National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3035

TDMS Study 05033-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             QUERCETIN


NTP Experiment-Test: 05033-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 20:31:54




       Facility:  TSI Mason Research

       Chemical CAS #:  117-39-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           18           13           19                                     
    Dead                                               1            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           28           35           27                                     
    Moribund                                                                                  1                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (11)         (8)          (48)                                   
      Necrosis, Acute, Coagulative                                                            1 (2%)                                
      Parasite Metazoan                                2 (4%)                                 4 (8%)                                
      Lymphoid Tissue, Hypoplasia                                   1 (9%)                                                          
   Intestine Large, Colon                             (50)         (11)         (7)          (48)                                   
      Parasite Metazoan                                9 (18%)      1 (9%)       2 (29%)      5 (10%)                               
   Intestine Large, Rectum                            (48)         (11)         (7)          (47)                                   
      Parasite Metazoan                                5 (10%)                                2 (4%)                                
   Intestine Small, Duodenum                          (50)         (48)         (50)         (49)                                   
      Autolysis                                                                  1 (2%)                                             
      Epithelium, Pigmentation                                                                1 (2%)                                
   Intestine Small, Ileum                             (49)         (48)         (49)         (49)                                   
      Epithelium, Pigmentation                                                  19 (39%)     32 (65%)                               
      Serosa, Fibrosis                                              1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (47)         (49)         (49)                                   
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Epithelium, Pigmentation                                                   3 (6%)      20 (41%)                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       5 (10%)      1 (2%)                                             
      Basophilic Focus                                40 (80%)     38 (76%)     41 (82%)     39 (78%)                               
      Clear Cell Focus                                 4 (8%)       4 (8%)       4 (8%)       2 (4%)                                
      Cyst                                                                                    2 (4%)                                
      Cyst Multilocular                                                          1 (2%)                                             
      Cytoplasmic Alteration                                        4 (8%)                    1 (2%)                                
      Degeneration                                                  1 (2%)       1 (2%)                                             
      Developmental Malformation                       3 (6%)                                 2 (4%)                                
      Eosinophilic Focus                               3 (6%)                                 3 (6%)                                
      Fatty Change                                    14 (28%)     12 (24%)     12 (24%)      7 (14%)                               
      Fibrosis, Focal                                                                         1 (2%)                                
      Granuloma                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hepatodiaphragmatic Nodule                                    3 (6%)       5 (10%)                                            
      Infarct                                                                                 1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    3 (6%)       3 (6%)                                
      Inflammation, Chronic, Granulomatous            12 (24%)     17 (34%)     10 (20%)      8 (16%)                               
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       2 (4%)       7 (14%)                               
      Mixed Cell Focus                                 4 (8%)       7 (14%)      4 (8%)       1 (2%)                                
      Necrosis, Coagulative                            4 (8%)       5 (10%)      5 (10%)      8 (16%)                               
      Pigmentation                                     1 (2%)       1 (2%)       1 (2%)                                             
      Bile Duct, Cyst Multilocular                                                            1 (2%)                                
      Bile Duct, Hyperplasia                          17 (34%)     14 (28%)     17 (34%)     15 (30%)                               
      Centrilobular, Necrosis, Coagulative                                                    1 (2%)                                
      Serosa, Fibrosis                                              1 (2%)                                                          
      Serosa, Hemorrhage                                            1 (2%)                                                          
   Mesentery                                          (2)          (6)          (2)          (1)                                    
      Fibrosis                                                      6 (100%)     1 (50%)                                            
      Inflammation, Chronic                                         3 (50%)                                                         
      Inflammation, Chronic, Granulomatous             1 (50%)      1 (17%)      1 (50%)                                            
      Inflammation, Chronic Active                                  2 (33%)                                                         
      Mineralization                                                1 (17%)      1 (50%)                                            
      Necrosis, Coagulative                            2 (100%)     3 (50%)                                                         
      Pigmentation                                                               1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Atrophy                                         21 (42%)     21 (43%)     21 (42%)     15 (30%)                               
      Cytoplasmic Alteration                                        2 (4%)       4 (8%)       2 (4%)                                
      Ectopic Liver                                                                           1 (2%)                                
      Inflammation, Chronic                           17 (34%)     22 (45%)     22 (44%)     17 (34%)                               
      Pigmentation                                                  1 (2%)                                                          
      Artery, Hyperplasia                                                        1 (2%)                                             
      Artery, Perivascular, Inflammation, Chronic,                                                                                  
           Necrotizing                                              1 (2%)                                                          
      Duct, Dilatation                                              1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)         (47)                                   
      Acanthosis                                       3 (6%)       3 (6%)       3 (6%)       7 (15%)                               
      Edema                                            1 (2%)       1 (2%)                    1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   3 (6%)       2 (4%)       1 (2%)       7 (15%)                               
      Hyperplasia, Basal Cell                          4 (8%)       2 (4%)       3 (6%)       5 (11%)                               
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     3 (6%)       3 (6%)                    2 (4%)                                
      Inflammation, Chronic Active, Necrotizing                                  1 (2%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)                    2 (4%)                                
      Artery, Mineralization                                                     1 (2%)                                             
      Artery, Muscularis, Mineralization                            1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Muscularis, Mineralization                                    1 (2%)       3 (6%)                                             
      Submucosa, Mineralization                                                  1 (2%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Edema                                                         1 (2%)                                                          
      Inflammation, Chronic Active                     3 (6%)       1 (2%)                    1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
      Artery, Mineralization                                        3 (6%)       1 (2%)                                             
      Epithelium, Pigmentation                                                   8 (16%)     38 (76%)                               
      Mucosa, Dilatation                               6 (12%)                   5 (10%)      4 (8%)                                
      Muscularis, Developmental Malformation           1 (2%)                                                                       
      Muscularis, Mineralization                       1 (2%)       2 (4%)       6 (12%)      4 (8%)                                
   Tongue                                             (29)         (43)         (43)         (39)                                   
      Hemorrhage                                                    2 (5%)       1 (2%)                                             
      Inflammation, Chronic                            7 (24%)      7 (16%)     12 (28%)      6 (15%)                               
      Arteriole, Necrosis, Fibrinoid                                2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (7)          (50)                                   
      Cardiomyopathy                                  47 (94%)      9 (69%)      3 (43%)     47 (94%)                               
      Atrium Left, Thrombosis                                                                 1 (2%)                                
      Coronary Artery, Inflammation, Chronic Active                                           1 (2%)                                
      Coronary Artery, Inflammation, Chronic                                                                                        
          Active, Necrotizing                          1 (2%)                                                                       
      Coronary Artery, Necrosis, Fibrinoid                                                    1 (2%)                                
      Epicardium, Fibrosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (13)         (13)         (50)                                   
      Angiectasis                                     28 (56%)      2 (15%)      2 (15%)     26 (52%)                               
      Atrophy                                                       1 (8%)                                                          
      Congestion                                       1 (2%)                    1 (8%)                                             
      Degeneration, Fatty                              1 (2%)                                                                       
      Hyperplasia                                     16 (32%)                   2 (15%)     15 (30%)                               
      Necrosis, Coagulative                            1 (2%)                                 1 (2%)                                
      Pigmentation                                                  1 (8%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                       28 (56%)      8 (62%)      3 (23%)     24 (48%)                               
   Adrenal Gland, Medulla                             (49)         (13)         (12)         (50)                                   
      Angiectasis                                      5 (10%)                   1 (8%)                                             
      Hyperplasia                                      3 (6%)                    1 (8%)       4 (8%)                                
      Necrosis, Coagulative                            1 (2%)                                                                       
   Islets, Pancreatic                                 (44)         (15)         (8)          (49)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Ectopic Tissue                                   1 (2%)                                                                       
      Hyperplasia                                                   1 (7%)                                                          
   Parathyroid Gland                                  (40)         (39)         (36)         (43)                                   
      Cyst                                             1 (3%)                                                                       
      Hyperplasia                                      1 (3%)                    1 (3%)                                             
   Pituitary Gland                                    (50)         (49)         (50)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia                                                                             2 (4%)                                
      Pars Distalis, Angiectasis                      14 (28%)     11 (22%)     12 (24%)      8 (16%)                               
      Pars Distalis, Cyst                             26 (52%)     21 (43%)     23 (46%)     28 (57%)                               
      Pars Distalis, Cyst, Multiple                                              1 (2%)       1 (2%)                                
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      18 (36%)     23 (47%)     18 (36%)     13 (27%)                               
      Pars Distalis, Infiltration Cellular,                                                                                         
          Histiocyte                                                             1 (2%)                                             
      Pars Distalis, Pigmentation                      1 (2%)       3 (6%)       3 (6%)                                             
      Pars Intermedia, Angiectasis                     5 (10%)      6 (12%)      4 (8%)       6 (12%)                               
      Pars Intermedia, Cyst                                         2 (4%)       7 (14%)      6 (12%)                               
      Pars Intermedia, Pigmentation                                              1 (2%)                                             
      Pars Nervosa, Angiectasis                        1 (2%)       1 (2%)                                                          
      Pars Nervosa, Cyst                                                         1 (2%)                                             
   Thyroid Gland                                      (50)         (43)         (47)         (50)                                   
      Ultimobranchial Cyst                             1 (2%)                                 3 (6%)                                
      C-Cell, Hyperplasia                             38 (76%)     37 (86%)     40 (85%)     37 (74%)                               
      Follicle, Cyst                                   2 (4%)                                 4 (8%)                                
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (14)         (20)         (14)         (12)                                   
      Abscess                                          1 (7%)       2 (10%)                   1 (8%)                                
      Cyst                                             3 (21%)      2 (10%)      1 (7%)                                             
      Hyperplasia                                      2 (14%)      1 (5%)                                                          
      Inflammation, Acute                                           1 (5%)       1 (7%)                                             
      Inflammation, Chronic                            6 (43%)     10 (50%)      4 (29%)      4 (33%)                               
      Inflammation, Chronic Active                     3 (21%)      2 (10%)      3 (21%)      1 (8%)                                
   Ovary                                              (50)         (17)         (15)         (48)                                   
      Congestion                                                                 1 (7%)                                             
      Cyst                                             3 (6%)                                 2 (4%)                                
      Periovarian Tissue, Cyst                         5 (10%)      3 (18%)      9 (60%)      5 (10%)                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                                                       3 (6%)                                             
      Hydrometra                                      11 (22%)      9 (18%)      5 (10%)     14 (28%)                               
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                         2 (4%)                                                          
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Metaplasia, Squamous                                                                    1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
      Cervix, Cyst                                                  1 (2%)                                                          
      Cervix, Inflammation, Chronic                                 1 (2%)                                                          
      Endometrium, Hyperplasia                         6 (12%)      7 (14%)      8 (16%)      7 (14%)                               
      Lumen, Exudate                                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (48)         (25)         (17)         (49)                                   
      Deep Cervical, Hyperplasia, Plasma Cell          1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Histiocyte                                               1 (2%)                                
      Lumbar, Pigmentation                                                                    1 (2%)                                
      Mediastinal, Depletion Lymphoid                                                         1 (2%)                                
      Mediastinal, Hemorrhage                          8 (17%)      3 (12%)      3 (18%)      7 (14%)                               
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (2%)                                
      Mediastinal, Necrosis, Coagulative                                                      1 (2%)                                
      Mediastinal, Pigmentation                        2 (4%)       1 (4%)       1 (6%)       2 (4%)                                
      Pancreatic, Ectasia                                                        1 (6%)       1 (2%)                                
      Pancreatic, Hemorrhage                           1 (2%)                                 2 (4%)                                
      Pancreatic, Infiltration Cellular, Histiocyte                              2 (12%)      2 (4%)                                
      Pancreatic, Pigmentation                                                   2 (12%)      3 (6%)                                
      Renal, Ectasia                                                2 (8%)                                                          
      Renal, Hemorrhage                                2 (4%)       1 (4%)       2 (12%)      3 (6%)                                
      Renal, Infiltration Cellular                     1 (2%)                                                                       
      Renal, Infiltration Cellular, Histiocyte         1 (2%)       3 (12%)      2 (12%)      4 (8%)                                
      Renal, Pigmentation                              1 (2%)       4 (16%)      2 (12%)      3 (6%)                                
   Lymph Node, Mandibular                             (46)         (19)         (10)         (46)                                   
      Congestion                                                    1 (5%)                                                          
      Ectasia                                         11 (24%)      5 (26%)                   6 (13%)                               
      Hemorrhage                                      22 (48%)      6 (32%)      3 (30%)     17 (37%)                               
      Hyperplasia, Plasma Cell                         2 (4%)                                                                       
      Infiltration Cellular, Histiocyte                             2 (11%)      1 (10%)      2 (4%)                                
      Necrosis, Coagulative                                                      1 (10%)                                            
      Pigmentation                                     1 (2%)       2 (11%)                   2 (4%)                                
   Lymph Node, Mesenteric                             (9)          (14)         (12)         (9)                                    
      Angiectasis                                                                1 (8%)                                             
      Ectasia                                                                    1 (8%)       1 (11%)                               
      Hemorrhage                                       1 (11%)                   2 (17%)                                            
      Infiltration Cellular, Histiocyte                8 (89%)     14 (100%)    10 (83%)      7 (78%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis, Coagulative                                                                   1 (11%)                               
      Pigmentation                                     8 (89%)     14 (100%)     8 (67%)      7 (78%)                               
      Thrombosis                                                                 1 (8%)                                             
   Spleen                                             (50)         (23)         (20)         (50)                                   
      Depletion Lymphoid                               5 (10%)      5 (22%)      4 (20%)      9 (18%)                               
      Fibrosis                                                      1 (4%)                                                          
      Hematopoietic Cell Proliferation                              2 (9%)       1 (5%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      3 (15%)                                            
      Inflammation, Chronic, Granulomatous                          2 (9%)       3 (15%)      1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)       1 (4%)                                                          
      Capsule, Hyperplasia                             1 (2%)                                                                       
   Thymus                                             (8)          (10)         (7)          (9)                                    
      Depletion Lymphoid                               5 (63%)      7 (70%)      1 (14%)      7 (78%)                               
      Hemorrhage                                                    1 (10%)      1 (14%)                                            
      Necrosis, Coagulative                                                                   1 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (36)         (24)         (22)                                   
      Galactocele                                                   1 (3%)       1 (4%)       1 (5%)                                
      Hyperplasia                                     13 (36%)     20 (56%)     13 (54%)     13 (59%)                               
      Hyperplasia, Cystic                              1 (3%)                                                                       
   Skin                                               (11)         (15)         (8)          (11)                                   
      Inflammation, Acute, Necrotizing                                           1 (13%)                                            
      Inflammation, Chronic                                         1 (7%)                                                          
      Subcutaneous Tissue, Edema                                                              1 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (8)          (50)                                   
      Hemorrhage                                                                              2 (4%)                                
      Hydrocephalus                                    2 (4%)       1 (7%)       1 (13%)      1 (2%)                                
      Meninges, Hemorrhage                                          2 (13%)                                                         
   Spinal Cord                                        (1)          (2)                       (2)                                    
      Hemorrhage                                                    1 (50%)                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (20)         (50)                                   
      Crystals                                         1 (2%)                                                                       
      Foreign Body                                                               1 (5%)                                             
      Hemorrhage                                       4 (8%)       3 (15%)      2 (10%)      4 (8%)                                
      Infiltration Cellular, Histiocyte               14 (28%)      5 (25%)      3 (15%)     18 (36%)                               
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                                               1 (5%)       1 (2%)                                
      Leukocytosis                                                               1 (5%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (5%)       2 (10%)      1 (2%)                                
      Artery, Mineralization                          24 (48%)      3 (15%)      6 (30%)     14 (28%)                               
   Nose                                               (7)          (12)         (7)          (10)                                   
      Congestion                                                    1 (8%)                                                          
      Capillary, Submucosa, Thrombosis                                                        1 (10%)                               
      Glands, Inflammation, Acute                                                1 (14%)      1 (10%)                               
      Lumen, Inflammation, Acute                                    1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (8)          (6)          (5)                                    
      Cataract                                         5 (83%)      2 (25%)      3 (50%)      1 (20%)                               
      Synechia                                         1 (17%)      3 (38%)      3 (50%)                                            
      Cornea, Fibrosis                                              2 (25%)                                                         
      Retina, Degeneration                             5 (83%)      6 (75%)      4 (67%)      2 (40%)                               
      Sclera, Metaplasia, Osseous                                                             1 (20%)                               
      Sclera, Mineralization                           1 (17%)                                                                      
   Harderian Gland                                                 (4)          (2)          (2)                                    
      Hemorrhage                                                    1 (25%)      1 (50%)                                            
      Inflammation, Acute                                           1 (25%)                                                         
      Inflammation, Chronic                                         3 (75%)      1 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (50)                                   
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Congestion                                                    1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Nephropathy                                     48 (98%)     48 (98%)     50 (100%)    48 (96%)                               
      Artery, Fibrosis                                              1 (2%)                                                          
      Artery, Thrombosis                                                         1 (2%)                                             
      Collecting Tubule, Mineralization                1 (2%)                                                                       
      Papilla, Necrosis, Coagulative                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                                     1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Inflammation, Acute                                       4 (8%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Pigmentation                                              1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Renal Tubule, Hyperplasia, Cystic                                          1 (2%)                                             
      Transitional Epithelium, Hyperplasia             7 (14%)      9 (18%)      5 (10%)      4 (8%)                                
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                         4 (8%)                                                          
      Subserosa, Mineralization                        1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                                                    2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund                                          21           15           22           21                                     
    Dead                                               3            7            3            6                                     
  Survivors                                                                                                                         
    Moribund                                                                     1            1                                     
    Terminal Sacrifice                                25           27           22           19                                     
    Dead                                               1            1            2            3                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (11)         (13)         (46)                                   
      Parasite Metazoan                                4 (8%)       1 (9%)                    4 (9%)                                
   Intestine Large, Colon                             (49)         (12)         (11)         (47)                                   
      Parasite Metazoan                                9 (18%)      2 (17%)      1 (9%)       3 (6%)                                
      Epithelium, Pigmentation                                                                1 (2%)                                
   Intestine Large, Rectum                            (49)         (11)         (10)         (46)                                   
      Parasite Metazoan                                3 (6%)                                 4 (9%)                                
   Intestine Small, Duodenum                          (48)         (47)         (48)         (46)                                   
      Epithelium, Pigmentation                                                                3 (7%)                                
   Intestine Small, Ileum                             (47)         (47)         (48)         (45)                                   
      Necrosis, Coagulative                                         1 (2%)                                                          
      Epithelium, Pigmentation                                      1 (2%)      15 (31%)     28 (62%)                               
      Peyer's Patch, Hyperplasia                                                 1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (44)         (43)         (44)                                   
      Autolysis                                                                  1 (2%)                                             
      Epithelium, Pigmentation                                                   2 (5%)      19 (43%)                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)       2 (4%)       2 (4%)                                
      Basophilic Focus                                16 (32%)     17 (34%)     18 (36%)     20 (40%)                               
      Clear Cell Focus                                 7 (14%)     10 (20%)      5 (10%)      8 (16%)                               
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Cyst Multilocular                                                                       1 (2%)                                
      Cytoplasmic Alteration                           2 (4%)       3 (6%)       1 (2%)                                             
      Degeneration                                     4 (8%)       2 (4%)       1 (2%)                                             
      Degeneration, Cystic                             6 (12%)      5 (10%)      9 (18%)      2 (4%)                                
      Eosinophilic Focus                               9 (18%)      5 (10%)      7 (14%)      3 (6%)                                
      Fatty Change                                     5 (10%)     12 (24%)      5 (10%)      8 (16%)                               
      Fibrosis                                         2 (4%)                                                                       
      Hemorrhage                                       1 (2%)       4 (8%)       3 (6%)       3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatodiaphragmatic Nodule                       2 (4%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Focal                               1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                           24 (48%)     30 (60%)     26 (52%)     23 (46%)                               
      Mixed Cell Focus                                 3 (6%)       4 (8%)       4 (8%)       3 (6%)                                
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
      Necrosis, Coagulative                            7 (14%)      8 (16%)      9 (18%)      7 (14%)                               
      Thrombosis                                                    1 (2%)       1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          46 (92%)     48 (96%)     47 (94%)     30 (60%)                               
      Centrilobular, Necrosis, Coagulative                          1 (2%)       1 (2%)       2 (4%)                                
   Mesentery                                          (7)          (6)          (5)          (5)                                    
      Fibrosis                                                      1 (17%)      1 (20%)                                            
      Inflammation, Chronic                            2 (29%)                                1 (20%)                               
      Inflammation, Chronic, Granulomatous                                                    2 (40%)                               
      Mineralization                                                             1 (20%)      1 (20%)                               
      Necrosis, Coagulative                            1 (14%)      2 (33%)      1 (20%)      1 (20%)                               
      Pigmentation                                     1 (14%)                   1 (20%)                                            
   Pancreas                                           (50)         (50)         (50)         (47)                                   
      Atrophy                                         23 (46%)     26 (52%)     23 (46%)     24 (51%)                               
      Cyst                                                                       1 (2%)       1 (2%)                                
      Cytoplasmic Alteration                                        2 (4%)                    3 (6%)                                
      Ectopic Liver                                                 1 (2%)                    1 (2%)                                
      Fibrosis                                                                   2 (4%)                                             
      Hyperplasia                                                   3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Chronic                           32 (64%)     28 (56%)     30 (60%)     34 (72%)                               
      Necrosis, Coagulative                                                      1 (2%)                                             
      Pigmentation                                     1 (2%)                    2 (4%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Fibrosis                                              3 (6%)                                                          
      Artery, Inflammation, Chronic Active,                                                                                         
          Necrotizing                                               1 (2%)       2 (4%)                                             
      Artery, Mineralization                                                                  1 (2%)                                
      Duct, Dilatation                                 1 (2%)       1 (2%)                                                          
      Perivascular, Inflammation, Chronic                           3 (6%)                                                          
      Serosa, Hyperplasia                                                        1 (2%)                                             
   Salivary Glands                                    (16)         (14)         (12)         (10)                                   
      Parotid Gland, Vacuolization Cytoplasmic                                   1 (8%)                                             
   Stomach, Forestomach                               (49)         (49)         (49)         (46)                                   
      Acanthosis                                                    6 (12%)      2 (4%)       5 (11%)                               
      Edema                                                                                   1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Hyperkeratosis                                                3 (6%)       2 (4%)       5 (11%)                               
      Hyperplasia, Basal Cell                          3 (6%)       9 (18%)      8 (16%)      2 (4%)                                
      Hyperplasia, Pseudoepitheliomatous                                                      1 (2%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    3 (7%)                                
      Mineralization                                                             3 (6%)       2 (4%)                                
      Ulcer                                                         1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Muscularis, Pigmentation                                                   1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (49)         (48)                                   
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
      Epithelium, Pigmentation                                                   3 (6%)      34 (71%)                               
      Mucosa, Mineralization                                                     3 (6%)       7 (15%)                               
      Muscularis, Mineralization                       1 (2%)                    1 (2%)                                             
      Submucosa, Fibrosis                              1 (2%)                                                                       
   Tongue                                             (45)         (48)         (47)         (44)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute, Necrotizing                                                        1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Artery, Mineralization                                                     1 (2%)       4 (9%)                                
      Artery, Endothelium, Hyperplasia                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (1)          (2)                                    
      Aorta, Mineralization                            1 (100%)                  1 (100%)     2 (100%)                              
   Heart                                              (50)         (18)         (18)         (50)                                   
      Cardiomyopathy                                  48 (96%)     14 (78%)     15 (83%)     49 (98%)                               
      Cytomegaly                                                    1 (6%)                                                          
      Edema                                                                                   1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Metaplasia, Osseous                                                        2 (11%)      1 (2%)                                
      Mineralization                                                                          2 (4%)                                
      Thrombosis                                       6 (12%)      1 (6%)       5 (28%)      1 (2%)                                
      Artery, Mineralization                                                                  3 (6%)                                
      Coronary Artery, Inflammation, Chronic Active    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (18)         (21)         (49)                                   
      Angiectasis                                      6 (12%)      1 (6%)       2 (10%)      8 (16%)                               
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)       3 (17%)                   2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                 1 (5%)                                             
      Hyperplasia                                     10 (20%)      2 (11%)      1 (5%)      14 (29%)                               
      Necrosis, Coagulative                                         2 (11%)      1 (5%)       1 (2%)                                
      Vacuolization Cytoplasmic                       26 (52%)     12 (67%)      8 (38%)     27 (55%)                               
   Adrenal Gland, Medulla                             (50)         (18)         (21)         (49)                                   
      Angiectasis                                      2 (4%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                                              2 (4%)                                
      Hyperplasia                                     22 (44%)      2 (11%)      3 (14%)     21 (43%)                               
      Necrosis, Coagulative                            1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (47)         (15)         (13)         (41)                                   
      Hyperplasia                                      1 (2%)       1 (7%)                    1 (2%)                                
   Parathyroid Gland                                  (43)         (45)         (43)         (43)                                   
      Hyperplasia                                      1 (2%)       6 (13%)      6 (14%)     17 (40%)                               
   Pituitary Gland                                    (46)         (49)         (50)         (48)                                   
      Autolysis                                                     1 (2%)                    3 (6%)                                
      Hemorrhage                                                                              1 (2%)                                
      Pars Distalis, Angiectasis                       2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Autolysis                                      1 (2%)       2 (4%)                                             
      Pars Distalis, Congestion                                                  1 (2%)                                             
      Pars Distalis, Cyst                              7 (15%)      6 (12%)      4 (8%)       7 (15%)                               
      Pars Distalis, Hyperplasia                      18 (39%)     24 (49%)     17 (34%)     20 (42%)                               
      Pars Distalis, Necrosis                                       1 (2%)                                                          
      Pars Distalis, Pigmentation                                   5 (10%)      1 (2%)                                             
      Pars Intermedia, Angiectasis                                  2 (4%)       3 (6%)                                             
      Pars Intermedia, Crystals                                                  1 (2%)                                             
      Pars Intermedia, Cyst                            6 (13%)     10 (20%)     14 (28%)      7 (15%)                               
      Pars Intermedia, Ectopic Tissue                                            1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Nervosa, Cyst                                                                      1 (2%)                                
      Pars Nervosa, Ectopic Tissue                                               1 (2%)                                             
      Pars Nervosa, Hyperplasia                                                  1 (2%)                                             
      Rathke's Cleft, Cyst                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (17)         (22)         (49)                                   
      Congestion                                                    1 (6%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Ultimobranchial Cyst                             2 (4%)                                                                       
      C-Cell, Hyperplasia                             17 (34%)      3 (18%)      6 (27%)     16 (33%)                               
      Follicle, Pigmentation                           1 (2%)                    1 (5%)       6 (12%)                               
      Follicular Cell, Cyst                                                                   3 (6%)                                
      Follicular Cell, Hyperplasia                     2 (4%)                    1 (5%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (1)          (2)                                                 
      Adventitia, Inflammation, Chronic Active         1 (50%)                                                                      
   Preputial Gland                                    (13)         (22)         (19)         (15)                                   
      Abscess                                                       5 (23%)      2 (11%)                                            
      Cyst                                             1 (8%)                                                                       
      Hyperplasia                                                                             1 (7%)                                
      Inflammation, Chronic                           12 (92%)     19 (86%)     13 (68%)     13 (87%)                               
      Duct, Dilatation                                              1 (5%)                                                          
   Prostate                                           (49)         (14)         (12)         (48)                                   
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                    1 (7%)                                                          
      Inflammation, Acute                                           1 (7%)                                                          
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                    25 (51%)      9 (64%)     10 (83%)     30 (63%)                               
      Epithelium, Hyperplasia                          2 (4%)                                 2 (4%)                                
   Seminal Vesicle                                    (50)         (22)         (23)         (49)                                   
      Atrophy                                         36 (72%)      9 (41%)      9 (39%)     39 (80%)                               
   Testes                                             (50)         (46)         (48)         (50)                                   
      Infarct                                                       1 (2%)                                                          
      Necrosis, Coagulative                            1 (2%)                                 1 (2%)                                
      Interstitial Cell, Hyperplasia                  34 (68%)     35 (76%)     41 (85%)     44 (88%)                               
      Seminiferous Tubule, Atrophy                    44 (88%)     44 (96%)     43 (90%)     46 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (11)         (12)         (12)         (9)                                    
      Fibrosis                                                                                1 (11%)                               
   Lymph Node                                         (49)         (29)         (26)         (50)                                   
      Angiectasis                                                   1 (3%)                                                          
      Artery, Pancreatic, Thrombosis                                             1 (4%)                                             
      Inguinal, Ectasia                                             1 (3%)                                                          
      Lumbar, Ectasia                                  1 (2%)       3 (10%)                                                         
      Lumbar, Hemorrhage                               1 (2%)       1 (3%)       1 (4%)                                             
      Lumbar, Hyperplasia, Plasma Cell                                           1 (4%)                                             
      Lumbar, Infiltration Cellular, Histiocyte                     1 (3%)                                                          
      Lumbar, Inflammation, Acute                                   1 (3%)                                                          
      Lumbar, Pigmentation                                          1 (3%)                                                          
      Mediastinal, Depletion Lymphoid                                                         1 (2%)                                
      Mediastinal, Ectasia                                          2 (7%)       3 (12%)                                            
      Mediastinal, Hemorrhage                          6 (12%)      4 (14%)      3 (12%)      6 (12%)                               
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                             1 (4%)                                             
      Mediastinal, Pigmentation                        1 (2%)       5 (17%)      2 (8%)       1 (2%)                                
      Pancreatic, Ectasia                              1 (2%)                                                                       
      Pancreatic, Hemorrhage                           3 (6%)       2 (7%)       2 (8%)       2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Hyperplasia, Plasma Cell             1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte    3 (6%)       5 (17%)      2 (8%)                                             
      Pancreatic, Pigmentation                         3 (6%)       2 (7%)       3 (12%)                                            
      Renal, Ectasia                                   1 (2%)       2 (7%)       2 (8%)       1 (2%)                                
      Renal, Fibrosis                                               1 (3%)                                                          
      Renal, Hemorrhage                                5 (10%)      4 (14%)      5 (19%)      5 (10%)                               
      Renal, Hyperplasia, Lymphoid                                               1 (4%)                                             
      Renal, Hyperplasia, Plasma Cell                  1 (2%)                                 1 (2%)                                
      Renal, Infiltration Cellular, Histiocyte                      4 (14%)      2 (8%)       2 (4%)                                
      Renal, Pigmentation                              6 (12%)      6 (21%)      3 (12%)      5 (10%)                               
   Lymph Node, Mandibular                             (46)         (18)         (15)         (47)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                    1 (6%)                    1 (2%)                                
      Depletion Lymphoid                                                                      1 (2%)                                
      Ectasia                                          3 (7%)       1 (6%)       3 (20%)     10 (21%)                               
      Hemorrhage                                      12 (26%)      4 (22%)      2 (13%)     12 (26%)                               
      Hyperplasia, Plasma Cell                         3 (7%)                                 1 (2%)                                
      Infiltration Cellular, Histiocyte                                                       3 (6%)                                
      Pigmentation                                                                            2 (4%)                                
   Lymph Node, Mesenteric                             (22)         (14)         (17)         (19)                                   
      Ectasia                                                                    1 (6%)      12 (63%)                               
      Hemorrhage                                       3 (14%)      1 (7%)       4 (24%)      3 (16%)                               
      Hyperplasia, Plasma Cell                         1 (5%)                                                                       
      Infiltration Cellular, Histiocyte               11 (50%)     10 (71%)     14 (82%)      9 (47%)                               
      Pigmentation                                     9 (41%)      9 (64%)     10 (59%)      8 (42%)                               
   Spleen                                             (50)         (25)         (38)         (50)                                   
      Congestion                                       1 (2%)       2 (8%)       1 (3%)                                             
      Depletion Lymphoid                               9 (18%)     14 (56%)     13 (34%)      9 (18%)                               
      Fibrosis                                         6 (12%)      5 (20%)      8 (21%)      1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (8%)       1 (3%)       3 (6%)                                
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
      Infarct                                          2 (4%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                                       
      Pigmentation                                     1 (2%)                    1 (3%)                                             
      Thrombosis                                                                 1 (3%)                                             
   Thymus                                             (14)         (11)         (13)         (5)                                    
      Congestion                                                                 1 (8%)                                             
      Depletion Lymphoid                               7 (50%)      5 (45%)      5 (38%)      5 (100%)                              
      Hemorrhage                                       1 (7%)       1 (9%)       1 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (13)         (10)         (14)         (9)                                    
      Abscess                                                       1 (10%)                                                         
      Galactocele                                      1 (8%)       1 (10%)                   1 (11%)                               
      Hyperplasia                                      7 (54%)      9 (90%)      9 (64%)      6 (67%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Pigmentation                                                  3 (30%)      3 (21%)      1 (11%)                               
   Skin                                               (20)         (18)         (19)         (18)                                   
      Acanthosis                                       1 (5%)                    1 (5%)       3 (17%)                               
      Cyst Epithelial Inclusion                        2 (10%)      3 (17%)                                                         
      Fibrosis                                                                   1 (5%)                                             
      Hyperkeratosis                                   1 (5%)       1 (6%)       1 (5%)       3 (17%)                               
      Hyperplasia, Basal Cell                                                                 1 (6%)                                
      Inflammation, Acute, Necrotizing                                                        1 (6%)                                
      Subcutaneous Tissue, Abscess                     1 (5%)                                 1 (6%)                                
      Subcutaneous Tissue, Edema                       1 (5%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (5%)                                             
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                1 (5%)       1 (6%)                    1 (6%)                                
      Subcutaneous Tissue, Necrosis, Coagulative                                              1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)                                                              
      Hindlimb, Mineralization                                      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (12)         (50)                                   
      Hemorrhage                                       2 (4%)       2 (13%)                   2 (4%)                                
      Cerebellum, Infarct                              1 (2%)                                                                       
      Cerebrum, Degeneration, Focal                                              1 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (28)         (31)         (50)                                   
      Congestion                                                    1 (4%)       1 (3%)       1 (2%)                                
      Edema                                                                      2 (6%)       1 (2%)                                
      Hemorrhage                                       4 (8%)       6 (21%)      5 (16%)      1 (2%)                                
      Infiltration Cellular, Histiocyte               31 (62%)     18 (64%)     18 (58%)     43 (86%)                               
      Inflammation, Chronic Active                                               1 (3%)                                             
      Metaplasia, Osseous                                                        1 (3%)       2 (4%)                                
      Necrosis, Coagulative                            1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                              4 (14%)      2 (6%)       3 (6%)                                
      Artery, Mineralization                          34 (68%)     13 (46%)     17 (55%)     43 (86%)                               
      Bronchiole, Epithelium, Hyperplasia                                        1 (3%)       1 (2%)                                
   Nose                                               (44)         (48)         (49)         (49)                                   
      Foreign Body                                                  1 (2%)                                                          
      Metaplasia, Squamous                                          1 (2%)       2 (4%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Inflammation, Acute                     11 (25%)     11 (23%)      4 (8%)       5 (10%)                               
      Lumen, Hemorrhage                                             1 (2%)                                                          
      Lumen, Inflammation, Acute                       2 (5%)       3 (6%)       9 (18%)      3 (6%)                                
      Mucosa, Congestion                                                         1 (2%)                                             
      Nasopharyngeal Duct, Inflammation, Acute                      1 (2%)                                                          
      Nasopharyngeal Duct, Inflammation, Chronic       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (9)          (6)          (3)                                    
      Atrophy                                                                                 1 (33%)                               
      Synechia                                                                                1 (33%)                               
      Artery, Mineralization                                                     1 (17%)                                            
      Cornea, Fibrosis                                 1 (50%)      1 (11%)                   1 (33%)                               
      Cornea, Inflammation, Chronic                                 1 (11%)                                                         
      Posterior Chamber, Inflammation, Chronic                                                1 (33%)                               
      Retina, Degeneration                             1 (50%)                                1 (33%)                               
      Sclera, Metaplasia, Osseous                                   1 (11%)                                                         
   Harderian Gland                                    (1)                       (1)          (1)                                    
      Hyperplasia                                      1 (100%)                                                                     
      Inflammation, Chronic                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Autolysis                                                     2 (4%)                                                          
      Congestion                                       2 (4%)                                 2 (4%)                                
      Cyst                                             2 (4%)       6 (12%)      1 (2%)       7 (14%)                               
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Nephropathy                                     48 (96%)     50 (100%)    50 (100%)    49 (98%)                               
      Artery, Inflammation, Chronic Active,                                                                                         
          Necrotizing                                               1 (2%)                                                          
      Collecting Tubule, Mineralization                                          1 (2%)                                             
      Interstitial Tissue, Inflammation, Acute                                                1 (2%)                                
      Interstitial Tissue, Proximal Convoluted                                                                                      
          Renal Tubule, Inflammation, Acute                         1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Mineralization                                            1 (2%)       2 (4%)       5 (10%)                               
      Proximal Convoluted Renal Tubule, Necrosis                    1 (2%)                    1 (2%)                                
      Proximal Convoluted Renal Tubule, Epithelium,                                                                                 
           Pigmentation                                5 (10%)      2 (4%)       3 (6%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Renal Tubule, Hyperplasia, Cystic                             1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia            14 (28%)      9 (18%)     16 (32%)     27 (54%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05033-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Mineralization          1 (2%)                                                                       
   Urethra                                                                                   (1)                                    
      Calculus Micro Observation Only                                                         1 (100%)                              
   Urinary Bladder                                    (50)         (49)         (49)         (48)                                   
      Calculus Micro Observation Only                  2 (4%)                                 1 (2%)                                
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Artery, Mineralization                                                     1 (2%)                                             
      Serosa, Mineralization                                                                  1 (2%)                                
      Submucosa, Hemorrhage                                         1 (2%)                                                          
      Subserosa, Mineralization                                     1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
      Wall, Mucosa, Muscularis, Inflammation,                                                                                       
          Acute, Diffuse, Necrotizing                                                         1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.