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TDMS Study 05031-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         MERCURIC CHLORIDE


NTP Experiment-Test: 05031-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 17:35:59




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           14            9                                                  
    Dead                                               1            7           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           27           29                                                  
    Moribund                                                        1            1                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (50)                                                
   Intestine Large, Rectum                            (50)         (46)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
   Liver                                              (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Neoplastic Nodule                                             1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
   Mesentery                                          (2)          (2)          (2)                                                 
   Pancreas                                           (50)         (49)         (50)                                                
   Salivary Glands                                    (50)         (49)         (50)                                                
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Schwannoma Malignant, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (49)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (49)         (49)                                                
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       2 (4%)                                             
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Adenoma                                                       1 (2%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          21 (42%)     20 (41%)     19 (38%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (48)         (49)                                                
      C-Cell, Adenoma                                  3 (6%)       3 (6%)       1 (2%)                                             
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (46)         (45)                                                
      Adenoma                                          1 (2%)       2 (4%)       3 (7%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       3 (7%)                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Arrhenoblastoma NOS                                           1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Luteoma                                                       1 (2%)                                                          
   Uterus                                             (50)         (49)         (50)                                                
      Leiomyoma                                                                  1 (2%)                                             
      Leiomyosarcoma                                                1 (2%)       1 (2%)                                             
      Polyp Stromal                                                 1 (2%)                                                          
      Endometrium, Polyp Stromal                       8 (16%)     11 (22%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (44)         (48)         (49)                                                
      Mediastinal, Follicular, Carcinoma,                                                                                           
          Metastatic, Thyroid Gland                    1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mesenteric                             (40)         (28)         (47)                                                
   Spleen                                             (50)         (49)         (50)                                                
      Capsule, Fibrous Histiocytoma, Metastatic,                                                                                    
           Uncertain Primary Site                                                1 (2%)                                             
   Thymus                                             (48)         (43)         (48)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)                                                
      Adenocarcinoma                                   3 (6%)                    2 (4%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    15 (30%)      5 (10%)      2 (4%)                                             
   Skin                                               (50)         (49)         (50)                                                
      Fibrosarcoma                                                  2 (4%)                                                          
      Keratoacanthoma                                               2 (4%)                                                          
      Lip, Squamous Cell Carcinoma                     1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Astrocytoma NOS                                               1 (2%)                                                          
      Ependymoma Benign                                             1 (2%)                                                          
      Glioma Benign                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Nose                                               (49)         (49)         (50)                                                
   Trachea                                            (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Monocytic                                                         1 (2%)                                             
      Leukemia Mononuclear                            20 (40%)     11 (22%)     13 (26%)                                            
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          42          39                                                   
     Total Primary Neoplasms                           82          76          67                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35          37          31                                                   
     Total Benign Neoplasms                            54          55          44                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          15          21                                                   
     Total Malignant Neoplasms                         28          19          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           2           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1           1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              2                                                               
     Total Uncertain Neoplasms                                      2                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          20           19           32                                                  
    Dead                                               4           21           13                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           10            5                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)                                                
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
   Intestine Small, Ileum                             (49)         (50)         (49)                                                
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Carcinoma                                        2 (4%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Neoplastic Nodule                                             1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Nose                   1 (2%)                                                                       
      Sarcoma, Metastatic                                                        1 (2%)                                             
   Mesentery                                          (2)          (10)         (6)                                                 
   Pancreas                                           (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Squamous Cell Papilloma                                       2 (4%)       6 (12%)                                            
      Squamous Cell Papilloma, Multiple                             1 (2%)       6 (12%)                                            
   Stomach, Glandular                                 (50)         (50)         (50)                                                
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Extra Adrenal Tissue, Adenoma                                 1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (50)         (49)                                                
      Pheochromocytoma Malignant                       2 (4%)                    1 (2%)                                             
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                         16 (33%)     11 (22%)     20 (41%)                                            
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                                                       
      Bilateral, Pheochromocytoma Benign               5 (10%)      7 (14%)      3 (6%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          3 (6%)                                                                       
   Parathyroid Gland                                  (49)         (44)         (49)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          14 (28%)      4 (8%)       4 (8%)                                             
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Nervosa, Adenoma                                                      1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  5 (10%)      3 (6%)       1 (2%)                                             
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       4 (8%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)       2 (4%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
   Preputial Gland                                    (49)         (46)         (48)                                                
      Adenoma                                          3 (6%)       2 (4%)       2 (4%)                                             
      Basal Cell Adenoma                               1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Prostate                                           (49)         (50)         (50)                                                
   Seminal Vesicle                                    (3)                       (1)                                                 
   Testes                                             (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Bilateral, Interstitial Cell, Adenoma           39 (78%)     28 (57%)     24 (48%)                                            
      Interstitial Cell, Adenoma                       6 (12%)      9 (18%)     15 (30%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (49)         (48)         (49)                                                
      Mandibular, Osteosarcoma, Metastatic, Nose       1 (2%)                                                                       
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Uncertain Primary Site           1 (2%)                                                                       
      Mediastinal, Hemangiosarcoma                                  1 (2%)                                                          
   Lymph Node, Mesenteric                             (42)         (42)         (44)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Capsule, Fibrous Histiocytoma, Metastatic,                                                                                    
           Uncertain Primary Site                      1 (2%)                                                                       
   Thymus                                             (46)         (46)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (45)                                                
      Fibroadenoma                                     2 (4%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Keratoacanthoma                                  5 (10%)      1 (2%)                                                          
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
      Face, Papilloma                                                            1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     3 (6%)       1 (2%)       3 (6%)                                             
      Tail, Neurofibroma                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma NOS                                                            2 (4%)                                             
      Glioma Benign                                    1 (2%)                                                                       
      Oligodendroglioma Benign                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Carcinoma, Metastatic, Adrenal Gland                                       1 (2%)                                             
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Alveolar Epithelium, Carcinoma                   1 (2%)                                                                       
   Nose                                               (50)         (47)         (50)                                                
      Osteosarcoma                                     1 (2%)                                                                       
      Mucosa, Polyp                                                 1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Lipoma                                                        1 (2%)                                                          
      Liposarcoma                                                                1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Renal Tubule, Adenoma                                         2 (4%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            28 (56%)     12 (24%)     14 (28%)                                            
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                           1 (2%)       1 (2%)                                                          
      Mesothelioma NOS                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05031-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          42          45                                                   
     Total Primary Neoplasms                          151         101         121                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          41          44                                                   
     Total Benign Neoplasms                           109          84          91                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          16          23                                                   
     Total Malignant Neoplasms                         42          16          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                                                   
     Total Metastatic Neoplasm                          8                       4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           2                                                   
     Total Uncertain Neoplasms                                      1           2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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