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TDMS Study 05031-02 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/04/94   
EXP: 05031                    MERCURIC CHLORIDE                TIME: 17:46:49   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60173    
CONT:                                                          CAS: 7487-94-7   
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/04/94  
EXP: 05031                    MERCURIC CHLORIDE                TIME: 17:46:49  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60173   
CONT:                                                          CAS: 7487-94-7  
PATHOLOGIST: P. HILDEBRANDT                  S. EUSTIS                         

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 24     CENSORED DEATHS 10   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      279   480   506   546   551   565   577   586   601   609                 |
 |      632   638   656   657   672   683   692   703   706   707                 |
 |      710   715   715   715                                                     |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.5MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 40     CENSORED DEATHS 10   TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      92    149   156   175   277   291   333   375   385   398                 |
 |      519   523   523   544   586   600   608   614   620   621                 |
 |      627   636   651   664   666   666   666   667   669   671                 |
 |      680   680   685   690   691   693   695   697   703   711                 |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 45     CENSORED DEATHS 10   TERMINAL 5         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      173   361   363   411   470   490   507   526   554   565                 |
 |      569   573   573   573   586   595   595   599   606   610                 |
 |      619   621   623   633   633   638   638   644   644   652                 |
 |      658   664   667   667   667   669   676   676   687   692                 |
 |      703   710   715   719   719                                               |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.3  98.3  96.3  94.3  82.3  72.2  52.2      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/KG   |   100.0  93.3  93.3  88.3  83.3  83.3  75.0  70.8  54.2  20.8      |
 |           |                                                                    |
 |           |                                                                    |
 |5 MG/KG    |   100.0  98.3  98.3  95.0  93.3  91.3  85.2  64.9  36.5  10.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2.5MG/KG         5 MG/KG       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.2%            20.8%            10.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P<0.001          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       620.9            547.4            598.5         |
 |NATURAL DEATHS (C)      |       (20.7)           (28.7)           (16.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       640.9            563.1            586.3         |
 |(STANDARD ERROR)        |       (14.8)           (21.7)           (14.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      531   572   573   576   590   614   621   641   643   655                 |
 |      656   657   659   666   698                                               |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.5MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      84    277   285   437   523   552   565   571   582   595                 |
 |      601   609   614   629   647   656   684   687   708   717                 |
 |      717                                                                       |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5.0MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      42    87    106   313   428   515   518   580   581   586                 |
 |      593   623   626   629   631   636   665   692   692   700                 |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460   460   460   460   460   460                 |
 |                                                                                |
 ==================================================================================

                                 MERCURIC CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  90.0  74.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/KG   |    98.3  98.3  98.3  94.9  94.9  93.2  91.1  78.7  68.4  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5.0MG/KG   |    96.7  95.0  95.0  93.3  93.3  91.7  87.6  79.4  67.2  61.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2.5MG/KG         5.0MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.0%            58.0%            61.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.271          P=0.210          P=0.305       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       623.5            559.0            512.2         |
 |NATURAL DEATHS (C)      |       (11.9)           (35.6)           (46.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       657.8            622.9            611.9         |
 |(STANDARD ERROR)        |       (13.2)           (18.7)           (21.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         MERCURIC CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.5MG/KG         = 2
                                                        5 MG/KG          = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1              2            3               1
      |                2        22  3               1            3                  1   1
      |                          2  2                            3       3              1     1
      |                             2               2 2                  3         3 3        11
   90 +                                               2      2                       3  3      1 1
      |                                                      2     2 2                  3   3    1 11
      |                                                              2 2                    3   3   1  1
      |                                                                2                   2    33     11
   80 +                                                                                          33     1   1
      |                                                                                    2  2             11 1
P     |                                                                                       2     2
E     |                                                                                           3 2  2       1  1
R  70 +                                                                                             3 3222        1 1
C     |                                                                                               33 22         11
E     |                                                                                                33            1 1
N     |                                                                                                 3322
T  60 +                                                                                                  3322          11
      |                                                                                                     2 2  2      11
S     |                                                                                                   3 3    22
U     |                                                                                                                  1  1
R  50 +                                                                                                     33
V     |
I     |
V     |                                                                                                      3 3  2 2
A  40 +
L     |                                                                                                        3 33
      |                                                                                                             22
      |
   30 +                                                                                                              22
      |                                                                                                           33
      |                                                                                                            3 322
      |                                                                                                                22
   20 +                                                                                                              3 32   2
      |                                                                                                                33
      |                                                                                                                 33
      |
   10 +                                                                                                                  3  3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                         MERCURIC CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.5MG/KG         = 2
                                                        5.0MG/KG         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1      3     2                                                                      1
      |        3     23                             2
      |                                                                                     1     1
      |               3   3                         22
   95 +                   3                          2    3                  2
      |                                                   3                 32             2      11
      |                                                                                            1  1
      |                                                                     3            3 2   2
   90 +                                                                                               1  1
      |                                                                                        2 2
P     |                                                                                  3       223     11
E     |                                                                                                   1  1
R  85 +                                                                                           2 2
C     |                                                                                            33
E     |                                                                                             2 2      1 1
N     |                                                                                             3 22
T  80 +                                                                                               3   3
      |                                                                                                22
S     |                                                                                                   33
U     |                                                                                                 22     1 1
R  75 +                                                                                                  2 2
V     |                                                                                                    33    11
I     |                                                                                                    2  2   1   1
V     |
A  70 +                                                                                                       22      1     1
L     |                                                                                                     3  2 3  2
      |                                                                                                          3   3
      |                                                                                                             22
   65 +
      |                                                                                                              23 2
      |                                                                                                                 22
      |                                                                                                               3     3
   60 +
      |
      |                                                                                                                  2  2
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.