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TDMS Study 05031-02 Pathology Tables

NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97
Route: GAVAGE                                                                                                     Time: 16:06:46




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|             
                                           | 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Angiectasis                          |                      1                                                   |             
      Basophilic Focus, Multiple           | X     X     X           X           X  X              X  X        X  X   |             
      Cytoplasmic Alteration, Focal        |                         2                                1           1   |             
      Hepatodiaphragmatic Nodule           |       X     X                          X     X           X               |             
      Inflammation, Chronic                |                               1                                          |             
      Inflammation, Granulomatous          | 2     2        1        2                             1        2         |             
      Necrosis, Acute                      |                                                                         2|             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                         3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis, Focal                 |                                           3                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Atrophy, Focal                       |                         1     1     1  1  2  2           1           2  2|             
      Inflammation, Chronic                |                                              1                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Hemorrhage, Focal                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                                              1                           |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Hemorrhage, Focal                    |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +  +  +                       +                 +         |             
      Aorta, Inflammation, Chronic         |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|             
                                           | 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Inflammation, Chronic                | 2     1        1  1  2        1  1  1        2  1     1  1     1  1  2   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                         2                                                |             
      Endocardium, Fibrosis                |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia, Focal                   |             1                          1                                 |             
      Hypertrophy, Focal                   |    1                                                     1              2|             
      Vacuolization Cytoplasmic, Focal     |       1        2  2              1     1                                2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     +  +  +  +  M  +  +     +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                               1                                         2|             
      Bilateral, Hyperplasia, Focal        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Hyperplasia, Focal                   | 1                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +  +  +  +  +     +  +  +  +  M  +  +     +  +     +  +  +  +|             
      Hyperplasia, Focal                   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                                         3  2                    2     2|             
      Pars Distalis, Cyst                  |                1        2        1           2        3                  |             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                 2           2                                         4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                                   1  1                       1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +     +  +  +  M  +     +  M  +  +  +  +  +     +  +     +  M  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |    1                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|             
                                           | 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  M  +     +  +  +  +  +  +  +     +  +     +  M  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  M  +           +  +  +  +  +     +        +  M  +  +|             
      Ectasia                              |                         1           1                                    |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                  2                                       |             
      Capsule, Fibrosis, Focal             |                                                                   1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  M  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Cyst                                 |                                           3                              |             
      Galactocele                          |                                                                      2  3|             
      Hyperplasia                          |                                  1                                       |             
      Duct, Ectasia                        |                                  3  2  1                             1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
      Inflammation, Chronic                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                      1                                                   |             
      Inflammation, Chronic                |                                           1     1                        |             
      Inflammation, Granulomatous          |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|             
                                           | 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
      Mucosa, Cyst                         |                                  1                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +                             +         |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                  3                             2         |             
      Lens, Degeneration                   |                               4                                          |             
      Retina, Degeneration                 |                               4  3                             4         |             
      Sclera, Degeneration                 |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
      Nephropathy                          | 1  1  1     1  1  1  2  1     1  1  1  2  1  3  1     2  1     1  1  2  1|             
      Pigmentation                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|             
                                           | 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus, Multiple           |    X     X     X  X  X                 X  X  X  X  X                    X|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X        X                       X                              |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |    1           3  1                    2  2     1  1                     |             
      Necrosis, Acute                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                              3                           |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Atrophy, Focal                       |          2  1  1           1  1        1        1                        |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Edema                                |       3                                                                  |             
      Hyperplasia                          |       2                                               2           2  1   |             
      Inflammation, Acute                  |       2                                               2                  |             
      Ulcer                                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Necrosis                             |                            1                          1              1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +        +  +  +  +                          +           +  +   |             
      Aorta, Inflammation, Chronic         |          2                                                               |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|             
                                           | 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Inflammation, Chronic                |          1  1  1  1        2           1     1     2  1           1  1  1|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Endocardium, Fibrosis                |                      3                                                   |             
      Epicardium, Inflammation, Chronic    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  M           +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  M           +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           1                              |             
      Degeneration, Fatty                  |          1                                                               |             
      Hyperplasia, Focal                   |                                                 1                        |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       1                 1                                         1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  M           +  +  +|             
      Cyst                                 |                                              2                           |             
      Hyperplasia, Focal                   |                                              2                           |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Pars Distalis, Angiectasis           |                2                                                  1  2   |             
      Pars Distalis, Cyst                  |       2           1     3  1                 1                           |             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hyperplasia           |                1           2              2                          2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      C-Cell, Hyperplasia                  |    1           1        1                    1     1                 1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Inflammation, Chronic                |                                           1                              |             
      Duct, Ectasia                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                              X                           |             
      Follicle, Cyst                       |                   1                                                      |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Hyperplasia, Cystic                  |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|             
                                           | 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Cyst                    |                                                                   4      |             
      Endometrium, Hyperplasia, Cystic     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Myelofibrosis                        |          3        2                                                      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  M           +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    M  +  +  +  +  +  +  +  +  +        +  +  +  +  +              +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Congestion                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Cyst                                 |                                                                          |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                                       1           2  2   |             
      Duct, Ectasia                        |                                        2        1                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Osteopetrosis                        |                                                 1                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Inflammation, Chronic                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Congestion                           |    1                          1           2                              |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |          1                                                               |             
      Inflammation, Granulomatous          |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|             
                                           | 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Autolysis                            |                            1                                             |             
      Mucosa, Cyst                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             1     2                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +           +                                          |             
      Hemorrhage                           |                   3           2                                          |             
      Lens, Cataract                       |                   2                                                      |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |                   4                                                      |             
      Sclera, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
      Autolysis                            |                            2                                             |             
      Nephropathy                          |    3  2  1  1  2     3  2  1  1        2  1  2  3  2  2           2  1  2|             
      Pigmentation                         |       2                                3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +           +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 0| 2| 4| 2| 3| 4| 2| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus, Multiple           | X     X     X     X     X  X                                             |     27     |
      Cytoplasmic Alteration, Focal        |                                                                          |      3  1.3|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |       2           1  2  1  1                                             |     18  1.6|
      Necrosis, Acute                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                      2                                                   |      2  2.5|
      Bile Duct, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   2        |
      Fat, Necrosis, Focal                 |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy, Focal                       |       2        3  1     1                                                |     20  1.4|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      5  1.6|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Necrosis                             |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 0| 2| 4| 2| 3| 4| 2| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |  15        |
      Aorta, Inflammation, Chronic         |                                                                          |      1  2.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                | 1           1           1  1                                             |     31  1.2|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Endocardium, Fibrosis                |                                                                          |      1  3.0|
      Epicardium, Inflammation, Chronic    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |          1  2                                                            |      5  1.2|
      Hypertrophy, Focal                   |                                                                          |      3  1.3|
      Vacuolization Cytoplasmic, Focal     |                1                                                         |     10  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                      1                                                   |      4  1.5|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Focal                   |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  47        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      8  2.0|
      Pars Distalis, Cyst                  | 2                    2  2                                                |     13  1.8|
      Pars Distalis, Ectasia               |       2                                                                  |      1  2.0|
      Pars Distalis, Hyperplasia           |             2              2                                             |     10  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  | 1     1  1     1           1                                             |     15  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 0| 2| 4| 2| 3| 4| 2| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Endometrium, Cyst                    |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                         2  1                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Myelofibrosis                        |                      1  1                                                |      4  1.8|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  M  M                                             |  44        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M                                             |  40        |
      Ectasia                              |                                                                          |      2  1.0|
      Hyperplasia, Plasma Cell             |                      1                                                   |      1  1.0|
      Inflammation                         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Galactocele                          |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      4  1.5|
      Duct, Ectasia                        |       1  1     1     1     2                                             |     11  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 0| 2| 4| 2| 3| 4| 2| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Osteopetrosis                        | 3                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           | 1     1     1              2                                             |      7  1.3|
      Hemorrhage                           |    1                                                                     |      2  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |          3                                                               |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Autolysis                            |                                                                          |      1  1.0|
      Mucosa, Cyst                         |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Lens, Cataract                       |                                                                          |      3  2.3|
      Lens, Degeneration                   |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      4  3.8|
      Sclera, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  2  1  2  2  1  1  2  1                                             |     49  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 4| 0| 2| 4| 2| 3| 4| 2| 4| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|             
                                           | 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +                 +  +  +  +  +  M     +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Autolysis                            |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Autolysis                            |                                           4                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Autolysis                            |                                           4                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus, Multiple           | X  X     X                 X  X     X  X        X  X     X  X     X  X  X|             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                   2      |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          | 2  1     2                 2        1  2              3           2  2  2|             
      Necrosis, Acute                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                    1                     |             
      Hepatocyte, Hyperplasia              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Atrophy, Focal                       | 1        2                          1                 2  2  1     2      |             
      Autolysis                            |                                           3                              |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                  1                    2  2               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Necrosis                             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|             
                                           | 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +        +              +           +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                | 1  2     1                 1  1  1  1  1  1     1  1  1     2        1  1|             
      Atrium Left, Thrombosis              |       2                          3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Congestion                           |                                                       3                  |             
      Degeneration, Fatty                  |                                                                      2   |             
      Hyperplasia, Focal                   |       1                                1        1  2  1           1  2  1|             
      Hypertrophy, Focal                   |                                        1  1                              |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                               1                 1                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |          1                          1           1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Pars Distalis, Angiectasis           | 2                                      2                          3      |             
      Pars Distalis, Cyst                  | 1                             2  3  3                                   1|             
      Pars Distalis, Ectasia               |                                                             2            |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                                               1           1            |             
      Pars Distalis, Hypertrophy           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +                 +  +  +  +  +  I     +  +  +  +  +     +  +  +|             
      Ultimobranchial Cyst                 |                                  X                                       |             
      C-Cell, Hyperplasia                  |       1                          1                                       |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  M  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                               3                    2                     |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|             
                                           | 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Dilatation                           | 2                                                                        |             
      Hemorrhage                           |    1                                                                     |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Cyst                    | 3                                                                       2|             
      Endometrium, Hyperplasia, Cystic     |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +                 +  M  +  +  +  +     +  +  +  +  +     +  +  +|             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +                 +  M  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | I  I  +  I                 +  +  +  +  +  +     +  +  +  +  +     +  M  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  M  +|             
      Galactocele                          |                                                          3               |             
      Hyperplasia                          |       1                                                                  |             
      Inflammation, Acute                  |                                                                          |             
      Duct, Ectasia                        |                                  2              2  1        1            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Osteopetrosis                        |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Demyelination, Focal                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |       2                                                                  |             
      White Matter, Vacuolization          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|             
                                           | 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic                      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Congestion                           |    1                       1  1        1  2                              |             
      Ectopic Tissue                       |       X                                                                  |             
      Hemorrhage                           |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                    1  2           1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Fungus                               |                                           X                              |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 2                                         4                              |             
      Mucosa, Mineralization, Focal        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Respiratory Epithelium, Degeneration |                                  2                                       |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                           4                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Hemorrhage                           |                                                                         3|             
      Lens, Cataract                       |                                                                         3|             
      Retina, Degeneration                 |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Hyaline                |                                                                          |             
      Karyomegaly                          |                            1                                             |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1  2  1                 1  1  1  1  1        2  2  2  2  1     1  1  2|             
      Pigmentation                         |                                  2                                       |             
      Renal Tubule, Hyperplasia, Oncocytic |                                  2                                       |             
      Renal Tubule, Hypertrophy            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +                 +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|             
                             DAY ON TEST   | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|             
                                           | 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  M     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Autolysis                            |                3                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Angiectasis                          |                                              1                           |             
      Basophilic Focus, Multiple           | X        X  X  X  X        X        X  X  X        X                     |             
      Congestion                           | 2     2                       2                                          |             
      Cytoplasmic Alteration, Focal        |                            3                       2                     |             
      Degeneration, Fatty                  |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X        X                       X                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |          2  1     1        1              1  1     2              2  2   |             
      Necrosis, Acute                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          2                                                               |             
      Bile Duct, Hyperplasia               |    1                                                                     |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis, Focal                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Atrophy, Focal                       |    2  1  1              1  1        1              2                     |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hyperplasia                          |       1                                                        1         |             
      Inflammation, Acute                  |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Autolysis                            |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|             
                             DAY ON TEST   | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|             
                                           | 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +        +        +     +  +           +           +  +     +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Inflammation, Chronic                | 1  1  1  1  2     1        1  1     1  1  1  1     2        1  1  2      |             
      Atrium Left, Thrombosis              |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Angiectasis                          |                                                                      3   |             
      Congestion                           | 3              2              2                          4               |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia, Focal                   |          2  1                          1                                 |             
      Hypertrophy, Focal                   |             1                                                            |             
      Necrosis, Focal                      |                                                 1                        |             
      Vacuolization Cytoplasmic, Focal     |       1     1                                                        1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hyperplasia, Focal                   |             1                       1           1              1     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hyperplasia, Focal                   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |             2     2     2                                                |             
      Pars Distalis, Cyst                  |                         2        2  1     2        2     1  2     2      |             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                             2            |             
      Pars Distalis, Hyperplasia           |             2           1           1     2              1     2         |             
      Pars Distalis, Hypertrophy           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                  1                                       |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +     +  +  +  +  +   |             
      Hyperplasia                          |             1                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|             
                             DAY ON TEST   | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|             
                                           | 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia                        |                            1                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Follicle, Cyst                       |                                           2        X           1         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis                        |                                     1                                    |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                   2      |             
      Mediastinal, Hemorrhage              |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +        +        +     +  +           +           +        +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  I  +     +  +  +  +  +   |             
      Cyst                                 |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Galactocele                          |                            3                                             |             
      Hyperplasia                          |                         1                                      2         |             
      Inflammation, Acute                  |                                                                2         |             
      Duct, Ectasia                        |    2                                            1              2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Demyelination, Focal                 |                                  2                                       |             
      Hemorrhage                           |                                                                2         |             
      Hydrocephalus                        |                                                                          |             
      White Matter, Vacuolization          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|             
                             DAY ON TEST   | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|             
                                           | 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Congestion                           | 2     2        3           1  2        1  1        1     2               |             
      Ectopic Tissue                       |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Inflammation, Chronic                |                                                                      1   |             
      Inflammation, Focal                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Fungus                               |                            X                                X            |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                            2                                3            |             
      Mucosa, Mineralization, Focal        |                                  2                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                          1        1      |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Inflammation, Granulomatous          |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                        3                                 |             
      Retina, Degeneration                 |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Congestion                           |                2              2                          1               |             
      Degeneration, Hyaline                |                         2                                                |             
      Karyomegaly                          |    2        1                                      1                     |             
      Mineralization                       |                               1              1                           |             
      Nephropathy                          | 1  1  1  1  3     1     1  3     1  1  1  2  1  2  2           1  2      |             
      Pigmentation                         |                                                                          |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Renal Tubule, Hypertrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Transitional Epithelium, Hyperplasia |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 7| 7| 5| 7| 6| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3|                                            |            |
                                           | 5| 4| 3| 7| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +                                             |  46        |
      Parasite Metazoan                    |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +                                             |  49        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +                                             |  49        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus, Multiple           |    X  X              X     X                                             |     28     |
      Congestion                           |             2                                                            |      4  2.0|
      Cytoplasmic Alteration, Focal        |          1                                                               |      4  2.0|
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
      Inflammation, Granulomatous          |    1  1              2     2                                             |     23  1.7|
      Necrosis, Acute                      |          1                                                               |      1  1.0|
      Vacuolization Cytoplasmic, Focal     | 1     2                                                                  |      3  1.7|
      Bile Duct, Hyperplasia               |    1        1                                                            |      4  1.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
      Fat, Necrosis, Focal                 |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +                                             |  49        |
      Atrophy, Focal                       |       1  1                 1                                             |     17  1.4|
      Autolysis                            |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia                          |                                                                          |      5  1.4|
      Inflammation, Acute                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 7| 7| 5| 7| 6| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3|                                            |            |
                                           | 5| 4| 3| 7| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +                                             |  49        |
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +        +     +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Inflammation, Chronic                |    1  2  1     1  2  1     1                                             |     38  1.2|
      Atrium Left, Thrombosis              |          3                                                               |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Angiectasis                          |          2           2     2                                             |      5  2.0|
      Congestion                           |                                                                          |      5  2.8|
      Degeneration, Fatty                  |          3                                                               |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |     11  1.3|
      Hypertrophy, Focal                   |                                                                          |      3  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     | 1  3                                                                     |      7  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +                                             |  49        |
      Pars Distalis, Angiectasis           |                            2                                             |      7  2.1|
      Pars Distalis, Cyst                  | 1        3  2                                                            |     16  1.9|
      Pars Distalis, Ectasia               |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                   1                                                      |     10  1.3|
      Pars Distalis, Hypertrophy           | 1                                                                        |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +                                             |  48        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 7| 7| 5| 7| 6| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3|                                            |            |
                                           | 5| 4| 3| 7| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +     M                                             |  46        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |             1     1                                                      |      2  1.0|
      Duct, Ectasia                        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      3  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Dilatation                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute                  |                      1                                                   |      1  1.0|
      Endometrium, Cyst                    |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +                                             |  49        |
      Hypoplasia                           |    1                                                                     |      1  1.0|
      Myelofibrosis                        |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +                                             |  48        |
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +        +     +                                                      |  28        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +     +                                             |  43        |
      Cyst                                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +     +                                             |  48        |
      Galactocele                          |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      3  1.3|
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 7| 7| 5| 7| 6| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3|                                            |            |
                                           | 5| 4| 3| 7| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Duct, Ectasia                        |                            2                                             |      8  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Inflammation, Acute                  |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Inflammation, Acute                  |                            2                                             |      1  2.0|
      Osteopetrosis                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +     +                                             |  49        |
      Demyelination, Focal                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      White Matter, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Congestion                           | 1           2                                                            |     16  1.5|
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Focal                  |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      4  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          1        1                                                      |      2  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +                                             |  49        |
      Fungus                               |                                                                          |      3     |
      Mucosa, Inflammation, Acute          | 1                                                                        |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  2.8|
      Mucosa, Mineralization, Focal        |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.0|
      Respiratory Epithelium, Degeneration |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 7| 7| 5| 7| 6| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3|                                            |            |
                                           | 5| 4| 3| 7| 5| 2| 9| 9| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    2.5MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +     +                                             |  49        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   3        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Lens, Cataract                       |                            2                                             |      3  2.7|
      Retina, Degeneration                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +     +                                             |  49        |
      Congestion                           |                                                                          |      3  1.7|
      Degeneration, Hyaline                |                                                                          |      1  2.0|
      Karyomegaly                          |                                                                          |      4  1.3|
      Mineralization                       |                                                                          |      2  1.0|
      Nephropathy                          | 1  1  3  2  1  2  1  1     2                                             |     43  1.4|
      Pigmentation                         |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  2.0|
      Renal Tubule, Hypertrophy            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  I  +  +  +  +  +  +     +                                             |  48        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|             
                                           | 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            | 4                             3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            | 4                             4                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            | 4                             4                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus, Multiple           |    X  X  X     X  X     X        X  X  X  X  X        X  X  X     X  X   |             
      Clear Cell Focus                     |          X        X                                               X      |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                           3                              |             
      Degeneration, Fatty                  |                                                                          |             
      Ectasia, Focal                       |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hemorrhage                           |                2                                                         |             
      Hepatodiaphragmatic Nodule           |                                                 X        X        X  X   |             
      Inflammation, Granulomatous          |       2  2     2  1     2        1     1  2  1                           |             
      Mixed Cell Focus                     |          X                                                               |             
      Mixed Cell Focus, Multiple           |                   X                                                      |             
      Necrosis, Acute                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       3                 2                             3                  |             
      Bile Duct, Hyperplasia               |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Atrophy, Focal                       |    1              1  1     2     2  1  1        1                 1      |             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration, Focal        |       2                                                                  |             
      Ectopic Liver                        |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|             
                                           | 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Cytoplasmic Alteration, Focal        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hyperplasia                          |    2              2  1     2              2                 1            |             
      Inflammation, Acute                  |                   1                       1                              |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            |                                                                          |             
      Necrosis                             |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                 +        +  +                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Inflammation, Chronic                |    1  1  1     1  1  1  1     1  1  1  1  2     2        1  1     1  1   |             
      Atrium Left, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Angiectasis                          |                         2                                                |             
      Hyperplasia, Focal                   |                            1              1     1                 1      |             
      Hypertrophy, Focal                   |                                  1           1                    1      |             
      Vacuolization Cytoplasmic, Focal     |                                                          1               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  I  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hyperplasia, Focal                   |                1                 1     1              1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  M  +  +  +  +  M  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          2                                                               |             
      Pars Distalis, Hyperplasia           |                1                       2                 1        2      |             
      Pars Distalis, Hypertrophy           |                                  2                                2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +     +  +  +     +  +   |             
      C-Cell, Hyperplasia                  |                                                          1           1   |             
      Follicle, Cyst                       |       1                                                  2  1            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  M  +  +  I  +  +  +  +  +  M     +  +  M     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|             
                                           | 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Duct, Ectasia                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Follicle, Cyst                       |    1                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Cyst                                 |                                                          2               |             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                              2                           |             
      Endometrium, Cyst                    |                         1              2                                 |             
      Endometrium, Hyperplasia, Cystic     |                                              1        1  1               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +     +  +  +  +  +  +  +     +     +  +  +     +  +   |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Cyst                                 |                                              2                           |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Galactocele                          |                                           3                              |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Acute                  |                                                                          |             
      Duct, Ectasia                        |                                     1     1     2                 2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Osteopetrosis                        |                                     2  1                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hydrocephalus                        |                                                 2                        |             
      Inflammation, Chronic, Focal         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|             
                                           | 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Congestion                           | 2     1        1        1     2     1  1     1           1  1            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                               1                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2  1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     1  1                                 |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            |                               2                                          |             
      Foreign Body                         |                                                 1                        |             
      Fungus                               |                                                          X               |             
      Mucosa, Inflammation, Acute          |                                                       1                  |             
      Mucosa, Inflammation, Chronic Active |                   1                             2        2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                          2               |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Inflammation, Acute                  |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Lens, Cataract                       |                                  3                                       |             
      Retina, Degeneration                 |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Autolysis                            |                                                                          |             
      Cyst                                 |                      2                                                   |             
      Hemorrhage, Focal                    |                                                                          |             
      Nephropathy                          |    2  1  1     1  2  2  1        1  2  2  2  1  2     3  1  2     1  1   |             
      Pigmentation                         |                         2                                                |             
      Renal Tubule, Hyperplasia            |          1                                                               |             
                                            __________________________________________________________________________|             
   Ureter                                  |       +                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +   |             
      Hemorrhage                           |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|             
                                           | 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                              3                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus, Multiple           | X     X  X        X     X     X  X              X  X  X  X  X     X  X   |             
      Clear Cell Focus                     |                   X     X     X  X              X                 X      |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Fatty                  |    2                       3                                             |             
      Ectasia, Focal                       | 2                                                                        |             
      Eosinophilic Focus                   | X                                                                        |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X        X                             X        X   |             
      Inflammation, Granulomatous          |             2     1     1           2              1  1  1           1   |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Necrosis, Acute                      |                            1                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                             1            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +                                             |             
      Fat, Necrosis, Focal                 | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Atrophy, Focal                       | 1  1     1  1     1              1  1                             1      |             
      Autolysis                            |                                              3                           |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Ectopic Liver                        | X                                                                        |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|             
                                           | 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Cytoplasmic Alteration, Focal        |                               1                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |    1  2  1  1        2     2        2                 1     3  3     1   |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                              2                           |             
      Necrosis                             |                                              1                 1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +        +  +     +     +        +        +           +     +     +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                | 1  1  1  1  1     1     1        1  1        1  1     1  1  2     2  2   |             
      Atrium Left, Thrombosis              |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                      3   |             
      Hyperplasia, Focal                   | 1        1              2                             1           1      |             
      Hypertrophy, Focal                   |                                                                1         |             
      Vacuolization Cytoplasmic, Focal     | 1                                                           3            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                          1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Focal                   |                   2           1                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                            3        1                                    |             
      Pars Distalis, Cyst                  | 1     1                                                        1         |             
      Pars Distalis, Hyperplasia           | 1     2  1                                            1                  |             
      Pars Distalis, Hypertrophy           |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |                                  3                          1            |             
      Follicle, Cyst                       |       1                                                                  |             
      Follicular Cell, Hyperplasia         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  M  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|             
                                           | 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Follicle, Cyst                       |                         2                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                   3                                                      |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Cyst                    |                                  1                                2      |             
      Endometrium, Hyperplasia, Cystic     |          1              1                             1                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                      2   |             
      Mediastinal, Congestion              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Re Cell                 | 2                                1                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                            2                                         2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +        +  +  +  +  I  +  +  +  +   |             
      Cyst                                 |                            1                 1                           |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                               1                                          |             
      Duct, Ectasia                        |                               2     2                             2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Osteopetrosis                        | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|             
                             DAY ON TEST   | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|             
                                           | 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Congestion                           |    2           3                 1           2           4           1   |             
      Hemorrhage                           |                                                    1                     |             
      Inflammation, Chronic                |             1                       1                                2   |             
      Inflammation, Granulomatous          |          1                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1                                                     1                  |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                                          3               |             
      Foreign Body                         |                                  1              1                        |             
      Fungus                               |                                              X                           |             
      Mucosa, Inflammation, Acute          |                                  1              3                        |             
      Mucosa, Inflammation, Chronic Active |    4        1              2                 2              1  2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |       1                                                                  |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Lens, Cataract                       | 3                                                                        |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Autolysis                            |                                              2                           |             
      Cyst                                 |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Nephropathy                          | 1     1  2  1     1  3  1  3  1  1  1           1  1  2     3  1  2      |             
      Pigmentation                         |                                                                      2   |             
      Renal Tubule, Hyperplasia            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 4| 4| 1| 6| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3|                                            |            |
                                           | 2| 2| 0| 8| 0| 6| 6| 0| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +     +  +                                             |  50        |
      Inflammation, Chronic                | 3                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +     +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Parasite Metazoan                    |    X                                                                     |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +     +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |                2                                                         |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |                3                                                         |      3  3.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |                3                                                         |      4  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +     +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus, Multiple           | X                          X                                             |     32     |
      Clear Cell Focus                     |                                                                          |      9     |
      Congestion                           |          2                                                               |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Degeneration, Fatty                  |                                                                          |      2  2.5|
      Ectasia, Focal                       |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Inflammation, Granulomatous          |                                                                          |     17  1.4|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           |                                                                          |      1     |
      Necrosis, Acute                      |                   1                                                      |      2  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      3  2.7|
      Bile Duct, Hyperplasia               | 1                                                                        |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +     +  +                                             |  50        |
      Atrophy, Focal                       |    1     1                 2                                             |     20  1.2|
      Autolysis                            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 4| 4| 1| 6| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3|                                            |            |
                                           | 2| 2| 0| 8| 0| 6| 6| 0| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Ectopic Liver                        |                                                                          |      1     |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Inflammation, Chronic                | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +     +  +                                             |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +     +  +                                             |  50        |
      Hyperplasia                          | 1  2              1                                                      |     20  1.7|
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Necrosis                             |    2                                                                     |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +     +  +                                                      |  19        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +     +  +                                             |  50        |
      Inflammation, Chronic                | 1  1     2        2     1  2                                             |     39  1.2|
      Atrium Left, Thrombosis              |                         1                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +     +  +                                             |  50        |
      Angiectasis                          |                   1                                                      |      3  2.0|
      Hyperplasia, Focal                   |          1                 1                                             |     11  1.1|
      Hypertrophy, Focal                   |                                                                          |      4  1.0|
      Vacuolization Cytoplasmic, Focal     | 1                                                                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +     +  +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +     +  +                                             |  50        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     M     +  +     +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +     +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |                         1                                                |      5  1.2|
      Pars Distalis, Hyperplasia           |          1                                                               |      9  1.3|
      Pars Distalis, Hypertrophy           |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 4| 4| 1| 6| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3|                                            |            |
                                           | 2| 2| 0| 8| 0| 6| 6| 0| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +     +  +                                             |  49        |
      C-Cell, Hyperplasia                  |                            1                                             |      5  1.4|
      Follicle, Cyst                       |                                                                          |      4  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +     +     +  +     +  +                                             |  45        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Duct, Ectasia                        |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +  +     +  +                                             |  50        |
      Follicle, Cyst                       |                         3                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +     +  +                                             |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Cervix, Cyst                         |                                                                          |      1  2.0|
      Endometrium, Cyst                    |                                                                          |      4  1.5|
      Endometrium, Hyperplasia, Cystic     |                            2                                             |      7  1.1|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +                                                                        |   1        |
      Inflammation, Acute                  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +     +  +                                             |  49        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +        +                                             |  47        |
      Hyperplasia, Re Cell                 |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +     +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +     +  +                                             |  48        |
      Cyst                                 |                                                                          |      3  1.3|
      Hemorrhage                           |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 4| 4| 1| 6| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3|                                            |            |
                                           | 2| 2| 0| 8| 0| 6| 6| 0| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          | 1                                                                        |      2  1.5|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      7  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +     +  +                                             |  50        |
      Osteopetrosis                        |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +     +  +                                             |  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +     +  +                                             |  50        |
      Congestion                           |          4     2                                                         |     18  1.7|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      4  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |          2                                                               |      3  2.3|
      Foreign Body                         |                   1                                                      |      4  1.0|
      Fungus                               |                                                                          |      2     |
      Mucosa, Inflammation, Acute          |                                                                          |      3  1.7|
      Mucosa, Inflammation, Chronic Active |    2              2     2                                                |     12  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +     +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 4| 4| 4| 1| 6| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3|                                            |            |
                                           | 2| 2| 0| 8| 0| 6| 6| 0| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +     +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Cyst                                 |    3                                                                     |      2  2.5|
      Hemorrhage, Focal                    |                3                                                         |      1  3.0|
      Nephropathy                          | 3  2     1        1     1  2                                             |     41  1.6|
      Pigmentation                         |    2                                                                     |      3  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +     +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|             
                                           | 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Edema                                |                            1                                             |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Inflammation, Chronic                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Necrosis                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                1                                                        1|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Metaplasia, Osseous                  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Basophilic Focus, Multiple           |                   X  X  X     X                                      X  X|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                           2                              |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration, Focal        |                      2     1           2           2                     |             
      Ectasia                              |          2                                         2                     |             
      Eosinophilic Focus                   |                                        X                                 |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X     X                                   X           X   |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Thrombosis, Focal                    |          2                                                               |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |          3        1     1                 2                 1           2|             
      Hepatocyte, Degeneration, Cystic     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Atrophy, Focal                       |    2           1           1  1                    1                    1|             
      Cytoplasmic Alteration, Focal        |                                  1                                       |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|             
                                           | 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Edema                                |                2                                   3                     |             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Acute                  |                1                                                         |             
      Ulcer                                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                           3                              |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                +     +     +  +        +            |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2     2     2     3  2  1     1  2  2  1     1  2     1  2     2  2  2|             
      Atrium Left, Thrombosis              |          4                                                               |             
      Endocardium, Fibrosis                |                                                                          |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                               3                                          |             
      Valve, Thrombosis                    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                            1  2        1                                 |             
      Hypertrophy, Focal                   |                                                                         1|             
      Vacuolization Cytoplasmic            |                               1  1                 3              1  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hyperplasia, Focal                   |    1           1     1        1                                          |             
      Thrombosis                           |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                     1                                    |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|             
                                           | 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hyperplasia           |                      1           1        2                          1   |             
      Pars Distalis, Hypertrophy           |                                                 1                        |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          1     1                 1  1                                    |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                                1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Duct, Epithelium, Degeneration       |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  M     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                     2  1                 1        1      |             
      Inflammation, Chronic                |    3                 1                                      1           1|             
      Inflammation, Chronic Active         |                2                                                         |             
      Duct, Ectasia                        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +     +|             
      Hyperplasia, Focal                   |                         1              1  2                             2|             
      Inflammation, Acute                  |                      2     3                                             |             
      Inflammation, Chronic                |          2                                                               |             
      Inflammation, Chronic Active         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Atrophy                              |                   3                                                      |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                2                                                         |             
      Interstitial Cell, Hyperplasia       |                                        2  1                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hypoplasia                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Axillary, Congestion                 |                                                                          |             
      Axillary, Hemorrhage                 |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|             
                                           | 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Plasma Cell                     |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           +     +  +     +  +  +  +  +     +  +        +        +  +|             
      Ectasia                              |                                                             3            |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  I|             
      Congestion                           |                                                                          |             
      Cyst                                 |                               2                                          |             
      Ectopic Parathyroid Gland            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +  +  +  M  +  +  +  +  +  I     +  +     +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Cyst                                 |                                                                      1   |             
      Face, Inflammation, Acute            |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Hydrocephalus                        |                                                                   1      |             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Congestion                           |                                           3                             1|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Inflammation, Acute, Multifocal      |                3                                                         |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Granulomatous          |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2     2                             1      |             
      Artery, Media, Hypertrophy           |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|             
                                           | 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Autolysis                            |                                                                          |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                            X                                             |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |          2                 3                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                         2                                2               |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                     +|             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                   4                                                     4|             
      Sclera, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Nephropathy                          |    3     3     3  2  3  2  2  4  4  3  3  2     2  1     2  3     2  3  3|             
      Pigmentation                         |                                                          3               |             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +  +  +  +  +  +  +  +  +  +     +  +     +  +     +  +  +|             
      Concretion                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|             
                                           | 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                               2        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Basophilic Focus, Multiple           | X           X  X  X                                   X  X        X  X   |             
      Clear Cell Focus                     |                                                                      X   |             
      Congestion                           |                                     3                                    |             
      Cyst                                 |                                                          2               |             
      Cytoplasmic Alteration, Focal        |                            2                 2                       2   |             
      Ectasia                              |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis, Focal                      |                                                                   1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                 X  X                             X   |             
      Hyperplasia, Focal                   |                               2                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                      1   |             
      Necrosis, Acute                      |          3              1           3              1                     |             
      Thrombosis, Focal                    |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2                                      2                  |             
      Bile Duct, Hyperplasia               | 1              2  2              2                    1  2        2  2   |             
      Hepatocyte, Degeneration, Cystic     |                                                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                       +                                       |             
      Fat, Necrosis, Focal                 |          3                       2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy, Focal                       | 4  3     3     1  1  1        2           2  1  1        1        1  1   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Inflammation, Acute                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|             
                                           | 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |             1                                                            |             
      Duct, Hyperplasia                    |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                               2                                          |             
      Necrosis                             |                            1                       2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                    +  +     +  +           +  +        +            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                | 2  2     2  2  2  2  1  2  1     1  3  1  1  1  1  2        1     2  1   |             
      Atrium Left, Thrombosis              |                                                                          |             
      Endocardium, Fibrosis                |    2                                                                     |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                                             2            |             
      Hyperplasia, Focal                   |             1     2  2                 1                             2   |             
      Hypertrophy, Focal                   |    1                                      1     1     1                  |             
      Vacuolization Cytoplasmic            |                1                                      1                 2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |                         1                          1                 2   |             
      Thrombosis                           |                                     4                                    |             
      Bilateral, Hyperplasia, Focal        |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 1                                                                       2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                           1                       2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Angiectasis           |                                                 3                        |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|             
                                           | 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Ectasia               |    2                                                                     |             
      Pars Distalis, Hyperplasia           |                1  1     1                 1     2     2                  |             
      Pars Distalis, Hypertrophy           |                            1                                             |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Ultimobranchial Cyst                 |                                                                         X|             
      C-Cell, Hyperplasia                  |                                  1                                      1|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Duct, Epithelium, Degeneration       |                               3                                          |             
      Fat, Necrosis, Focal                 |                2                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |    2     3                                                               |             
      Inflammation, Acute                  |          2                 2              1        3                    4|             
      Inflammation, Chronic                |    2        1  1  1                                   1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |                               2           2                              |             
      Inflammation, Acute                  |          1                                         1                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |    3                          3                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                         2        1                                       |             
      Interstitial Cell, Hyperplasia       |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hypoplasia                           |                                                                         2|             
      Myeloid Cell, Hyperplasia            | 2                       2  2                       3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Axillary, Congestion                 |                                                                          |             
      Axillary, Hemorrhage                 |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                         2                                                |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|             
                                           | 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                              2           2           2  2|             
      Fibrosis                             |          3                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 4                                                  2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  I  +  +  +  I  +  +  +  +  I  +  +  +  +  +     +  +  +|             
      Congestion                           |                                                             2            |             
      Cyst                                 |                                                          1           1   |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Hyperplasia                          |                               1                                          |             
      Duct, Ectasia                        |    1                             2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Face, Inflammation, Acute            |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrous Osteodystrophy               |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hydrocephalus                        |                                  2                                       |             
      Inflammation, Acute, Focal           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                   1                 2                       3     1      |             
      Foreign Body                         |                   2                                                      |             
      Hemorrhage                           |    1                                                                     |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic                | 1                                                        2               |             
      Inflammation, Granulomatous          |                   2                                                      |             
      Metaplasia, Focal, Osseous           |    1                                                                     |             
      Necrosis, Focal                      |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Media, Hypertrophy           |                                           2                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|             
                                           | 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Autolysis                            |                                                             2            |             
      Foreign Body                         |                                                                         2|             
      Fungus                               |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                              2           1               |             
      Mucosa, Inflammation, Chronic Active |             3                                   3     2              3  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                  2                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                        3                                 |             
      Respiratory Epithelium, Hyperplasia  |             3                                2        2              3  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                      2                                                   |             
      Retina, Degeneration                 |                      4                                                   |             
      Sclera, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute, Focal           |                                                                         3|             
      Nephropathy                          | 3  3     2  3  2  3  2  2  2  3  2  3  3  3  4  2  1  4  3  1     4  3  3|             
      Pigmentation                         |                                                    2                     |             
      Cortex, Cyst                         |                   2                                   2                  |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Concretion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +     +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +     +  +  +  +                                             |  50        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +                                             |  49        |
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +     +  +  +  +                                             |  50        |
      Basophilic Focus, Multiple           |          X           X     X                                             |     17     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      7  1.9|
      Ectasia                              |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Necrosis, Acute                      |                                                                          |      4  2.0|
      Thrombosis, Focal                    |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |             2                                                            |      3  2.0|
      Bile Duct, Hyperplasia               |    3                 1     2                                             |     17  1.8|
      Hepatocyte, Degeneration, Cystic     | 2  2                 2                                                   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +     +  +  +  +                                             |  50        |
      Atrophy, Focal                       | 2  1     1  1           1  2                                             |     25  1.5|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +     +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +     +  +  +  +                                             |  49        |
      Edema                                |                                                                          |      2  2.5|
      Hyperplasia                          |                         1                                                |      3  1.7|
      Inflammation, Acute                  |                         2                                                |      2  1.5|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +     +  +  +  +                                             |  50        |
      Hyperplasia                          |             1                                                            |      1  1.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Necrosis                             |                   1                                                      |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +           +                                                |  16        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +     +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2  2     1  2     1  2  2  2                                             |     44  1.7|
      Atrium Left, Thrombosis              |                                                                          |      1  4.0|
      Endocardium, Fibrosis                |                                                                          |      1  2.0|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Valve, Thrombosis                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +     +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |          1        1                                                      |     10  1.4|
      Hypertrophy, Focal                   |                                                                          |      5  1.0|
      Vacuolization Cytoplasmic            |             1     1                                                      |     10  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     M  +     +  +  +  +                                             |  48        |
      Hyperplasia, Focal                   | 1                                                                        |      8  1.1|
      Thrombosis                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +                                             |  50        |
      Hyperplasia                          | 2                                                                        |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  +     M  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +     +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                         2                                                |      2  2.5|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  1.0|
      Pars Distalis, Ectasia               |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    2                       2                                             |     12  1.4|
      Pars Distalis, Hypertrophy           |                                                                          |      2  1.0|
      Pars Distalis, Necrosis, Focal       |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +     +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                                                          |      6  1.0|
      Follicle, Cyst                       |          1                                                               |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +     +  +  +  +                                             |  50        |
      Duct, Epithelium, Degeneration       |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +     +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Acute                  |    2        1                                                            |     11  1.8|
      Inflammation, Chronic                |                                                                          |      9  1.3|
      Inflammation, Chronic Active         |                            2                                             |      2  2.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +     +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |    2     2                                                               |      8  1.8|
      Inflammation, Acute                  |                         1                                                |      5  1.6|
      Inflammation, Chronic                |                      1                                                   |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                   +        +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +     +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      3  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      3  1.7|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +     +  +  +  +                                             |  50        |
      Hypoplasia                           |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +     +  +  +  M                                             |  49        |
      Axillary, Congestion                 |                      1                                                   |      1  1.0|
      Axillary, Hemorrhage                 |                   2                                                      |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +     +  +  +                                                |  42        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +     +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      4  2.0|
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +     +  +  +  +                                             |  46        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      3  1.3|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +     +  +  +  +                                             |  47        |
      Hyperplasia                          |             1                                                            |      2  1.0|
      Duct, Ectasia                        |                         1  2                                             |      5  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +     +  +  +  +                                             |  50        |
      Cyst                                 | 2                                                                        |      2  1.5|
      Face, Inflammation, Acute            |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +     +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +     +  +  +  +                                             |  50        |
      Hydrocephalus                        |          2  3                                                            |      4  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +     +  +  +  +                                             |  50        |
      Congestion                           |          2              1                                                |      8  1.8|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           | 1  1              2                                                      |      5  1.4|
      Inflammation, Acute, Multifocal      |                                                                          |      1  3.0|
      Inflammation, Chronic                | 2                                                                        |      4  2.0|
      Inflammation, Granulomatous          |                            1                                             |      2  1.5|
      Metaplasia, Focal, Osseous           |                                                                          |      1  1.0|
      Necrosis, Focal                      |                   1                                                      |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.7|
      Artery, Media, Hypertrophy           |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +     +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |                                                                          |      1     |
      Mucosa, Cyst                         |                   1                                                      |      1  1.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  1.5|
      Mucosa, Inflammation, Chronic Active |                                                                          |      7  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      3  2.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  2.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 4| 7| 7| 5| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3|                                            |            |
                                           | 2| 2| 0| 4| 0| 0| 5| 4| 6| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                         4                                                |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      3  4.0|
      Sclera, Inflammation, Acute          |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +     +  +  +  +                                             |  50        |
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Nephropathy                          | 3  3     4  2     3  2  2  3                                             |     50  2.7|
      Pigmentation                         |                                                                          |      2  2.5|
      Cortex, Cyst                         |          2                                                               |      3  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +     +  +  +  +                                             |  50        |
      Concretion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|             
                             DAY ON TEST   | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|             
                                           | 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                        3                                 |             
      Edema                                |                                                                          |             
      Hemorrhage                           |       2                                                                  |             
      Inflammation, Acute                  |                                  1              4                        |             
      Inflammation, Chronic                |                                                    1                     |             
      Ulcer                                |                                  1                    4  3               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |          X     X           X  X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  I  +  +  +  +  +  +  I  +  +  +  +  M     +     +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
      Mineralization                       |                      2                                                   |             
      Parasite Metazoan                    |                                     X                                   X|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +     +|             
      Autolysis                            | 3  3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Autolysis                            | 3  3                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Autolysis                            | 4  3                          3        4              4                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Angiectasis                          |       2                                         2                        |             
      Autolysis                            |                                                                          |             
      Basophilic Focus, Multiple           |                         X                                   X            |             
      Congestion                           |    2     2                                   2                           |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Ectasia                              |                                                                          |             
      Eosinophilic Focus                   |                                  X              X                        |             
      Hepatodiaphragmatic Nodule           |                                                          X        X     X|             
      Inflammation, Chronic                |                1                                                         |             
      Necrosis, Acute                      |                                  1                    2  2               |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |       3              2     2                    2  1        2     1     2|             
      Hepatocyte, Degeneration, Cystic     |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +  +              +     +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|             
                             DAY ON TEST   | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|             
                                           | 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |                         2  3              3     3                        |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Atrophy, Focal                       |          2        1  1                    1     1        1              2|             
      Autolysis                            |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hyperplasia                          |                            1     2           1     3  1  2        2     2|             
      Inflammation, Acute                  |                                                    4              1      |             
      Mineralization                       |                      2           2              4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                                           2                              |             
      Inflammation, Chronic                |                                                    2                     |             
      Mineralization                       |                      3     2                    3  1                     |             
      Necrosis                             |                                           1                              |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +        +     +|             
      Mineralization                       |                      2                          4                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2  2  2  3     2  1  2  2  3  1  3  1     1     2  2  2  3  1     2     2|             
      Mineralization                       |                      2                          2     1           2      |             
      Atrium Left, Thrombosis              |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |                                                                         2|             
      Hyperplasia, Focal                   |                                                    1                     |             
      Vacuolization Cytoplasmic            |                   1  2                             1     2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hyperplasia, Focal                   |                      3     1                             1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +     +     +|             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|             
                             DAY ON TEST   | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|             
                                           | 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       2              2  2  2                    2        2  2     1      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hemorrhage                           |                                        3                                 |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                         1                 2                              |             
      Pars Distalis, Hyperplasia           |          1                                         1  2     1            |             
      Pars Distalis, Hypertrophy           |                         2                                                |             
      Pars Nervosa, Cyst                   |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                 2                 1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hemorrhage                           |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2                          2                                    |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |          4                                                               |             
      Follicular Cell, Hyperplasia         |                                                 1           1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Cytomegaly                           |                                                                          |             
      Duct, Epithelium, Degeneration       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                      4     2        1                       1     4      |             
      Inflammation, Chronic                |          2                                                               |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute                  |                                                    2                     |             
      Inflammation, Chronic                |       2                                                  1               |             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Atrophy                              |       4                                                                  |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                            2                                             |             
      Interstitial Cell, Hyperplasia       |                                           1        1              2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     M|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +     +|             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|             
                             DAY ON TEST   | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|             
                                           | 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Mandibular, Hemorrhage               |                                                                          |             
      Mandibular, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +     +  +  +  +  +  M  +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             1            |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Atrophy, Focal                       |       2                                                                  |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Pigmentation                         |                                                 2                        |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Congestion                           | 2                 2                                                      |             
      Hemorrhage                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     M|             
      Fibrous Osteodystrophy               |       2              2     2     2              3  1  2     1     1      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Hemorrhage                           |                                                                          |             
      Meninges, Congestion                 |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|             
                             DAY ON TEST   | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|             
                                           | 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           | 2  2     2     3  2           2                             1           2|             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                2                                                         |             
      Inflammation, Acute, Chronic         |                                              4                           |             
      Inflammation, Acute, Multifocal      |                                              3                    3      |             
      Inflammation, Chronic                |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     |                         2           2                       1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +     +     M|             
      Autolysis                            | 2  2                                         2     1                     |             
      Foreign Body                         |                2                                                         |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Mucosa, Inflammation, Acute          |                                              2                           |             
      Mucosa, Inflammation, Chronic Active |                2                                                         |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Bilateral, Lens, Cataract            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
      Congestion                           |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Nephropathy                          |    3  4  3     1  2  4  4  4  1  4  3  2  4     4  4  4  4  4     4     3|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|             
                             DAY ON TEST   | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|             
                                           | 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4                                                     4            |             
      Edema                                |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Inflammation, Acute                  |             1                                                  1     2  4|             
      Inflammation, Chronic                |                                                    3                     |             
      Ulcer                                | 3  4              4                                4                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4                                                     3            |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |             2                                                            |             
      Parasite Metazoan                    |                X           X                                X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +           I  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             2            |             
      Inflammation, Chronic                |                                                       3                  |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                             X            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4                                                     3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4        4                                            3            |             
      Inflammation, Chronic                |    2                                                                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       4        4        3                                   3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2           2   |             
      Autolysis                            |                                                                   3      |             
      Basophilic Focus, Multiple           |                                        X           X                 X   |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2                                                        3     2         |             
      Ectasia                              |                                                    2                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                X                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Acute                      |                         3                                         3     1|             
      Vacuolization Cytoplasmic, Focal     | 2                                                                        |             
      Bile Duct, Hyperplasia               |    2  1     2        1     1           1  2           1  2        2     1|             
      Hepatocyte, Degeneration, Cystic     |    2              2                             2  1                 1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                       +     +        +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|             
                             DAY ON TEST   | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|             
                                           | 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                          2               |             
      Inflammation, Chronic                |                                           1                              |             
      Fat, Necrosis, Focal                 |                   2                       2                       2      |             
      Fat, Necrosis                        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |             2     2                                2  2              1  1|             
      Autolysis                            |       3                                                     3            |             
      Artery, Inflammation, Chronic        |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                          1              1        3  2      |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |             3                          2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |             2                          2           2                    3|             
      Necrosis                             |                                                                1         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +     +  +  +           +  +     +        +  +  +  +  +   |             
      Mineralization                       |             3                          2                             3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                   1      |             
      Inflammation, Chronic                | 2  3  1     3  1  2  1  2  2           2  2     2  3  2  2  1  2  2  2  2|             
      Mineralization                       | 2           2        2  1              2                       3     2  1|             
      Atrium Left, Thrombosis              |             3           3              2                       3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                                                    1                     |             
      Vacuolization Cytoplasmic            |                   2                             1              2     1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 1  1              1                                                  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3                                                     3            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  M  +  +  +  +           +  +     +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|             
                             DAY ON TEST   | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|             
                                           | 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 2  2              2     2              2        2  2  2  1     2     2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  M  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                2        2|             
      Pars Distalis, Cyst                  |                                        2                                 |             
      Pars Distalis, Hyperplasia           |    1                    2              2                       3         |             
      Pars Distalis, Hypertrophy           |                                                                          |             
      Pars Nervosa, Cyst                   |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
      Follicular Cell, Hyperplasia         |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  M  +  +|             
      Cytomegaly                           |                                                                2         |             
      Duct, Epithelium, Degeneration       |                   2     2                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  M  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  M  +  +|             
      Inflammation, Acute                  |             3           2              1              3                 4|             
      Inflammation, Chronic                |                                                          1               |             
      Duct, Ectasia                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                          2               |             
      Inflammation, Acute                  |                         3                                                |             
      Inflammation, Chronic                |                   1                             1                        |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  M  +  +|             
      Atrophy                              |                   2                             4                        |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                   1  3                    3     2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|             
                             DAY ON TEST   | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|             
                                           | 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |    2                                                                     |             
      Mandibular, Hemorrhage               |                                                                         2|             
      Mandibular, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M     +  +  +  +  +  +           +  +     +  +  +     +  +  +      |             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                    2                     |             
      Hyperplasia, Plasma Cell             |    2                                                                     |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                                           1        2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                        1        2                        |             
      Hematopoietic Cell Proliferation     |                      3                    2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                      2   |             
      Pigmentation                         |                                                                          |             
      Capsule, Fibrosis                    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  I  +  +  +           +  +     +  +  M  +  +  +  I  +  +|             
      Congestion                           |                            2                                             |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2  3        2     2  2  2              3        2  2  2        2     2  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Hemorrhage                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Meninges, Congestion                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|             
                             DAY ON TEST   | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|             
                                           | 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |       2        2           2                                2            |             
      Fibrosis, Focal                      |    1                                                                     |             
      Hemorrhage                           |             1     2                                            1         |             
      Inflammation, Acute, Chronic         |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                   3  4   |             
      Inflammation, Chronic                |       2                                                  1               |             
      Alveolar Epithelium, Hyperplasia     |             1                                            2               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           1                              |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |       3                                                           3      |             
      Foreign Body                         |                                                                      2   |             
      Fungus                               |                                                 X                        |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Squamous                |                                                          4               |             
      Mucosa, Inflammation, Acute          |                                                                1  1      |             
      Mucosa, Inflammation, Chronic Active |                                                 2        3           2   |             
      Nasolacrimal Duct, Cyst              |    1                                                                     |             
      Respiratory Epithelium, Hyperplasia  |                                                          2               |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                          4               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Bilateral, Lens, Cataract            |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2           2                                2            |             
      Inflammation, Acute, Focal           |                                                                   2      |             
      Nephropathy                          | 4  4  2     4     4  4  4  1           4  2     4  4  4  3     4  3  4  4|             
      Cortex, Cyst                         | 2                                               1  1                     |             
      Renal Tubule, Hyperplasia, Cystic    |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +           +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      3  3.7|
      Edema                                |                         2                                                |      1  2.0|
      Hemorrhage                           |                         3                                                |      3  2.3|
      Inflammation, Acute                  |                                                                          |      6  2.2|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Ulcer                                |                      4                                                   |      8  3.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      2  3.5|
      Inflammation, Acute                  |                1                                                         |      1  1.0|
      Mineralization                       |                2                                                         |      2  2.0|
      Parasite Metazoan                    | X                                                                        |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +                                                |  46        |
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |          X                                                               |      4     |
      Ulcer                                |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +                                                |  49        |
      Autolysis                            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      5  3.4|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      9  3.6|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +                                                |  50        |
      Angiectasis                          |             2     2                                                      |      6  2.0|
      Autolysis                            |                                                                          |      1  3.0|
      Basophilic Focus, Multiple           |          X        X                                                      |      7     |
      Congestion                           |                                                                          |      3  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      3  2.3|
      Ectasia                              |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |          X                                                               |      6     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Acute                      |                                                                          |      6  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          2     1  2                                                      |     22  1.6|
      Hepatocyte, Degeneration, Cystic     |                   2                                                      |      7  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |  10        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Fat, Necrosis, Focal                 |                   2                                                      |      8  2.4|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +  +                                                |  50        |
      Atrophy, Focal                       | 2           1                                                            |     15  1.5|
      Autolysis                            |                                                                          |      2  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +                                                |  50        |
      Hyperplasia                          |    1                 2  1                                                |     16  1.6|
      Inflammation, Acute                  |                      1                                                   |      3  2.0|
      Mineralization                       |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +  +                                                |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1                                                |      2  1.5|
      Mineralization                       |                1                                                         |      9  2.1|
      Necrosis                             |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +           +     +  +                                                |  41        |
      Mineralization                       |                1                                                         |      6  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +  +                                                |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2  2     2  2  2  3  2  1                                                |     48  2.0|
      Mineralization                       |                2                                                         |     13  1.8|
      Atrium Left, Thrombosis              |                                                                          |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |    X                                                                     |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                1                                                         |      3  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      8  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +                                                |  50        |
      Hyperplasia, Focal                   |                2                                                         |      8  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +                                                |  50        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     +  +  +  +  +  +                                                |  44        |
      Hyperplasia, Focal                   | 2           2                                                            |      2  2.0|
      Hyperplasia                          |          2     2  2                                                      |     23  1.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +                                                |  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |             3                                                            |      4  2.0|
      Pars Distalis, Hyperplasia           |    1                                                                     |      9  1.6|
      Pars Distalis, Hypertrophy           |                1                                                         |      2  1.5|
      Pars Nervosa, Cyst                   |             3                                                            |      1  3.0|
      Pars Nervosa, Hyperplasia            |                         1                                                |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +  +                                                |  50        |
      Hemorrhage                           |                      1                                                   |      2  2.0|
      Ultimobranchial Cyst                 |                   X                                                      |      1     |
      C-Cell, Hyperplasia                  |                                                                          |      2  2.0|
      Follicle, Cyst                       |                         1                                                |      1  1.0|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      1  4.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +  +  +  +                                                |  49        |
      Cytomegaly                           |                                                                          |      1  2.0|
      Duct, Epithelium, Degeneration       |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  M  +  +  +  M                                                |  46        |
      Inflammation, Acute                  |    2     1                                                               |     12  2.3|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Duct, Ectasia                        |          1                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Acute                  |             1     1                                                      |      4  1.8|
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +  +  +  +                                                |  49        |
      Atrophy                              |                                                                          |      3  3.3|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 2                                                                        |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +  +                                                |  49        |
      Myeloid Cell, Hyperplasia            |                      3                                                   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +  +  +                                                |  48        |
      Granuloma                            |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mandibular, Hemorrhage               |                                                                          |      1  2.0|
      Mandibular, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +        +     +  +  +                                                |  42        |
      Autolysis                            |                                                                          |      1  2.0|
      Hemorrhage                           |                      2                                                   |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +  +                                                |  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Congestion                           | 2                                                                        |      1  2.0|
      Fibrosis                             |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +  +  +  +                                                |  46        |
      Congestion                           |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +  +  +  +  +                                                |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Duct, Ectasia                        |    1           1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +  +                                                |  49        |
      Fibrous Osteodystrophy               |          2     2  2  2  3                                                |     27  2.1|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +  +                                                |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Meninges, Congestion                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +  +  +  +                                                |  50        |
      Congestion                           | 2                                                                        |     13  2.0|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      4  1.5|
      Inflammation, Acute, Chronic         |                                                                          |      1  4.0|
      Inflammation, Acute, Multifocal      |    3                                                                     |      5  3.2|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          2                                                               |      3  1.3|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +                                                |  47        |
      Autolysis                            |                                                                          |      6  2.2|
      Foreign Body                         | 2                                                                        |      3  2.0|
      Fungus                               |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
      Mucosa, Inflammation, Acute          | 2                                                                        |      4  1.5|
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 7| 7| 6| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6|                                            |            |
                                           | 3| 6| 0| 4| 3| 7| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Cyst              |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Bilateral, Lens, Cataract            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      3  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Nephropathy                          | 3  3     4  3  4  4  4  3                                                |     46  3.4|
      Cortex, Cyst                         |          2              3                                                |      5  1.8|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|             
                                           | 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    4                                                                     |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                3           2                    2                       4|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                                                                X         |             
      Ulcer                                |    4        3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             3                                1                          2|             
      Parasite Metazoan                    |       X  X                                                     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute, Chronic         |                                                                          |             
      Inflammation, Chronic                |                                                                         1|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    4                                   3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    4                                   4              4                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Basophilic Focus                     |                                              X                           |             
      Basophilic Focus, Multiple           |                                                                X         |             
      Congestion                           | 1                                                                        |             
      Cytoplasmic Alteration, Focal        |                      2                                                   |             
      Eosinophilic Focus                   |                                              X                           |             
      Hepatodiaphragmatic Nodule           |       X                                      X              X  X         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Acute                      |    2           2                    1                                    |             
      Bile Duct, Hyperplasia               | 2              1  1  3        2        1                    1           1|             
      Hepatocyte, Degeneration, Cystic     |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +              +        +           +               |             
      Inflammation, Acute, Focal           |                                     2                                    |             
      Fat, Necrosis, Focal                 |                      2                       2                           |             
      Fat, Necrosis                        |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|             
                                           | 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Atrophy, Focal                       |       1  2  4  2  2  2     1  1  1  1  1                    1  2         |             
      Autolysis                            |    4                                                                     |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Duct, Metaplasia, Squamous           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    2                                                                     |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia                          | 2        1  2  2  1  2     1  1  1  1     2     1     1  1  2        3  2|             
      Inflammation, Acute                  |                      1                    1                          2   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    2                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                   1                                                  4   |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +           +  +|             
      Mineralization                       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Inflammation, Chronic                | 3  2  1  2  2  1  2  2  1  2  2  2  3  2  2  2  2     2     1  2     3  1|             
      Mineralization                       |                3  1  3     1                 2        2                  |             
      Atrium Left, Thrombosis              |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Congestion                           | 2                                      2                                 |             
      Hyperplasia, Focal                   |                      1                                      3  1         |             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                      2   |             
      Mineralization, Multifocal           |                                                                      2   |             
      Vacuolization Cytoplasmic            |             1                             2                    2        1|             
      Capsule, Ectopic Tissue              |                                                          1               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +     +  +|             
      Hyperplasia, Focal                   |                      1                                                   |             
      Bilateral, Hyperplasia, Focal        |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|             
                                           | 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            |    4                                                                     |             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |                2  2  2              2        2        2        1     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Pars Distalis, Angiectasis           |       1                                                                  |             
      Pars Distalis, Hyperplasia           |                                        1     2                          2|             
      Pars Nervosa, Cyst                   |                      1                                                   |             
      Pars Nervosa, Inflammation,          |                                                                          |             
          Granulomatous                    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Duct, Epithelium, Degeneration       |       3                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  M|             
      Inflammation, Acute                  |                1     1     1        1                                    |             
      Inflammation, Chronic                | 1     2     3                 1                             1            |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Atrophy                              |                                                                          |             
      Bilateral, Atrophy                   |                                                       2                 3|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |       2                                                                  |             
      Interstitial Cell, Hyperplasia       |             2                    1                    2  1     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Depletion Cellular, Focal            |       2                                                                 3|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |       2        2                 1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|             
                                           | 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Iliac, Hyperplasia                   |       1                                                                  |             
      Inguinal, Hyperplasia, Lymphoid      |       2                                                                  |             
      Mediastinal, Hyperplasia             |       1                                                                  |             
      Renal, Hemorrhage                    |                                     1                                    |             
      Renal, Hyperplasia                   |       1                                                                  |             
      Renal, Pigmentation                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +        +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                       1                  |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Atrophy, Focal                       |                                              2                           |             
      Fibrosis                             |                                                                2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       2        3                                                         |             
      Necrosis, Focal                      |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +     +  +  +  +     +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  +     +  +|             
      Hyperplasia                          | 1                                                                        |             
      Duct, Ectasia                        |                                  1                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperkeratosis                       |                                                                          |             
      Face, Inflammation, Acute            |                            1              1                              |             
      Tail, Hemorrhage                     | 2                                                                        |             
      Tail, Subcutaneous Tissue, Necrosis  | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Fibrous Osteodystrophy               |    2           3  2        2        1        2        3              2  2|             
      Osteomalacia                         |                      4                                                   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Inflammation, Acute, Focal           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|             
                                           | 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Congestion                           |                         2              2                                 |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                              2              2  1         |             
      Inflammation, Acute, Multifocal      |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis, Focal                      |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     | 2     1                             2        1                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                             1            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Autolysis                            | 2                       2              2                                1|             
      Foreign Body                         |                                     1                                    |             
      Fungus                               |                                                       X                  |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Mucosa, Inflammation, Acute          |                                                                      2   |             
      Mucosa, Inflammation, Chronic Active |                2                 3  2        3        2                  |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       2                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             1                                2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Mineralization                       |       2                                                                  |             
      Nephropathy                          | 2  4  2  1  4  4  4  3  1  4  3  3  4  2  4  4  4     4  3  3  4     4  4|             
      Cortex, Cyst                         |                                              2                 2         |             
      Renal Tubule, Hyperplasia, Cystic    |                1                                                         |             
      Renal Tubule, Hyperplasia            |                   3              2                                      2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|             
                             DAY ON TEST   | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|             
                                           | 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |    3                                                                     |             
      Congestion                           |                                           1                              |             
      Hemorrhage                           |          1                                                               |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation, Acute                  | 4                                                     1                  |             
      Inflammation, Chronic                |          1  1                                                            |             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |    4                       4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation, Acute                  |                                                 4  4                     |             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Hemorrhage                           |                                           1                              |             
      Inflammation, Acute, Chronic         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |             X                       X           X        X               |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                         1|             
      Eosinophilic Focus                   |                                              X                           |             
      Hepatodiaphragmatic Nodule           |          X                                         X     X               |             
      Inflammation, Chronic                |                                     1                                    |             
      Necrosis, Acute                      |    2                                            1  3  2                  |             
      Bile Duct, Hyperplasia               |             1                       1                    1  1     2      |             
      Hepatocyte, Degeneration, Cystic     | 1                 2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Inflammation, Acute, Focal           |                                                                          |             
      Fat, Necrosis, Focal                 |                                                          3               |             
      Fat, Necrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|             
                             DAY ON TEST   | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|             
                                           | 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Atrophy, Focal                       |          1                                      3        2               |             
      Autolysis                            |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Cyst Epithelial Inclusion            |                         4                                                |             
      Hyperplasia                          | 1  1     1  1     1     1  1              1  2  1  2        2     1      |             
      Inflammation, Acute                  |             1                                                            |             
      Mineralization                       |                                           3           1                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                     1                                    |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             2                                                            |             
      Mineralization                       |                                           1           1                  |             
      Necrosis                             |             2              1                 2  1                        |             
      Ulcer                                |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +     +     +  +     +  +              +  +  +  +  +     +     +      |             
      Mineralization                       |                                           3                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Inflammation, Chronic                | 2  3     1  2  1  1     2  1        2     2  2  2  3  3  1  2     3     2|             
      Mineralization                       |    2                                      1  1  2  2  1                  |             
      Atrium Left, Thrombosis              | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |    1                    1           1                 1                  |             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                    1              2      |             
      Capsule, Ectopic Tissue              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Hyperplasia, Focal                   |                                              1  1     1                  |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|             
                             DAY ON TEST   | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|             
                                           | 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Hyperplasia                          |    2              1        1              2  2  2  2  2     2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                   2                                      1               |             
      Pars Nervosa, Cyst                   |                                                                          |             
      Pars Nervosa, Inflammation,          |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Ultimobranchial Cyst                 |                                     1                                    |             
      C-Cell, Hyperplasia                  |                   1                                                      |             
      Follicle, Cyst                       |    2                    1                                                |             
      Follicular Cell, Hyperplasia         | 1                                                  1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Duct, Epithelium, Degeneration       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     M  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |    1                                                              1     1|             
      Inflammation, Chronic                |                         1                                1               |             
      Duct, Hyperplasia                    |                                                                         3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Atrophy                              |                         4                                                |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |          2                                                        2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Congestion                           |                                                                          |             
      Depletion Cellular, Focal            |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|             
                             DAY ON TEST   | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|             
                                           | 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +  +     +  +              +  +  +  +  +  +  +     +     +|             
      Congestion                           |                                                                         1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Atrophy, Focal                       |                                                                          |             
      Fibrosis                             |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis, Focal                      |                   2                                                      |             
      Capsule, Fibrosis                    |    1                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +     +  +        +     I  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                    2                     |             
      Hemorrhage                           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +     +  +        +     +  I  +  +  +  +  +     +     I|             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Hyperkeratosis                       |                                                                          |             
      Face, Inflammation, Acute            |                   1                                                      |             
      Tail, Hemorrhage                     |                                                                          |             
      Tail, Subcutaneous Tissue, Necrosis  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Fibrous Osteodystrophy               |    X                                      X  2  3  2  2     X           2|             
      Osteomalacia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|             
                             DAY ON TEST   | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|             
                                           | 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Congestion                           |                3                          2  2                           |             
      Fibrosis, Focal                      |                                                          1               |             
      Hemorrhage                           |                   2                                                     2|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic                |    2                    2                                   2            |             
      Inflammation, Granulomatous          |                                              1                           |             
      Necrosis, Focal                      |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                   1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Autolysis                            |                                           2                              |             
      Foreign Body                         |                                                 1                        |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                          1               |             
      Mucosa, Inflammation, Chronic Active | 2        2     1           2              1     1     1     2           1|             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Inflammation, Acute                  |          1     2                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
      Congestion                           |                2                                                         |             
      Mineralization                       |                                                                   2      |             
      Nephropathy                          | 4  4     4  4     3     3  3        3     4  4  4  4  4  3  4     3     4|             
      Cortex, Cyst                         |                                              2        2                  |             
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +     +  +        +     +  +  +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      2  3.5|
      Congestion                           |                      1                                                   |      2  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                            3                                             |      7  2.7|
      Inflammation, Chronic                | 3                                                                        |      3  1.7|
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                   2                                                      |      2  2.0|
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Parasite Metazoan                    |                X                                                         |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute, Chronic         |          4                                                               |      1  4.0|
      Inflammation, Chronic                | 1                                                                        |      2  1.0|
      Ulcer                                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +                                             |  49        |
      Autolysis                            |    3                                                                     |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |    3                                                                     |      4  3.8|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |       X                                                                  |      6     |
      Congestion                           |                                                                          |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      2  1.5|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis, Acute                      |       1  1     1           1                                             |     11  1.5|
      Bile Duct, Hyperplasia               | 2                       2                                                |     15  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hepatocyte, Degeneration, Cystic     |                            2                                             |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  2.3|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +                                             |  50        |
      Atrophy, Focal                       |                   2  1                                                   |     18  1.7|
      Autolysis                            |    2                                                                     |      2  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Duct, Metaplasia, Squamous           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Hyperplasia                          | 1     1  2           1  2                                                |     35  1.4|
      Inflammation, Acute                  |                                                                          |      4  1.3|
      Mineralization                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Acute                  |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |       2                                                                  |      5  1.8|
      Necrosis                             |                            1                                             |      5  1.4|
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +     +  +  +  +  +                                             |  42        |
      Mineralization                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                | 1  2  2  2     1  3     2  2                                             |     48  1.9|
      Mineralization                       |       3        2                                                         |     14  1.9|
      Atrium Left, Thrombosis              |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |                         1                                                |      8  1.3|
      Hypertrophy, Focal                   |                            1                                             |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1        1              1  3                                             |     10  1.5|
      Capsule, Ectopic Tissue              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |                1           1                                             |      6  1.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia                          |                      1                                                   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +                                             |  49        |
      Hyperplasia                          | 1     2                                                                  |     19  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                1                                                         |      6  1.5|
      Pars Nervosa, Cyst                   |                                                                          |      1  1.0|
      Pars Nervosa, Inflammation,          |                                                                          |            |
          Granulomatous                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      2  1.5|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +                                             |  50        |
      Duct, Epithelium, Degeneration       |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +  +                                             |  48        |
      Inflammation, Acute                  |       2              1                                                   |      9  1.1|
      Inflammation, Chronic                |                1                                                         |      8  1.4|
      Duct, Hyperplasia                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                2                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Bilateral, Atrophy                   |                                                                          |      2  2.5|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                            1                                             |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                   3                                                      |      1  3.0|
      Depletion Cellular, Focal            |                                                                          |      2  2.5|
      Myelofibrosis                        |                   4                                                      |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +                                             |  49        |
      Iliac, Hyperplasia                   |                                                                          |      1  1.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  1.0|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Hyperplasia                   |                                                                          |      1  1.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +                                             |  44        |
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  2.5|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  I  +  +                                             |  45        |
      Autolysis                            |    3                                                                     |      1  3.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  M  +  +                                             |  45        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hyperkeratosis                       |       3                                                                  |      1  3.0|
      Face, Inflammation, Acute            | 2                                                                        |      4  1.3|
      Tail, Hemorrhage                     |                                                                          |      1  2.0|
      Tail, Subcutaneous Tissue, Necrosis  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Fibrous Osteodystrophy               | 3     2  2     2                                                         |     21  2.2|
      Osteomalacia                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      5  2.2|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      5  1.8|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      5  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Autolysis                            |                   2                                                      |      6  1.8|
      Foreign Body                         |                                                                          |      2  1.0|
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05031-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 04/28/97  
Route: GAVAGE                                                                                                     Time: 16:06:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 7| 6| 4| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9|                                            |            |
                                           | 5| 1| 0| 7| 0| 6| 6| 0| 8| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Acute          |                                                                          |      2  1.5|
      Mucosa, Inflammation, Chronic Active |       1                    4                                             |     16  1.9|
      Nasolacrimal Duct, Cyst              |                1                                                         |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |          1              1                                                |      3  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                      2                                                   |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Mineralization                       |    2                                                                     |      3  2.0|
      Nephropathy                          | 4     4  4     4  4  3  3  4                                             |     48  3.5|
      Cortex, Cyst                         |                                                                          |      4  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |          2                                                               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
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