tubule, Regeneration           |                                                                      1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +                             +                             +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                      +  +  M           +  +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                      +  +  +           +  +|  10        |
      Parasite Metazoan                    |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                      +  +  +           +  +|  10        |
      Parasite Metazoan                    |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +              +  +     +  +  +  +  +  +  +  +        +  +  +|  32        |
      Basophilic Focus                     | X        X  X                 3     X  X  X              X           X  X|     17  1.7|
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Fatty Change                         |                            1                          2  1        2     2|     11  1.8|
      Granuloma                            |                                        3     2                           |      4  2.5|
      Hemorrhage, Focal                    | 2                                                                        |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                 X     X           X      |      7     |
      Necrosis, Focal                      |                                                 3  3                 1   |      5  2.4|
      Bile Duct, Cyst                      |                                     4                                    |      1  4.0|
      Bile Duct, Hyperplasia               | 2           2              2                                            1|      5  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +                    +                    +                  |   5        |
      Accessory Spleen                     |                                                       X                  |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Fat, Inflammation                    |             3                                                            |      1  3.0|
      Fat, Necrosis                        |       4                          4                                       |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +                                      +  +  +           +  +|  12        |
      Inflammation, Chronic, Focal         |                                                                      1   |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                      +  +  +           +  +|  10        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +                                      +  +  +           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                                      +  +  +           +  +|  12        |
      Acanthosis                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                                      +  +  +           +  +|  11        |
      Cardiomyopathy                       |                                                                         2|      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +                                      +  +  +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +                                      +  +  +           +  +|  15        |
      Atrophy                              |                                                                          |      1  4.0|
      Congestion                           |                                                       2                  |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                          2           2   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +                                      +  +  +           +  +|  15        |
      Inflammation, Focal                  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +                                      +  +  +           +  +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +  M|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                        3                                 |      1  3.0|
      Pars Distalis, Cyst                  | X  X  X  X           X  X              X                 X  X  X     X  X|     21     |
      Pars Distalis, Hyperplasia, Focal    |                         3                    2        3           3  2   |     11  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                              1  2                        |     11  1.8|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                    +  +  +  +        +  +|  10        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +              +                       +  +  +  +        +  +|  14        |
      Congestion                           |                                                                      2   |      1  2.0|
      Cyst                                 |    X        X                                               X            |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +  +           +     +        +     +  +  +  +  +     +  +  +|  25        |
      Dilatation                           | 3                                                                        |      5  3.4|
      Inflammation, Acute, Focal           |                                                       2                  |      1  2.0|
      Thrombosis                           |                X                                                         |      2     |
      Cervix, Hypertrophy                  |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                             +        +  +  +           +  +|  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +              +     +                 +  +  +        +  +  +|  17        |
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                  3                                       |      1  3.0|
      Pancreatic, Hemorrhage               |       2                                                                  |      1  2.0|
      Renal, Congestion                    |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +                                      +  +  M        +  +  +|  10        |
      Congestion                           |                                                                   2      |      2  2.0|
      Infiltration Cellular, Plasma Cell   |             4                                                     4      |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +              +                       +  +  +           +  +|  12        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +           +  +     +        +  +  +  +  +  +           +  +|  23        |
      Hematopoietic Cell Proliferation     |                                  4                       2           2  2|      5  2.8|
      Necrosis, Focal                      |                            4                                             |      1  4.0|
      Pigmentation, Hemosiderin            |             3           2                    2           2               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +              +                       +  +  +           M  +|  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           M  +  +              +  +  +  +        +  +  +     +  +  +  +|  28        |
      Galactocele                          |                   X              X  X  X  X                    X  X  X   |     16     |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +                 +                    +  +  +           +  +|  12        |
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                      +  +  +           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                      +  +  +           +  +|  10        |
      Hemorrhage                           |                                                    4                     |      1  4.0|
      Hydrocephalus                        |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +     +     +  +  +  +              +  +  +  +           +  +|  29        |
      Congestion                           |                   2     2        2                                   2   |     14  1.9|
      Granuloma                            |                                                                          |      1  4.0|
      Hemorrhage, Focal                    |       2                       3                 2                        |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5|            |
                             DAY ON TEST   | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9|            |
                                           | 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .08 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  3.0|
      Alveolus, Atypia Cellular            |             2                                                            |      1  2.0|
      Peribronchial, Inflammation, Chronic |    2                                                     2           2  2|     10  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                      +     +           +  +|   9        |
      Inflammation, Chronic                |                                                    2     1              1|      3  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                      +  +  +           +  +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                               +     +                  |   6        |
      Lens, Mineralization, Focal          |                                                 2                        |      2  2.0|
      Posterior Chamber, Hemorrhage        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +        +                                                |   3        |
      Inflammation, Chronic, Focal         |                2                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Mineralization                       | 1     1     1  1                       1        1           1            |     22  1.0|
      Nephropathy                          |    2  1  2  2     2  2        2  1  2  2  1  2  3     2     1  1  2  2  1|     42  1.6|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                    2                     |      2  1.5|
      Renal Tubule, Regeneration           | 1                                                                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +           +                          +  +  +           +  +|  11        |
      Hyperplasia                          |                         4                                                |      1  4.0|
      Inflammation, Chronic                |                         3                                               2|      2  2.5|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Squamous                        |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       2                          2  4  3                    2        4   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          4     4  2                             4                    3  3|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X        X     2  X  X  X        X  X     X  X     X     X|             
      Fatty Change                         |          3  2  1  2     1  2              3  2              1           3|             
      Granuloma                            |                                                       2              3   |             
      Hepatodiaphragmatic Nodule           |       X                 X                                                |             
      Necrosis, Focal                      |    1           1        1     1     2        3  2  1                    3|             
      Bile Duct, Hyperplasia               | 1        3  2     2                 2           2  1     2              2|             
      Periductular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Granuloma                            |                                                                          |             
      Fat, Necrosis                        |                                                                         4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Acinus, Atrophy                      |                   2              4                                       |             
      Acinus, Hyperplasia, Focal           |                4                                            3            |             
      Artery, Inflammation                 |                4                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3                                                               |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |          4                                                               |             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Chronic, Focal         |                                  2                                       |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1  2           3  2        2  2  2  3           1  2  2  1  3  2  1  2   |             
      Artery, Inflammation, Chronic, Focal |                4                                                         |             
      Atrium Right, Thrombosis             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |    3  3  2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                 3  1              3  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   3  4              4                                4   |             
      Pars Distalis, Cyst                  |       X  X                 X     X     X  X     3  X        X           X|             
      Pars Distalis, Hyperplasia, Focal    |                                  3  3           3           2            |             
      Pars Intermedia, Angiectasis         |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 4                        |             
      C-Cell, Hyperplasia                  | 4  4     2                          4                          2         |             
      Follicle, Cyst                       |                                  X                                       |             
      Follicle, Hyperplasia, Focal         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  M  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +|             
      Abscess                              |       4                                                                  |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Acute                  |                                                                   1      |             
      Inflammation, Chronic                |                1                                                        2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Dilatation                           |                3                 3                       4              3|             
      Inflammation, Chronic                |                                                 4                        |             
      Thrombosis                           |                                  X                                   X   |             
      Endometrium, Cyst                    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2        3              4                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Congestion               |                                                                         2|             
      Renal, Congestion                    |       2        2                                                         |             
      Renal, Granuloma                     |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                               2                 4                        |             
      Infiltration Cellular, Plasma Cell   |    4  2  3  2  3              2  4  3        4  3  2  3  3     4  2  3  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Pigmentation, Hemosiderin            |       3                                                                  |             
      Pigmentation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Hematopoietic Cell Proliferation     |    2                    2                 3  2  2           2  2        2|             
      Pigmentation, Hemosiderin            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  M  M  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       2  4              2|             
      Galactocele                          |    X  3        X                 X                 X                    X|             
      Inflammation, Focal, Subacute        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                          3               |             
      Infarct                              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +     +              +  +  +        +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .16 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +     +              +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2  2                                             |             
      Granuloma                            |                   2                                            2         |             
      Hemorrhage, Focal                    |                               3                                          |             
      Alveolar Epithelium, Metaplasia      |          2                       3           2                           |             
      Artery, Thrombosis                   |                               X                                          |             
      Peribronchial, Inflammation, Chronic | 2  2  2        2           2     2        2  2  2  1     2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3     2        3           2  2  2  2  1     1  2        3     3     2  3|             
      Metaplasia, Squamous                 | 3  2  2  2  2  3     2        2  2  2  3     2  2  2  2  3  2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cataract                             |                                                                          |             
      Retinal Detachment                   |                                                 4                        |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Vitreous, Degeneration               |                                                 4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |                                           1                              |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                1     1        2           1  2  2  1                    2|             
      Nephropathy                          | 2  2  2     1  2  2     2  2  1  2  2        2  1  2  3  3  1  2  2  3  2|             
      Renal Tubule, Cyst                   |                                              X                       X   |             
      Renal Tubule, Pigmentation           |    2     1                                                               |             
      Renal Tubule, Regeneration           |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
      Wall, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    4           2  2                                                  2   |      5  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |          2                                                               |      7  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    | 2                 4        4              X                 2     2      |     12  3.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X              X     X  X  X  X  X           X  X           X  X     X   |     28  2.0|
      Fatty Change                         |          2     2  1           1           1        1  3  3        1     1|     20  1.8|
      Granuloma                            |       1                             3                             2      |      5  2.2|
      Hepatodiaphragmatic Nodule           |    X                                      X                              |      4     |
      Necrosis, Focal                      |    2           1                          2  1              1            |     14  1.6|
      Bile Duct, Hyperplasia               | 1        2     2  2     1     2  1           2     3           2  2     2|     21  1.9|
      Periductular, Inflammation, Chronic  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +     +                                   +   |   5        |
      Granuloma                            |                                                                      2   |      1  2.0|
      Fat, Necrosis                        |                         4  4     4                                   4   |      5  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                3                                   2  2                  |      5  2.6|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  3.5|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Thrombosis                    |                                           X                              |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    2                                      3                              |      3  2.7|
      Hyperkeratosis                       |                                           3                              |      1  3.0|
      Inflammation, Chronic Active         |                                           2                              |      2  3.0|
      Mineralization, Focal                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Mineralization, Focal                |          2                                                              3|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1  3     2  2  1  3  2     2  2              2           2|     27  2.0|
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  4.0|
      Atrium Right, Thrombosis             |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      X                                                   |      1     |
      Cytoplasmic Alteration, Focal        |                                                 2        2               |      5  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |                            3                                3            |      7  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  +  I  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                3  2     4                                                |      7  3.4|
      Pars Distalis, Cyst                  |       X  X                    X  X  X  X     X  X  X  X     X        X  X|     23  3.0|
      Pars Distalis, Hyperplasia, Focal    | 2                                   2                 3              3   |      8  2.6|
      Pars Intermedia, Angiectasis         |       4                                                        4         |      3  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                     X                                    |      2  4.0|
      C-Cell, Hyperplasia                  |       3                    1        4                 3        4  4  2   |     12  3.1|
      Follicle, Cyst                       |                                              X                           |      2     |
      Follicle, Hyperplasia, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +|  39        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           |                                                                   3      |      1  3.0|
      Hemorrhage                           |                               4                                          |      1  4.0|
      Hypertrophy                          |                                                 3                        |      1  3.0|
      Inflammation, Acute                  | 2                       2                                                |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |             2                                         1                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                         2        2                                       |      2  2.0|
      Cyst                                 | X                                                        X               |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                4                                                         |      1  4.0|
      Dilatation                           |                                                                          |      4  3.3|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      2     |
      Endometrium, Cyst                    |                                                                          |      1     |
      Endometrium, Hyperplasia             |                                              4                           |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            3                                             |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Congestion              |    2                                                                     |      1  2.0|
      Pancreatic, Angiectasis              |                            4                                             |      1  4.0|
      Pancreatic, Congestion               |                                                                          |      1  2.0|
      Renal, Congestion                    |                                                                          |      2  2.0|
      Renal, Granuloma                     |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  I  +  +|  43        |
      Angiectasis                          |                                                                          |      2  3.0|
      Infiltration Cellular, Plasma Cell   | 3  4  4        4     3  2  3  3     3        3              3  3         |     29  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                               3                                          |      2  2.5|
      Granuloma                            |                                     2                                2   |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Pigmentation                         |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          2               |      2  2.0|
      Hematopoietic Cell Proliferation     |                   2     2  4  2           3  2           2        2  2  2|     18  2.2|
      Pigmentation, Hemosiderin            |             3                                                           2|      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Ectasia                              |    3  4                       3                 3                        |      7  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |    X  X                 X        4                             X     X   |     12  3.5|
      Inflammation, Focal, Subacute        |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             2                                                            |      1  2.0|
      Hemorrhage                           |             2                                                            |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +        +  +  +  +  +  M  M  +        +  +     M     M  +  +  M   |  30        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +        +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +|  38        |
      Degeneration                         |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             3                                            1               |      4  2.0|
      Granuloma                            |       2                                                                  |      3  2.0|
      Hemorrhage, Focal                    |    2        3                                                            |      3  2.7|
      Alveolar Epithelium, Metaplasia      | 2                                                                        |      4  2.3|
      Artery, Thrombosis                   |                                                                          |      1     |
      Peribronchial, Inflammation, Chronic | 2  2        2  2  2  2  1  2  2  2  2        2              2  1  2  1  2|     32  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |       3        2     3              2  2                 1               |     20  2.2|
      Metaplasia, Squamous                 | 2  2  3  2     2  3  2  2  2  2  2  3        2  2  2  2     2  3  2  3   |     41  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                    +  +                 +|   6        |
      Cataract                             |                               1                                          |      1  1.0|
      Retinal Detachment                   |                                                                          |      1  4.0|
      Cornea, Inflammation, Acute          |    4                                                                     |      1  4.0|
      Vitreous, Degeneration               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6|            |
                                           | 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .16 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |                                           4                              |      2  2.5|
      Inflammation, Chronic                |                                           3                              |      1  3.0|
      Mineralization                       |          1     1        1        1                          1            |     13  1.3|
      Nephropathy                          | 1  3  3  1     1  3  1  3  2  2  2  2  2  4  2  1  2  2  1  1  1  2  3  2|     45  2.0|
      Renal Tubule, Cyst                   |                                                                          |      2     |
      Renal Tubule, Pigmentation           |                                                          2               |      3  1.7|
      Renal Tubule, Regeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Transitional Epithelium, Hyperplasia |                                                                         4|      1  4.0|
      Wall, Inflammation, Chronic Active   |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic Active                  |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    2                             4           4     2  4              2   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 2                 2     3                                   4            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Basophilic Focus                     |                         X        2        2              2        1  2   |             
      Congestion                           |                               3                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change                         |    1  3  3  3     1     1  2        2  3  2     2        3        1      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
      Necrosis, Focal                      |    1        1     2     1        2              2        2  1     2  1   |             
      Bile Duct, Hyperplasia               | 3  1  2     2  2  2  4  3  2     2  3     3  1  2  3     2  3  3     3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 1  1  2                 1  4     2  2  1        3  2  4  3        2      |             
      Acinus, Hyperplasia                  |                      4                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |             3                             2           2                  |             
      Hyperplasia, Basal Cell              |             3                                                            |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |          4  4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3  2     2  2  3  2  3  3  3     4  2     2  3  3  4  3  2  2     2  2|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                       3                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |       4        2                    3              2                     |             
      Hyperplasia, Focal                   |                   2                                            2         |             
      Vacuolization Cytoplasmic            |                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             3                                                  3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3        2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                  3        2        3     4           2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2           3     2                 2     2  3  2           2   |             
      Follicle, Cyst                       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                    4     3               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                   4      |             
      Inflammation, Chronic                | 1  2  2  2     2  1  2  2  2     3  2     3  2     3                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                            4                             2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2              2  1                 2           1                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3        4  4     3           3  3  3     3  4     4           3      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                3     3              3           4              4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Angiectasis                |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                  3                                       |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Mediastinal, Congestion              |       2                                                           1      |             
      Pancreatic, Congestion               |                                                                   1      |             
      Renal, Congestion                    |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                  4                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           4                              |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |    3  3  3     3  3  3  3        4  3  3           3     3  3     3  3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                          4      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                         2                                                |             
      Hematopoietic Cell Proliferation     |       3                    3              3                              |             
      Necrosis                             |                                                       4                  |             
      Pigmentation, Hemosiderin            |    3        3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  M  +  +  M  +  M  M  M  +  +  +  M  M  +  +  +  +  M|             
      Ectasia                              |       3                                                                  |             
      Galactocele                          |                                                                X         |             
      Hyperplasia, Glandular               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Back, Hemorrhage, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                         4|             
      Hydrocephalus                        |    3  2  2              2              2                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Embolus                              |                                                                          |             
      Fungus                               |                                                                          |             
      Granuloma                            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |                      2                                                   |             
      Peribronchial, Inflammation, Chronic | 2  2  2  2  2  2  2  2  2  3     2  2  2  2     2  2     2  2     2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     3                                    |             
      Fungus                               |                                           4     3                        |             
      Inflammation, Chronic                | 3              2  2  2  3  2  3  1  3  2     2  4  2     2  2  1  2  3   |             
      Inflammation, Chronic Active         |                                           3                              |             
      Metaplasia, Squamous                 | 3        2     2  2  2  3        1  3        4  3  4  2  3  3  3  2  3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
      Inflammation, Chronic, Focal         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                    +|             
      Cataract                             |    2                                                                     |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +  +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       1                  |             
      Mineralization                       |                                                       1                  |             
      Nephropathy                          | 2  2  4  4  4  2  2  2  2  1     4  3  2  3  2  2  2  3  2  2  3  2  2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|             
                                           | 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cyst                   |                      X                                               X   |             
      Renal Tubule, Hyperplasia            |                                  2                 1                     |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |          4        4                 4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             2  2     2                                                   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                4  3           3              4                           |     10  3.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | 2           4  2  3                                         4           2|     10  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    1           2                             2     1           1         |     11  1.6|
      Congestion                           |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |    2                             2                                       |      2  2.0|
      Fatty Change                         |       2     2  2        2  2  2        1     2  1           2  1  1  3  3|     27  2.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis, Focal                      | 1           2  1  1              1  1        1     2           1  1      |     20  1.4|
      Bile Duct, Hyperplasia               | 2  2     3  4  2  2  2     3     2  2  4  3  1  2  3  2  2  3  2  2  2   |     40  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Acinus, Atrophy                      | 3           3                    2  3  2  3  4        2           2  3   |     23  2.4|
      Acinus, Hyperplasia                  |                               3           4        4        3            |      5  3.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                      3                                                   |      1  3.0|
      Hyperkeratosis                       |                      3                                                   |      4  2.5|
      Hyperplasia, Basal Cell              |                                                                          |      1  3.0|
      Inflammation, Focal                  |                      2                                   2               |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    3  3  2     3  2  3  2  4  3        2  3     2     2  3     2  1     4|     37  2.6|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                         2|      1  2.0|
      Atrium, Thrombosis                   |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                  X                                       |      1     |
      Cytoplasmic Alteration, Focal        | 2              2                                                         |      6  2.5|
      Hyperplasia, Focal                   | 2                                                                        |      3  2.0|
      Vacuolization Cytoplasmic            |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |       3                                         3           3     2      |      6  2.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                         3                              |      4  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  41        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                               3                                      2   |      2  2.5|
      Pars Distalis, Cyst                  |                                        X                                 |      1     |
      Pars Distalis, Hemorrhage            |                                                                         4|      1  4.0|
      Pars Distalis, Hyperplasia, Focal    | 3     3  2              2                          3  3                  |     11  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |    2                                               2                     |     10  2.2|
      Follicle, Cyst                       |                                                             X            |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Atrophy                              |    4                                                                     |      1  4.0|
      Ectasia                              |                                                                          |      2  3.5|
      Hyperplasia                          | 3                                                                        |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                | 3     2  2        2  3           2  1     2  4  3     1  1  2     1     2|     29  2.1|
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  3.0|
      Inflammation, Acute                  |                      2                                3                 3|      3  2.7|
      Inflammation, Chronic                |             2  1                          2                              |      8  1.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  3  3        4  4           4     4  4  4        2  3     4  4  3  3   |     27  3.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Seminiferous Tubule, Atrophy         |       4                 2                                   4            |      8  3.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Angiectasis                |                                              4                           |      1  4.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  3.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                           4                              |      1  4.0|
      Mediastinal, Congestion              |                               3                                          |      3  2.0|
      Pancreatic, Congestion               |                                                                          |      1  1.0|
      Renal, Congestion                    |                                                 3                        |      1  3.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                           4                              |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M|  45        |
      Angiectasis                          |                                  4                                3      |      3  3.7|
      Congestion                           |                                     3        2                           |      2  2.5|
      Infiltration Cellular, Plasma Cell   |    4        3  2        3     2     3     3  2     3  4           3      |     26  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                           2                              |      1  2.0|
      Pigmentation, Hemosiderin            |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                   2      |      1  2.0|
      Fibrosis, Focal                      |                   2              2                                       |      3  2.0|
      Hematopoietic Cell Proliferation     |                      2                                4              3   |      6  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                            2                                            3|      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  M  M  +  M  M  +  +  +  M|  33        |
      Ectasia                              |                                                                          |      1  3.0|
      Galactocele                          |                                                                          |      1     |
      Hyperplasia, Glandular               |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Cyst Epithelial Inclusion            |                                  X                                       |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +  +                                +            |   4        |
      Back, Hemorrhage, Focal              |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                         2                                2              4|      4  3.0|
      Hydrocephalus                        |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            I                                             |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                         3|      2  3.0|
      Embolus                              |                                                    3                     |      1  3.0|
      Fungus                               |                                              X                           |      1     |
      Granuloma                            |                                              4                           |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                                                                          |      1  2.0|
      Peribronchial, Inflammation, Chronic | 2           2     2  2        2  2  2     2  2  2  2           1  2  2   |     34  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5|            |
                                           | 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |                                              X                           |      3  3.5|
      Inflammation, Chronic                | 2  2  2  1     2  3  2  2  2  2  2  2     3  4     4     3  3  2         |     36  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 | 2  2  2  2  2  2  2              2  2  1  3  3  2  4        4  2  3      |     34  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                       +              +               |   5        |
      Cataract                             |                   2                       4                              |      3  2.7|
      Retina, Degeneration                 |                   4                                                      |      1  4.0|
      Sclera, Mineralization, Focal        |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                         3|      2  2.0|
      Mineralization                       |                               2                                          |      2  1.5|
      Nephropathy                          | 1  3  1  2  2  3  4  2  2  2  4  3  4  2  2  1  2  2  3  3  2  3  2  2   |     48  2.4|
      Renal Tubule, Cyst                   |                                                                          |      2     |
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation           |                                                             3            |      1  3.0|
      Renal Tubule, Regeneration           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Concretion                           |                         4                                                |      4  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +              +           M  +              +              +|             
      Foreign Body                         |                                                                          |             
      Perforation                          |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  +  +              +           A  +              +              +|             
      Parasite Metazoan                    |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  M              +           +  +              +              +|             
      Parasite Metazoan                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    M  +  +  +              +           +  +              +              +|             
      Parasite Metazoan                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +           +  +           A  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +           +  +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +     +  +     +     +     +  +|             
      Basophilic Focus                     |    1  1                    1              1     1                    2  1|             
      Congestion                           |                                                          4               |             
      Cytoplasmic Alteration, Focal        |                                                    2           2         |             
      Fatty Change                         |       1  1        1     3  2           2  2              2              2|             
      Hepatodiaphragmatic Nodule           |                            3                                             |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |    1                                                           3         |             
      Bile Duct, Hyperplasia               |    1  2        2  1  2  2  3  4     3  2  2     2  3     2              2|             
      Centrilobular, Necrosis, Focal       |                                                          2               |             
      Serosa, Proliferation                |                                           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +  +                                   +|             
      Fat, Necrosis                        |                                  3  4                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +     +     +     +  +              +           +  +|             
      Acinus, Atrophy                      |       3                    2     3                                       |             
      Duct, Hyperplasia, Focal             |                                           2                              |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                       +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +           +  +  +        +  +              +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +           +  +  +        +  +              +     +        +|             
      Acanthosis                           |    4                       2           2                                 |             
      Hyperkeratosis                       |    3                       3           2                                 |             
      Hyperplasia, Basal Cell              |                               1                                          |             
      Ulcer                                |    3                    4                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +           +  +  +        +  +              +     +        +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +              +        +  +  +              +     +        +|             
      Cardiomyopathy                       |    3  3  3  3              2           3  4              4     4        3|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Chronic                |                                                          3               |             
      Pigmentation, Hemosiderin            |                                                          2               |             
      Atrium, Dilatation                   |                                     4                          4         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                      2   |             
      Hyperplasia, Focal                   |                                  1                             2        2|             
      Vacuolization Cytoplasmic            |       2     3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2  2           2                       3                                 |             
      Thrombosis                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +     +     +     +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                   X                                                      |             
      Pars Distalis, Hemorrhage            |       3                                                                  |             
      Pars Distalis, Hyperplasia, Focal    |                                              2  2  2  1                  |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2        2           1              1            |             
      Follicle, Cyst                       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +              +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +              +     +     +  +        +     +              +|             
      Abscess                              |                                  3                                       |             
      Inflammation, Chronic                |          2                       3                                      2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +              +           +  +              +              +|             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |    2        4                                                            |             
      Inflammation, Chronic                |          2                 2                                            2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +     +        +  +  +     +  +           +  +              +|             
      Atrophy                              |          3        3        2  3  4        2           4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Necrosis                             |                                                                         2|             
      Interstitial Cell, Hyperplasia       |             2                                                            |             
      Seminiferous Tubule, Atrophy         |             4                          2                                4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +              +           +  +              +              +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +        +  +  +  +  +  +  +        +     +  +        +  +|             
      Axillary, Congestion                 |                                                                          |             
      Lumbar, Congestion                   |                                                                          |             
      Mediastinal, Congestion              |             3                 3     3              2                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |    2        4                                                            |             
      Pancreatic, Congestion               |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +        +  +           +  +              +  +        +  +|             
      Congestion                           |                         2                                                |             
      Infiltration Cellular, Plasma Cell   |    3  4        4        3  3           3                    3        4  3|             
      Lymphatic, Angiectasis               |                4        3                                               3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +              +     +     +  +              +              +|             
      Congestion                           |                                                                         3|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +     +  +  +  +  +  +     +  +     +     +     +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                                                                2     4   |             
      Hematopoietic Cell Proliferation     |             3                          2  2                             4|             
      Pigmentation, Hemosiderin            |          2                 2     2                       3               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +              M           +  +              +               |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  M  +  +     +     +           +  +           +  +              +|             
      Galactocele                          |                X                       X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +              +     +     +  +              +           +  +|             
      Subcutaneous Tissue, Necrosis        |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +              +           +  +              +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           M                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +              +           +  +              +              +|             
      Hemorrhage, Focal                    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +              +  +     +  +  +              +              +|             
      Congestion                           |    2  4                                2                 4               |             
      Edema                                |                                                          2               |             
      Foreign Body                         |                                                                          |             
      Granuloma                            |          3                                                               |             
      Hemorrhage, Focal                    |       3                                   2                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal                           |                                                                          |             
      Peribronchial, Inflammation, Chronic |       2  2                                2                             2|             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +              +           +  +              +              +|             
      Fungus                               |    3                                                                     |             
      Hemorrhage, Focal                    |                                        2                                 |             
      Inflammation, Acute                  |                            4                                             |             
      Inflammation, Chronic                |    3  1  2                                2              2              1|             
      Metaplasia, Squamous                 |                            3                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +              +           +  +              +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       | 1           2        2           1                                       |             
      Nephropathy                          | 4  4  2  4  1  4  2  2  4  3  3  3  2  3  2  2  2  2  2  2  3  4  2  3  2|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Pelvis, Inflammation, Acute          |             4                                                  3         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                2                                               2     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .01 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cyst                   |             X                                                            |             
      Renal Tubule, Hyperplasia            |                         1                                               3|             
      Renal Tubule, Pigmentation           |          2           3                                                  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  A  +  +              +           A  +              +              +|             
      Concretion                           |                                                                          |             
      Lumen, Thrombosis                    |             X                                                            |             
      Transitional Epithelium, Hyperplasia |             3                                                            |             
      Wall, Inflammation, Acute            |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +                                      +  +  +              +|  13        |
      Foreign Body                         |                                                    3                     |      1  3.0|
      Perforation                          |                                                    X                     |      1     |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +                                         +  +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +                                         +  +           +  +|  12        |
      Parasite Metazoan                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +                                         +  +           +  +|  13        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                         +  +              +|  12        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +              +              +           +  +              +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +              +                          +  +              +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +              +              +           A  +              +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             M              +                          +  +              +|  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +  +  +           +        +        +  +  +           +  +|  31        |
      Basophilic Focus                     |                2     1                             2                     |     10  1.3|
      Congestion                           |                                                    3                     |      2  3.5|
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.0|
      Fatty Change                         |             2  2                 2                       2              3|     14  1.9|
      Hepatodiaphragmatic Nodule           |    X                                                                 X   |      3  3.0|
      Hyperplasia, Focal                   |                   2                                                      |      1  2.0|
      Necrosis, Focal                      |                                                                      2   |      3  2.0|
      Bile Duct, Hyperplasia               |    2           4  2              2        2        3     2           1  3|     24  2.3|
      Centrilobular, Necrosis, Focal       |                                                                          |      1  2.0|
      Serosa, Proliferation                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   5        |
      Fat, Necrosis                        |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +                                         +  A              +|  18        |
      Acinus, Atrophy                      |                                                                          |      3  2.7|
      Duct, Hyperplasia, Focal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +                                         +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +           +                             +  +     +     +  +|  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +           +                             +  +           +  +|  18        |
      Acanthosis                           |                                                                          |      3  2.7|
      Hyperkeratosis                       |                                                                          |      3  2.7|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                      4   |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +           +                             +  +     +     +  +|  19        |
      Infiltration Cellular, Lymphocyte    |                         4                                      4         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +                                         +  +              +|  15        |
      Cardiomyopathy                       |             3                                         2  3              4|     14  3.1|
      Hemorrhage, Focal                    |                                                          2               |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Atrium, Dilatation                   |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                               1                                2         |      5  1.6|
      Vacuolization Cytoplasmic            |          2              2  3        2                                1  3|      8  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  45        |
      Hyperplasia, Focal                   |                                                                          |      4  2.3|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +                                         +  A              +|  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    | 2              1  3     4        3  1              4     2     3         |     13  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                   3      |      1  3.0|
      Pars Intermedia, Cyst                |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                         4     2           4  3  2                 1      |     10  2.2|
      Follicle, Cyst                       |                                              X                 X         |      3     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +                                         +  +              +|  14        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                    +                    +  +        +     +|  17        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |             3                                            2              3|      6  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +                                            +  +           +|  13        |
      Abscess                              |                                                             3            |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                          1              2|      5  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        +  +     +  +  +                 +  +        +     +|  23        |
      Atrophy                              |                      3  4     4  4  4                                    |     12  3.3|
      Dilatation                           |                                                       4           3      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|  46        |
      Edema                                |                      4                                                   |      1  4.0|
      Necrosis                             |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                                          3               |      2  2.5|
      Seminiferous Tubule, Atrophy         |                   4                                                      |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +                                         +  +              +|  13        |
      Hyperplasia                          |                                                                         3|      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +        +  +  +     +  +  +        +  +  +  +        +  +  +|  31        |
      Axillary, Congestion                 |                                  4                                       |      1  4.0|
      Lumbar, Congestion                   |                         2                                                |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      4  2.8|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  3.0|
      Pancreatic, Congestion               |                         4                                                |      1  4.0|
      Renal, Congestion                    |                         4  2                                             |      2  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +        +              +  +        +  +  +  +           +  +|  23        |
      Congestion                           |                      4              2           2  3                     |      5  2.6|
      Infiltration Cellular, Plasma Cell   |                      3              2  4        3  4                 4  3|     16  3.3|
      Lymphatic, Angiectasis               |                                     4                                    |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +           +                             +  +              +|  15        |
      Congestion                           |                         4                                                |      2  3.5|
      Infiltration Cellular, Plasma Cell   |                                                                         3|      1  3.0|
      Necrosis                             |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +                 +           +     +     +  +        +  +  +|  28        |
      Congestion                           | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis, Focal                      |                                                                      4   |      1  4.0|
      Fibrosis                             |                               3                                          |      3  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.8|
      Pigmentation, Hemosiderin            |                                                 4                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M           M                          +  M  +           +  +|  11        |
      Congestion                           |                                                    3                 2   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             M                    +           +  +     M  M  +        +  +|  16        |
      Galactocele                          |                                                             X        X   |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +     +        +                    +  +  +              +|  21        |
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +                                         +  +              +|  13        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +  +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +                                         +  +              +|  13        |
      Hemorrhage, Focal                    |             4                                         4  4               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +           +        +  +     +     +  +  +  +     +  +  +  +|  24        |
      Congestion                           |                                     2           2              1         |      7  2.4|
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                    3                     |      1  3.0|
      Granuloma                            |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |             2                                            2               |      4  2.3|
      Infiltration Cellular, Histiocyte    |                                                                      3   |      1  3.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Focal                           |                                  3                                       |      1  3.0|
      Peribronchial, Inflammation, Chronic |                                     2                                    |      5  2.0|
      Pleura, Inflammation, Acute          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +                                         +  +              +|  13        |
      Fungus                               |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                         3|      7  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1|            |
                                           | 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .01 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +                                         +  +              +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +              +                    +|   3        |
      Cataract                             |                                                                         3|      1  3.0|
      Retina, Degeneration                 |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   2        |
      Inflammation, Chronic                |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |             2                                                            |      1  2.0|
      Hyperplasia                          |                                     1                                    |      1  1.0|
      Mineralization                       |       1           2     1     2        1        2  2  2  2     1     1   |     15  1.5|
      Nephropathy                          | 2  3  4  2     3  2  1  2  4  4  2     2  2  4  3  3  2  2  4  4  2  4  2|     48  2.7|
      Artery, Inflammation, Chronic        |                                              4                           |      1  4.0|
      Pelvis, Inflammation, Acute          |                                                                          |      2  3.5|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                         3  3     1           2                           |      7  2.3|
      Renal Tubule, Cyst                   |                                              X                 X         |      3     |
      Renal Tubule, Hyperplasia            |                         1                                            1   |      4  1.5|
      Renal Tubule, Pigmentation           |          2                                                               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             A                                   +     A  +              +|  10        |
      Concretion                           |                                                          4               |      1  4.0|
      Lumen, Thrombosis                    |                                                                          |      1     |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
      Wall, Inflammation, Acute            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    2              1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    3     2        2           2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  1        1     1        1        1  1  X  X           1     X      |             
      Cytoplasmic Alteration, Focal        |                                  2                                       |             
      Fatty Change                         |    1        2        1  1  2        3  2  2              1        1  2  3|             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X  X                                                                  |             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      | 1  1     1                    2        1  2  1     2        1  1  1  1   |             
      Bile Duct, Hyperplasia               | 3  2  2  1  1  2  3  2  2     2  3     2     3  2  3  1     2  2  3     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +              +               |             
      Fat, Necrosis                        |                                                          3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 3        3        2                                                      |             
      Acinus, Hyperplasia                  |                                                                3         |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                      +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Karyomegaly, Focal                   |             2                                         3                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Fibrosis                     |                                                       4                  |             
      Serosa, Inflammation, Chronic Active |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            3                                             |             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Hyperkeratosis                       |                                                       4                  |             
      Hyperplasia, Basal Cell              |                1                                                         |             
      Ulcer                                |                            4     3                                       |             
      Epithelium, Hyperplasia              |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        3     2  1     2  3  2  3  2  4  2  4  3  3  2  2  2  4  1     4|             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                  3              X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                         2                                                |             
      Hyperplasia, Focal                   |                                  1           2                           |             
      Hypertrophy                          |                1                                                         |             
      Vacuolization Cytoplasmic            |                                           1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              3  4  3           2     3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X        X                        |             
      Pars Distalis, Hyperplasia, Focal    |    1                          2  2              2     2                 2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Pars Intermedia, Cyst                |                      X                                                   |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          3     1  3           3              2  1  4                     |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                                     |             
      Dilatation, Focal                    |          3                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                 4  4                     |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  | 2              4                                         2               |             
      Inflammation, Chronic                |             2     2        2  2     1     2  1                    2  3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
      Hyperplasia, Focal                   | 3  3                 2                       3                 3         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 3     2           2                                2     2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                          3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  4        4  3  4  4  4  3        2  2  4  2        4     4  4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                          2     3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                                2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia                  |                      2                                                   |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                           4                              |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   | 4  3  3  3     3  3        3     4     3     2  4  3        4  3  4  4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                         X|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                       2     2  2     2                       3|             
      Pigmentation, Hemosiderin            |                            3           2           3  3  3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  M  +  +  M  +  +  M  M  +  +  M  +  M  M  M  M  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |             2                                                            |             
      Hydrocephalus                        |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                     3                                    |             
      Granuloma                            |                                                 2           2        2   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |                                                                3         |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal                           | 4                                                                 1      |             
      Artery, Ectasia                      |                                                                          |             
      Peribronchial, Inflammation, Chronic | 2  2           1     2  2  2  2           1  2  2  2  2     2     2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |    X                                                                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 3  4     1     1  3           3  2  2  3  2     2           3  2  3  2   |             
      Metaplasia, Squamous                 | 3  3  2  3     3  3  2        3  2           2  2  2        3  3  3     4|             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       M                  |             
      Retina, Degeneration                 |                                                                          |             
      Vitreous, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|             
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .02 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts                                |                                                       4                  |             
      Cytomegaly                           |    1     1                                                               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Mineralization                       | 2  2  2  1     1  3  3  2  2  3     3        3     3     2     3     2  3|             
      Nephropathy                          | 4  4  3  4  2  4     2  3  4  4  4  2  2     4  1  3  4     3  1  3  2  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       2                    3     3           3                           |             
      Renal Tubule, Cyst                   |                               X                                          |             
      Renal Tubule, Hyperplasia            |                   2        1                          2           3      |             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
      Renal Tubule, Pigmentation           |                                           4        2                    1|             
      Renal Tubule, Regeneration           |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                          3               |             
      Wall, Inflammation, Chronic Active   |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  45        |
      Parasite Metazoan                    |                2                                               2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                  3              4                        |      4  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                   2              2  4                       3            |      8  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    1  X        1  X  X        X  X     1        1  1  1        X  1  1   |     26  1.0|
      Cytoplasmic Alteration, Focal        |                      2                                                   |      2  2.0|
      Fatty Change                         |                1           2           2  3  1  1        3        2  2  2|     22  1.8|
      Fibrosis, Focal                      |                               2                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mineralization, Focal                |                               2                                          |      1  2.0|
      Necrosis, Focal                      | 1  1  2                       1  1           1  1     3     2  1        3|     23  1.4|
      Bile Duct, Hyperplasia               | 2  1  3  3     2  3  2  3  3  2  1  3  3  2  2  2  2  4     2  2  3  2   |     42  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +        +        M           +                  |   5        |
      Fat, Necrosis                        |                                  4                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    3        4                          2  2  2              1  2        1|     11  2.3|
      Acinus, Hyperplasia                  | 4     2  4     4                                                         |      5  3.4|
      Artery, Inflammation                 |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Karyomegaly, Focal                   |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Serosa, Fibrosis                     |                                                                          |      1  4.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |          4                                                  1            |      3  2.7|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |          4                                                               |      2  4.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |          3                                                               |      3  3.3|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                          2               |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  3  2  3  4  3  2  4  2  4  2  4  2  3  3  2  3        1  3  2  2  4|     43  2.6|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Atrium, Dilatation                   |                                                    4  4  4               |      3  4.0|
      Atrium, Thrombosis                   |                      4        4              X                           |      5  3.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                 2                        |      2  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Hypertrophy                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |             2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Hyperplasia, Focal                   |    2                       4        2        2                       2   |     10  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M|  43        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Focal    |    2        2     2                       2  2              3     2      |     13  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                   3      |      1  3.0|
      Pars Distalis, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                         4                                                |      1  4.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Nervosa, Cyst                   |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 4                             4     1                 2                  |     11  2.5|
      Follicle, Cyst                       |       X                       X  X           X                           |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  2                                       |      2  2.5|
      Dilatation, Focal                    |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                      2                                                   |      3  3.3|
      Ectasia                              |                                              3                 4         |      2  3.5|
      Inflammation, Acute                  |                   3                                                      |      4  2.8|
      Inflammation, Chronic                | 2  2     2                 2  1  1        2                       3     1|     18  1.8|
      Inflammation, Chronic Active         |                                                                      1   |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                        2                                 |      2  2.5|
      Hyperplasia, Focal                   |                                     2                                    |      6  2.7|
      Inflammation, Acute                  |                                                                4         |      1  4.0|
      Inflammation, Chronic                |                                                                          |      5  2.2|
      Inflammation, Chronic Active         |                                                                      2   |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 4  4  4        4     4  4        4  4  2     4     2  4                  |     29  3.6|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         |                            1                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             3     3                    2              3  3               |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Hyperplasia                  |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                      4  2                    3                           |      3  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  4.0|
      Pancreatic, Pigmentation, Hemosiderin|                3                                                         |      1  3.0|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  44        |
      Angiectasis                          |       3     3                                                            |      2  3.0|
      Congestion                           |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Plasma Cell   | 3  3  3  3     2        2  3  2  3           2  3     3     4            |     29  3.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                           4  3                           |      2  3.5|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                         4  4                                             |      2  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                           2                              |      1  2.0|
      Fibrosis, Focal                      | 3                                                                        |      1  3.0|
      Hematopoietic Cell Proliferation     |                         4              2                                 |      8  2.4|
      Pigmentation, Hemosiderin            |          3                 3              3                       2  2  3|     11  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  I  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  +  M  M  M  M  M  M  +  M  +  +  +  M  M  +  +  M  +|  23        |
      Hemorrhage                           |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                         X                    X                           |      3     |
      Hyperkeratosis                       |                                                       4                  |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                           1                             1|      3  1.3|
      Hydrocephalus                        |          3                 3                                   2     3   |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           4                             4|      2  4.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Granuloma                            |                                                                   4      |      4  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                                              2                           |      2  2.5|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05028-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 08:33:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2|            |
                                           | 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .02 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                                                          |      2  2.5|
      Artery, Ectasia                      |                                              4                           |      1  4.0|
      Peribronchial, Inflammation, Chronic | 2  1  2  2  2  3     2  2  2  2  2        2  2  2  2        1            |     32  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |                                              X                           |      2     |
      Inflammation, Acute                  |                                              3                           |      1  3.0|
      Inflammation, Chronic                | 3     2        3  2        3  3  2  3  1  2           3     3  3     2  1|     30  2.4|
      Metaplasia, Squamous                 | 4  2  2  2     3  2  4     3  4  3  3        3  2  2  3     3  3         |     33  2.8|
      Lymphatic, Angiectasis               |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +              +                                 |   2        |
      Retina, Degeneration                 |                         3                                                |      1  3.0|
      Vitreous, Hemorrhage                 |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts                                |                                                                      1   |      2  2.5|
      Cytomegaly                           |                                                                          |      2  1.0|
      Hyperplasia                          |                                                       1                  |      1  1.0|
      Inflammation, Chronic                |                                                                      1   |      2  1.5|
      Mineralization                       | 2        2  3  2        3  3           1  2  3     3  3  3  2  4  2      |     32  2.4|
      Nephropathy                          | 3  2  3  3  3  2  2  4  3  3  4  3  2  2  2  4  3  4  3  2  4  3  3  1  1|     47  2.9|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     | 2                             2                             2            |      7  2.4|
      Renal Tubule, Cyst                   |                                                                          |      1     |
      Renal Tubule, Hyperplasia            | 2  2           2              2                 2           2     1      |     11  1.9|
      Renal Tubule, Necrosis, Focal        |                                                                         2|      1  2.0|
      Renal Tubule, Pigmentation           |                                           2                       2      |      5  2.2|
      Renal Tubule, Regeneration           |                                                                      2  2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +|  46        |
      Concretion                           |                            4                 3                           |      2  3.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
      Wall, Inflammation, Chronic Active   |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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