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TDMS Study 05033-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             QUERCETIN


NTP Experiment-Test: 05033-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 20:31:55




       Facility:  TSI Mason Research

       Chemical CAS #:  117-39-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           18           13           19                                     
    Dead                                               1            4            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           28           35           27                                     
    Moribund                                                                                  1                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (11)         (8)          (48)                                   
   Intestine Large, Colon                             (50)         (11)         (7)          (48)                                   
   Intestine Large, Rectum                            (48)         (11)         (7)          (47)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Duodenum                          (50)         (48)         (50)         (49)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (49)         (48)         (49)         (49)                                   
   Intestine Small, Jejunum                           (50)         (47)         (49)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Neoplastic Nodule                                             1 (2%)                    1 (2%)                                
   Mesentery                                          (2)          (6)          (2)          (1)                                    
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Salivary Glands                                    (7)          (12)         (7)          (11)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (47)                                   
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
   Tongue                                             (29)         (43)         (43)         (39)                                   
      Squamous Cell Carcinoma                                                                 2 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (7)          (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (8%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (14)         (13)         (50)                                   
   Adrenal Gland, Cortex                              (50)         (13)         (13)         (50)                                   
      Adenoma                                                                    1 (8%)       1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                             1 (8%)                                             
   Adrenal Gland, Medulla                             (49)         (13)         (12)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (8%)                                                          
      Pheochromocytoma Benign                          3 (6%)                    3 (25%)      1 (2%)                                
   Islets, Pancreatic                                 (44)         (15)         (8)          (49)                                   
      Adenoma                                          2 (5%)       3 (20%)      1 (13%)                                            
   Parathyroid Gland                                  (40)         (39)         (36)         (43)                                   
      Adenoma                                          1 (3%)                                                                       
   Pituitary Gland                                    (50)         (49)         (50)         (49)                                   
      Pars Distalis, Adenoma                          32 (64%)     27 (55%)     26 (52%)     25 (51%)                               
      Pars Distalis, Adenoma, Multiple                 5 (10%)      4 (8%)       9 (18%)      2 (4%)                                
      Pars Distalis, Carcinoma                                      1 (2%)                    1 (2%)                                
      Pars Distalis, Pars Intermedia, Pars Nervosa,                                                                                 
           Leukemia Mononuclear                        1 (2%)                                                                       
   Thyroid Gland                                      (50)         (43)         (47)         (50)                                   
      C-Cell, Adenoma                                  6 (12%)      3 (7%)       4 (9%)       2 (4%)                                
      C-Cell, Carcinoma                                2 (4%)       3 (7%)       2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (14)         (20)         (14)         (12)                                   
      Adenoma                                          4 (29%)      4 (20%)      3 (21%)      4 (33%)                               
      Carcinoma                                        1 (7%)       1 (5%)       2 (14%)                                            
      Sarcoma                                                                    1 (7%)                                             
   Ovary                                              (50)         (17)         (15)         (48)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Malignant                                                         1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    7 (14%)      8 (16%)     16 (32%)     10 (20%)                               
      Polyp Stromal, Multiple                                       1 (2%)                    1 (2%)                                
      Sarcoma Stromal                                               2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (8)          (11)         (7)          (11)                                   
   Lymph Node                                         (48)         (25)         (17)         (49)                                   
      Lumbar, Fibrosarcoma, Metastatic, Skin                                     1 (6%)                                             
   Lymph Node, Mandibular                             (46)         (19)         (10)         (46)                                   
   Lymph Node, Mesenteric                             (9)          (14)         (12)         (9)                                    
   Spleen                                             (50)         (23)         (20)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
   Thymus                                             (8)          (10)         (7)          (9)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (36)         (24)         (22)                                   
      Adenocarcinoma                                   1 (3%)                    3 (13%)      2 (9%)                                
      Fibroadenoma                                    21 (58%)     17 (47%)     14 (58%)      6 (27%)                               
      Fibroadenoma, Multiple                           8 (22%)     10 (28%)      2 (8%)       3 (14%)                               
   Skin                                               (11)         (15)         (8)          (11)                                   
      Subcutaneous Tissue, Carcinosarcoma, Poorly                                                                                   
          Differentiated                               1 (9%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (18%)      3 (20%)      1 (13%)                                            
      Subcutaneous Tissue, Fibrosarcoma                                          1 (13%)                                            
      Subcutaneous Tissue, Sarcoma, Poorly                                                                                          
          Differentiated                                                                      1 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                           (3)                                    
      Sarcoma                                                                                 1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (8)          (50)                                   
      Carcinoma, Extension, Metastatic, Pituitary                                                                                   
          Gland                                                                               1 (2%)                                
      Medulla, Carcinoma, Metastatic, Pituitary                                                                                     
          Gland                                                     1 (7%)                                                          
   Spinal Cord                                        (1)          (2)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (20)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)                   1 (5%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (5%)                                                          
      Carcinosarcoma, Metastatic, Skin                 1 (2%)                                                                       
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                              1 (2%)                                
      Hepatocellular Carcinoma, Metastatic,                                                                                         
          Uncertain Primary Site                                                              1 (2%)                                
      Pheochromocytoma Malignant, Metastatic                        1 (5%)                                                          
      Sarcoma, Metastatic, Lung                                     1 (5%)                                                          
      Sarcoma, Metastatic, Poorly Differentiated,                                                                                   
           Skin                                                                               1 (2%)                                
      Pleura, Alveolar/Bronchiolar Carcinoma,                                                                                       
          Metastatic, Lung                                          1 (5%)                                                          
   Nose                                               (7)          (12)         (7)          (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (1)                                                 
      Fibrosarcoma                                     1 (100%)                                                                     
   Zymbal's Gland                                     (2)          (2)                                                              
      Adenoma                                          1 (50%)                                                                      
      Squamous Cell Carcinoma                          1 (50%)      2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (50)                                   
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Papilloma                                        1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Monocytic                                                                      1 (2%)                                
      Leukemia Mononuclear                             9 (18%)     10 (20%)     13 (26%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.1% LF      1.0% MF      4.0% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          43          44                                       
     Total Primary Neoplasms                          118         103         106          81                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          44          42          35                                       
     Total Benign Neoplasms                           101          82          82          59                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          19          19          19                                       
     Total Malignant Neoplasms                         17          21          24          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           1           4                                       
     Total Metastatic Neoplasm                          1           6           3           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund                                          21           15           22           21                                     
    Dead                                               3            7            3            6                                     
  Survivors                                                                                                                         
    Moribund                                                                     1            1                                     
    Terminal Sacrifice                                25           27           22           19                                     
    Dead                                               1            1            2            3                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (11)         (13)         (46)                                   
   Intestine Large, Colon                             (49)         (12)         (11)         (47)                                   
   Intestine Small, Duodenum                          (48)         (47)         (48)         (46)                                   
   Intestine Small, Ileum                             (47)         (47)         (48)         (45)                                   
      Adenoma                                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (48)         (44)         (43)         (44)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                                         1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                                      1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                           3 (6%)       1 (2%)                                                          
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Neoplastic Nodule                                             1 (2%)       2 (4%)                                             
      Neoplastic Nodule, Multiple                                   1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Mesentery                                          (7)          (6)          (5)          (5)                                    
      Sarcoma, Poorly Differentiated                                                          1 (20%)                               
   Pancreas                                           (50)         (50)         (50)         (47)                                   
      Adenoma                                                       2 (4%)       2 (4%)                                             
   Salivary Glands                                    (16)         (14)         (12)         (10)                                   
   Stomach, Forestomach                               (49)         (49)         (49)         (46)                                   
   Stomach, Glandular                                 (50)         (50)         (49)         (48)                                   
   Tongue                                             (45)         (48)         (47)         (44)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (18)         (18)         (50)                                   
      Schwannoma Benign                                1 (2%)                                                                       
      Schwannoma Malignant                                                       1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (18)         (21)         (49)                                   
   Adrenal Gland, Medulla                             (50)         (18)         (21)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)                    1 (5%)       2 (4%)                                
      Pheochromocytoma Benign                          8 (16%)      4 (22%)      9 (43%)      9 (18%)                               
      Pheochromocytoma Benign, Multiple                4 (8%)                    1 (5%)       2 (4%)                                
   Islets, Pancreatic                                 (47)         (15)         (13)         (41)                                   
      Adenoma                                                       2 (13%)                   3 (7%)                                
      Carcinoma                                                                  1 (8%)                                             
   Parathyroid Gland                                  (43)         (45)         (43)         (43)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (46)         (49)         (50)         (48)                                   
      Pars Distalis, Adenoma                          14 (30%)     14 (29%)     18 (36%)     11 (23%)                               
      Pars Distalis, Adenoma, Multiple                              3 (6%)       1 (2%)       1 (2%)                                
      Pars Distalis, Pars Intermedia, Pars Nervosa,                                                                                 
           Leukemia Mononuclear                                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (17)         (22)         (49)                                   
      C-Cell, Adenoma                                  4 (8%)       1 (6%)       4 (18%)      1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (12%)      1 (5%)                                             
      Follicular Cell, Adenocarcinoma                                                         1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Basosquamous Tumor Benign                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (13)         (13)         (49)                                   
   Preputial Gland                                    (13)         (22)         (19)         (15)                                   
      Adenoma                                          2 (15%)      5 (23%)      3 (16%)      1 (7%)                                
      Carcinoma                                        1 (8%)                    1 (5%)       3 (20%)                               
      Squamous Cell Carcinoma                                       1 (5%)                                                          
   Prostate                                           (49)         (14)         (12)         (48)                                   
   Seminal Vesicle                                    (50)         (22)         (23)         (49)                                   
   Testes                                             (50)         (46)         (48)         (50)                                   
      Interstitial Cell, Adenoma                      44 (88%)     43 (93%)     45 (94%)     45 (90%)                               
                                                             Page   8                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (11)         (12)         (12)         (9)                                    
   Lymph Node                                         (49)         (29)         (26)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (4%)                                             
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (18)         (15)         (47)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (6%)                                                          
   Lymph Node, Mesenteric                             (22)         (14)         (17)         (19)                                   
   Spleen                                             (50)         (25)         (38)         (50)                                   
      Hemangioma                                                                 1 (3%)                                             
      Hemangiosarcoma                                                            1 (3%)                                             
      Sarcoma                                                                    1 (3%)                                             
   Thymus                                             (14)         (11)         (13)         (5)                                    
      Mediastinum, Basosquamous Tumor NOS              1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (13)         (10)         (14)         (9)                                    
      Fibroadenoma                                     5 (38%)      1 (10%)      5 (36%)      3 (33%)                               
   Skin                                               (20)         (18)         (19)         (18)                                   
      Basal Cell Carcinoma                             1 (5%)                                                                       
      Basosquamous Tumor Benign                                                  1 (5%)                                             
      Keratoacanthoma                                                            1 (5%)                                             
      Squamous Cell Papilloma                          2 (10%)                   3 (16%)      1 (6%)                                
      Subcutaneous Tissue, Fibroma                     2 (10%)      1 (6%)       1 (5%)       3 (17%)                               
      Subcutaneous Tissue, Fibrosarcoma                1 (5%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (5%)                                                                       
      Subcutaneous Tissue, Myxoma                                                1 (5%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (6%)       1 (5%)       1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (10)         (12)         (15)         (23)                                   
      Osteoma                                          1 (10%)                                                                      
   Skeletal Muscle                                    (1)          (2)                                                              
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (12)         (50)                                   
      Meningioma Benign                                             1 (7%)                                                          
      Choroid Plexus, Sarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (28)         (31)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (3%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       1 (4%)       1 (3%)                                             
      Cholangiocarcinoma, Metastatic, Liver                                      1 (3%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Mediastinum, Schwannoma Malignant,                                                                                            
          Metastatic, Heart                                                      1 (3%)                                             
   Nose                                               (44)         (48)         (49)         (49)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Glands, Carcinoma                                             1 (2%)                                                          
   Trachea                                            (50)         (12)         (12)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (9)          (6)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
      Proximal Convoluted Renal Tubule, Adenoma                                               1 (2%)                                
      Renal Tubule, Adenocarcinoma                                                            1 (2%)                                
      Renal Tubule, Adenoma                                                                   2 (4%)                                
   Urinary Bladder                                    (50)         (49)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            16 (32%)     18 (36%)     22 (44%)     13 (26%)                               
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant Lymphocytic                   3 (6%)                                                                       
      Lymphoma Malignant Mixed                                      1 (2%)       1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
      Mesothelioma Benign                                           1 (2%)       1 (2%)                                             
      Mesothelioma Malignant                           4 (8%)       3 (6%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 05033-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             QUERCETIN                                         Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 20:31:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.1% LM      1.0% MM      4.0% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          48                                       
     Total Primary Neoplasms                          125         111         139         113                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          48          50          48                                       
     Total Benign Neoplasms                            95          82         102          88                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          27          32          21                                       
     Total Malignant Neoplasms                         29          29          37          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           3           1                                       
     Total Metastatic Neoplasm                          8           2           4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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