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TDMS Study 05031-01 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/04/94   
EXP: 05031                    MERCURIC CHLORIDE                TIME: 16:34:18   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60173    
CONT:                                                          CAS: 7487-94-7   
PATHOLOGIST: D. GOODMAN                      S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/04/94  
EXP: 05031                    MERCURIC CHLORIDE                TIME: 16:34:18  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60173   
CONT:                                                          CAS: 7487-94-7  
PATHOLOGIST: D. GOODMAN                      S. EUSTIS                         

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      62    85    96    99    105   112   129   197   457   595                 |
 |      637   695   699   701                                                     |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5MG/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      12    12    49    88    187   187   230   325   456   509                 |
 |      547   673   686   693                                                     |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      6     9     31    48    129   136   138   173   309   471                 |
 |      471   544   548   551   555   642   687   704   728                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    96.7  88.3  86.7  86.7  86.7  84.6  84.6  82.5  80.5  74.3      |
 |           |                                                                    |
 |           |                                                                    |
 |5MG/KG     |    93.3  93.3  88.3  86.7  86.7  85.0  82.9  80.9  80.9  74.6      |
 |           |                                                                    |
 |           |                                                                    |
 |10MG/KG    |    93.3  86.7  86.7  85.0  85.0  80.9  78.8  72.6  70.5  64.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          5MG/KG           10MG/KG       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       74.3%            74.6%            64.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.339          P=1.000          P=0.398       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       333.5            332.4            362.1         |
 |NATURAL DEATHS (C)      |       (73.5)           (68.8)           (60.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       591.2            591.0            567.3         |
 |(STANDARD ERROR)        |       (28.0)           (27.4)           (29.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 9      CENSORED DEATHS 10   TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      211   535   560   565   593   671   700   705   717                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5MG/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      7     400   464   558   632   639   670   673   678   680                 |
 |      701   704   709   715   719                                               |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 11   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      82    325   325   364   471   492   551   562   573   637                 |
 |      651   656   661   669   670   672   688   719                             |
 |  CENSORED DEATHS                                                               |
 |      432   456   456   456   456   456   456   456   456   456                 |
 |      456                                                                       |
 |                                                                                |
 ==================================================================================

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.3  98.3  98.3  98.3  96.3  90.3  90.3  82.3      |
 |           |                                                                    |
 |           |                                                                    |
 |5MG/KG     |    98.3  98.3  98.3  98.3  96.7  94.7  94.7  92.6  88.6  70.5      |
 |           |                                                                    |
 |           |                                                                    |
 |10MG/KG    |    98.3  98.3  98.3  93.3  93.3  91.3  89.2  83.0  74.7  64.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          5MG/KG           10MG/KG       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.3%            70.5%            64.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.038          P=0.251          P=0.051       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       584.1            596.6            542.7         |
 |NATURAL DEATHS (C)      |       (52.2)           (48.7)           (40.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       661.8            650.4            622.7         |
 |(STANDARD ERROR)        |       (15.6)           (17.9)           (19.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         MERCURIC CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        5MG/KG           = 2
                                                        10MG/KG          = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  103.66 +
         |
         |
         |
   99.51 +132       1
         | 33       1   1
         |
         |  2   3 2     11
   95.37 +      3 2     21 1
         |
         |        3     2      3        2
         |
P  91.22 +                 11  33
E        |                  1  1        2     2
R        |
C        |                     13     3   1   2               2
E  87.07 +                            3   1                 3 2                    1
N        |
T        |                                                  3                      1 3    2             1
         |
S  82.93 +                                                                                2      2      1     1
U        |
R        |                                                                           3          32            1      2  1
V        |
I  78.78 +                                                                                      33                   22
V        |
A        |                                                                                                            2211
L        |
   74.63 +                                                                                       33                    2 1    1
         |
         |                                                                                        3            3
         |
   70.49 +                                                                                                     3       3
         |
         |                                                                                                             3 3
         |
   66.34 +                                                                                                               3  3
         |
         |                                                                                                                  3 3
         |
   62.20 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 7 obs hidden.

                                                         MERCURIC CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        5MG/KG           = 2
                                                        10MG/KG          = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 12           3                    1
      |  2           3                    1                 3           2                    1
      |
      |                                                                 2         2          1  1
   95 +                                                     3    3                2             2
      |                                                          3                 3            11
      |                                                                                         21    1     2
      |                                                                            3  3                     22
P  90 +                                                                                               1           1
E     |                                                                               3        3             2    1   1
R     |                                                                                        3 3
C     |                                                                                                           22  11
E  85 +                                                                                          33
N     |                                                                                                                1 1
T     |                                                                                           3         3      22    1  1
      |                                                                                                     3 3
S  80 +                                                                                                             2  2
U     |                                                                                                       33
R     |
V     |                                                                                                        3 3     22
I  75 +                                                                                                          33     22
V     |
A     |
L     |
   70 +                                                                                                                  2  2
      |                                                                                                           3  3
      |
      |                                                                                                              3   3
   65 +
      |                                                                                                                  3  3
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.