Share This:
https://ntp.niehs.nih.gov/go/3011

TDMS Study 05031-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MERCURIC CHLORIDE


NTP Experiment-Test: 05031-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 17:35:59




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           14            9                                                  
    Dead                                               1            7           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           27           29                                                  
    Moribund                                                        1            1                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (50)                                                
      Inflammation, Chronic                                                      2 (4%)                                             
   Intestine Large, Colon                             (50)         (49)         (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                1 (2%)       1 (2%)       2 (4%)                                             
   Intestine Large, Rectum                            (50)         (46)         (50)                                                
      Parasite Metazoan                                2 (4%)       2 (4%)       2 (4%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       3 (6%)                                             
   Intestine Small, Ileum                             (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (50)                                                
      Autolysis                                                     2 (4%)       4 (8%)                                             
   Liver                                              (50)         (49)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Basophilic Focus, Multiple                      27 (54%)     28 (57%)     32 (64%)                                            
      Clear Cell Focus                                                           9 (18%)                                            
      Congestion                                                    4 (8%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                    3 (6%)       4 (8%)       1 (2%)                                             
      Degeneration, Fatty                                           1 (2%)       2 (4%)                                             
      Ectasia, Focal                                                             1 (2%)                                             
      Eosinophilic Focus                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                       8 (16%)      4 (8%)       8 (16%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                     18 (36%)     23 (47%)     17 (34%)                                            
      Mixed Cell Focus                                                           1 (2%)                                             
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis, Acute                                  1 (2%)       1 (2%)       2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 2 (4%)       3 (6%)       3 (6%)                                             
      Bile Duct, Hyperplasia                           1 (2%)       4 (8%)       3 (6%)                                             
      Hepatocyte, Hyperplasia                                       1 (2%)                                                          
   Mesentery                                          (2)          (2)          (2)                                                 
      Fat, Necrosis, Focal                             2 (100%)     2 (100%)     1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Atrophy, Focal                                  20 (40%)     17 (35%)     20 (40%)                                            
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Ectopic Liver                                                              1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)                                                
      Cytoplasmic Alteration, Focal                                              2 (4%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Edema                                            1 (2%)                                                                       
      Hyperplasia                                      5 (10%)      5 (10%)     20 (40%)                                            
      Inflammation, Acute                              2 (4%)       1 (2%)       2 (4%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                         3 (6%)       1 (2%)       4 (8%)                                             
   Tongue                                             (1)                                                                           
      Hemorrhage, Focal                                1 (100%)                                                                     
   Tooth                                                           (1)                                                              
      Inflammation, Acute                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (15)         (18)         (19)                                                
      Aorta, Inflammation, Chronic                     1 (7%)                                                                       
      Mesenteric Artery, Inflammation, Chronic         1 (7%)                                                                       
   Heart                                              (50)         (49)         (50)                                                
      Inflammation, Chronic                           31 (62%)     38 (78%)     39 (78%)                                            
      Atrium Left, Thrombosis                                       4 (8%)       2 (4%)                                             
      Coronary Artery, Inflammation, Chronic           1 (2%)                                                                       
      Endocardium, Fibrosis                            1 (2%)                                                                       
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (49)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Angiectasis                                                   5 (10%)      3 (6%)                                             
      Congestion                                                    5 (10%)                                                         
      Degeneration, Fatty                              1 (2%)       2 (4%)                                                          
      Hyperplasia, Focal                               5 (10%)     11 (22%)     11 (22%)                                            
      Hypertrophy, Focal                               3 (6%)       3 (6%)       4 (8%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                10 (20%)      7 (14%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (48)         (49)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Focal                               4 (8%)       8 (16%)      5 (10%)                                            
      Bilateral, Hyperplasia, Focal                    1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Hyperplasia, Focal                               2 (4%)                    2 (4%)                                             
   Parathyroid Gland                                  (47)         (49)         (45)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Angiectasis                       8 (16%)      7 (14%)      2 (4%)                                             
      Pars Distalis, Cyst                             13 (26%)     16 (33%)      5 (10%)                                            
      Pars Distalis, Ectasia                           1 (2%)       1 (2%)                                                          
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     10 (20%)      9 (18%)                                            
      Pars Distalis, Hypertrophy                                    1 (2%)       3 (6%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (48)         (49)                                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                             15 (30%)      3 (6%)       5 (10%)                                            
      Follicle, Cyst                                                1 (2%)       4 (8%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (46)         (45)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Duct, Ectasia                                    2 (4%)       2 (4%)       2 (4%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Bilateral, Periovarian Tissue, Cyst              1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)       3 (6%)       3 (6%)                                             
      Periovarian Tissue, Cyst                         1 (2%)                                                                       
   Uterus                                             (50)         (49)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Cervix, Cyst                                                               1 (2%)                                             
      Endometrium, Cyst                                1 (2%)       2 (4%)       4 (8%)                                             
      Endometrium, Hyperplasia, Cystic                 3 (6%)       2 (4%)       7 (14%)                                            
   Vagina                                             (2)                       (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hypoplasia                                                    1 (2%)                                                          
      Myelofibrosis                                    4 (8%)       1 (2%)                                                          
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (2%)                                                          
   Lymph Node                                         (44)         (48)         (49)                                                
      Inguinal, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mandibular, Hyperplasia, Plasma Cell                          1 (2%)                                                          
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
   Lymph Node, Mesenteric                             (40)         (28)         (47)                                                
      Ectasia                                          2 (5%)                                                                       
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Hyperplasia, Re Cell                                                       2 (4%)                                             
      Inflammation                                     1 (3%)                                                                       
   Spleen                                             (50)         (49)         (50)                                                
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)                    2 (4%)                                             
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
   Thymus                                             (48)         (43)         (48)                                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)       3 (6%)                                             
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Galactocele                                      2 (4%)       2 (4%)       1 (2%)                                             
      Hyperplasia                                      4 (8%)       3 (6%)       2 (4%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Duct, Ectasia                                   11 (22%)      8 (17%)      7 (14%)                                            
   Skin                                               (50)         (49)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Osteopetrosis                                    2 (4%)       1 (2%)       3 (6%)                                             
   Skeletal Muscle                                    (2)                                                                           
      Inflammation, Chronic                            2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Demyelination, Focal                                          1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                                 1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      White Matter, Vacuolization Cytoplasmic                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Congestion                                       7 (14%)     16 (33%)     18 (36%)                                            
      Ectopic Tissue                                                1 (2%)                                                          
      Hemorrhage                                       2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       1 (2%)       4 (8%)                                             
      Inflammation, Focal                                           1 (2%)                                                          
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       4 (8%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       2 (4%)       4 (8%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                1 (2%)       2 (4%)                                             
   Nose                                               (49)         (49)         (50)                                                
      Autolysis                                        1 (2%)                    3 (6%)                                             
      Foreign Body                                                               4 (8%)                                             
      Fungus                                                        3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Cyst                                     1 (2%)                                                                       
      Mucosa, Inflammation, Acute                                   1 (2%)       3 (6%)                                             
      Mucosa, Inflammation, Chronic Active                          4 (8%)      12 (24%)                                            
      Mucosa, Mineralization, Focal                                 1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Acute           2 (4%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                    1 (2%)                                             
      Respiratory Epithelium, Degeneration                          1 (2%)                                                          
      Respiratory Epithelium, Hyperplasia                                        1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                  1 (2%)       1 (2%)                                             
   Trachea                                            (50)         (49)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (3)          (2)                                                 
      Hemorrhage                                       2 (40%)      1 (33%)                                                         
      Lens, Cataract                                   3 (60%)      3 (100%)     2 (100%)                                           
      Lens, Degeneration                               1 (20%)                                                                      
      Retina, Degeneration                             4 (80%)      2 (67%)      1 (50%)                                            
      Sclera, Degeneration                             1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Congestion                                                    3 (6%)                                                          
      Cyst                                                                       2 (4%)                                             
      Degeneration, Hyaline                                         1 (2%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Karyomegaly                                                   4 (8%)                                                          
      Mineralization                                                2 (4%)                                                          
      Nephropathy                                     49 (98%)     43 (88%)     41 (82%)                                            
      Pigmentation                                     3 (6%)       1 (2%)       3 (6%)                                             
      Renal Tubule, Hyperplasia                                                  2 (4%)                                             
      Renal Tubule, Hyperplasia, Oncocytic                          1 (2%)                                                          
      Renal Tubule, Hypertrophy                                     1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          20           19           32                                                  
    Dead                                               4           21           13                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           10            5                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)                                                
      Autolysis                                                     3 (6%)       2 (4%)                                             
      Congestion                                                                 2 (4%)                                             
      Edema                                            1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    3 (6%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)                                             
      Inflammation, Acute                                           6 (12%)      7 (14%)                                            
      Inflammation, Chronic                            1 (2%)       2 (4%)       3 (6%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
      Ulcer                                                         8 (16%)      4 (8%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)                                                
      Autolysis                                                     2 (4%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Inflammation, Acute                                           1 (2%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                    3 (6%)                                             
      Mineralization                                                2 (4%)                                                          
      Parasite Metazoan                                1 (2%)       8 (16%)      5 (10%)                                            
   Intestine Large, Rectum                            (50)         (46)         (50)                                                
      Autolysis                                                     1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute, Chronic                                               1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       2 (4%)       2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                             4 (9%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Autolysis                                                     4 (8%)       2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (50)         (49)                                                
      Autolysis                                                     5 (10%)      3 (6%)                                             
      Hyperplasia, Lymphoid                            4 (8%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Autolysis                                                     9 (18%)      4 (8%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   6 (12%)                                                         
      Autolysis                                                     1 (2%)                                                          
      Basophilic Focus                                                           1 (2%)                                             
      Basophilic Focus, Multiple                      17 (34%)      7 (14%)      6 (12%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                       2 (4%)       3 (6%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    7 (14%)      3 (6%)       2 (4%)                                             
      Ectasia                                          2 (4%)       1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       2 (4%)       2 (4%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (16%)      6 (12%)      7 (14%)                                            
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
      Necrosis, Acute                                  4 (8%)       6 (12%)     11 (22%)                                            
      Thrombosis, Focal                                1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 3 (6%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          17 (34%)     22 (44%)     15 (30%)                                            
      Hepatocyte, Degeneration, Cystic                 5 (10%)      7 (14%)      4 (8%)                                             
   Mesentery                                          (2)          (10)         (6)                                                 
      Hemorrhage, Focal                                             1 (10%)                                                         
      Inflammation, Acute, Focal                                                 1 (17%)                                            
      Inflammation, Chronic                                         1 (10%)                                                         
      Fat, Necrosis                                                 1 (10%)      1 (17%)                                            
      Fat, Necrosis, Focal                             2 (100%)     8 (80%)      3 (50%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy, Focal                                  25 (50%)     15 (30%)     18 (36%)                                            
      Autolysis                                                     2 (4%)       2 (4%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
      Duct, Metaplasia, Squamous                                                 1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Autolysis                                                                  1 (2%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Edema                                            2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                      3 (6%)      16 (32%)     35 (70%)                                            
      Inflammation, Acute                              2 (4%)       3 (6%)       4 (8%)                                             
      Mineralization                                                5 (10%)      2 (4%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Autolysis                                                                  1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Mineralization                                                9 (18%)      5 (10%)                                            
      Necrosis                                         3 (6%)       2 (4%)       5 (10%)                                            
      Ulcer                                                         1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (16)         (41)         (42)                                                
      Mineralization                                                6 (15%)      2 (5%)                                             
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                           44 (88%)     48 (96%)     48 (96%)                                            
      Mineralization                                               13 (26%)     14 (28%)                                            
      Atrium Left, Thrombosis                          1 (2%)       5 (10%)      2 (4%)                                             
      Endocardium, Fibrosis                            1 (2%)                                                                       
      Epicardium, Inflammation, Chronic, Focal         1 (2%)                                                                       
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Congestion                                       1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Focal                              10 (20%)      3 (6%)       8 (16%)                                            
      Hypertrophy, Focal                               5 (10%)                   1 (2%)                                             
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                       10 (20%)      8 (16%)     10 (20%)                                            
      Capsule, Ectopic Tissue                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (50)         (49)                                                
      Hyperplasia, Focal                               8 (17%)      8 (16%)      6 (12%)                                            
      Thrombosis                                       1 (2%)                                                                       
      Bilateral, Hyperplasia, Focal                    1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Autolysis                                                     2 (4%)       1 (2%)                                             
      Hyperplasia                                      3 (6%)                    2 (4%)                                             
   Parathyroid Gland                                  (49)         (44)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      2 (4%)      23 (52%)     19 (39%)                                            
      Hyperplasia, Focal                                            2 (5%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Pars Distalis, Angiectasis                       2 (4%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       4 (8%)                                                          
      Pars Distalis, Cytoplasmic Alteration, Focal     1 (2%)                                                                       
      Pars Distalis, Ectasia                           1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      12 (24%)      9 (18%)      6 (12%)                                            
      Pars Distalis, Hypertrophy                       2 (4%)       2 (4%)                                                          
      Pars Distalis, Necrosis, Focal                   1 (2%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)       1 (2%)                                             
      Pars Nervosa, Hyperplasia                                     3 (6%)                                                          
      Pars Nervosa, Inflammation, Granulomatous                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Hemorrhage                                                    2 (4%)                                                          
      Ultimobranchial Cyst                             1 (2%)       1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                              6 (12%)      2 (4%)       1 (2%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     2 (4%)       3 (6%)       2 (4%)                                             
      Follicular Cell, Hyperplasia, Cystic                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
      Cytomegaly                                                    1 (2%)                                                          
      Duct, Epithelium, Degeneration                   1 (2%)       3 (6%)       2 (4%)                                             
      Fat, Necrosis, Focal                             3 (6%)                                                                       
   Preputial Gland                                    (49)         (46)         (48)                                                
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Acute                             11 (22%)     12 (26%)      9 (19%)                                            
      Inflammation, Chronic                            9 (18%)      2 (4%)       8 (17%)                                            
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Duct, Ectasia                                    1 (2%)       2 (4%)                                                          
      Duct, Hyperplasia                                                          1 (2%)                                             
   Prostate                                           (49)         (50)         (50)                                                
      Hyperplasia, Focal                               8 (16%)      1 (2%)                                                          
      Inflammation, Acute                              5 (10%)      4 (8%)       1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic Active                     3 (6%)       1 (2%)                                                          
   Testes                                             (50)         (49)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                          3 (6%)       3 (6%)       1 (2%)                                             
      Bilateral, Atrophy                                                         2 (4%)                                             
      Bilateral, Interstitial Cell, Hyperplasia        3 (6%)       1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                   3 (6%)       4 (8%)       8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Depletion Cellular, Focal                                                  2 (4%)                                             
      Hypoplasia                                       1 (2%)                                                                       
      Myelofibrosis                                                              1 (2%)                                             
      Myeloid Cell, Hyperplasia                        5 (10%)      5 (10%)      4 (8%)                                             
   Lymph Node                                         (49)         (48)         (49)                                                
      Granuloma                                                     1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Axillary, Congestion                             1 (2%)                                                                       
      Axillary, Hemorrhage                             1 (2%)                                                                       
      Iliac, Hyperplasia                                                         1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                    1 (2%)                                             
      Mandibular, Hemorrhage                                        1 (2%)                                                          
      Mandibular, Inflammation, Acute, Focal                        1 (2%)                                                          
      Mediastinal, Hyperplasia                                                   1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)                                                                       
      Renal, Hemorrhage                                                          1 (2%)                                             
      Renal, Hyperplasia                                                         1 (2%)                                             
      Renal, Pigmentation                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (42)         (42)         (44)                                                
      Autolysis                                                     1 (2%)                                                          
      Congestion                                                                 1 (2%)                                             
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (5%)       1 (2%)       2 (5%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                         2 (5%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Atrophy, Focal                                                1 (2%)       1 (2%)                                             
      Congestion                                       4 (8%)       1 (2%)                                                          
      Fibrosis                                         2 (4%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    2 (4%)       1 (2%)       2 (4%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Fibrosis                                             1 (2%)       1 (2%)                                             
   Thymus                                             (46)         (46)         (45)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       1 (2%)       3 (7%)                                                          
      Cyst                                             3 (7%)                    1 (2%)                                             
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (45)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
      Duct, Ectasia                                    5 (11%)      2 (4%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Cyst                                             2 (4%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Face, Inflammation, Acute                        2 (4%)                    4 (8%)                                             
      Tail, Hemorrhage                                                           1 (2%)                                             
      Tail, Subcutaneous Tissue, Necrosis                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Fibrous Osteodystrophy                           1 (2%)      27 (55%)     21 (42%)                                            
      Osteomalacia                                                               1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)                                                 
      Hemorrhage                                                    1 (100%)                                                        
      Inflammation, Acute, Focal                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                    4 (8%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Meninges, Congestion                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       8 (16%)     13 (26%)      5 (10%)                                            
      Fibrosis, Focal                                               1 (2%)       1 (2%)                                             
      Foreign Body                                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                       5 (10%)      4 (8%)       5 (10%)                                            
      Inflammation, Acute, Chronic                                  1 (2%)                                                          
      Inflammation, Acute, Multifocal                  1 (2%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       3 (6%)       3 (6%)                                             
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       5 (10%)      5 (10%)                                            
      Alveolus, Infiltration Cellular, Histiocyte                   3 (6%)       1 (2%)                                             
      Artery, Media, Hypertrophy                       1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (2%)       2 (4%)       1 (2%)                                             
   Nose                                               (50)         (47)         (50)                                                
      Autolysis                                        1 (2%)       6 (13%)      6 (12%)                                            
      Foreign Body                                     1 (2%)       3 (6%)       2 (4%)                                             
      Fungus                                           1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mucosa, Cyst                                     1 (2%)                                                                       
      Mucosa, Inflammation, Acute                                   4 (9%)       2 (4%)                                             
      Mucosa, Inflammation, Chronic                    2 (4%)                                                                       
      Mucosa, Inflammation, Chronic Active             7 (14%)      4 (9%)      16 (32%)                                            
      Nasolacrimal Duct, Cyst                                       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                    3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         3 (6%)                    1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              5 (10%)      1 (2%)       3 (6%)                                             
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (1)                                                              
      Hemorrhage                                       1 (25%)                                                                      
      Bilateral, Lens, Cataract                                     1 (100%)                                                        
      Lens, Cataract                                   1 (25%)                                                                      
      Retina, Degeneration                             3 (75%)                                                                      
      Sclera, Inflammation, Acute                      1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                                    3 (6%)       1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)                                                          
      Mineralization                                                             3 (6%)                                             
      Nephropathy                                     50 (100%)    46 (92%)     48 (96%)                                            
      Pigmentation                                     2 (4%)                                                                       
      Cortex, Cyst                                     3 (6%)       5 (10%)      4 (8%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)                    4 (8%)                                             
      Renal Tubule, Hyperplasia, Cystic                             1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Concretion                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------