National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3007

TDMS Study 05031-01 Pathology Tables

NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97
Route: GAVAGE                                                                                                     Time: 15:37:58




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|             
                                           | 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  M     +     +  +  +  +     +  +  +  +  +  +     +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +     +     +  M  +  +     +  +  +  +  +  +     +  +  +|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  M  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |    2                          4                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                        1                                 |             
      Eosinophilic Focus                   |    1                                                                     |             
      Inflammation, Acute                  |                                        1                                 |             
      Inflammation, Chronic                |          1              2        4  1                    1        1  3   |             
      Thrombosis                           |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                 +|             
      Inflammation, Chronic                |                                                                         2|             
      Fat, Necrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                                              4                           |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic                |                                                                      3   |             
      Duct, Cyst                           |             X                                X                       X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Hyperkeratosis                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                     +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|             
                                           | 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Degeneration                         |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             |    2  2  3  2  2  1     2     2  2  2  1     2  2  2  2  3  3     2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +     +     +  +  +  +     +  +  M  M  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |             1                                                            |             
      Cyst                                 |    X  X     X  X        X              X                 X           X   |             
      Cyst, Multiple                       |                                     X           X                        |             
      Hyperplasia, Tubular                 |             1                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Cervix, Inflammation, Acute          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3  2  2  3  3        2     3  3  3  3     2  3  2  2  3  3     3  3   |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Myelofibrosis                        |    2  2     3  2        2        3  2  2     1     4  2  1  3     1  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M  +  M  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Fibrosis                |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|             
                                           | 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mediastinal, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                               4                                          |             
      Hyperplasia, Lymphoid                |    3                             2                                   4   |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  +     +     +  +  +  +     M  +  +  +  M  +     +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  M     +     +  +  +  +     +  +  +  +  M  +     +  +  +|             
      Duct, Cyst                           |                                                                         X|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Acanthosis                           |                                  1  1                                    |             
      Cyst                                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Hydrocephalus                        |             2                                                            |             
      Mineralization                       |    2           2              2  3           2  2  2        3        2   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Media, Hypertrophy           |                                                                          |             
      Bronchus, Inflammation, Acute        |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                               1                          2        1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|             
                                           | 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Exudate                              |                                        1                             3   |             
      Inflammation, Acute                  |                               1                                          |             
      Olfactory Epithelium, Metaplasia     |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Nephropathy                          |                                  1  1        2  1     1  1               |             
      Glomerulus, Thrombosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                  2                                       |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|             
                                           | 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  M        +  +  +  M  +  +     +  +  +  +  I  A  +  M  A     +  +|             
      Cyst                                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  A  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +  +  A  +  +     +  +  +  +  +  A  +  +  +     +  +|             
      Serosa, Fibrosis                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  A  +  +  +     +  +|             
      Serosa, Fibrosis                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +        +  +  +  +  +  +     +  +  +  +  M  A  +  +  M     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  A  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +  +  A  +  +     +  +  +  +  +  A  +  +  A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +  +  A  +  +     +  +  +  +  +  A  +  +  +     +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
      Serosa, Fibrosis                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  A  +  +  +     +  +|             
      Serosa, Fibrosis                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Clear Cell Focus                     |                      3                                                   |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         1     1        1        1                        |             
      Thrombosis                           |                                                                2         |             
      Serosa, Fibrosis                     |                                                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                     +                  |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |                                                          4           4   |             
      Eosinophilic Focus                   |                         1                                                |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |                               X                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  M  M     +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
      Erosion                              | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                +  +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                1         |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|             
                                           | 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
      Degeneration                         |                                        3                                 |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             | 2  2  2  2        2  3  2  2  2  2     2  2  3  2  2  2  2           2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M        +  +  +  +  +  +     +  +  +  +  +  +  M  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  I  +  +  +     +  +|             
      Cyst                                 |                                                    X                     |             
      Hyperplasia, Focal                   |                               1        2        3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Follicle, Cyst                       |                                                          X               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
      Angiectasis                          |                                           2                              |             
      Cyst                                 |                      X     X                    X     X                  |             
      Cyst, Multiple                       |    X  X                 X                                X               |             
      Hyperplasia, Tubular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Cervix, Inflammation, Acute          |                                                          1               |             
      Endometrium, Hyperplasia, Cystic     | 1  3  3  3        3  3  2     3  3     3  2  3  3  2     4     1     3  3|             
      Serosa, Fibrosis                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +                 +                                                   |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Myelofibrosis                        | 1  3  2  3        3  1  2     2  2     3  2  2  2  3     2           3  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        M  +  +  +  +  M     +  +  +  +  I  +  +  +  +     +  +|             
      Iliac, Pigmentation                  |                                                                      2   |             
      Inguinal, Hyperplasia, Lymphoid      |                               2                                          |             
      Mediastinal, Fibrosis                |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         3|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|             
                                           | 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mediastinal, Thrombosis              |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  A  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                               3           3        2           2         |             
      Capsule, Fibrosis                    |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +        +  +  +  +  +  +     +  +  +  +  M  M  +  +  M     +  +|             
      Atrophy                              |       2                                                                  |             
      Cyst                                 |                                                          X               |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +  +  +  +  +  +     +  +  +  +  I  +  +  +  +     +  +|             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Acanthosis                           |                                                                         3|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +        +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       | 2  1  3           2  2           3        2           3              2   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Fungus                               |                                                             X            |             
      Hemorrhage                           |          2                                                           1   |             
      Inflammation, Granulomatous          |                                                             3            |             
      Thrombosis                           |                                                                3         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                         3|             
      Artery, Media, Hypertrophy           |                      2                                               2   |             
      Bronchus, Inflammation, Acute        |                      1                                                   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|             
                                           | 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Exudate                              |                                                                          |             
      Inflammation, Acute                  |                            1                                             |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +|             
      Nephropathy                          |    1                 1        1  1     1        1  1                 1   |             
      Glomerulus, Thrombosis               |                                                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 2| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2|                                            |            |
                                           | 4| 9| 5| 4| 4| 1| 3| 4| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  A  +  +     M                                             |  38        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  A  +  +     +                                             |  45        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +     +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  A  +  +     +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +     +                                             |  47        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      2  3.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +     +                                             |  48        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
      Clear Cell Focus                     |                                                                          |      1  3.0|
      Congestion                           |                            1                                             |      2  1.0|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1        1                                                            |     13  1.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                                                               |   6        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis                        |          2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  50        |
      Atrophy                              |                                                                          |      3  4.0|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                                             |  48        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +     +                                             |  48        |
      Erosion                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 2| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2|                                            |            |
                                           | 4| 9| 5| 4| 4| 1| 3| 4| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |    1     1                                                               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Degeneration                         |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |          1                                                               |      1  1.0|
      Subcapsular, Hyperplasia             | 2  2  3  2  3  2  3  2     1                                             |     48  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia, Focal                   |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  M  +  +     +                                             |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  49        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Focal                   |                            2                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  50        |
      Follicle, Cyst                       |                            X                                             |      2     |
      Follicular Cell, Hyperplasia         | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Angiectasis                          |                                                                          |      2  1.5|
      Cyst                                 |    X  X     X  X                                                         |     16     |
      Cyst, Multiple                       |                                                                          |      6     |
      Hyperplasia, Tubular                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  50        |
      Cervix, Inflammation, Acute          |                                                                          |      1  1.0|
      Endometrium, Hyperplasia, Cystic     | 3  3  2  2  3     3  2                                                   |     43  2.7|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       +                                                                  |   4        |
      Hyperkeratosis                       |       4                                                                  |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 2| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2|                                            |            |
                                           | 4| 9| 5| 4| 4| 1| 3| 4| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  50        |
      Myelofibrosis                        | 2  1  1  1  2     2  2     2                                             |     40  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  +  +  +  +  +     +                                             |  44        |
      Iliac, Pigmentation                  |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Fibrosis                |    2                                                                     |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |             4              2                                             |      3  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |    1                                                                     |      1  1.0|
      Mediastinal, Thrombosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                            2                                             |      8  2.6|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +     +                                             |  41        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +     +                                             |  47        |
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Hyperplasia                    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
      Acanthosis                           |                                                                          |      3  1.7|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization                       |    2        1        1                                                   |     21  2.1|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 2| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2|                                            |            |
                                           | 4| 9| 5| 4| 4| 1| 3| 4| 6| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
      Congestion                           |    2                                                                     |      1  2.0|
      Fungus                               |                                                                          |      1     |
      Hemorrhage                           |                            1                                             |      3  1.3|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2                                                      |      2  2.5|
      Artery, Media, Hypertrophy           |                   3        1                                             |      4  2.0|
      Bronchus, Inflammation, Acute        |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  50        |
      Exudate                              |       1                                                                  |      3  1.7|
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Nephropathy                          | 1  1     1  1     2  1     1                                             |     21  1.1|
      Glomerulus, Thrombosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +     +                                             |  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |          2                                                               |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|             
                                           | 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Erosion                              |                1                                                         |             
      Inflammation, Chronic Active         |                1                                                         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  A  +     +  A     M  +|             
      Inflammation, Chronic                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +  +     +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Serosa, Fibrosis                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +     +  +     +  +|             
      Submucosa, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +     +  +|             
      Serosa, Fibrosis                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +  A     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +  +     +  +|             
      Hyperplasia, Lymphoid                |                   4     2                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Angiectasis                          |                                        2                                 |             
      Eosinophilic Focus                   |                                        X                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1        1     2        1                 1  1        3|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                         2|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                         3                                                |             
      Serosa, Fibrosis                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Atrophy                              |                               2                       3                  |             
      Fibrosis                             |    2                                                  4                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                   1              1                                       |             
      Duct, Cyst                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +     +  +|             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Hyperplasia, Squamous                |          2                                                               |             
      Inflammation, Chronic                |                                                                         3|             
      Serosa, Fibrosis                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|             
                                           | 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                              2                           |             
      Ulcer, Multiple                      |                                                                          |             
      Serosa, Fibrosis                     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +  +                             M              +  +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Mineralization                       |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Epicardium, Fibrosis                 |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +     +  +|             
      Congestion                           |                                              1                           |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             | 3  2  3  2  2  2  3  3  3  3  3  3  2  3  3     2  3        2  2     2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +     +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M     +  +     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +     +  +     +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                         1|             
      Follicle, Cyst                       |                   X                                                      |             
      Follicular Cell, Hyperplasia         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                           +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Angiectasis                          |                   2                                                      |             
      Cyst                                 | X        X                    X  X     X        X  X        X  X         |             
      Cyst, Multiple                       |                                                                          |             
      Pigmentation                         |                                                                         3|             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|             
                                           | 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |          2                 2                                             |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |          X                                                               |             
      Cervix, Hyperplasia, Squamous        |          2                                                               |             
      Cervix, Inflammation, Acute          |                                                 1                        |             
      Endometrium, Hyperplasia, Cystic     | 3     2  3     1  3  1  2  3  2  2  3  3  3     3  1  1     1        3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Atrophy                              |                                                                3         |             
      Myelofibrosis                        | 3     3  2        2     1  2  1  1  1  2  1     2  2  2              2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     I  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |          3                                                               |             
      Inguinal, Hyperplasia, Plasma Cell   |                         3                                                |             
      Mandibular, Hyperplasia, Lymphoid    |                         2                                                |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Hematopoietic Cell Proliferation     |          3                                                               |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Capsule, Fibrosis                    |                                                       4                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  M  +  M  +  +  +  +  +     +  +     M  +|             
      Atrophy                              |                3                                      1     2            |             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Acinus, Hyperplasia                  |       2                                                                  |             
      Duct, Cyst                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Acanthosis                           |                                  1                                   1  1|             
      Exudate                              |                                                       1                  |             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Mineralization                       |          2  2           2     2     2              2  2     2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|             
                                           | 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               2                                          |             
      Artery, Media, Hypertrophy           |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                         3     2                                         2|             
      Pleura, Fibrosis                     |                1                                      3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Angiectasis                          |                                                                      2   |             
      Exudate                              | 1  1  2                                   1        1                     |             
      Inflammation, Acute                  |                                                                      1   |             
      Inflammation, Chronic                |                                                                          |             
      Olfactory Epithelium, Metaplasia     | 1  3  2     1     1  2        1           1                    2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +|             
      Nephropathy                          | 1  1  1  1     1  1     1  1     1  1  1  1     1  1  1        1     1  1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                         3                                                |             
      Renal Tubule, Necrosis, Acute        |                2                                                         |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M     +  +     +  +|             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |                                  2                                      3|             
      Transitional Epithelium, Hyperplasia |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|             
                                           | 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +     +  +  +  M  +     +        M  +     +  +  +  +  A|             
      Inflammation, Chronic                |                         2                                   1     1      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Submucosa, Cyst                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  A|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +     A  +  +  +  +     +        +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Acute                  |                                                                2         |             
      Inflammation, Chronic                |    1        2              1     1  1              2        2     1      |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Necrosis                             |                                                    2  2                 1|             
      Pigmentation                         |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Atrophy                              |                4                                                         |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             4            |             
      Inflammation, Chronic                |                                  2                                       |             
      Duct, Cyst                           |                X  X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    M  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|             
                                           | 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                         1                                      2         |             
      Ulcer, Multiple                      |                         1                                                |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Granulomatous                   |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                 +                    +         |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hypertrophy, Focal                   |                                  2                                       |             
      Subcapsular, Hyperplasia             |    2  2  2  3  3  3     1  3  2  2  3     3        2  3     2  3  3  3  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +     M  +  +  +  +     +        +  +     +  +  +  +  +|             
      Hyperplasia, Focal                   |                            2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +     M  +  +  +  +     M        +  +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2              1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Inflammation, Acute                  |                         1                                                |             
      Inflammation, Chronic                |                                  1                                       |             
      Follicle, Cyst                       |    X           X                                                         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  M  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    X           X  X           X                                X  X      |             
      Cyst, Multiple                       |          X              X  X        X                       X            |             
      Pigmentation                         |                                                                          |             
      Interstitium, Hyperplasia            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|             
                                           | 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |                                                                          |             
      Cervix, Hyperplasia, Squamous        |                                                                          |             
      Cervix, Inflammation, Acute          |                1                 1  1              2                     |             
      Endometrium, Hyperplasia, Cystic     |    3  2  1  4  3  4        3  3  3  2     2        2  3     3     2  2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Myelofibrosis                        |    1  2     2  3  3        3  2  2  2              1  1     2     2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    M  +  +  +  +  +     +  +  I  +  +     +        I  I     +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                             4            |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                             4            |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                             4            |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                             4            |             
      Renal, Hyperplasia, Lymphoid         |                                                             4            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                       2     3            |             
      Capsule, Fibrosis                    |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  M  +  +     +  M  +  M  I     +        +  +     +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  M  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Acanthosis                           |                   1        1        1                       1     1      |             
      Exudate                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Mineralization                       |    2     2  2  2        1  2  2  2  2     2                 2     1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|             
                                           | 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5MG/KG                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Fibrosis, Multifocal                 |                            1                                             |             
      Hemorrhage                           |                                     2                                    |             
      Leukocytosis                         |                                                                         2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Media, Hypertrophy           |                                                       2                  |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                1         |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Exudate                              |    1              1                                               1      |             
      Inflammation, Acute                  |    1                                                                     |             
      Inflammation, Chronic                |                                                             1            |             
      Olfactory Epithelium, Metaplasia     |             1     1     1     2           1        2  1     1     1      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Nephropathy                          |    1  1     1  1  1     1  1  2  2  2     1        2  2     1  1  1  1   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +     +  +  +  +  +     +        +  +     +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3|                                            |            |
                                           | 9| 3| 9| 3| 6| 6| 3| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +        +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +        +  M  +  +                                             |  41        |
      Inflammation, Chronic                |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +        +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +        +  +  +  +                                             |  50        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +        +  +  +  +                                             |  46        |
      Submucosa, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +        +  +  +  +                                             |  47        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +        +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +        +  +  +  +                                             |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +        +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1  2  1  1        1     1                                                |     21  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      3  1.7|
      Pigmentation                         |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +        +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      3  3.0|
      Fibrosis                             |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Duct, Cyst                           |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +        +  +  +  +                                             |  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +        +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3|                                            |            |
                                           | 9| 3| 9| 3| 6| 6| 3| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +        +  +  +  +                                             |  50        |
      Hyperplasia, Squamous                |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +        +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      3  1.7|
      Ulcer, Multiple                      |                                                                          |      1  1.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   8        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +        +  +  +  +                                             |  50        |
      Mineralization                       |    1                                                                     |      1  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                   3                                                      |      1  3.0|
      Epicardium, Fibrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +        +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  1.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Subcapsular, Hyperplasia             | 2  3  2  2        2  3  2  2                                             |     48  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +        +  +  +  +                                             |  48        |
      Hyperplasia, Focal                   |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +        +  +  +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +        +  +  +  +                                             |  47        |
      Hyperplasia, Focal                   | 2                       2                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +        +  +  +  +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Follicle, Cyst                       |                                                                          |      3     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3|                                            |            |
                                           | 9| 3| 9| 3| 6| 6| 3| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +        +  +  +  +                                             |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |    X  X                    X                                             |     18     |
      Cyst, Multiple                       |                   X                                                      |      6     |
      Pigmentation                         |                                                                          |      1  3.0|
      Interstitium, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +        +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Fibrosis                             |                            2                                             |      1  2.0|
      Inflammation, Acute                  |    2                                                                     |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Cervix, Hyperplasia, Squamous        |          2        1                                                      |      3  1.7|
      Cervix, Inflammation, Acute          |                      1                                                   |      6  1.2|
      Endometrium, Hyperplasia, Cystic     | 3  3  2  3        3  3  3  3                                             |     44  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +        +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Myelofibrosis                        | 3     2  2        2     1  2                                             |     36  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | I  +  +  +        +  +  +  +                                             |  44        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      2  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +        +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Capsule, Fibrosis                    |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +        +  +  M  +                                             |  39        |
      Atrophy                              |    2                                                                     |      4  2.0|
      Cyst                                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3|                                            |            |
                                           | 9| 3| 9| 3| 6| 6| 3| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +        M  +  +  +                                             |  46        |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +        +  +  +  +                                             |  50        |
      Acanthosis                           |                      1     1                                             |     10  1.0|
      Exudate                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +        +  +  +  +                                             |  50        |
      Mineralization                       | 1        1        2                                                      |     23  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +        +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Multifocal                 |                                                                          |      1  1.0|
      Hemorrhage                           |                            2                                             |      2  2.0|
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2                    3                                             |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1                                                                        |      2  1.5|
      Artery, Media, Hypertrophy           |          1                                                               |      2  1.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |          1           1                                                   |      6  1.7|
      Pleura, Fibrosis                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +        +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Exudate                              |    1                 1                                                   |     10  1.1|
      Inflammation, Acute                  |    2                                                                     |      3  1.3|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                   1        1                                             |     20  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +        +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3|                                            |            |
                                           | 9| 3| 9| 3| 6| 6| 3| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    5MG/KG                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +        +  +  +  +                                             |  50        |
      Nephropathy                          | 2  2  2  1        1  1  1  1                                             |     43  1.2|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Acute        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +        +  +  +  +                                             |  48        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|             
                                           | 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +     +  A  +           A  M     +  +  +  M     +  +  +  +|             
      Cyst                                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Anus, Inflammation, Acute            |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  A  +           A  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +           A  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  A  +           A  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  A  +           A  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  A  +           A  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  A  +           A  +     +  +  +  +     A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Inflammation, Acute                  |                         3                                                |             
      Inflammation, Chronic                | 1  1  2  2  1        1     2                          1           1     3|             
      Necrosis                             |                         3              2                                 |             
      Pigmentation                         |                                                                          |             
      Hepatocyte, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +  +               |             
      Inflammation, Chronic Active         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +           A  +     +  +  +  +     +  +  +  +|             
      Atrophy                              |       2                                                                  |             
      Eosinophilic Focus                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Hyperkeratosis                       |                         2                                                |             
      Hyperplasia, Squamous                |          2                                               2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Erosion                              |                         2                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Developmental Malformation           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +              +              +           +  +        +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|             
                                           | 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Active                           |                                                       1                  |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                         2                                                |             
      Hypertrophy, Focal                   |                                                                          |             
      Mineralization                       |                         3                                                |             
      Subcapsular, Hyperplasia             | 3  3  1  2  3  3     2  3  1           2  2     3  3  2  2     3  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +           A  +     +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +     +  M  +           M  +     +  +  M  M     M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M     M  +  +           M  +     +  +  +  +     +  M  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Follicle, Cyst                       |                            X                                             |             
      Follicular Cell, Hyperplasia         |                            2                    1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Abscess                              |                                                       4                  |             
      Angiectasis                          |                                                          2               |             
      Cyst                                 |                            X           X  X        X                    X|             
      Cyst, Multiple                       |                      X                                            X      |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                       3                  |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Inflammation, Acute                  |                                                 2                        |             
      Cervix, Inflammation, Acute          |                                                                          |             
      Cervix, Inflammation, Chronic        |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2        4     1     3              3     2        1        2  4  4|             
                                            __________________________________________________________________________|             
   Vagina                                  |       +        +     +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|             
                                           | 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |       1        1     1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Myelofibrosis                        |    1  2        2     3     2              2              1        2  2  3|             
      Pigmentation                         |                                                                          |             
      Myeloid Cell, Hyperplasia            |          3  2           2              3           3  3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Mandibular, Cyst, Multiple           |             X                                                            |             
      Mandibular, Hyperplasia, Lymphoid    |          4                                                               |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Cyst                     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                        3              4                  |             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M     +  +  +           M  +     +  +  +  +     +  +  +  +|             
      Atrophy                              |                         3                             2                  |             
      Congestion                           |                                                                      2   |             
      Cyst                                 |                                                                          |             
      Ectopic Parathyroid Gland            |                                                    X                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +           M  +     +  +  +  +     M  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Hyperplasia                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Mineralization                       | 1              1     1                    2           2           2      |             
      Meninges, Fibrosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Congestion                           |                      1                                         3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|             
                                           | 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Artery, Media, Hypertrophy           |                                           2                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |    2                                                                     |             
      Pleura, Inflammation, Chronic Active |                                                       3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Exudate                              |                         1                                         1      |             
      Inflammation, Acute                  | 3           3           2              2                       1         |             
      Inflammation, Chronic Active         |          4                                      2  4  2  2               |             
      Olfactory Epithelium, Metaplasia     | 1  3  4  4  4  3     3  3  4           3  3     1  3  4  3     4  2  3  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
      Metaplasia, Squamous                 |                                                    1                     |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +           +  +     +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 1  2  2  1  1  2     1     1              1     1  1  1  1     1  1  2  2|             
      Pelvis, Mineralization               |                                                                2         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +           A  +     +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|             
                                           | 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    10MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  M  +  +  A     A  A  +     +        +  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Inflammation, Acute            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  A     A  A  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  A     A  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +     +  A  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A     A  A  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                  1           1  1     2  2              1|             
      Necrosis                             |                      1                                                   |             
      Pigmentation                         |                                                                      3   |             
      Hepatocyte, Atrophy                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2                                                                     |             
      Hyperplasia, Squamous                |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         1                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Hyperplasia, Squamous                |                                           2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +           +  +     +  +  +                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                      2                                                   |             
      Inflammation, Chronic                |                                                    1                     |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|             
                                           | 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    10MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Active                           |                                                                          |             
      Valve, Thrombosis                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hypertrophy, Focal                   |                                                    2                     |             
      Mineralization                       |                                                                          |             
      Subcapsular, Hyperplasia             | 3  2  2  3  3  3     2  2  2     2        2  2  3  4  3  2  3  2  2  3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +     M  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M     M  M  M     +        M  +  +  +  M  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                      X   |             
      Follicular Cell, Hyperplasia         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    X  X     X                    X              X     X              X  X|             
      Cyst, Multiple                       |                                                          X               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                       3                  |             
      Inflammation, Acute                  |                                                                          |             
      Cervix, Inflammation, Acute          |                                           2                              |             
      Cervix, Inflammation, Chronic        |                                                                   1      |             
      Endometrium, Hyperplasia, Cystic     |    1  3  2  1                    3        2  2  2  2     2  2  3  2  2  1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|             
                                           | 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    10MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    1  1  2                       1        1  1  1  1  2     2  3  2  1  2|             
      Pigmentation                         |                                                                      2   |             
      Myeloid Cell, Hyperplasia            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Cyst, Multiple           |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Cyst                     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      4   |             
      Hyperplasia, Lymphoid                |       2                                                  2               |             
      Thrombosis                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     M  +  M     +        +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                   X      |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |       3                                                           3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |    1                                                                     |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Inflammation, Chronic                |                                              1                       1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1     2                             2  2        2           2     1|             
      Meninges, Fibrosis                   |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|             
                                           | 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    10MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                         1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             2           3                                                |             
      Artery, Media, Hypertrophy           |                                           2                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       1                                                                  |             
      Pleura, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             1  1     1     2     1           1  1  2     2  1           1|             
      Inflammation, Acute                  | 1                          2     1                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Olfactory Epithelium, Metaplasia     |    2  4  4  2           2  3     3        4  3  3  4  3  3  4  3  3  4  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +     +        +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 3                    3                                                   |             
      Cyst                                 |                                  X                                       |             
      Hydronephrosis                       |                                                                      1   |             
      Nephropathy                          |    1  1  2  1              2     1        2  2  2  2  2  1  2  2  2  2  2|             
      Pelvis, Mineralization               |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  M     +        +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 0| 4| 7| 6| 7| 3|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6|                                            |            |
                                           | 9| 4| 4| 1| 2| 2| 3| 0| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  A  +  I  +  +  A                                             |  35        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Anus, Inflammation, Acute            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  A                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  M  +  +  +  +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  A                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  A                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  A                                             |  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                1                                                         |      1  1.0|
      Clear Cell Focus                     |       2                                                                  |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                | 1  1                                                                     |     18  1.4|
      Necrosis                             |                                                                          |      3  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Hepatocyte, Atrophy                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +  +  +                                             |  47        |
      Atrophy                              |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  M  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +                                             |  48        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     M  +  +  +  +  A                                             |  46        |
      Erosion                              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 0| 4| 7| 6| 7| 3|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6|                                            |            |
                                           | 9| 4| 4| 1| 2| 2| 3| 0| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +  +  +     +     +                                             |  17        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Degeneration                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                3                                                         |      2  2.5|
      Mineralization                       |                                                                          |      1  3.0|
      Subcapsular, Hyperplasia             | 2  2  2  3  1  2  2  3  2  2                                             |     50  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +                                             |  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  M  +  +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  45        |
      Hyperplasia, Focal                   |    2              1                                                      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +                                             |  49        |
      Follicle, Cyst                       | X                                                                        |      3     |
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   3        |
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |          X              X                                                |     15     |
      Cyst, Multiple                       |                      X                                                   |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 0| 4| 7| 6| 7| 3|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6|                                            |            |
                                           | 9| 4| 4| 1| 2| 2| 3| 0| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  A  +  +  +  +  +                                             |  49        |
      Hydrometra                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Cervix, Inflammation, Acute          |                                                                          |      1  2.0|
      Cervix, Inflammation, Chronic        |                                                                          |      1  1.0|
      Endometrium, Hyperplasia, Cystic     | 2  4  2  1        2  2  3                                                |     34  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |             +     +  +                                                   |   8        |
      Inflammation, Acute                  |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Myelofibrosis                        | 2  2  2  3        3     2                                                |     30  1.8|
      Pigmentation                         |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +                                             |  48        |
      Mandibular, Cyst, Multiple           |                                                                          |      1     |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Mesenteric, Angiectasis              |                      3                                                   |      1  3.0|
      Mesenteric, Cyst                     |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  M  +  +  +  +  A                                             |  48        |
      Hematopoietic Cell Proliferation     |          3                                                               |      4  3.5|
      Hyperplasia, Lymphoid                |    2                    2                                                |      5  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  M                                             |  43        |
      Atrophy                              |          2                                                               |      4  2.3|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |          X                                                               |      2     |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                         2                                                |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |    2           3                                                         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 0| 4| 7| 6| 7| 3|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6|                                            |            |
                                           | 9| 4| 4| 1| 2| 2| 3| 0| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       | 2                 1     2                                                |     16  1.6|
      Meninges, Fibrosis                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |             2              2                                             |      3  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2                                                                  |      4  2.0|
      Artery, Media, Hypertrophy           |       2                                                                  |      3  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      | 1  1                                                                     |      4  1.3|
      Pleura, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Exudate                              |    1        3  1        1                                                |     17  1.3|
      Inflammation, Acute                  |    1                                                                     |      9  1.8|
      Inflammation, Chronic Active         |                                                                          |      5  2.8|
      Olfactory Epithelium, Metaplasia     | 3  4  3  2  2  3  2  2  3                                                |     46  3.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Autolysis                            |                            3                                             |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 0| 4| 7| 6| 7| 3|                                            |            |
                             DAY ON TEST   | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6|                                            |            |
                                           | 9| 4| 4| 1| 2| 2| 3| 0| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    10MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Nephropathy                          | 2  1  2     1  1  1  1  2                                                |     42  1.5|
      Pelvis, Mineralization               |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  I  +  +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|             
                                           | 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  M     +  +  A  +  +     +  M  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  A  +     +  +  +  +  +     +  +  +  +  +  M  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  I      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  A  A     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                        3                                 |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Erosion                              |             1                                                            |             
      Infiltration Cellular, Mast Cell     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Developmental Malformation           |                                  X                                       |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +           +  +              +                           |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|             
                                           | 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                      1                                                   |             
      Mineralization                       |                         2              1  2     2  1              2      |             
      Thrombosis                           |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                        2                                 |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             |    1  1  2  2        2  2  1     1     1  1     1  2  1  2     2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  M  +  +     +  +  M  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M  +  M     +  +  M  +  M     M  +  +  +  +  +  +     +  +      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  M     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                            +                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Hypospermia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
      Inflammation, Acute                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                             +                             +         |             
      Abscess                              |                                                                4         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    4                                                                     |             
      Duct, Cyst                           |                                  X                             X         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +     +  +  M  +  +     +  +  +  M  +  +  +     +  +      |             
      Inflammation, Acute                  |                                              2                           |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +           +  +                                          |             
      Dilatation                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Degeneration                         |                         1                    1                           |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|             
                                           | 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Infiltration Cellular, Mast Cell     |                                                                   2      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  M      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  +  +     M  +  +  +  M     M  +  +  M  M  +  M     M  +      |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         X                                                |             
      Ectopic Parathyroid Gland            |                         X                                                |             
      Necrosis                             |                3                             3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M     M  M  M  M  M     M  M  M  M  M  M  M     M  M      |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Inflammation, Acute                  |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Prepuce, Abscess                     |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Inflammation, Acute       |                                                                          |             
      Abdominal, Mineralization            |                                                                          |             
      Thoracic, Inflammation, Acute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|             
                                           | 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |             2        2           3     2        1     1        2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1                                               1                     |             
      Artery, Thrombosis                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Exudate                              |                                                    1  1                  |             
      Inflammation, Acute                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |          1                                         2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +      |             
      Cyst                                 |                                                       X                  |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                              2                           |             
      Nephropathy                          |    1  1  1  1        1  2  2     1     1  1     1  2  1  1     1  1      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Glomerulus, Inflammation, Acute      |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
      Dilatation                           |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  M     +  +      |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                              X                           |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|             
                             DAY ON TEST   | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|             
                                           | 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  A  +     +  +  +  +  +  +  A  +  +  +  M     +  M  +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +     +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +     +  +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  M  +  +  +  +  +  M  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +     +  +  +  +  A  +  +  +  +  +  +     +  +  A  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +     +  +  +  +  A  +  A  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                3         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Basophilic Focus                     |       X                                      X                           |             
      Congestion                           |    3                          3                             3            |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                          4               |             
      Inflammation, Chronic                |    1                                1                                    |             
      Leukocytosis                         |                   3                    3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +  +                              |             
      Inflammation, Acute                  |                                        3                                 |             
      Artery, Inflammation, Chronic Active |                                     2                                    |             
      Fat, Necrosis                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Atrophy                              |                                              2                           |             
      Basophilic Focus                     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 2        3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Acute                  |                                        2                                 |             
      Inflammation, Chronic                |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
      Erosion                              |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +  +                                                   |             
      Developmental Malformation           |                      X                                                   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                      4                                                   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +                    +                             +            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|             
                             DAY ON TEST   | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|             
                                           | 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |             1                                                            |             
      Thrombosis                           |                                        X                                 |             
      Valve, Thrombosis                    |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                 1                        |             
      Hypertrophy, Focal                   |                                  1                                      1|             
      Subcapsular, Hyperplasia             |    1  1     1     1  1  1  1     1  1  1     1  2     1  2  1  2  1     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  M  M  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +     +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +     M  +  +  +  M  +  M  +  +  +  M     +  M  M  +  M     +|             
      Cyst                                 |                      X                       X                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +     +  M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                   +      |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hypospermia                          |                                                             X            |             
                                            __________________________________________________________________________|             
   Penis                                   | +                       +                                                |             
      Inflammation, Acute                  | 3                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +        +        +     +  +     +                                    |             
      Abscess                              |             4                       2                                    |             
      Inflammation, Acute                  |    3                       3                                             |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Duct, Cyst                           |                      X     X  X     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
      Inflammation, Acute                  | 4                                                                        |             
      Inflammation, Chronic Active         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +                                +     +                 +      |             
      Dilatation                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Degeneration                         |                                                             3            |             
      Artery, Inflammation, Chronic        |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|             
                             DAY ON TEST   | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|             
                                           | 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Myeloid Cell, Hyperplasia            |    2              2     3                 3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  I  M     +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +     +|             
      Iliac, Hyperplasia, Lymphoid         |                      4                                                   |             
      Inguinal, Hyperplasia, Lymphoid      |                               3        3                                 |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Pigmentation               |                                                          1               |             
      Mediastinal, Hyperplasia, Lymphoid   |                         3              3                                 |             
      Mediastinal, Inflammation, Acute     |                                        2                                 |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                         3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     | 3                 3     4                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                        4                                 |             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M     M  +  M  M  +  +  M  M  M  M  +     M  M  +  +  M     +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                 X              X         |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Necrosis                             | 3                             3                             1            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +     M  M  M  M  M  +  M  +  M  M  M     M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |       1              2  2                                                |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Prepuce, Abscess                     |                                                                          |             
      Prepuce, Ulcer                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
      Abdominal, Inflammation, Acute       |                                                                          |             
      Abdominal, Mineralization            |                                                                          |             
      Thoracic, Inflammation, Acute        |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Congestion                           |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|             
                             DAY ON TEST   | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|             
                                           | 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Mineralization                       |          2        3              2  2        2  2        1     2  1     1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                               +                             +     +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Congestion                           |                            1                                3           1|             
      Inflammation, Acute                  |                                        2                                 |             
      Leukocytosis                         |                               2        3                                 |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                   3     1                             2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Exudate                              |                         1                                                |             
      Inflammation, Acute                  |                                                                   1      |             
      Olfactory Epithelium, Metaplasia     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Cyst                                 |                                                                         X|             
      Hydronephrosis                       | 3                                                                        |             
      Infarct                              |                               3                                          |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Nephropathy                          |       2  1  1     1  1  1  1     2  1  3     2  3     1  1     2        1|             
      Artery, Inflammation, Chronic Active |                                                 2        3               |             
      Glomerulus, Inflammation, Acute      |                      3                                                   |             
      Pelvis, Inflammation, Acute          |                                        2                                 |             
      Renal Tubule, Hyperplasia, Focal     |                      1                                                   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +     I  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +     +|             
      Calculus Gross Observation           |                                        X                                 |             
      Calculus Micro Observation Only      | X                                                                        |             
      Dilatation                           | 3                                                                        |             
      Inflammation, Acute                  | 2                                      3                                 |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5|                                            |            |
                                           | 2| 0| 4| 4| 1| 0| 4| 9| 3| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  M  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +                                                |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  48        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Basophilic Focus                     |                                                                          |      2     |
      Congestion                           |             2                                                            |      4  2.8|
      Cyst                                 |                   X                                                      |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |       2                                                                  |      3  1.3|
      Leukocytosis                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     |                X                                                         |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  49        |
      Erosion                              |                                                                          |      1  1.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Developmental Malformation           |                                                                          |      2     |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  4.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5|                                            |            |
                                           | 2| 0| 4| 4| 1| 0| 4| 9| 3| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Degeneration                         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      7  1.6|
      Thrombosis                           |                                                                          |      1     |
      Valve, Thrombosis                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Cyst                                 |             X                                                            |      1     |
      Hyperplasia                          |                                                                          |      2  1.5|
      Hypertrophy, Focal                   |       1                                                                  |      3  1.0|
      Subcapsular, Hyperplasia             |    1  1     1  2  1  1  1                                                |     41  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +                                                |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  49        |
      Hyperplasia                          |       1                                                                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M                                                |  34        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
      Follicle, Cyst                       |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hypospermia                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   4        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +  +                                                         |  12        |
      Abscess                              |                                                                          |      3  3.3|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                1                                                         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5|                                            |            |
                                           | 2| 0| 4| 4| 1| 0| 4| 9| 3| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |       4                                                                  |      3  4.0|
      Duct, Cyst                           |                X                                                         |      7     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  I  +  +  +  +  +  +  +                                                |  46        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   9        |
      Dilatation                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Degeneration                         |                   2                                                      |      4  1.8|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  50        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  M  +                                                |  44        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |       2                                                                  |      1  2.0|
      Inguinal, Pigmentation               |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  3.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.3|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  I  +  M  M  +                                                |  26        |
      Atrophy                              | 2                                                                        |      1  2.0|
      Cyst                                 |                X                                                         |      4     |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Necrosis                             |                                                                          |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  M  M  M  M                                                |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Inflammation, Acute                  | 3                                                                        |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5|                                            |            |
                                           | 2| 0| 4| 4| 1| 0| 4| 9| 3| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Prepuce, Abscess                     | 4                                                                        |      1  4.0|
      Prepuce, Ulcer                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   2        |
      Abdominal, Inflammation, Acute       | 2                                                                        |      1  2.0|
      Abdominal, Mineralization            | 2                                                                        |      1  2.0|
      Thoracic, Inflammation, Acute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |       2     3     3  2                                                   |     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +                                                                        |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Leukocytosis                         |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Exudate                              |                                                                          |      3  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5|                                            |            |
                                           | 2| 0| 4| 4| 1| 0| 4| 9| 3| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Cyst                                 |    X           X                                                         |      4     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Nephropathy                          |    1  2  2  1  2  1  1  1                                                |     40  1.4|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Glomerulus, Inflammation, Acute      |                                                                          |      1  3.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +                                                |  45        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|             
                                           | 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  M        +  +   |             
      Periesophageal Tissue, Foreign Body  |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  +  +  +  +  M     +  +     +  M  A  +  +  A  M  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  A     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Serosa, Inflammation, Acute          |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  A     +  +  +  +  +  A  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  A  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  A     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Abscess, Chronic                     |                                           4                              |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                 2                        |             
      Infarct                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Necrosis                             |                                           1                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Atrophy                              |    1                                   1                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Duct, Cyst                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                              +           +               |             
      Cyst                                 |                                              X                           |             
      Inflammation, Acute                  |                                              1           1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Atrophy                              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Chronic                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Developmental Malformation           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +           +        +                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|             
                                           | 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                        3                                 |             
      Epicardium, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Congestion                           |                                                                          |             
      Hypertrophy, Focal                   |                2  2                                                      |             
      Subcapsular, Hyperplasia             | 1  1        1  2  4  2     1  1     1  1        1  1  1  2        2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Hyperplasia                          | 4                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +     +  M     M  M  +  +  +  +  +  M        +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
      Fat, Pelvic, Inflammation, Chronic   |                                                       3                  |             
      Mediastinum, Angiectasis             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                      +                                                   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +           +  +     +  +     +     +                     |             
      Abscess                              |                                              4     3                     |             
      Inflammation, Chronic                |                            4                                             |             
      Duct, Cyst                           |                X           X  X     X  X     X     X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Inflammation, Acute                  |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +     +                                +                        |             
      Dilatation                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Degeneration                         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|             
                                           | 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                               1                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                            3                          3                  |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  M     M  A     +  +  M  +  M  M  M  M        +  +   |             
      Cyst                                 |    X                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M     M  M     M  M  M  M  M  M  M  M        M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Acanthosis                           |                      1                          2                        |             
      Fibrosis                             |       2                                                                  |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Ulcer                                |                                                                          |             
      Face, Cyst                           |                                                 X                        |             
      Inguinal, Ulcer                      |                                                                          |             
      Prepuce, Ulcer                       |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Thoracic, Metaplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Mineralization                       | 3        2  3  3     3     2        3  3     2  3  2  2  1        2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           |             2                                                            |             
      Mineralization                       |                            1                                             |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|             
                                           | 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |    3                                                                     |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Angiectasis                          |                                                                          |             
      Exudate                              |                                              2     2                 1   |             
      Inflammation, Acute                  |                                              1           1           1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Olfactory Epithelium, Metaplasia     |          1  1              2                                         2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Peritracheal Tissue, Foreign Body    |                                                                          |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +        +  +   |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                 4                        |             
      Nephropathy                          | 3  2  2  2  2  2  2  3     2        3  3  2  2  1  1  2  2        2  3   |             
      Pelvis, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                               +                                          |             
      Inflammation, Acute                  |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +     M  +  +  +  +  +  +  +        +  +   |             
      Calculus Gross Observation           |                            X                                             |             
      Inflammation, Acute                  |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|             
                             DAY ON TEST   | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|             
                                           | 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5MG/KG                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Periesophageal Tissue, Foreign Body  |                                  1                                       |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A     +  +  +  +  +  +     M  +  +  +  +  +  +  M  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +     M  +  +  A  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +     +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +     +  +  +  +  +  +     M  +  +  A  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +     +  +  +  +  +  +     A  +  +  A  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +     +  +  +  +  +  +     A  +  +  A  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Abscess, Chronic                     |                                                                          |             
      Cyst                                 |                                                    X                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Infarct                              |                                                                         4|             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  M     +  +  +  +  +  M     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |             1                       1                    1     4         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  M     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +                          +  +     +                    +  +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mineralization                       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|             
                             DAY ON TEST   | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|             
                                           | 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5MG/KG                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Epicardium, Inflammation, Acute      |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                             2            |             
      Hypertrophy, Focal                   |                                                       2                  |             
      Subcapsular, Hyperplasia             |          1  1     1  2  2        1  1  2  1  1  2  2  1  1  1        1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M     +  +  +  +  +  M     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M     +  +  +  +  +  +     +  +  +  M  +  +  +  M  M  M  +  M     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +     +  +  I  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +     +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fat, Pelvic, Inflammation, Chronic   |                                                                          |             
      Mediastinum, Angiectasis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +                 +        +                          +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                   3                                                      |             
      Duct, Cyst                           |                   X                 X        X                          X|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Acute                  | 1                                                           3            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Degeneration                         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|             
                             DAY ON TEST   | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|             
                                           | 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5MG/KG                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     I  +|             
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                               4                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hemorrhage                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     M  +  M  M  +  +     +  +  +  +  +  +  +  +  M  +  +  +     M  +|             
      Cyst                                 |                                                                         X|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Necrosis                             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M  M  M  M  M  M     M  M  M  M  M  M  M  M  M  M  M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Acanthosis                           |                      1                                                   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Face, Cyst                           |                                                                          |             
      Inguinal, Ulcer                      |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Thoracic, Metaplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | M  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mineralization                       |          2     4  2     2        2     2  2  4  3  3     2           3  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                               3                                          |             
      Hemorrhage                           | 2                    1                                                   |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|             
                             DAY ON TEST   | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|             
                                           | 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5MG/KG                                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                                                          |             
      Pleura, Inflammation, Acute          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                      1   |             
      Exudate                              |    1           1              3  2     1                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                    2  3              1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Peritracheal Tissue, Foreign Body    |                                  1                                       |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Autolysis                            |                               3                                          |             
      Cyst                                 |                   X                       X                              |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          |          2  2  2  2  2  2        1  2  1  2  2  2  2  2  2     2     2  2|             
      Pelvis, Inflammation, Acute          |                                                             2            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Acute                  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 2| 6| 4| 7| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3|                                            |            |
                                           | 7| 0| 9| 0| 3| 6| 9| 6| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +     +  +                                             |  48        |
      Periesophageal Tissue, Foreign Body  |                                                                          |      1  1.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +     A  +                                             |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +                                             |  47        |
      Serosa, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +     +     +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +     +     +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +     +     A  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +     +     A  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Abscess, Chronic                     |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |    3     2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +     +     +  +                                             |  46        |
      Atrophy                              |                                                                          |      6  1.5|
      Inflammation, Chronic                |                            1                                             |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   2        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +     +  +                                             |  48        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +     +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  I  +  +  +     +     +  +                                             |  47        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 2| 6| 4| 7| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3|                                            |            |
                                           | 7| 0| 9| 0| 3| 6| 9| 6| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +        +  +           +                                                |  14        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
      Epicardium, Inflammation, Acute      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                   1                                                      |      4  1.8|
      Subcapsular, Hyperplasia             | 1  1  1           1     2                                                |     38  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +                                             |  47        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +     I     +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +     +  +                                             |  47        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +     +  +                                             |  47        |
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Fat, Pelvic, Inflammation, Chronic   |                                                                          |      1  3.0|
      Mediastinum, Angiectasis             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                                |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                 +                                                |  17        |
      Abscess                              | 2  3                                                                     |      4  3.0|
      Inflammation, Chronic                |                         3                                                |      3  3.3|
      Duct, Cyst                           | X  X                    X                                                |     14     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 2| 6| 4| 7| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3|                                            |            |
                                           | 7| 0| 9| 0| 3| 6| 9| 6| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +     +     +  +                                             |  49        |
      Inflammation, Acute                  | 2                                                                        |      4  2.0|
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   3        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Degeneration                         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +     +  +                                             |  50        |
      Myeloid Cell, Hyperplasia            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +     +  +                                             |  48        |
      Axillary, Hyperplasia, Plasma Cell   |    4                                                                     |      1  4.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      2  3.0|
      Inguinal, Hyperplasia, Plasma Cell   | 4  3                                                                     |      2  3.5|
      Mesenteric, Hyperplasia, Lymphoid    | 2                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +     +  +                                             |  49        |
      Hematopoietic Cell Proliferation     |    3                                                                     |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     M     +  +                                             |  34        |
      Cyst                                 | X  X  X  X                                                               |      6     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     M     M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Acanthosis                           |                                                                          |      3  1.3|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Focal, Squamous         |             2                                                            |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |          3                                                               |      1  3.0|
      Face, Cyst                           |                                                                          |      1     |
      Inguinal, Ulcer                      | 4                                                                        |      1  4.0|
      Prepuce, Ulcer                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 2| 6| 4| 7| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3|                                            |            |
                                           | 7| 0| 9| 0| 3| 6| 9| 6| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   2        |
      Thoracic, Metaplasia                 |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +     +  +                                             |  49        |
      Mineralization                       |    1        1                                                            |     29  2.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Congestion                           |       1                                                                  |      3  2.3|
      Hemorrhage                           |             1                                                            |      4  1.5|
      Mineralization                       |                                                                          |      1  1.0|
      Thrombosis                           | 1                                                                        |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Exudate                              |    2                                                                     |      9  1.7|
      Inflammation, Acute                  |                                                                          |      3  1.0|
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Olfactory Epithelium, Metaplasia     |    2                                                                     |      8  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +     +  +                                             |  50        |
      Peritracheal Tissue, Foreign Body    |                                                                          |      1  1.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      2     |
      Inflammation, Acute                  |          2                                                               |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Nephropathy                          | 1  2  1  1  2     2     1  2                                             |     45  1.9|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 2| 6| 4| 7| 4| 5| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3|                                            |            |
                                           | 7| 0| 9| 0| 3| 6| 9| 6| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    5MG/KG                                 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +     +     +  +                                             |  48        |
      Calculus Gross Observation           |          X                                                               |      2     |
      Inflammation, Acute                  |          4                                                               |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|             
                                           | 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Ulcer, Chronic                       |             2                                                            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A     +  +  +  +  +  +     +  +     M  +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  I  +|             
      Prolapse                             |                                                                          |             
      Serosa, Inflammation, Acute          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A     +  +  +  +  +  A     +  +     +  +     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A     +  +  +  +  +  A     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Clear Cell Focus                     |       X                                                                  |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic                |                                                                   1      |             
      Necrosis                             |                2                                                         |             
      Vein, Inflammation, Chronic Active   |                3                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Acute                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Duct, Cyst                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  M  +  +  +|             
      Atrophy                              |                                                             1            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Hyperplasia, Squamous                |                1                                                     2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +  +              +  +  +                          +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Degeneration                         | 1                                                                        |             
      Inflammation, Chronic                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|             
                                           | 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Epicardium, Fibrosis                 |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Hypertrophy, Focal                   |    1                                                                     |             
      Subcapsular, Hyperplasia             | 1     1  1  1  1     2  2  1        1        1        2     2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +     +  M  +  M  +  +     +  M     M  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  I  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Crystals                   |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Dilatation                           |                                                             1            |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +     +  +  I  +  M  +     +  +     +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |          2                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                                                              +         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Degeneration                         | 3           2                       1                       1            |             
      Seminiferous Tubule, Dilatation,     |                                                                          |             
           Focal                           | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|             
                                           | 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  M  M  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                     2                                    |             
      Inguinal, Pigmentation               | 1  1                                                                     |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Mesenteric, Hyperplasia, Lymphoid    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                    M                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                4                                                         |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  I  M  M  +     +  +  M  +  +  +     M  +     +  M     M  M  +  M  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Necrosis                             |                                  3  3                                    |             
      Epithelial Cell, Hyperplasia         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M     +  M  M  M  M  M     M  M     M  M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Abscess                              |             3                                                            |             
      Inflammation, Acute                  |                                     2                 2                  |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Abdominal, Abscess                   |                4                                                         |             
      Prepuce, Ulcer                       |                                  2                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Mineralization                       |       2  3     2           1                 2        3     2  4  3     3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                               +     +                                +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Congestion                           |                                                                         3|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                               2                                          |             
      Leukocytosis                         |                1                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|             
                             DAY ON TEST   | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|             
                                           | 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                         2                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2                                                  1                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      | 1                                                                        |             
      Pleura, Fibrosis                     |                                                                      2   |             
      Vein, Thrombosis                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Exudate                              |             1                 1  2                 1                 2   |             
      Inflammation, Acute                  |    1  1  1  1              1  2  2                                   2  2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Cyst              |                                                             X            |             
      Olfactory Epithelium, Metaplasia     | 2  2  3  3  1  2     2  2  2     1  1     2  3     3  2     3  3  2  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Cyst                                 | X     X              X                                      X            |             
      Hydronephrosis                       |                                  3                                       |             
      Inflammation, Acute                  |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 3  3  3  3  3  3     4  2  2     1  1     3  3     3  3     3  3  2  3  2|             
      Pelvis, Inflammation, Acute          |          2                                                               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                         2                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |          +                          +                                    |             
      Dilatation                           |                                     3                                    |             
      Inflammation, Chronic Active         |          1                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A     +  +  +  +  +  +     +  +     +  +     +  +  +  +  +|             
      Calculus Micro Observation Only      |                                  X                                       |             
      Inflammation, Acute                  |          1                                                               |             
      Inflammation, Chronic Active         |                                  1                                       |             
      Mineralization                       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|             
                                           | 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Ulcer, Chronic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A  A  +  +  +  +     +  M  +  +  +  A  +  +  +  +     +  A     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Prolapse                             |                                                                          |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  A  +  +  +  +     +  +  +  +  +  A  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                     2                                    |             
      Inflammation, Chronic                |                            1                    2                        |             
      Necrosis                             |                                                                          |             
      Vein, Inflammation, Chronic Active   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Atrophy                              |                                                                   4      |             
      Duct, Cyst                           |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                             +      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                     2                                    |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Granulomatous                   |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +        +                       +                    +           +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Abscess                              |                                                                          |             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|             
                                           | 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             |          2        2     3  2  2  2  1        1  1  1     1        1     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  +  +     +  M  +  +  +  M  M  +  M  +     M  +     M     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Cyst                                 |                                     X                                    |             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Inflammation, Chronic                |                2                                                         |             
      Follicle, Crystals                   |             1                                                            |             
      Follicle, Cyst                       |             X                                                            |             
      Follicular Cell, Hyperplasia         |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Dilatation                           |                                                                          |             
      Granuloma Sperm                      |          2                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                 +           +                                   +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                   +|             
      Abscess                              |                                     3                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                         2|             
      Duct, Cyst                           |                                     X                                   X|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  I  +        +     +     +|             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Degeneration                         |          1                             1                                 |             
      Seminiferous Tubule, Dilatation,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Myeloid Cell, Hyperplasia            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|             
                                           | 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | I  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     M     +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                         3|             
      Inguinal, Pigmentation               |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                          2               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Hematopoietic Cell Proliferation     | 3                                                                        |             
      Hyperplasia, Lymphoid                |                                              3                          2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M     M  +  M  M  M  +  M  +  M  M     +  I     M     +|             
      Atrophy                              | 2                                      3                                 |             
      Cyst                                 |                            X                                             |             
      Necrosis                             |    2  3                                                                  |             
      Epithelial Cell, Hyperplasia         |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M     M  M  M  M  M  M  M  M  M  M     M  M     M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                  2                                       |             
      Ulcer                                |                                                                          |             
      Abdominal, Abscess                   |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Mineralization                       |       1     1     2     1  1  1     2     2  3           3        1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Congestion                           |                                  1                                       |             
      Hemorrhage                           |                2                                                         |             
      Inflammation, Acute                  | 2                                                           3            |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|             
                                           | 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                           1                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     1                                    |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Pleura, Fibrosis                     |                                                                          |             
      Vein, Thrombosis                     | 2              1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Exudate                              | 2  2  3     1  3        1  1  2                 1                 2      |             
      Inflammation, Acute                  | 2                                      1                                 |             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Chronic Active         |                                                             3            |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Olfactory Epithelium, Metaplasia     |          1  2           1  3  2  2  3     1  2  4  2     3  4     3     3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Inflammation, Acute                  |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +     +|             
      Cyst                                 |             X                                X           X               |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                        3                                 |             
      Nephropathy                          |       1  3  3     2     3  2  3  2  4     3  4  3  3     3  2     3     3|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                        1                                 |             
      Renal Tubule, Hyperplasia            |                   1                                                      |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                           |             
      Inflammation, Chronic                |                                              3                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +     +  +  +  +  +  +  +  I  +  +     +  +     +     +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                        3                                 |             
      Mineralization                       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 7| 0| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4|                                            |            |
                                           | 9| 7| 6| 6| 3| 8| 0| 9| 3| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +  +  +  +  +  I                                             |  49        |
      Ulcer, Chronic                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A        +  +  M  +  +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +        +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +        +  +  +  +  +  +                                             |  49        |
      Prolapse                             |                            X                                             |      1     |
      Serosa, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +        +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +        +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +        +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +        +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +  +  +  +  +  +                                             |  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |    X                                                                     |      1     |
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Necrosis                             |                                                                          |      1  2.0|
      Vein, Inflammation, Chronic Active   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +  +  +  +  +  +                                             |  49        |
      Atrophy                              |             3                                                            |      3  2.7|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +  +  +  +  +  +                                             |  49        |
      Atrophy                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +        +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Squamous                | 3                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   3        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Granulomatous                   |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 7| 0| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4|                                            |            |
                                           | 9| 7| 6| 6| 3| 8| 0| 9| 3| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +           +           +                                             |  18        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +  +  +  +  +  +                                             |  50        |
      Abscess                              |                            4                                             |      1  4.0|
      Degeneration                         |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Epicardium, Fibrosis                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +        +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +        +  +  +  +  +  +                                             |  49        |
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Subcapsular, Hyperplasia             | 1  1        2  1     1  2  2                                             |     36  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +        +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M        M  M  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +  +  +  +                                             |  47        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +        +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Follicle, Crystals                   |                                                                          |      1  1.0|
      Follicle, Cyst                       |                      X                                                   |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +        +  +  +  +  +  +                                             |  50        |
      Dilatation                           |                      1                                                   |      2  1.0|
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |             +                                                            |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   3        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Duct, Cyst                           |                      X                                                   |      3     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +  +  +  +  +  +                                             |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 7| 0| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4|                                            |            |
                                           | 9| 7| 6| 6| 3| 8| 0| 9| 3| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +        +  +  +  +  +  +                                             |  50        |
      Degeneration                         |                      3                                                   |      7  1.7|
      Seminiferous Tubule, Dilatation,     |                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +  +  +  +  +  +                                             |  50        |
      Myeloid Cell, Hyperplasia            |                2           3                                             |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +        +  +  +  +  M  +                                             |  43        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.5|
      Inguinal, Pigmentation               |                      1                                                   |      3  1.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Mesenteric, Hyperplasia, Lymphoid    |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +  +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     |                4           4                                             |      4  3.8|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +        +  +  M  M  +  +                                             |  27        |
      Atrophy                              |                            3                                             |      3  2.7|
      Cyst                                 |                                                                          |      2     |
      Necrosis                             |                3                                                         |      5  2.8|
      Epithelial Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M        M  M  M  M  M  +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                2                                                         |      1  2.0|
      Abdominal, Abscess                   |                                                                          |      1  4.0|
      Prepuce, Ulcer                       |             2                                                            |      2  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 7| 0| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4|                                            |            |
                                           | 9| 7| 6| 6| 3| 8| 0| 9| 3| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +  +  +  +  +  +                                             |  50        |
      Mineralization                       | 2  3              2  2  1                                                |     26  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +                       +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +        +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      3  2.3|
      Leukocytosis                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.3|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Pleura, Fibrosis                     |                                                                          |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +  +  +  +  +  +                                             |  50        |
      Exudate                              | 1  2           2  2        2                                             |     20  1.7|
      Inflammation, Acute                  | 2  3                       1                                             |     14  1.6|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Cyst              |                                                                          |      1     |
      Olfactory Epithelium, Metaplasia     | 4           1     3  2  4  3                                             |     41  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +  +  +  +  +  +                                             |  49        |
      Cyst                                 | X                 X                                                      |      9     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05031-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 15:37:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 7| 0| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4|                                            |            |
                                           | 9| 7| 6| 6| 3| 8| 0| 9| 3| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Acute                  |                            1                                             |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nephropathy                          | 4  3        4     3  3  3  3                                             |     44  2.8|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +  +  +  +  +  M                                             |  46        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Mineralization                       |                1                                                         |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.