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TDMS Study 05031-02 Pathology Tables


NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: IRDC                                                   MERCURIC CHLORIDE                                  DATE: 09/04/94       
EXPERIMENT: 05031 TEST: 02                                                                                     TIME: 17:46:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 60173        
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                                                         CAS: 7487-94-7       
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: IRDC                                                   MERCURIC CHLORIDE                                  DATE: 09/04/94      
EXPERIMENT: 05031 TEST: 02                                                                                     TIME: 17:46:44      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 60173       
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                                                         CAS: 7487-94-7      
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: IRDC                                                   MERCURIC CHLORIDE                                  DATE: 09/04/94       
EXPERIMENT: 05031 TEST: 02                                                                                     TIME: 17:46:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 60173        
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                                                         CAS: 7487-94-7       
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF MERCURIC CHLORIDE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Brain                         Astrocytoma NOS
                             Intestine Small               Carcinoma
                             Islets, Pancreatic            Adenoma
                             Liver                         Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Skin                          Keratoacanthoma
                             Skin: Subcutaneous Tissue     Fibroma
                             Stomach, Forestomach          Squamous Cell Papilloma
                             Testes                        Adenoma
                             Thyroid Gland: C-Cell         Carcinoma or Adenoma
                             Thyroid Gland: Follicular Cell
                                                           Carcinoma
                                                           Carcinoma or Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: IRDC                                                   MERCURIC CHLORIDE                                  DATE: 09/04/94       
EXPERIMENT: 05031 TEST: 02                                                                                     TIME: 17:46:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 60173        
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                                                         CAS: 7487-94-7       
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF MERCURIC CHLORIDE
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma or Adenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   1
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       0/50 (0%)      |     1/49 (2%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      6.5%            5.6%            0.0%          |      2.9%            3.1%            0.0%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |     1/35 (3%)       0/28 (0%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      672             685             ---           |      729 (T)         687             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.400N        P=0.724         P=0.540N       |     P=0.361N        P=0.722         P=0.531N       |
|INCIDENTAL TUMOR       |     P=0.184N        P=0.511N        P=0.353N       |     P=0.385N        P=0.754         P=0.531N       |
|LOGISTIC REGRESSION    |     P=0.235N        P=0.623N        P=0.359N       |     P=0.356N        P=0.738         P=0.531N       |
|COCHRAN-ARMITAGE       |     P=0.142N                                       |     P=0.327N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.247N       |                     P=0.753N        P=0.495N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    21/48 (44%)     18/50 (36%)     23/49 (47%)     |     2/48 (4%)       1/49 (2%)       3/49 (6%)      |
|ADJUSTED (b)           |     55.0%           88.2%           88.8%          |      5.9%            3.3%            9.6%          |
|TERMINAL (d)           |     8/24 (33%)      8/10 (80%)      3/5 (60%)      |     2/34 (6%)       0/28 (0%)       2/29 (7%)      |
|FIRST INCIDENCE (DAYS) |      586             544             526           |      729 (T)         717             636           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.037 *       P<0.001 **     |     P=0.337         P=0.563N        P=0.424        |
|INCIDENTAL TUMOR       |     P=0.229         P=0.572N        P=0.559        |     P=0.350         P=0.527N        P=0.465        |
|LOGISTIC REGRESSION    |     P=0.074         P=0.401         P=0.156        |     P=0.352         P=0.546N        P=0.447        |
|COCHRAN-ARMITAGE       |     P=0.412                                        |     P=0.407                                        |
|FISHER EXACT           |                     P=0.282N        P=0.456        |                     P=0.492N        P=0.510        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   2
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/48 (6%)       0/50 (0%)       1/49 (2%)      |     0/48 (0%)       0/49 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |     12.5%            0.0%            4.3%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/24 (13%)      0/10 (0%)       0/5 (0%)       |     0/34 (0%)       0/28 (0%)       0/29 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             644           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.536N        P=0.309N        P=0.690        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.399N        P=0.309N        P=0.635N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.363N        P=0.309N        P=0.568N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.170N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.114N        P=0.301N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/48 (50%)     18/50 (36%)     23/49 (47%)     |     2/48 (4%)       1/49 (2%)       3/49 (6%)      |
|ADJUSTED (b)           |     63.4%           88.2%           88.8%          |      5.9%            3.3%            9.6%          |
|TERMINAL (d)           |    11/24 (46%)      8/10 (80%)      3/5 (60%)      |     2/34 (6%)       0/28 (0%)       2/29 (7%)      |
|FIRST INCIDENCE (DAYS) |      586             544             526           |      729 (T)         717             636           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.073         P<0.001 **     |     P=0.337         P=0.563N        P=0.424        |
|INCIDENTAL TUMOR       |     P=0.349         P=0.411N        P=0.533N       |     P=0.350         P=0.527N        P=0.465        |
|LOGISTIC REGRESSION    |     P=0.178         P=0.570N        P=0.293        |     P=0.352         P=0.546N        P=0.447        |
|COCHRAN-ARMITAGE       |     P=0.424N                                       |     P=0.407                                        |
|FISHER EXACT           |                     P=0.116N        P=0.461N       |                     P=0.492N        P=0.510        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   3
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma NOS                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%           15.7%          |      0.0%            3.6%            0.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     0/35 (0%)       1/28 (4%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             633           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.033 *         (e)           P=0.086        |     P=0.704         P=0.455           (e)          |
|INCIDENTAL TUMOR       |     P=0.172           (e)           P=0.380        |     P=0.704         P=0.455           (e)          |
|LOGISTIC REGRESSION    |     P=0.066           (e)           P=0.173        |     P=0.704         P=0.455           (e)          |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.730                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.495           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       2/46 (4%)       2/48 (4%)      |     1/46 (2%)       2/46 (4%)       3/45 (7%)      |
|ADJUSTED (b)           |      9.8%           17.0%            6.9%          |      3.1%            6.2%            9.7%          |
|TERMINAL (d)           |     2/26 (8%)       1/9 (11%)       0/5 (0%)       |     1/32 (3%)       0/27 (0%)       2/28 (7%)      |
|FIRST INCIDENCE (DAYS) |      586             693             599           |      729 (T)         684             631           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.351         P=0.516         P=0.543        |     P=0.188         P=0.457         P=0.256        |
|INCIDENTAL TUMOR       |     P=0.478N        P=0.632         P=0.493N       |     P=0.159         P=0.523         P=0.271        |
|LOGISTIC REGRESSION    |     P=0.533N        P=0.685         P=0.545N       |     P=0.190         P=0.467         P=0.265        |
|COCHRAN-ARMITAGE       |     P=0.416N                                       |     P=0.215                                        |
|FISHER EXACT           |                     P=0.530N        P=0.510N       |                     P=0.500         P=0.300        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   4
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       0/46 (0%)       1/48 (2%)      |     1/46 (2%)       1/46 (2%)       3/45 (7%)      |
|ADJUSTED (b)           |      0.0%            0.0%           20.0%          |      3.1%            3.7%            9.8%          |
|TERMINAL (d)           |     0/26 (0%)       0/9 (0%)        1/5 (20%)      |     1/32 (3%)       1/27 (4%)       2/28 (7%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             729 (T)       |      729 (T)         729 (T)         636           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.073           (e)           P=0.179        |     P=0.168         P=0.724         P=0.254        |
|INCIDENTAL TUMOR       |     P=0.073           (e)           P=0.179        |     P=0.178         P=0.724         P=0.271        |
|LOGISTIC REGRESSION    |     P=0.073           (e)           P=0.179        |     P=0.172         P=0.724         P=0.264        |
|COCHRAN-ARMITAGE       |     P=0.268                                        |     P=0.195                                        |
|FISHER EXACT           |                       (e)           P=0.495        |                     P=0.753N        P=0.300        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       2/46 (4%)       3/48 (6%)      |     2/46 (4%)       3/46 (7%)       6/45 (13%)     |
|ADJUSTED (b)           |      9.8%           17.0%           25.5%          |      6.3%            9.6%           19.0%          |
|TERMINAL (d)           |     2/26 (8%)       1/9 (11%)       1/5 (20%)      |     2/32 (6%)       1/27 (4%)       4/28 (14%)     |
|FIRST INCIDENCE (DAYS) |      586             693             599           |      729 (T)         684             631           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.139         P=0.516         P=0.244        |     P=0.066         P=0.436         P=0.094        |
|INCIDENTAL TUMOR       |     P=0.420         P=0.632         P=0.573        |     P=0.057         P=0.487         P=0.105        |
|LOGISTIC REGRESSION    |     P=0.420         P=0.685         P=0.579        |     P=0.065         P=0.521N        P=0.099        |
|COCHRAN-ARMITAGE       |     P=0.578                                        |     P=0.084                                        |
|FISHER EXACT           |                     P=0.530N        P=0.651        |                     P=0.500         P=0.126        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   5
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/49 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      5.0%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     0/35 (0%)       0/28 (0%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      565             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.165N        P=0.339N        P=0.363N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.042N*       P=0.196N        P=0.116N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.091N        P=0.219N        P=0.203N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.095N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.247N        P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       1/49 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |     11.5%            0.0%            0.0%          |      0.0%            3.6%            6.7%          |
|TERMINAL (d)           |     3/26 (12%)      0/10 (0%)       0/5 (0%)       |     0/35 (0%)       1/28 (4%)       2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.208N        P=0.329N        P=0.510N       |     P=0.123         P=0.455         P=0.205        |
|INCIDENTAL TUMOR       |     P=0.208N        P=0.329N        P=0.510N       |     P=0.123         P=0.455         P=0.205        |
|LOGISTIC REGRESSION    |     P=0.208N        P=0.329N        P=0.510N       |     P=0.123         P=0.455         P=0.205        |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |     P=0.143                                        |
|FISHER EXACT           |                     P=0.121N        P=0.121N       |                     P=0.495         P=0.247        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   6
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/49 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%           13.5%            0.0%          |      0.0%            0.0%            3.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     0/35 (0%)       0/28 (0%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             691             ---           |      ---             ---             692           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.396         P=0.083           (e)          |     P=0.262           (e)           P=0.483        |
|INCIDENTAL TUMOR       |     P=0.618N        P=0.330           (e)          |     P=0.208           (e)           P=0.419        |
|LOGISTIC REGRESSION    |     P=0.556         P=0.160           (e)          |     P=0.259           (e)           P=0.485        |
|COCHRAN-ARMITAGE       |     P=0.669                                        |     P=0.270                                        |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            5.0%           31.4%          |      0.0%            3.6%            0.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       1/5 (20%)      |     0/35 (0%)       1/28 (4%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             680             719           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.015 *       P=0.388         P=0.020 *      |     P=0.704         P=0.455           (e)          |
|INCIDENTAL TUMOR       |     P=0.077         P=0.581         P=0.107        |     P=0.704         P=0.455           (e)          |
|LOGISTIC REGRESSION    |     P=0.036 *       P=0.450         P=0.030 *      |     P=0.704         P=0.455           (e)          |
|COCHRAN-ARMITAGE       |     P=0.142                                        |     P=0.730                                        |
|FISHER EXACT           |                     P=0.500         P=0.247        |                     P=0.495           (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   7
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            5.0%           31.4%          |      0.0%            3.6%            0.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       1/5 (20%)      |     0/35 (0%)       1/28 (4%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             680             719           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.015 *       P=0.388         P=0.020 *      |     P=0.704         P=0.455           (e)          |
|INCIDENTAL TUMOR       |     P=0.077         P=0.581         P=0.107        |     P=0.704         P=0.455           (e)          |
|LOGISTIC REGRESSION    |     P=0.036 *       P=0.450         P=0.030 *      |     P=0.704         P=0.455           (e)          |
|COCHRAN-ARMITAGE       |     P=0.142                                        |     P=0.730                                        |
|FISHER EXACT           |                     P=0.500         P=0.247        |                     P=0.495           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     3/50 (6%)       0/49 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      7.7%            0.0%            6.7%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     2/35 (6%)       0/28 (0%)       2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      573             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.447N        P=0.161N        P=0.566N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.430N        P=0.142N        P=0.545N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.426N        P=0.119N        P=0.542N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.391N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.125N        P=0.500N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   8
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     4/50 (8%)       0/49 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     10.5%            0.0%            6.7%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     3/35 (9%)       0/28 (0%)       2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      573             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.276N        P=0.094N        P=0.407N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.262N        P=0.083N        P=0.388N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.258N        P=0.070N        P=0.386N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.223N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.061N        P=0.339N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |    15/50 (30%)      5/49 (10%)      2/50 (4%)      |
|ADJUSTED (b)           |      7.2%            0.0%            2.8%          |     35.8%           16.7%            6.7%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |     9/35 (26%)      4/28 (14%)      2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      715             ---             586           |      576             629             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.641         P=0.478N        P=0.673        |     P=0.001N**      P=0.047N*       P=0.003N**     |
|INCIDENTAL TUMOR       |     P=0.374N        P=0.285N        P=0.523N       |     P<0.001N**      P=0.023N*       P=0.002N**     |
|LOGISTIC REGRESSION    |     P=0.443N        P=0.415N        P=0.594N       |     P<0.001N**      P=0.020N*       P=0.001N**     |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P<0.001N**                                     |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.013N*       P<0.001N**     |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE   9
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |    15/50 (30%)      5/49 (10%)      2/50 (4%)      |
|ADJUSTED (b)           |      7.2%            0.0%            2.8%          |     35.8%           16.7%            6.7%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |     9/35 (26%)      4/28 (14%)      2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      715             ---             586           |      576             629             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.641         P=0.478N        P=0.673        |     P=0.001N**      P=0.047N*       P=0.003N**     |
|INCIDENTAL TUMOR       |     P=0.374N        P=0.285N        P=0.523N       |     P<0.001N**      P=0.023N*       P=0.002N**     |
|LOGISTIC REGRESSION    |     P=0.443N        P=0.415N        P=0.594N       |     P<0.001N**      P=0.020N*       P=0.001N**     |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P<0.001N**                                     |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.013N*       P<0.001N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |    18/50 (36%)      5/49 (10%)      4/50 (8%)      |
|ADJUSTED (b)           |      7.2%            0.0%            2.8%          |     42.0%           16.7%           13.3%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |    11/35 (31%)      4/28 (14%)      4/30 (13%)     |
|FIRST INCIDENCE (DAYS) |      715             ---             586           |      573             629             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.641         P=0.478N        P=0.673        |     P=0.001N**      P=0.014N*       P=0.004N**     |
|INCIDENTAL TUMOR       |     P=0.374N        P=0.285N        P=0.523N       |     P<0.001N**      P=0.005N**      P=0.003N**     |
|LOGISTIC REGRESSION    |     P=0.443N        P=0.415N        P=0.594N       |     P<0.001N**      P=0.004N**      P=0.002N**     |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P<0.001N**                                     |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.002N**      P<0.001N**     |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  10
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    14/50 (28%)      4/49 (8%)       4/50 (8%)      |    21/50 (42%)     20/49 (41%)     19/50 (38%)     |
|ADJUSTED (b)           |     42.8%           28.2%           29.1%          |     51.9%           59.9%           49.7%          |
|TERMINAL (d)           |     9/26 (35%)      2/9 (22%)       1/5 (20%)      |    16/35 (46%)     15/28 (54%)     11/30 (37%)     |
|FIRST INCIDENCE (DAYS) |      506             666             595           |      573             571             580           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.369N        P=0.293N        P=0.502N       |     P=0.458         P=0.331         P=0.510        |
|INCIDENTAL TUMOR       |     P=0.067N        P=0.054N        P=0.097N       |     P=0.461         P=0.436         P=0.511        |
|LOGISTIC REGRESSION    |     P=0.026N*       P=0.053N        P=0.038N*      |     P=0.514         P=0.448         P=0.577        |
|COCHRAN-ARMITAGE       |     P=0.004N**                                     |     P=0.380N                                       |
|FISHER EXACT           |                     P=0.010N**      P=0.009N**     |                     P=0.534N        P=0.419N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    15/50 (30%)      4/49 (8%)       4/50 (8%)      |    22/50 (44%)     20/49 (41%)     19/50 (38%)     |
|ADJUSTED (b)           |     43.9%           28.2%           29.1%          |     54.4%           59.9%           49.7%          |
|TERMINAL (d)           |     9/26 (35%)      2/9 (22%)       1/5 (20%)      |    17/35 (49%)     15/28 (54%)     11/30 (37%)     |
|FIRST INCIDENCE (DAYS) |      480             666             595           |      573             571             580           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.271N        P=0.220N        P=0.392N       |     P=0.529         P=0.397         P=0.570N       |
|INCIDENTAL TUMOR       |     P=0.034N*       P=0.024N*       P=0.049N*      |     P=0.540         P=0.510         P=0.578N       |
|LOGISTIC REGRESSION    |     P=0.009N**      P=0.024N*       P=0.014N*      |     P=0.491N        P=0.525         P=0.514N       |
|COCHRAN-ARMITAGE       |     P=0.002N**                                     |     P=0.306N                                       |
|FISHER EXACT           |                     P=0.005N**      P=0.005N**     |                     P=0.453N        P=0.342N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  11
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       2/49 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            6.4%            0.0%          |
|TERMINAL (d)           |     0/26 (0%)       0/10 (0%)       0/5 (0%)       |     0/35 (0%)       0/28 (0%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             687             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.640         P=0.210           (e)          |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.601         P=0.265           (e)          |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.644         P=0.213           (e)          |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.668                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.242           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      1/50 (2%)       0/50 (0%)      |     0/50 (0%)       2/49 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |     17.7%            6.7%            0.0%          |      0.0%            7.1%            0.0%          |
|TERMINAL (d)           |     4/26 (15%)      0/10 (0%)       0/5 (0%)       |     0/35 (0%)       2/28 (7%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      672             693             ---           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.159N        P=0.398N        P=0.304N       |     P=0.631         P=0.190           (e)          |
|INCIDENTAL TUMOR       |     P=0.065N        P=0.229N        P=0.201N       |     P=0.631         P=0.190           (e)          |
|LOGISTIC REGRESSION    |     P=0.067N        P=0.265N        P=0.162N       |     P=0.631         P=0.190           (e)          |
|COCHRAN-ARMITAGE       |     P=0.011N*                                      |     P=0.668                                        |
|FISHER EXACT           |                     P=0.102N        P=0.028N*      |                     P=0.242           (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  12
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      1/50 (2%)       2/50 (4%)      |     1/50 (2%)       2/49 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |     21.5%            6.7%            6.7%          |      2.8%            7.1%            0.0%          |
|TERMINAL (d)           |     5/26 (19%)      0/10 (0%)       0/5 (0%)       |     0/35 (0%)       2/28 (7%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      672             693             565           |      698             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.495N        P=0.314N        P=0.652        |     P=0.406N        P=0.431         P=0.530N       |
|INCIDENTAL TUMOR       |     P=0.201N        P=0.175N        P=0.384N       |     P=0.422N        P=0.466         P=0.581N       |
|LOGISTIC REGRESSION    |     P=0.177N        P=0.198N        P=0.288N       |     P=0.399N        P=0.448         P=0.518N       |
|COCHRAN-ARMITAGE       |     P=0.070N                                       |     P=0.361N                                       |
|FISHER EXACT           |                     P=0.056N        P=0.134N       |                     P=0.492         P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       1/50 (2%)       3/50 (6%)      |     1/50 (2%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |     11.5%            2.5%           45.5%          |      2.9%            2.6%            0.0%          |
|TERMINAL (d)           |     3/26 (12%)      0/10 (0%)       2/5 (40%)      |     1/35 (3%)       0/28 (0%)       0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         519             692           |      729 (T)         609             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.093         P=0.591N        P=0.049 *      |     P=0.368N        P=0.716         P=0.531N       |
|INCIDENTAL TUMOR       |     P=0.157         P=0.485N        P=0.109        |     P=0.338N        P=0.749         P=0.531N       |
|LOGISTIC REGRESSION    |     P=0.362         P=0.383N        P=0.125        |     P=0.332N        P=0.766N        P=0.531N       |
|COCHRAN-ARMITAGE       |     P=0.594                                        |     P=0.332N                                       |
|FISHER EXACT           |                     P=0.309N        P=0.661N       |                     P=0.747         P=0.500N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  13
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       3/50 (6%)      12/50 (24%)     |     0/50 (0%)       0/49 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%           17.7%           66.3%          |      0.0%            0.0%            6.7%          |
|TERMINAL (d)           |     0/26 (0%)       1/10 (10%)      2/5 (40%)      |     0/35 (0%)       0/28 (0%)       2/30 (7%)      |
|FIRST INCIDENCE (DAYS) |      ---             664             490           |      ---             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.041 *       P<0.001 **     |     P=0.085           (e)           P=0.205        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.105         P=0.001 **     |     P=0.085           (e)           P=0.205        |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.066         P<0.001 **     |     P=0.085           (e)           P=0.205        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.096                                        |
|FISHER EXACT           |                     P=0.121         P<0.001 **     |                       (e)           P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    45/50 (90%)     37/49 (76%)     39/50 (78%)     |                                                    |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |                                                    |
|TERMINAL (d)           |    26/26 (100%)    10/10 (100%)     5/5 (100%)     |                                                    |
|FIRST INCIDENCE (DAYS) |      546             523             470           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.002 **      P<0.001 **     |                                                    |
|INCIDENTAL TUMOR       |     P=0.570N        P=0.400         P=0.562        |                                                    |
|LOGISTIC REGRESSION    |     P=0.482N        P=0.380         P=0.608N       |                                                    |
|COCHRAN-ARMITAGE       |     P=0.080N                                       |                                                    |
|FISHER EXACT           |                     P=0.049N*       P=0.086N       |                                                    |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  14
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      3/50 (6%)       1/50 (2%)      |     3/50 (6%)       3/48 (6%)       1/49 (2%)      |
|ADJUSTED (b)           |     17.7%           18.9%           20.0%          |      8.6%            9.7%            3.4%          |
|TERMINAL (d)           |     4/26 (15%)      1/10 (10%)      1/5 (20%)      |     3/35 (9%)       2/28 (7%)       1/29 (3%)      |
|FIRST INCIDENCE (DAYS) |      657             608             729 (T)       |      729 (T)         629             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.551N        P=0.520         P=0.648N       |     P=0.311N        P=0.560         P=0.374N       |
|INCIDENTAL TUMOR       |     P=0.325N        P=0.627N        P=0.553N       |     P=0.296N        P=0.574         P=0.374N       |
|LOGISTIC REGRESSION    |     P=0.258N        P=0.583N        P=0.428N       |     P=0.298N        P=0.595         P=0.374N       |
|COCHRAN-ARMITAGE       |     P=0.070N                                       |     P=0.247N                                       |
|FISHER EXACT           |                     P=0.357N        P=0.102N       |                     P=0.641         P=0.316N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |     1/50 (2%)       2/48 (4%)       1/49 (2%)      |
|ADJUSTED (b)           |      7.7%            0.0%            0.0%          |      2.9%            6.5%            3.4%          |
|TERMINAL (d)           |     2/26 (8%)       0/10 (0%)       0/5 (0%)       |     1/35 (3%)       1/28 (4%)       1/29 (3%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      729 (T)         684             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.314N        P=0.465N        P=0.636N       |     P=0.566         P=0.438         P=0.720        |
|INCIDENTAL TUMOR       |     P=0.314N        P=0.465N        P=0.636N       |     P=0.546         P=0.466         P=0.720        |
|LOGISTIC REGRESSION    |     P=0.314N        P=0.465N        P=0.636N       |     P=0.568         P=0.448         P=0.720        |
|COCHRAN-ARMITAGE       |     P=0.095N                                       |     P=0.615                                        |
|FISHER EXACT           |                     P=0.247N        P=0.247N       |                     P=0.485         P=0.747        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  15
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      3/50 (6%)       1/50 (2%)      |     4/50 (8%)       5/48 (10%)      2/49 (4%)      |
|ADJUSTED (b)           |     25.2%           18.9%           20.0%          |     11.4%           15.8%            6.9%          |
|TERMINAL (d)           |     6/26 (23%)      1/10 (10%)      1/5 (20%)      |     4/35 (11%)      3/28 (11%)      2/29 (7%)      |
|FIRST INCIDENCE (DAYS) |      657             608             729 (T)       |      729 (T)         629             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.379N        P=0.610N        P=0.508N       |     P=0.377N        P=0.376         P=0.426N       |
|INCIDENTAL TUMOR       |     P=0.197N        P=0.458N        P=0.421N       |     P=0.375N        P=0.404         P=0.426N       |
|LOGISTIC REGRESSION    |     P=0.135N        P=0.388N        P=0.295N       |     P=0.364N        P=0.409         P=0.426N       |
|COCHRAN-ARMITAGE       |     P=0.017N*                                      |     P=0.293N                                       |
|FISHER EXACT           |                     P=0.159N        P=0.030N*      |                     P=0.474         P=0.349N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       4/50 (8%)       0/50 (0%)      |     0/50 (0%)       2/48 (4%)       0/49 (0%)      |
|ADJUSTED (b)           |      3.8%           18.3%            0.0%          |      0.0%            6.0%            0.0%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |     0/35 (0%)       1/28 (4%)       0/29 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         627             ---           |      ---             601             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.513         P=0.059         P=0.821N       |     P=0.629         P=0.200           (e)          |
|INCIDENTAL TUMOR       |     P=0.307N        P=0.168         P=0.821N       |     P=0.658         P=0.215           (e)          |
|LOGISTIC REGRESSION    |     P=0.490N        P=0.116         P=0.821N       |     P=0.666         P=0.233           (e)          |
|COCHRAN-ARMITAGE       |     P=0.390N                                       |     P=0.663                                        |
|FISHER EXACT           |                     P=0.181         P=0.500N       |                     P=0.237           (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  16
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       6/50 (12%)     |     1/50 (2%)       2/48 (4%)       0/49 (0%)      |
|ADJUSTED (b)           |      3.8%           11.6%           31.9%          |      2.9%            7.1%            0.0%          |
|TERMINAL (d)           |     1/26 (4%)       0/10 (0%)       0/5 (0%)       |     1/35 (3%)       2/28 (7%)       0/29 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         671             569           |      729 (T)         729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002 **      P=0.244         P=0.005 **     |     P=0.415N        P=0.422         P=0.538N       |
|INCIDENTAL TUMOR       |     P=0.076         P=0.489         P=0.129        |     P=0.415N        P=0.422         P=0.538N       |
|LOGISTIC REGRESSION    |     P=0.017 *       P=0.368         P=0.044 *      |     P=0.415N        P=0.422         P=0.538N       |
|COCHRAN-ARMITAGE       |     P=0.029 *                                      |     P=0.367N                                       |
|FISHER EXACT           |                     P=0.500         P=0.056        |                     P=0.485         P=0.505N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       6/50 (12%)      6/50 (12%)     |     1/50 (2%)       4/48 (8%)       0/49 (0%)      |
|ADJUSTED (b)           |      7.7%           27.7%           31.9%          |      2.9%           13.0%            0.0%          |
|TERMINAL (d)           |     2/26 (8%)       0/10 (0%)       0/5 (0%)       |     1/35 (3%)       3/28 (11%)      0/29 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         627             569           |      729 (T)         601             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.006 **      P=0.020 *       P=0.010 **     |     P=0.459N        P=0.124         P=0.538N       |
|INCIDENTAL TUMOR       |     P=0.246         P=0.119         P=0.172        |     P=0.439N        P=0.131         P=0.538N       |
|LOGISTIC REGRESSION    |     P=0.062         P=0.061         P=0.091        |     P=0.440N        P=0.142         P=0.538N       |
|COCHRAN-ARMITAGE       |     P=0.114                                        |     P=0.398N                                       |
|FISHER EXACT           |                     P=0.134         P=0.134        |                     P=0.168         P=0.505N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  17
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     8/50 (16%)     12/49 (24%)      9/50 (18%)     |
|ADJUSTED (b)           |                                                    |     20.9%           39.2%           30.0%          |
|TERMINAL (d)           |                                                    |     6/35 (17%)     10/28 (36%)      9/30 (30%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      614             523             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.300         P=0.101         P=0.359        |
|INCIDENTAL TUMOR       |                                                    |     P=0.346         P=0.142         P=0.389        |
|LOGISTIC REGRESSION    |                                                    |     P=0.323         P=0.138         P=0.380        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.450                                        |
|FISHER EXACT           |                                                    |                     P=0.212         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    28/50 (56%)     12/50 (24%)     14/50 (28%)     |    20/50 (40%)     11/49 (22%)     14/50 (28%)     |
|ADJUSTED (b)           |     67.6%           67.3%           58.8%          |     42.7%           30.5%           37.7%          |
|TERMINAL (d)           |    13/26 (50%)      6/10 (60%)      1/5 (20%)      |     9/35 (26%)      5/28 (18%)      8/30 (27%)     |
|FIRST INCIDENCE (DAYS) |      546             398             361           |      531              84             515           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.303         P=0.395N        P=0.304        |     P=0.268N        P=0.164N        P=0.323N       |
|INCIDENTAL TUMOR       |     P=0.007N**      P=0.018N*       P=0.004N**     |     P=0.135N        P=0.024N*       P=0.188N       |
|LOGISTIC REGRESSION    |     P=0.014N*       P=0.011N*       P=0.016N*      |     P=0.111N        P=0.024N*       P=0.154N       |
|COCHRAN-ARMITAGE       |     P=0.002N**                                     |     P=0.115N                                       |
|FISHER EXACT           |                     P=0.001N**      P=0.004N**     |                     P=0.047N*       P=0.146N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  18
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    48/50 (96%)     41/50 (82%)     44/50 (88%)     |    35/50 (70%)     37/49 (76%)     31/50 (62%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     77.5%           92.4%           79.4%          |
|TERMINAL (d)           |    26/26 (100%)    10/10 (100%)     5/5 (100%)     |    25/35 (71%)     25/28 (89%)     22/30 (73%)     |
|FIRST INCIDENCE (DAYS) |      506             375             470           |      573             523             580           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.002 **      P<0.001 **     |     P=0.443         P=0.073         P=0.507        |
|INCIDENTAL TUMOR       |     P=0.380N        P=0.716         P=0.547N       |     P=0.493         P=0.128         P=0.539        |
|LOGISTIC REGRESSION    |     P=0.415N        P=0.425         P=0.671N       |     P=0.547         P=0.110         P=0.576        |
|COCHRAN-ARMITAGE       |     P=0.135N                                       |     P=0.224N                                       |
|FISHER EXACT           |                     P=0.026N*       P=0.134N       |                     P=0.349         P=0.263N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    34/50 (68%)     16/50 (32%)     23/50 (46%)     |    24/50 (48%)     15/49 (31%)     21/50 (42%)     |
|ADJUSTED (b)           |     76.8%           79.8%           85.9%          |     51.5%           40.5%           53.1%          |
|TERMINAL (d)           |    16/26 (62%)      7/10 (70%)      3/5 (60%)      |    13/35 (37%)      7/28 (25%)     12/30 (40%)     |
|FIRST INCIDENCE (DAYS) |      480             398             361           |      531              84             515           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.027 *       P=0.499N        P=0.033 *      |     P=0.530         P=0.222N        P=0.541        |
|INCIDENTAL TUMOR       |     P=0.049N*       P=0.008N**      P=0.024N*      |     P=0.395N        P=0.039N*       P=0.451N       |
|LOGISTIC REGRESSION    |     P=0.085N        P=0.006N**      P=0.068N       |     P=0.351N        P=0.045N*       P=0.410N       |
|COCHRAN-ARMITAGE       |     P=0.018N*                                      |     P=0.305N                                       |
|FISHER EXACT           |                     P<0.001N**      P=0.021N*      |                     P=0.059N        P=0.344N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05031 TEST: 02                                                 PAGE  19
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2.5MG/KG        5 MG/KG       |      CONTROL         2.5MG/KG        5.0MG/KG      |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    49/50 (98%)     42/50 (84%)     45/50 (90%)     |    46/50 (92%)     42/49 (86%)     39/50 (78%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     92.0%           97.7%           90.7%          |
|TERMINAL (d)           |    26/26 (100%)    10/10 (100%)     5/5 (100%)     |    31/35 (89%)     27/28 (96%)     26/30 (87%)     |
|FIRST INCIDENCE (DAYS) |      480             375             361           |      531              84             515           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.002 **      P<0.001 **     |     P=0.498N        P=0.265         P=0.517N       |
|INCIDENTAL TUMOR       |     P=0.270N        P=0.669N        P=0.378N       |     P=0.215N        P=0.494N        P=0.303N       |
|LOGISTIC REGRESSION    |     P=0.183N        P=0.669N        P=0.382N       |     P=0.180N        P=0.510N        P=0.242N       |
|COCHRAN-ARMITAGE       |     P=0.114N                                       |     P=0.033N*                                      |
|FISHER EXACT           |                     P=0.015N*       P=0.102N       |                     P=0.251N        P=0.045N*      |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).