TDMS Study 05031-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 01 TIME: 16:34:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: D. GOODMAN S. EUSTIS CAS: 7487-94-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 01 TIME: 16:34:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: D. GOODMAN S. EUSTIS CAS: 7487-94-7
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 01 TIME: 16:34:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: D. GOODMAN S. EUSTIS CAS: 7487-94-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF MERCURIC CHLORIDE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Kidney: Renal Tubule Carcinoma or Adenoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/49 (2%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.6% 0.0% 3.2% | 0.0% 0.0% 3.2% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 1/31 (3%) | 0/41 (0%) 0/34 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399N P=0.238N P=0.552N | P=0.234 (e) P=0.444 |
|INCIDENTAL TUMOR | P=0.399N P=0.238N P=0.552N | P=0.234 (e) P=0.444 |
|LOGISTIC REGRESSION | P=0.399N P=0.238N P=0.552N | P=0.234 (e) P=0.444 |
|COCHRAN-ARMITAGE | P=0.366N | P=0.273 |
|FISHER EXACT | P=0.247N P=0.508N | (e) P=0.505 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 2.8% 7.9% 3.2% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 1/36 (3%) 2/36 (6%) 1/31 (3%) | 0/41 (0%) 1/35 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 509 729 (T) | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.564 P=0.307 P=0.728 | P=0.691 P=0.468 (e) |
|INCIDENTAL TUMOR | P=0.582N P=0.366 P=0.728 | P=0.691 P=0.468 (e) |
|LOGISTIC REGRESSION | P=0.592 P=0.304 P=0.728 | P=0.691 P=0.468 (e) |
|COCHRAN-ARMITAGE | P=0.610 | P=0.731 |
|FISHER EXACT | P=0.309 P=0.753N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.8% 7.9% 3.2% | 0.0% 2.9% 3.2% |
|TERMINAL (d) | 1/36 (3%) 2/36 (6%) 1/31 (3%) | 0/41 (0%) 1/35 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 509 729 (T) | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.564 P=0.307 P=0.728 | P=0.275 P=0.468 P=0.444 |
|INCIDENTAL TUMOR | P=0.582N P=0.366 P=0.728 | P=0.275 P=0.468 P=0.444 |
|LOGISTIC REGRESSION | P=0.592 P=0.304 P=0.728 | P=0.275 P=0.468 P=0.444 |
|COCHRAN-ARMITAGE | P=0.610 | P=0.331 |
|FISHER EXACT | P=0.309 P=0.753N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/49 (4%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 1/31 (3%) | 0/40 (0%) 0/35 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 642 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.083 (e) P=0.212 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.145 (e) P=0.295 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.089 (e) P=0.224 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.093 | (e) |
|FISHER EXACT | (e) P=0.242 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/49 (6%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 9.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 2/31 (6%) | 0/40 (0%) 0/35 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 642 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029 * (e) P=0.100 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.054 (e) P=0.141 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.032 * (e) P=0.107 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.036 * | (e) |
|FISHER EXACT | (e) P=0.117 | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 5.6% 2.8% 3.2% | 2.4% 0.0% 5.8% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 1/31 (3%) | 1/41 (2%) 0/35 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 729 (T) --- 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.424N P=0.500N P=0.552N | P=0.298 P=0.532N P=0.416 |
|INCIDENTAL TUMOR | P=0.424N P=0.500N P=0.552N | P=0.358 P=0.532N P=0.513 |
|LOGISTIC REGRESSION | P=0.424N P=0.500N P=0.552N | P=0.335 P=0.532N P=0.465 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.360 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 6/50 (12%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 13.5% 8.3% 19.4% | 4.9% 2.9% 0.0% |
|TERMINAL (d) | 4/36 (11%) 3/36 (8%) 6/31 (19%) | 2/41 (5%) 1/35 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 699 729 (T) 729 (T) | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.339 P=0.360N P=0.396 | P=0.192N P=0.555N P=0.302N |
|INCIDENTAL TUMOR | P=0.346 P=0.357N P=0.405 | P=0.192N P=0.555N P=0.302N |
|LOGISTIC REGRESSION | P=0.351 P=0.364N P=0.409 | P=0.192N P=0.555N P=0.302N |
|COCHRAN-ARMITAGE | P=0.432 | P=0.142N |
|FISHER EXACT | P=0.357N P=0.500 | P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 4/50 (8%) 6/50 (12%) | 3/50 (6%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 18.9% 11.1% 19.4% | 7.3% 2.9% 5.8% |
|TERMINAL (d) | 6/36 (17%) 4/36 (11%) 6/31 (19%) | 3/41 (7%) 1/35 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 699 729 (T) 729 (T) | 729 (T) 729 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.542N P=0.264N P=0.615N | P=0.505N P=0.363N P=0.615N |
|INCIDENTAL TUMOR | P=0.536N P=0.261N P=0.607N | P=0.454N P=0.363N P=0.541N |
|LOGISTIC REGRESSION | P=0.528N P=0.268N P=0.601N | P=0.462N P=0.363N P=0.569N |
|COCHRAN-ARMITAGE | P=0.437N | P=0.399N |
|FISHER EXACT | P=0.262N P=0.500N | P=0.309N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 4/50 (8%) 6/50 (12%) | 3/50 (6%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 18.9% 11.1% 19.4% | 7.3% 2.9% 5.8% |
|TERMINAL (d) | 6/36 (17%) 4/36 (11%) 6/31 (19%) | 3/41 (7%) 1/35 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 699 729 (T) 729 (T) | 729 (T) 729 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.542N P=0.264N P=0.615N | P=0.505N P=0.363N P=0.615N |
|INCIDENTAL TUMOR | P=0.536N P=0.261N P=0.607N | P=0.454N P=0.363N P=0.541N |
|LOGISTIC REGRESSION | P=0.528N P=0.268N P=0.601N | P=0.462N P=0.363N P=0.569N |
|COCHRAN-ARMITAGE | P=0.437N | P=0.399N |
|FISHER EXACT | P=0.262N P=0.500N | P=0.309N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 4/50 (8%) | 2/50 (4%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 16.7% 22.2% 12.9% | 4.9% 12.4% 9.7% |
|TERMINAL (d) | 6/36 (17%) 8/36 (22%) 4/31 (13%) | 2/41 (5%) 2/35 (6%) 3/31 (10%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 729 (T) 673 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.420N P=0.384 P=0.466N | P=0.284 P=0.179 P=0.373 |
|INCIDENTAL TUMOR | P=0.420N P=0.384 P=0.466N | P=0.405 P=0.317 P=0.373 |
|LOGISTIC REGRESSION | P=0.420N P=0.384 P=0.466N | P=0.342 P=0.209 P=0.373 |
|COCHRAN-ARMITAGE | P=0.322N | P=0.421 |
|FISHER EXACT | P=0.387 P=0.370N | P=0.218 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 11.1% 0.0% 6.5% | 2.4% 7.6% 5.0% |
|TERMINAL (d) | 4/36 (11%) 0/36 (0%) 2/31 (6%) | 1/41 (2%) 2/35 (6%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 729 (T) 400 573 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.265N P=0.063N P=0.407N | P=0.326 P=0.266 P=0.435 |
|INCIDENTAL TUMOR | P=0.265N P=0.063N P=0.407N | P=0.468 P=0.321 P=0.579 |
|LOGISTIC REGRESSION | P=0.265N P=0.063N P=0.407N | P=0.453 P=0.328 P=0.531 |
|COCHRAN-ARMITAGE | P=0.222N | P=0.399 |
|FISHER EXACT | P=0.059N P=0.339N | P=0.309 P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 8/50 (16%) 6/50 (12%) | 3/50 (6%) 8/50 (16%) 5/50 (10%) |
|ADJUSTED (b) | 27.8% 22.2% 19.4% | 7.3% 19.4% 14.2% |
|TERMINAL (d) | 10/36 (28%) 8/36 (22%) 6/31 (19%) | 3/41 (7%) 4/35 (11%) 3/31 (10%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 729 (T) 400 573 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251N P=0.393N P=0.303N | P=0.185 P=0.075 P=0.235 |
|INCIDENTAL TUMOR | P=0.251N P=0.393N P=0.303N | P=0.341 P=0.159 P=0.308 |
|LOGISTIC REGRESSION | P=0.251N P=0.393N P=0.303N | P=0.304 P=0.104 P=0.310 |
|COCHRAN-ARMITAGE | P=0.170N | P=0.314 |
|FISHER EXACT | P=0.398N P=0.207N | P=0.100 P=0.357 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 4/49 (8%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | | 9.8% 2.9% 2.9% |
|TERMINAL (d) | | 4/41 (10%) 1/34 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) 670 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.161N P=0.239N P=0.272N |
|INCIDENTAL TUMOR | | P=0.126N P=0.239N P=0.205N |
|LOGISTIC REGRESSION | | P=0.131N P=0.239N P=0.225N |
|COCHRAN-ARMITAGE | | P=0.098N |
|FISHER EXACT | | P=0.181N P=0.175N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/47 (0%) 0/47 (0%) | 2/49 (4%) 4/47 (9%) 2/45 (4%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% | 4.9% 11.8% 5.8% |
|TERMINAL (d) | 1/34 (3%) 0/34 (0%) 0/29 (0%) | 2/41 (5%) 4/34 (12%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 729 (T) 729 (T) 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.289N P=0.500N P=0.532N | P=0.425 P=0.254 P=0.577 |
|INCIDENTAL TUMOR | P=0.289N P=0.500N P=0.532N | P=0.491 P=0.254 P=0.690 |
|LOGISTIC REGRESSION | P=0.289N P=0.500N P=0.532N | P=0.518 P=0.254 P=0.679 |
|COCHRAN-ARMITAGE | P=0.273N | P=0.548 |
|FISHER EXACT | P=0.505N P=0.505N | P=0.319 P=0.659 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 0/47 (0%) 1/47 (2%) | 1/49 (2%) 0/47 (0%) 0/45 (0%) |
|ADJUSTED (b) | 5.9% 0.0% 3.4% | 2.4% 0.0% 0.0% |
|TERMINAL (d) | 2/34 (6%) 0/34 (0%) 1/29 (3%) | 1/41 (2%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401N P=0.238N P=0.556N | P=0.322N P=0.537N P=0.576N |
|INCIDENTAL TUMOR | P=0.401N P=0.238N P=0.556N | P=0.322N P=0.537N P=0.576N |
|LOGISTIC REGRESSION | P=0.401N P=0.238N P=0.556N | P=0.322N P=0.537N P=0.576N |
|COCHRAN-ARMITAGE | P=0.366N | P=0.281N |
|FISHER EXACT | P=0.253N P=0.508N | P=0.510N P=0.521N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 8.3% 0.0% | 0.0% 10.3% 0.0% |
|TERMINAL (d) | 2/36 (6%) 3/36 (8%) 0/31 (0%) | 0/41 (0%) 2/35 (6%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- 673 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.238N P=0.500 P=0.272N | P=0.531 P=0.053 (e) |
|INCIDENTAL TUMOR | P=0.238N P=0.500 P=0.272N | P=0.579N P=0.102 (e) |
|LOGISTIC REGRESSION | P=0.238N P=0.500 P=0.272N | P=0.589 P=0.061 (e) |
|COCHRAN-ARMITAGE | P=0.202N | P=0.622 |
|FISHER EXACT | P=0.500 P=0.247N | P=0.059 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/49 (0%) 0/49 (0%) | 1/49 (2%) 2/50 (4%) 1/48 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.4% 5.0% 2.6% |
|TERMINAL (d) | 0/36 (0%) 0/35 (0%) 0/31 (0%) | 1/41 (2%) 0/35 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 678 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.544 P=0.462 P=0.713 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.456N P=0.726 P=0.696N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.613 P=0.502 P=0.759 |
|COCHRAN-ARMITAGE | (e) | P=0.616 |
|FISHER EXACT | (e) (e) | P=0.508 P=0.747 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 2.8% 3.2% | 2.4% 0.0% 8.6% |
|TERMINAL (d) | 0/36 (0%) 1/36 (3%) 1/31 (3%) | 1/41 (2%) 0/35 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | 729 (T) --- 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299 P=0.500 P=0.470 | P=0.129 P=0.532N P=0.225 |
|INCIDENTAL TUMOR | P=0.299 P=0.500 P=0.470 | P=0.196 P=0.532N P=0.373 |
|LOGISTIC REGRESSION | P=0.299 P=0.500 P=0.470 | P=0.159 P=0.532N P=0.275 |
|COCHRAN-ARMITAGE | P=0.331 | P=0.176 |
|FISHER EXACT | P=0.500 P=0.500 | P=0.500N P=0.309 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 3.2% | 0.0% 0.0% 5.7% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 1/31 (3%) | 0/41 (0%) 0/35 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- --- 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248 (e) P=0.470 | P=0.077 (e) P=0.195 |
|INCIDENTAL TUMOR | P=0.248 (e) P=0.470 | P=0.100 (e) P=0.278 |
|LOGISTIC REGRESSION | P=0.248 (e) P=0.470 | P=0.090 (e) P=0.225 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.095 |
|FISHER EXACT | (e) P=0.500 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | | 4.9% 0.0% 3.2% |
|TERMINAL (d) | | 2/41 (5%) 0/35 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.438N P=0.274N P=0.597N |
|INCIDENTAL TUMOR | | P=0.438N P=0.274N P=0.597N |
|LOGISTIC REGRESSION | | P=0.438N P=0.274N P=0.597N |
|COCHRAN-ARMITAGE | | P=0.360N |
|FISHER EXACT | | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.4% 7.7% 5.7% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/31 (0%) | 1/41 (2%) 1/35 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 678 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.305 P=0.266 P=0.419 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.455 P=0.418 P=0.513 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.362 P=0.296 P=0.467 |
|COCHRAN-ARMITAGE | (e) | P=0.399 |
|FISHER EXACT | (e) (e) | P=0.309 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 2.6% 2.4% 3.2% | 2.4% 10.4% 8.3% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 1/31 (3%) | 1/41 (2%) 2/35 (6%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 695 509 729 (T) | 729 (T) 678 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.606 P=0.751 P=0.725 | P=0.169 P=0.147 P=0.230 |
|INCIDENTAL TUMOR | P=0.563N P=0.686N P=0.744 | P=0.298 P=0.244 P=0.373 |
|LOGISTIC REGRESSION | P=0.634 P=0.763 P=0.744 | P=0.218 P=0.170 P=0.282 |
|COCHRAN-ARMITAGE | P=0.640 | P=0.252 |
|FISHER EXACT | P=0.753N P=0.753N | P=0.181 P=0.309 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 2/50 (4%) 3/50 (6%) | 9/50 (18%) 9/50 (18%) 5/50 (10%) |
|ADJUSTED (b) | 21.0% 4.9% 9.7% | 19.8% 21.9% 13.8% |
|TERMINAL (d) | 6/36 (17%) 0/36 (0%) 3/31 (10%) | 5/41 (12%) 4/35 (11%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 695 456 729 (T) | 560 558 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.083N P=0.055N P=0.155N | P=0.340N P=0.491 P=0.363N |
|INCIDENTAL TUMOR | P=0.053N P=0.032N* P=0.140N | P=0.073N P=0.391N P=0.088N |
|LOGISTIC REGRESSION | P=0.065N P=0.048N* P=0.136N | P=0.170N P=0.600 P=0.188N |
|COCHRAN-ARMITAGE | P=0.055N | P=0.166N |
|FISHER EXACT | P=0.046N* P=0.100N | P=0.602N P=0.194N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 2/50 (4%) 3/50 (6%) | 9/50 (18%) 9/50 (18%) 5/50 (10%) |
|ADJUSTED (b) | 21.0% 4.9% 9.7% | 19.8% 21.9% 13.8% |
|TERMINAL (d) | 6/36 (17%) 0/36 (0%) 3/31 (10%) | 5/41 (12%) 4/35 (11%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 695 456 729 (T) | 560 558 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.083N P=0.055N P=0.155N | P=0.340N P=0.491 P=0.363N |
|INCIDENTAL TUMOR | P=0.053N P=0.032N* P=0.140N | P=0.073N P=0.391N P=0.088N |
|LOGISTIC REGRESSION | P=0.065N P=0.048N* P=0.136N | P=0.170N P=0.600 P=0.188N |
|COCHRAN-ARMITAGE | P=0.055N | P=0.166N |
|FISHER EXACT | P=0.046N* P=0.100N | P=0.602N P=0.194N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 15/50 (30%) 10/50 (20%) | 13/50 (26%) 14/50 (28%) 12/50 (24%) |
|ADJUSTED (b) | 33.9% 40.4% 31.1% | 31.7% 35.1% 32.2% |
|TERMINAL (d) | 11/36 (31%) 14/36 (39%) 9/31 (29%) | 13/41 (32%) 10/35 (29%) 7/31 (23%) |
|FIRST INCIDENCE (DAYS) | 457 509 642 | 729 (T) 632 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.430N P=0.406 P=0.466N | P=0.336 P=0.337 P=0.390 |
|INCIDENTAL TUMOR | P=0.332N P=0.469 P=0.372N | P=0.543 P=0.440 P=0.589N |
|LOGISTIC REGRESSION | P=0.364N P=0.398 P=0.399N | P=0.502 P=0.453 P=0.551 |
|COCHRAN-ARMITAGE | P=0.283N | P=0.455N |
|FISHER EXACT | P=0.412 P=0.318N | P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 11/50 (22%) 12/50 (24%) | 14/50 (28%) 21/50 (42%) 12/50 (24%) |
|ADJUSTED (b) | 51.3% 28.1% 37.5% | 31.0% 46.5% 30.7% |
|TERMINAL (d) | 17/36 (47%) 8/36 (22%) 11/31 (35%) | 10/41 (24%) 11/35 (31%) 5/31 (16%) |
|FIRST INCIDENCE (DAYS) | 695 456 728 | 560 400 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.110N P=0.049N* P=0.152N | P=0.389 P=0.065 P=0.484 |
|INCIDENTAL TUMOR | P=0.072N P=0.026N* P=0.124N | P=0.222N P=0.241 P=0.273N |
|LOGISTIC REGRESSION | P=0.075N P=0.038N* P=0.122N | P=0.409N P=0.100 P=0.448N |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.373N |
|FISHER EXACT | P=0.041N* P=0.066N | P=0.104 P=0.410N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5MG/KG 10MG/KG | CONTROL 5MG/KG 10MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 21/50 (42%) 18/50 (36%) | 23/50 (46%) 32/50 (64%) 19/50 (38%) |
|ADJUSTED (b) | 70.0% 52.4% 54.5% | 51.0% 69.5% 46.8% |
|TERMINAL (d) | 24/36 (67%) 17/36 (47%) 16/31 (52%) | 19/41 (46%) 21/35 (60%) 10/31 (32%) |
|FIRST INCIDENCE (DAYS) | 457 456 642 | 560 400 364 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093N P=0.124N P=0.114N | P=0.375 P=0.023 * P=0.478 |
|INCIDENTAL TUMOR | P=0.036N* P=0.054N P=0.061N | P=0.224N P=0.086 P=0.239N |
|LOGISTIC REGRESSION | P=0.043N* P=0.101N P=0.062N | P=0.341N P=0.043 * P=0.365N |
|COCHRAN-ARMITAGE | P=0.028N* | P=0.242N |
|FISHER EXACT | P=0.115N P=0.035N* | P=0.054 P=0.272N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).