TDMS Study 05031-01 Pathology Tables
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
Facility: International Research and Development Corp.
Chemical CAS #: 7487-94-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|
| 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + +|
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 4 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Congestion | 1 |
Eosinophilic Focus | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2 4 1 1 1 3 |
Thrombosis | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic | 2|
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Eosinophilic Focus | |
Inflammation, Chronic | 3 |
Duct, Cyst | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|
| 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 2 2 3 2 2 1 2 2 2 2 1 2 2 2 2 3 3 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | X X X X X X X X |
Cyst, Multiple | X X |
Hyperplasia, Tubular | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 3 2 3 3 3 3 2 3 2 2 3 3 3 3 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Vagina | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 3 2 2 3 2 2 1 4 2 1 3 1 2 |
__________________________________________________________________________|
Lymph Node | + + M + M + + + + + + + + + + + + + + +|
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Fibrosis | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|
| 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | |
Mediastinal, Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 2 4 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + M + + + +|
Atrophy | |
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + +|
Duct, Cyst | X|
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Cyst | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Mineralization | 2 2 2 3 2 2 2 3 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | |
Hemorrhage | |
Inflammation, Granulomatous | |
Thrombosis | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Media, Hypertrophy | |
Bronchus, Inflammation, Acute | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 5| 3| 3| 3| 2| 3| 7| 5| 3| 5| 3| 2| 3| 3| 5| 3| 2| 3| 3| 2| 3| 5| 3| 2| 9|
| 6| 3| 0| 4| 9| 4| 1| 6| 4| 6| 3| 9| 0| 3| 6| 0| 9| 3| 0| 9| 4| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 3 |
Inflammation, Acute | 1 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 |
Glomerulus, Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|
| 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + M + + + M + + + + + + I A + M A + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + A + + + + +|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + +|
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + M A + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + A + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + A + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + +|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 3 |
Congestion | |
Eosinophilic Focus | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 |
Thrombosis | 2 |
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Eosinophilic Focus | 1 |
Inflammation, Chronic | |
Duct, Cyst | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M M + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|
| 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + +|
Degeneration | 3 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + +|
Cyst | X |
Hyperplasia, Focal | 1 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 2 |
Cyst | X X X X |
Cyst, Multiple | X X X X |
Hyperplasia, Tubular | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cervix, Inflammation, Acute | 1 |
Endometrium, Hyperplasia, Cystic | 1 3 3 3 3 3 2 3 3 3 2 3 3 2 4 1 3 3|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Vagina | + + + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 3 2 3 3 1 2 2 2 3 2 2 2 3 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + M + + + + M + + + + I + + + + + +|
Iliac, Pigmentation | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Fibrosis | |
Mediastinal, Hyperplasia, Lymphoid | 3|
Mediastinal, Hyperplasia, Plasma Cell| 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|
| 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | |
Mediastinal, Thrombosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 3 2 2 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + M M + + M + +|
Atrophy | 2 |
Cyst | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + I + + + + + +|
Duct, Cyst | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3|
Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Mineralization | 2 1 3 2 2 3 2 3 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | X |
Hemorrhage | 2 1 |
Inflammation, Granulomatous | 3 |
Thrombosis | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3|
Artery, Media, Hypertrophy | 2 2 |
Bronchus, Inflammation, Acute | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 5| 4| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 5| 5| 3| 3| 3| 3| 2| 3| 5| 3| 2| 3| 2| 2| 1| 3| 6| 6| 5| 3| 3|
| 0| 4| 3| 0| 6| 6| 3| 3| 0| 5| 9| 0| 6| 0| 9| 3| 9| 9| 7| 0| 0| 5| 6| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Inflammation, Acute | 1 |
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 |
Glomerulus, Thrombosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 2|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2| | |
| 4| 9| 5| 4| 4| 1| 3| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + A + + M | 38 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + A + + + | 45 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + | 47 |
Peyer's Patch, Hyperplasia, Lymphoid | | 2 3.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + | 48 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Clear Cell Focus | | 1 3.0|
Congestion | 1 | 2 1.0|
Eosinophilic Focus | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 1 | 13 1.5|
Thrombosis | | 1 2.0|
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Atrophy | | 3 4.0|
Eosinophilic Focus | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Duct, Cyst | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 48 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + | 48 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2| | |
| 4| 9| 5| 4| 4| 1| 3| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 6 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Degeneration | | 1 3.0|
Hypertrophy, Focal | 1 | 1 1.0|
Subcapsular, Hyperplasia | 2 2 3 2 3 2 3 2 1 | 48 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + M + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Cyst | | 1 |
Hyperplasia, Focal | 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Angiectasis | | 2 1.5|
Cyst | X X X X | 16 |
Cyst, Multiple | | 6 |
Hyperplasia, Tubular | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Cervix, Inflammation, Acute | | 1 1.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 2 3 3 2 | 43 2.7|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
Hyperkeratosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2| | |
| 4| 9| 5| 4| 4| 1| 3| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Myelofibrosis | 2 1 1 1 2 2 2 2 | 40 2.1|
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + + | 44 |
Iliac, Pigmentation | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Fibrosis | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 4 2 | 3 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Pigmentation | 1 | 1 1.0|
Mediastinal, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 8 2.6|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + | 41 |
Atrophy | | 1 2.0|
Cyst | | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 47 |
Duct, Cyst | | 1 |
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Acanthosis | | 3 1.7|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Hydrocephalus | | 1 2.0|
Mineralization | 2 1 1 | 21 2.1|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 2| 7| 7| 4| 7| | |
DAY ON TEST | 3| 2| 0| 3| 3| 1| 3| 3| 5| 2| | |
| 4| 9| 5| 4| 4| 1| 3| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 2 | 1 2.0|
Fungus | | 1 |
Hemorrhage | 1 | 3 1.3|
Inflammation, Granulomatous | | 1 3.0|
Thrombosis | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.5|
Artery, Media, Hypertrophy | 3 1 | 4 2.0|
Bronchus, Inflammation, Acute | | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Exudate | 1 | 3 1.7|
Inflammation, Acute | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 49 |
Nephropathy | 1 1 1 1 2 1 1 | 21 1.1|
Glomerulus, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + | 48 |
Inflammation, Chronic | | 1 2.0|
Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|
| 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + I + + + + + + + A + + A M +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + M M + + + + + + + +|
Submucosa, Cyst | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + M + + + + + + +|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Eosinophilic Focus | X |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 2 1 1 1 3|
Inflammation, Chronic Active | |
Necrosis | |
Pigmentation | 2|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Fibrosis | 2 4 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 1 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Chronic | 3|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|
| 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Ulcer, Multiple | |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + M + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Coronary Artery, Inflammation, | |
Chronic Active | |
Epicardium, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + +|
Congestion | 1 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 3 2 3 2 2 2 3 3 3 3 3 3 2 3 3 2 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + + M + + + + + M + + + M + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M M + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X X X X X X |
Cyst, Multiple | |
Pigmentation | 3|
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|
| 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 2 2 |
Fibrosis | |
Inflammation, Acute | |
Thrombosis | X |
Cervix, Hyperplasia, Squamous | 2 |
Cervix, Inflammation, Acute | 1 |
Endometrium, Hyperplasia, Cystic | 3 2 3 1 3 1 2 3 2 2 3 3 3 3 1 1 1 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Myelofibrosis | 3 3 2 2 1 2 1 1 1 2 1 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + I +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 |
Capsule, Fibrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + M + M + + + + + + + M +|
Atrophy | 3 1 2 |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + M + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 |
Duct, Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1|
Exudate | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 4| 6| 6| 4| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 5| 6| 3| 3| 1| 3| 3| 3| 2| 3| 3| 0| 2| 0| 2| 5| 7| 7| 5| 3| 3|
| 3| 0| 9| 9| 8| 4| 3| 4| 5| 3| 4| 0| 9| 0| 0| 7| 9| 9| 9| 6| 0| 8| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Multifocal | |
Hemorrhage | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Media, Hypertrophy | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 2 2|
Pleura, Fibrosis | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Exudate | 1 1 2 1 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Olfactory Epithelium, Metaplasia | 1 3 2 1 1 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
Renal Tubule, Necrosis, Acute | 2 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + M + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 3|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|
| 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + M + + + + + A|
Inflammation, Chronic | 2 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Submucosa, Cyst | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A|
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Eosinophilic Focus | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 2 1 1 1 2 2 1 |
Inflammation, Chronic Active | 2 |
Necrosis | 2 2 1|
Pigmentation | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Fibrosis | |
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic | 2 |
Duct, Cyst | X X |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
Inflammation, Chronic | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|
| 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 2 |
Ulcer, Multiple | 1 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Coronary Artery, Inflammation, | |
Chronic Active | |
Epicardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypertrophy, Focal | 2 |
Subcapsular, Hyperplasia | 2 2 2 3 3 3 1 3 2 2 3 3 2 3 2 3 3 3 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Follicle, Cyst | X X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X |
Cyst, Multiple | X X X X X |
Pigmentation | |
Interstitium, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|
| 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | |
Fibrosis | |
Inflammation, Acute | |
Thrombosis | |
Cervix, Hyperplasia, Squamous | |
Cervix, Inflammation, Acute | 1 1 1 2 |
Endometrium, Hyperplasia, Cystic | 3 2 1 4 3 4 3 3 3 2 2 2 3 3 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myelofibrosis | 1 2 2 3 3 3 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Lymph Node | M + + + + + + + I + + + I I + + + + +|
Iliac, Hyperplasia, Lymphoid | 4 |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Plasma Cell | |
Mandibular, Hyperplasia, Lymphoid | 4 |
Mesenteric, Hyperplasia, Lymphoid | 4 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3|
Hyperplasia, Lymphoid | 2 3 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + M M + + + M + M I + + + + + + + M|
Atrophy | |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | |
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 |
Exudate | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 1 2 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 1| 3| 3| 3| 5| 8| 2| 3| 3| 3| 5| 3| 5| 5| 3| 3| 5| 3| 3| 3| 0| 0|
| 6| 0| 3| 9| 4| 0| 0| 6| 0| 9| 0| 4| 3| 6| 2| 6| 6| 0| 4| 6| 4| 9| 3| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Multifocal | 1 |
Hemorrhage | 2 |
Leukocytosis | 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Media, Hypertrophy | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Exudate | 1 1 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Olfactory Epithelium, Metaplasia | 1 1 1 2 1 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
Renal Tubule, Necrosis, Acute | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3| | |
| 9| 3| 9| 3| 6| 6| 3| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
Erosion | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + | 41 |
Inflammation, Chronic | | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + | 46 |
Submucosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 47 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis | | 2 2.5|
Eosinophilic Focus | | 1 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 2 1 1 1 1 | 21 1.3|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | | 3 1.7|
Pigmentation | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy | | 3 3.0|
Fibrosis | | 2 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic | | 3 1.3|
Duct, Cyst | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3| | |
| 9| 3| 9| 3| 6| 6| 3| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperplasia, Squamous | | 2 1.5|
Inflammation, Chronic | | 1 3.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Erosion | | 3 1.7|
Ulcer, Multiple | | 1 1.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 8 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Mineralization | 1 | 1 1.0|
Coronary Artery, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Epicardium, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 49 |
Congestion | | 1 1.0|
Hypertrophy, Focal | | 1 2.0|
Subcapsular, Hyperplasia | 2 3 2 2 2 3 2 2 | 48 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + | 47 |
Hyperplasia, Focal | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Follicle, Cyst | | 3 |
Follicular Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3| | |
| 9| 3| 9| 3| 6| 6| 3| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 49 |
Angiectasis | | 1 2.0|
Cyst | X X X | 18 |
Cyst, Multiple | X | 6 |
Pigmentation | | 1 3.0|
Interstitium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Angiectasis | | 2 2.0|
Fibrosis | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Thrombosis | | 1 |
Cervix, Hyperplasia, Squamous | 2 1 | 3 1.7|
Cervix, Inflammation, Acute | 1 | 6 1.2|
Endometrium, Hyperplasia, Cystic | 3 3 2 3 3 3 3 3 | 44 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Atrophy | | 1 3.0|
Myelofibrosis | 3 2 2 2 1 2 | 36 1.9|
__________________________________________________________________________|____________|
Lymph Node | I + + + + + + + | 44 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | | 2 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 2 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
Capsule, Fibrosis | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + | 39 |
Atrophy | 2 | 4 2.0|
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3| | |
| 9| 3| 9| 3| 6| 6| 3| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + | 46 |
Acinus, Hyperplasia | | 1 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Acanthosis | 1 1 | 10 1.0|
Exudate | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Mineralization | 1 1 2 | 23 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 1 2.0|
Fibrosis, Multifocal | | 1 1.0|
Hemorrhage | 2 | 2 2.0|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.5|
Artery, Media, Hypertrophy | 1 | 2 1.5|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 6 1.7|
Pleura, Fibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Exudate | 1 1 | 10 1.1|
Inflammation, Acute | 2 | 3 1.3|
Inflammation, Chronic | | 1 1.0|
Olfactory Epithelium, Metaplasia | 1 1 | 20 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 2| 3| 5| 5| 3| 3| 2| 3| | |
| 9| 3| 9| 3| 6| 6| 3| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Nephropathy | 2 2 2 1 1 1 1 1 | 43 1.2|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
Renal Tubule, Necrosis, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 48 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|
| 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + A + A M + + + M + + + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
Anus, Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 1 2 2 1 1 2 1 1 3|
Necrosis | 3 2 |
Pigmentation | |
Hepatocyte, Atrophy | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + +|
Atrophy | 2 |
Eosinophilic Focus | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Chronic | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|
| 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Active | 1 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Hypertrophy, Focal | |
Mineralization | 3 |
Subcapsular, Hyperplasia | 3 3 1 2 3 3 2 3 1 2 2 3 3 2 2 3 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M + M + + + M M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + M + + + + + + M + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | 2 |
Cyst | X X X X X|
Cyst, Multiple | X X |
Periovarian Tissue, Inflammation, | |
Chronic Active | 3 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Acute | 2 |
Cervix, Inflammation, Acute | |
Cervix, Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 2 2 2 4 1 3 3 2 1 2 4 4|
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|
| 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 2 3 2 2 1 2 2 3|
Pigmentation | |
Myeloid Cell, Hyperplasia | 3 2 2 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst, Multiple | X |
Mandibular, Hyperplasia, Lymphoid | 4 |
Mesenteric, Angiectasis | |
Mesenteric, Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | 2|
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + M + M + + + M + + + + + + + + +|
Atrophy | 3 2 |
Congestion | 2 |
Cyst | |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + M + + +|
Inflammation, Chronic | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 2 2 2 |
Meninges, Fibrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 1 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 4| 4| 4| 6| 7| 4| 7| 5| 6| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 5| 2| 5| 5| 5| 8| 3| 5| 3| 6| 7| 2| 5| 6| 3| 3| 3|
| 0| 3| 0| 7| 0| 4| 6| 9| 1| 9| 6| 6| 6| 8| 0| 6| 3| 2| 2| 9| 6| 9| 4| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Artery, Media, Hypertrophy | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
Pleura, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 |
Inflammation, Acute | 3 3 2 2 1 |
Inflammation, Chronic Active | 4 2 4 2 2 |
Olfactory Epithelium, Metaplasia | 1 3 4 4 4 3 3 3 4 3 3 1 3 4 3 4 2 3 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Metaplasia, Squamous | 1 |
Peritracheal Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Hydronephrosis | |
Nephropathy | 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1 2 2|
Pelvis, Mineralization | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|
| 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
10MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M + + A A A + + + + + + + + + A + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
Anus, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 2 2 1|
Necrosis | 1 |
Pigmentation | 3 |
Hepatocyte, Atrophy | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Eosinophilic Focus | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Inflammation, Chronic | 1 |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|
| 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
10MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Active | |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hypertrophy, Focal | 2 |
Mineralization | |
Subcapsular, Hyperplasia | 3 2 2 3 3 3 2 2 2 2 2 2 3 4 3 2 3 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M M M M + M + + + M M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Cyst | X X X X X X X X|
Cyst, Multiple | X |
Periovarian Tissue, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Inflammation, Acute | |
Cervix, Inflammation, Acute | 2 |
Cervix, Inflammation, Chronic | 1 |
Endometrium, Hyperplasia, Cystic | 1 3 2 1 3 2 2 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|
| 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
10MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 1 1 1 1 2 2 3 2 1 2|
Pigmentation | 2 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst, Multiple | |
Mandibular, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | |
Mesenteric, Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 2 2 |
Thrombosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + + + + + + + + + +|
Atrophy | 2 |
Congestion | |
Cyst | X |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic | 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 2 2 2 1|
Meninges, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 5| 3| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 7| 2| 5| 3| 5| 7| 5| 3| 5| 5| 3| 3| 2| 3| 2| 2| 3| 6| 3| 3| 3|
| 5| 9| 4| 4| 3| 5| 6| 2| 6| 1| 6| 0| 6| 6| 0| 3| 9| 3| 9| 9| 0| 1| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
10MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Artery, Media, Hypertrophy | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 1 2 1 1 1 2 2 1 1|
Inflammation, Acute | 1 2 1 |
Inflammation, Chronic Active | |
Olfactory Epithelium, Metaplasia | 2 4 4 2 2 3 3 4 3 3 4 3 3 4 3 3 4 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia, Squamous | |
Peritracheal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Cyst | X |
Hydronephrosis | 1 |
Nephropathy | 1 1 2 1 2 1 2 2 2 2 2 1 2 2 2 2 2|
Pelvis, Mineralization | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 4| 7| 6| 7| 3| | |
DAY ON TEST | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6| | |
| 9| 4| 4| 1| 2| 2| 3| 0| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + A + I + + A | 35 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
Anus, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + M + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + A | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + + A | 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | 1 | 1 1.0|
Clear Cell Focus | 2 | 1 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 1 1 | 18 1.4|
Necrosis | | 3 2.0|
Pigmentation | | 1 3.0|
Hepatocyte, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + | 47 |
Atrophy | | 1 2.0|
Eosinophilic Focus | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + | 48 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Squamous | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + M + + + + A | 46 |
Erosion | | 2 1.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 4| 7| 6| 7| 3| | |
DAY ON TEST | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6| | |
| 9| 4| 4| 1| 2| 2| 3| 0| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 17 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Degeneration | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Epicardium, Inflammation, Chronic | | |
Active | | 1 1.0|
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Hypertrophy, Focal | 3 | 2 2.5|
Mineralization | | 1 3.0|
Subcapsular, Hyperplasia | 2 2 2 3 1 2 2 3 2 2 | 50 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + | 49 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + | 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M M + + + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 45 |
Hyperplasia, Focal | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + | 49 |
Follicle, Cyst | X | 3 |
Follicular Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Angiectasis | | 1 2.0|
Cyst | X X | 15 |
Cyst, Multiple | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 4| 7| 6| 7| 3| | |
DAY ON TEST | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6| | |
| 9| 4| 4| 1| 2| 2| 3| 0| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + A + + + + + | 49 |
Hydrometra | | 1 3.0|
Inflammation, Acute | | 1 2.0|
Cervix, Inflammation, Acute | | 1 2.0|
Cervix, Inflammation, Chronic | | 1 1.0|
Endometrium, Hyperplasia, Cystic | 2 4 2 1 2 2 3 | 34 2.2|
__________________________________________________________________________|____________|
Vagina | + + + | 8 |
Inflammation, Acute | | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Myelofibrosis | 2 2 2 3 3 2 | 30 1.8|
Pigmentation | | 1 2.0|
Myeloid Cell, Hyperplasia | | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + | 48 |
Mandibular, Cyst, Multiple | | 1 |
Mandibular, Hyperplasia, Lymphoid | | 1 4.0|
Mesenteric, Angiectasis | 3 | 1 3.0|
Mesenteric, Cyst | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + M + + + + A | 48 |
Hematopoietic Cell Proliferation | 3 | 4 3.5|
Hyperplasia, Lymphoid | 2 2 | 5 2.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + M | 43 |
Atrophy | 2 | 4 2.3|
Congestion | | 1 2.0|
Cyst | X | 2 |
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 46 |
Inflammation, Chronic | | 1 1.0|
Acinus, Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 4| 7| 6| 7| 3| | |
DAY ON TEST | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6| | |
| 9| 4| 4| 1| 2| 2| 3| 0| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Mineralization | 2 1 2 | 16 1.6|
Meninges, Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 2 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 2 2.0|
Hemorrhage | 2 2 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 4 2.0|
Artery, Media, Hypertrophy | 2 | 3 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 4 1.3|
Pleura, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Exudate | 1 3 1 1 | 17 1.3|
Inflammation, Acute | 1 | 9 1.8|
Inflammation, Chronic Active | | 5 2.8|
Olfactory Epithelium, Metaplasia | 3 4 3 2 2 3 2 2 3 | 46 3.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Metaplasia, Squamous | | 1 1.0|
Peritracheal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Autolysis | 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 4| 7| 6| 7| 3| | |
DAY ON TEST | 2| 3| 3| 5| 8| 9| 3| 7| 2| 6| | |
| 9| 4| 4| 1| 2| 2| 3| 0| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst | | 1 |
Hydronephrosis | | 1 1.0|
Nephropathy | 2 1 2 1 1 1 1 2 | 42 1.5|
Pelvis, Mineralization | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + I + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|
| 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + M + + A + + + M + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + I |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Congestion | |
Cyst | |
Infarct | |
Inflammation, Chronic | |
Leukocytosis | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute | |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Basophilic Focus | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Erosion | 1 |
Infiltration Cellular, Mast Cell | 3 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Peridontal Tissue, Inflammation, | |
Acute | |
Peridontal Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|
| 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | 1 |
Mineralization | 2 1 2 2 1 2 |
Thrombosis | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hyperplasia | 2 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 1 1 2 2 2 2 1 1 1 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + M + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + M + M M + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Hypospermia | |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Duct, Cyst | X X |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + M + + + + + |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Degeneration | 1 1 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|
| 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Mast Cell | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Pigmentation | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, Acute | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + M + + M + + + M M + + M M + M M + |
Atrophy | |
Cyst | X |
Ectopic Parathyroid Gland | X |
Necrosis | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Prepuce, Abscess | |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Inflammation, Acute | |
Abdominal, Mineralization | |
Thoracic, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 0| 4| 7| 7| 5| 0| 7| 4| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4|
DAY ON TEST | 5| 3| 3| 3| 3| 9| 5| 3| 3| 9| 9| 2| 5| 3| 2| 9| 3| 3| 2| 3| 5| 3| 3| 5| 5|
| 6| 0| 4| 3| 4| 9| 6| 3| 3| 5| 6| 9| 6| 0| 9| 7| 3| 0| 9| 0| 6| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
Mineralization | 2 2 3 2 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Inflammation, Acute | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Artery, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Exudate | 1 1 |
Inflammation, Acute | |
Olfactory Epithelium, Metaplasia | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Hydronephrosis | |
Infarct | |
Inflammation, Chronic Active | 2 |
Nephropathy | 1 1 1 1 1 2 2 1 1 1 1 2 1 1 1 1 |
Artery, Inflammation, Chronic Active | |
Glomerulus, Inflammation, Acute | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urethra | + |
Dilatation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + |
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Dilatation | |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|
DAY ON TEST | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|
| 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M A + + + + + + + A + + + M + M + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Congestion | 3 3 3 |
Cyst | |
Infarct | 4 |
Inflammation, Chronic | 1 1 |
Leukocytosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | 3 |
Artery, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | |
Artery, Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + M + + + +|
Erosion | |
Infiltration Cellular, Mast Cell | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
Peridontal Tissue, Inflammation, | |
Acute | 4 |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|
DAY ON TEST | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|
| 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration | |
Mineralization | 1 |
Thrombosis | X |
Valve, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 |
Hypertrophy, Focal | 1 1|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + + + M + M + + + M + M M + M +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | X |
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 2 |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Duct, Cyst | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|
DAY ON TEST | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|
| 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Myeloid Cell, Hyperplasia | 2 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + I M + + + + + + + + + + + + + + M + +|
Iliac, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Lymphoid | 3 3 |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Pigmentation | 1 |
Mediastinal, Hyperplasia, Lymphoid | 3 3 |
Mediastinal, Inflammation, Acute | 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + M M M + M M + + M M M M + M M + + M +|
Atrophy | |
Cyst | X X |
Ectopic Parathyroid Gland | |
Necrosis | 3 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M + M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 2 2 |
Inflammation, Chronic Active | 4 |
Prepuce, Abscess | |
Prepuce, Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Inflammation, Acute | |
Abdominal, Mineralization | |
Thoracic, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 7| 4| 7| 4| 6| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 4| 7| 7| 0| 7| 6| 4| 7|
DAY ON TEST | 6| 0| 3| 5| 2| 5| 3| 2| 3| 2| 2| 3| 9| 2| 3| 3| 3| 5| 2| 3| 8| 3| 9| 5| 3|
| 2| 5| 4| 7| 9| 6| 7| 9| 0| 9| 9| 4| 9| 9| 4| 3| 4| 6| 9| 0| 5| 3| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 2 |
Mineralization | 2 3 2 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 3 1|
Inflammation, Acute | 2 |
Leukocytosis | 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Inflammation, Acute | 1 |
Olfactory Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Hydronephrosis | 3 |
Infarct | 3 |
Inflammation, Chronic Active | 3 |
Nephropathy | 2 1 1 1 1 1 1 2 1 3 2 3 1 1 2 1|
Artery, Inflammation, Chronic Active | 2 3 |
Glomerulus, Inflammation, Acute | 3 |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urethra | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + A + I + + + A + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Dilatation | 3 |
Inflammation, Acute | 2 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5| | |
| 2| 0| 4| 4| 1| 0| 4| 9| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + | 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 48 |
Peyer's Patch, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | | 2 |
Congestion | 2 | 4 2.8|
Cyst | X | 1 |
Infarct | | 1 4.0|
Inflammation, Chronic | 2 | 3 1.3|
Leukocytosis | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Acute | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Atrophy | | 1 2.0|
Basophilic Focus | X | 1 |
Artery, Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Erosion | | 1 1.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Developmental Malformation | | 2 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 4.0|
Peridontal Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5| | |
| 2| 0| 4| 4| 1| 0| 4| 9| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Degeneration | | 1 1.0|
Mineralization | | 7 1.6|
Thrombosis | | 1 |
Valve, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Cyst | X | 1 |
Hyperplasia | | 2 1.5|
Hypertrophy, Focal | 1 | 3 1.0|
Subcapsular, Hyperplasia | 1 1 1 2 1 1 1 | 41 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M | 34 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 49 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 3 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Hypospermia | | 1 |
__________________________________________________________________________|____________|
Penis | + | 4 |
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 12 |
Abscess | | 3 3.3|
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5| | |
| 2| 0| 4| 4| 1| 0| 4| 9| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 | 3 4.0|
Duct, Cyst | X | 7 |
__________________________________________________________________________|____________|
Prostate | + I + + + + + + + | 46 |
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 9 |
Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Degeneration | 2 | 4 1.8|
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Myeloid Cell, Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + M + | 44 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | | 2 3.0|
Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Inguinal, Pigmentation | | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Inflammation, Acute | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 3 3.3|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + I + M M + | 26 |
Atrophy | 2 | 1 2.0|
Cyst | X | 4 |
Ectopic Parathyroid Gland | | 1 |
Necrosis | | 5 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Inflammation, Acute | 3 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5| | |
| 2| 0| 4| 4| 1| 0| 4| 9| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 3 1.7|
Inflammation, Chronic Active | | 2 3.0|
Prepuce, Abscess | 4 | 1 4.0|
Prepuce, Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Abdominal, Inflammation, Acute | 2 | 1 2.0|
Abdominal, Mineralization | 2 | 1 2.0|
Thoracic, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
Mineralization | 2 3 3 2 | 21 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 5 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 3 1.7|
Inflammation, Acute | | 1 2.0|
Leukocytosis | | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
Artery, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Exudate | | 3 1.0|
Inflammation, Acute | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 1| 3| 3| 3| 0| 3| 3| 2| 3| 5| | |
| 2| 0| 4| 4| 1| 0| 4| 9| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Cyst | X X | 4 |
Hydronephrosis | | 1 3.0|
Infarct | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
Nephropathy | 1 2 2 1 2 1 1 1 | 40 1.4|
Artery, Inflammation, Chronic Active | | 2 2.5|
Glomerulus, Inflammation, Acute | | 1 3.0|
Pelvis, Inflammation, Acute | | 1 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + | 45 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
Dilatation | | 1 3.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|
| 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + M + + |
Periesophageal Tissue, Foreign Body | |
Periesophageal Tissue, Inflammation, | |
Acute | |
__________________________________________________________________________|
Gallbladder | M M + + + + + M + + + M A + + A M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Abscess, Chronic | 4 |
Cyst | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Infarct | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Duct, Cyst | X |
__________________________________________________________________________|
Pharynx | + + |
Cyst | X |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 |
__________________________________________________________________________|
Stomach | M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|
| 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, | |
Chronic Active | 3 |
Epicardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hypertrophy, Focal | 2 2 |
Subcapsular, Hyperplasia | 1 1 1 2 4 2 1 1 1 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + M M M + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fat, Pelvic, Inflammation, Chronic | 3 |
Mediastinum, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Abscess | 4 3 |
Inflammation, Chronic | 4 |
Duct, Cyst | X X X X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|
| 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myeloid Cell, Hyperplasia | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hyperplasia, Plasma Cell | 3 3 |
Inguinal, Hyperplasia, Plasma Cell | |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | M + + M + + + M M A + + M + M M M M + + |
Cyst | X |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 1 2 |
Fibrosis | 2 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic | 1 |
Ulcer | |
Face, Cyst | X |
Inguinal, Ulcer | |
Prepuce, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Thoracic, Metaplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 2 3 3 3 2 3 3 2 3 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hemorrhage | 2 |
Mineralization | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 0| 4| 7| 7| 6| 7| 7| 5| 7| 7| 4| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 8| 5| 3| 3| 9| 2| 3| 4| 3| 2| 5| 5| 3| 3| 5|
| 4| 4| 0| 9| 3| 0| 3| 3| 6| 0| 8| 6| 0| 4| 3| 9| 0| 7| 0| 9| 6| 6| 0| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 3 |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Exudate | 2 2 1 |
Inflammation, Acute | 1 1 1 |
Inflammation, Chronic Active | |
Olfactory Epithelium, Metaplasia | 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Peritracheal Tissue, Foreign Body | |
Peritracheal Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Cyst | |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 |
Nephropathy | 3 2 2 2 2 2 2 3 2 3 3 2 2 1 1 2 2 2 3 |
Pelvis, Inflammation, Acute | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + |
Calculus Gross Observation | X |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|
DAY ON TEST | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|
| 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Foreign Body | 1 |
Periesophageal Tissue, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Gallbladder | A A + + + + + + M + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + A + + + + + + + + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + M + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + A + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic | |
Cyst | X |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Infarct | 4|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + M + + + + + M A + + + + + + + + + + + + +|
Atrophy | 1 1 1 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Duct, Cyst | X |
__________________________________________________________________________|
Pharynx | |
Cyst | |
Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | M M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|
DAY ON TEST | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|
| 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, | |
Chronic Active | |
Epicardium, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hypertrophy, Focal | 2 |
Subcapsular, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 2 2 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + M A + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + + M + + + M M M + M + M|
__________________________________________________________________________|
Pituitary Gland | M + + + I + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + A + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Pelvic, Inflammation, Chronic | |
Mediastinum, Angiectasis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + +|
Abscess | |
Inflammation, Chronic | 3 |
Duct, Cyst | X X X X|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|
DAY ON TEST | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|
| 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + I +|
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Plasma Cell | |
Mesenteric, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hemorrhage | 3 |
__________________________________________________________________________|
Thymus | + + M + M M + + + + + + + + + + M + + + M +|
Cyst | X|
Hyperplasia, Lymphoid | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Fibrosis | |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic | |
Ulcer | |
Face, Cyst | |
Inguinal, Ulcer | |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Thoracic, Metaplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | M + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 4 2 2 2 2 2 4 3 3 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 1 |
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 0| 4| 7| 7| 7| 7| 7| 7| 4| 0| 3| 7| 6| 7| 7| 7| 7| 7| 7| 1| 4| 4| 7| 7|
DAY ON TEST | 1| 1| 5| 3| 3| 3| 3| 3| 3| 5| 4| 2| 2| 8| 2| 3| 3| 2| 3| 3| 8| 5| 5| 3| 2|
| 2| 2| 6| 4| 4| 4| 3| 3| 3| 6| 9| 5| 9| 6| 9| 4| 4| 9| 3| 0| 7| 6| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
Pleura, Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Exudate | 1 1 3 2 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Olfactory Epithelium, Metaplasia | 2 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Foreign Body | 1 |
Peritracheal Tissue, Inflammation, | |
Acute | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Cyst | X X |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Nephropathy | 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2|
Pelvis, Inflammation, Acute | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 2| 6| 4| 7| 4| 5| 7| | |
DAY ON TEST | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3| | |
| 7| 0| 9| 0| 3| 6| 9| 6| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 48 |
Periesophageal Tissue, Foreign Body | | 1 1.0|
Periesophageal Tissue, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + | 38 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 47 |
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + A + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + A + | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Abscess, Chronic | | 1 4.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 46 |
Atrophy | | 6 1.5|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Pharynx | | 2 |
Cyst | | 1 |
Inflammation, Acute | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 48 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + I + + + + + + | 47 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 2| 6| 4| 7| 4| 5| 7| | |
DAY ON TEST | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3| | |
| 7| 0| 9| 0| 3| 6| 9| 6| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 14 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Mineralization | | 1 1.0|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 3.0|
Epicardium, Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hypertrophy, Focal | 1 | 4 1.8|
Subcapsular, Hyperplasia | 1 1 1 1 2 | 38 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 47 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + I + + | 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 47 |
Inflammation, Chronic | 1 | 1 1.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Fat, Pelvic, Inflammation, Chronic | | 1 3.0|
Mediastinum, Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 17 |
Abscess | 2 3 | 4 3.0|
Inflammation, Chronic | 3 | 3 3.3|
Duct, Cyst | X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 2| 6| 4| 7| 4| 5| 7| | |
DAY ON TEST | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3| | |
| 7| 0| 9| 0| 3| 6| 9| 6| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + M + + + + | 49 |
Inflammation, Acute | 2 | 4 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 3 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Degeneration | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myeloid Cell, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 48 |
Axillary, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Iliac, Hyperplasia, Plasma Cell | | 2 3.0|
Inguinal, Hyperplasia, Plasma Cell | 4 3 | 2 3.5|
Mesenteric, Hyperplasia, Lymphoid | 2 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + | 34 |
Cyst | X X X X | 6 |
Hyperplasia, Lymphoid | | 1 3.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Acanthosis | | 3 1.3|
Fibrosis | | 1 2.0|
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 3 | 1 3.0|
Face, Cyst | | 1 |
Inguinal, Ulcer | 4 | 1 4.0|
Prepuce, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 2| 6| 4| 7| 4| 5| 7| | |
DAY ON TEST | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3| | |
| 7| 0| 9| 0| 3| 6| 9| 6| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Thoracic, Metaplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 49 |
Mineralization | 1 1 | 29 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 1 | 3 2.3|
Hemorrhage | 1 | 4 1.5|
Mineralization | | 1 1.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Pleura, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Angiectasis | | 1 1.0|
Exudate | 2 | 9 1.7|
Inflammation, Acute | | 3 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 2 | 8 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Peritracheal Tissue, Foreign Body | | 1 1.0|
Peritracheal Tissue, Inflammation, | | |
Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Autolysis | | 1 3.0|
Cyst | | 2 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Nephropathy | 1 2 1 1 2 2 1 2 | 45 1.9|
Pelvis, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 2| 6| 4| 7| 4| 5| 7| | |
DAY ON TEST | 8| 3| 2| 3| 7| 5| 2| 5| 0| 3| | |
| 7| 0| 9| 0| 3| 6| 9| 6| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + | 48 |
Calculus Gross Observation | X | 2 |
Inflammation, Acute | 4 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|
| 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + M + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + I +|
Prolapse | |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + A + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Cyst | |
Eosinophilic Focus | |
Inflammation, Chronic | 1 |
Necrosis | 2 |
Vein, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Acute | |
Peridontal Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Degeneration | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|
| 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Epicardium, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 |
Subcapsular, Hyperplasia | 1 1 1 1 1 2 2 1 1 1 2 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + M + M + + + M M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + M + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + I + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Crystals | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
Granuloma Sperm | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + I + M + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 2 1 1 |
Seminiferous Tubule, Dilatation, | |
Focal | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|
| 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M M + +|
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Pigmentation | 1 1 |
Mandibular, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + I M M + + + M + + + M + + M M M + M +|
Atrophy | |
Cyst | X |
Necrosis | 3 3 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | |
Ulcer | |
Abdominal, Abscess | 4 |
Prepuce, Ulcer | 2 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 2 1 2 3 2 4 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Hemorrhage | |
Inflammation, Acute | 2 |
Leukocytosis | 1 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 4| 7| 7| 7| 0| 1| 1| 4| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 0| 7| 5| 5| 3| 3| 3| 0| 2| 3| 5| 2| 3| 5| 3| 3| 5| 3| 2| 3| 7| 4|
| 3| 0| 9| 4| 1| 1| 6| 0| 0| 4| 6| 9| 8| 6| 9| 4| 6| 3| 0| 6| 3| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
Pleura, Fibrosis | 2 |
Vein, Thrombosis | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 2 1 2 |
Inflammation, Acute | 1 1 1 1 1 2 2 2 2|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Cyst | X |
Olfactory Epithelium, Metaplasia | 2 2 3 3 1 2 2 2 2 1 1 2 3 3 2 3 3 2 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Hydronephrosis | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Nephropathy | 3 3 3 3 3 3 4 2 2 1 1 3 3 3 3 3 3 2 3 2|
Pelvis, Inflammation, Acute | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Ureter | |
Inflammation, Chronic | |
__________________________________________________________________________|
Urethra | + + |
Dilatation | 3 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 |
Mineralization | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|
| 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic | |
__________________________________________________________________________|
Gallbladder | A A A + + + + + M + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Prolapse | |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | 2 |
Inflammation, Chronic | 1 2 |
Necrosis | |
Vein, Inflammation, Chronic Active | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Acute | 2 |
Peridontal Tissue, Inflammation, | |
Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Degeneration | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|
| 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Epicardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 2 2 3 2 2 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + + + + + M + + + M M + M + M + M +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Follicle, Crystals | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + +|
Abscess | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2|
Duct, Cyst | X X|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + I + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
Seminiferous Tubule, Dilatation, | |
Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|
| 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | I A + + + + + + + + + + + + + + + + + M +|
Inguinal, Hyperplasia, Lymphoid | 3|
Inguinal, Pigmentation | |
Mandibular, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 2|
__________________________________________________________________________|
Thymus | + + + + M + M M + M M M + M + M M + I M +|
Atrophy | 2 3 |
Cyst | X |
Necrosis | 2 3 |
Epithelial Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Ulcer | |
Abdominal, Abscess | |
Prepuce, Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 1 1 1 2 2 3 3 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 2 |
Inflammation, Acute | 2 3 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
_____________________________________________________________________________________________________________________
| 0| 1| 1| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 7| 5| 4| 7| 4| 5|
DAY ON TEST | 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 0| 3| 2| 2| 2| 5| 3| 5| 5| 3| 5| 4|
| 1| 6| 3| 4| 3| 9| 3| 6| 0| 4| 4| 4| 3| 9| 0| 9| 9| 9| 6| 4| 5| 6| 4| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
Pleura, Fibrosis | |
Vein, Thrombosis | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 2 3 1 3 1 1 2 1 2 |
Inflammation, Acute | 2 1 |
Inflammation, Chronic | 1|
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Cyst | |
Olfactory Epithelium, Metaplasia | 1 2 1 3 2 2 3 1 2 4 2 3 4 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hydronephrosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Nephropathy | 1 3 3 2 3 2 3 2 4 3 4 3 3 3 2 3 3|
Pelvis, Inflammation, Acute | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Ureter | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urethra | |
Dilatation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + I + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Mineralization | |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 0| 7| 7| 7| 5| | |
DAY ON TEST | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4| | |
| 9| 7| 6| 6| 3| 8| 0| 9| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + I | 49 |
Ulcer, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + A + + M + + + | 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
Prolapse | X | 1 |
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Clear Cell Focus | | 1 |
Cyst | X | 1 |
Eosinophilic Focus | | 1 2.0|
Inflammation, Chronic | | 3 1.3|
Necrosis | | 1 2.0|
Vein, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Atrophy | 3 | 3 2.7|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 49 |
Atrophy | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperplasia, Squamous | 3 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Tooth | + | 3 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Granulomatous | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 0| 7| 7| 7| 5| | |
DAY ON TEST | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4| | |
| 9| 7| 6| 6| 3| 8| 0| 9| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 18 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Abscess | 4 | 1 4.0|
Degeneration | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Epicardium, Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 49 |
Hypertrophy, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 1 1 2 1 1 2 2 | 36 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + + + | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 47 |
Cyst | | 1 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Inflammation, Chronic | | 1 2.0|
Follicle, Crystals | | 1 1.0|
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Dilatation | 1 | 2 1.0|
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Penis | + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
Abscess | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Duct, Cyst | X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 0| 7| 7| 7| 5| | |
DAY ON TEST | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4| | |
| 9| 7| 6| 6| 3| 8| 0| 9| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Degeneration | 3 | 7 1.7|
Seminiferous Tubule, Dilatation, | | |
Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myeloid Cell, Hyperplasia | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | M + + + + + M + | 43 |
Inguinal, Hyperplasia, Lymphoid | | 2 2.5|
Inguinal, Pigmentation | 1 | 3 1.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Mesenteric, Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 4 4 | 4 3.8|
Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + M M + + | 27 |
Atrophy | 3 | 3 2.7|
Cyst | | 2 |
Necrosis | 3 | 5 2.8|
Epithelial Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Abscess | | 1 3.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | 2 | 1 2.0|
Abdominal, Abscess | | 1 4.0|
Prepuce, Ulcer | 2 | 2 2.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 0| 7| 7| 7| 5| | |
DAY ON TEST | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4| | |
| 9| 7| 6| 6| 3| 8| 0| 9| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Mineralization | 2 3 2 2 1 | 26 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 7 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 2 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 3 2.3|
Leukocytosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.3|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
Pleura, Fibrosis | | 1 2.0|
Vein, Thrombosis | | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Exudate | 1 2 2 2 2 | 20 1.7|
Inflammation, Acute | 2 3 1 | 14 1.6|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Nasolacrimal Duct, Cyst | | 1 |
Olfactory Epithelium, Metaplasia | 4 1 3 2 4 3 | 41 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 49 |
Cyst | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05031-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 15:37:58
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 0| 7| 7| 7| 5| | |
DAY ON TEST | 2| 8| 5| 5| 3| 4| 3| 2| 3| 4| | |
| 9| 7| 6| 6| 3| 8| 0| 9| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
10MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | | 1 3.0|
Inflammation, Acute | 1 | 2 1.5|
Inflammation, Chronic Active | | 1 3.0|
Nephropathy | 4 3 4 3 3 3 3 | 44 2.8|
Pelvis, Inflammation, Acute | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
Renal Tubule, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Dilatation | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M | 46 |
Calculus Micro Observation Only | | 1 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | | 2 2.0|
Mineralization | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
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