National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3045

TDMS Study 05033-01 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/04/94   
EXP: 05033                        QUERCETIN                    TIME: 20:46:15   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 60106    
CONT: N01CP9561903                                             CAS: 117-39-5    
PATHOLOGIST: R. FLEISCHMAN                   S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/04/94  
EXP: 05033                        QUERCETIN                    TIME: 20:46:15  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 60106   
CONT: N01CP9561903                                             CAS: 117-39-5   
PATHOLOGIST: R. FLEISCHMAN                   S. EUSTIS                         

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 724 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL UM                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 24     CENSORED DEATHS 20   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      226   458   519   562   573   575   590   620   636   636                 |
 |      640   654   654   656   664   674   679   682   689   704                 |
 |      717   717   720   721                                                     |
 |  CENSORED DEATHS                                                               |
 |      189   189   189   189   189   189   189   191   191   191                 |
 |      463   463   465   465   465   465   465   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 22     CENSORED DEATHS 20   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      458   509   546   556   562   572   584   599   618   618                 |
 |      620   643   654   671   678   685   695   704   716   720                 |
 |      721   723                                                                 |
 |  CENSORED DEATHS                                                               |
 |      189   189   189   189   189   191   191   191   191   191                 |
 |      463   463   463   463   463   465   465   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 25     CENSORED DEATHS 20   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      420   427   549   555   555   574   592   608   617   624                 |
 |      643   643   673   673   674   674   680   684   687   690                 |
 |      695   699   703   704   704                                               |
 |  CENSORED DEATHS                                                               |
 |      189   189   189   189   189   191   191   191   191   191                 |
 |      463   463   463   463   463   465   465   465   465   465                 |
 |                                                                                |
 ==================================================================================

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 724 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 4.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 27     CENSORED DEATHS 20   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      315   326   422   555   574   581   617   626   662   667                 |
 |      673   674   676   676   686   690   692   693   694   697                 |
 |      698   700   704   713   715   723   723                                   |
 |  CENSORED DEATHS                                                               |
 |      189   189   189   189   189   191   191   191   191   191                 |
 |      463   463   463   463   463   463   463   465   465   465                 |
 |                                                                                |
 ==================================================================================

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 724 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   724 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL UM |   100.0 100.0  98.3  98.3  98.3  96.7  94.7  86.6  70.5  52.4      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1%       |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  84.3  74.3  56.2      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0%       |   100.0 100.0 100.0 100.0  98.3  96.7  96.7  86.6  76.5  50.3      |
 |           |                                                                    |
 |           |                                                                    |
 |4.0%       |   100.0 100.0 100.0  96.7  95.0  95.0  95.0  88.9  82.9  46.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL UM   0.1%         1.0%         4.0%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.4%        56.2%        50.3%        46.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.603      P=0.838N     P=0.940      P=0.824  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       623.6        629.6        629.9        636.0    |
 |NATURAL DEATHS (C)      |       (22.0)       (16.0)       (16.0)       (21.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       576.2        580.9        577.0        576.6    |
 |(STANDARD ERROR)        |       (22.8)       (22.3)       (22.2)       (22.9)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 723 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL UF                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 20     CENSORED DEATHS 20   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      422   597   606   613   619   625   632   641   660   660                 |
 |      672   672   686   687   687   700   700   718   718   718                 |
 |  CENSORED DEATHS                                                               |
 |      191   191   191   191   191   193   193   193   193   193                 |
 |      464   464   464   464   464   466   466   466   466   466                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 22     CENSORED DEATHS 20   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      497   504   515   543   548   596   597   603   603   612                 |
 |      613   626   645   668   676   680   680   683   687   696                 |
 |      704   721                                                                 |
 |  CENSORED DEATHS                                                               |
 |      191   191   191   191   191   193   193   193   193   193                 |
 |      464   464   464   464   464   464   466   466   466   466                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 15     CENSORED DEATHS 20   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      337   441   521   548   548   603   605   660   666   685                 |
 |      697   697   707   709   718                                               |
 |  CENSORED DEATHS                                                               |
 |      191   191   191   191   191   193   193   193   193   193                 |
 |      464   464   464   464   464   466   466   466   466   466                 |
 |                                                                                |
 ==================================================================================

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 723 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 4.0%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 22     CENSORED DEATHS 20   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      284   457   492   549   553   560   594   597   623   630                 |
 |      632   637   660   667   668   686   688   688   688   715                 |
 |      716   716                                                                 |
 |  CENSORED DEATHS                                                               |
 |      191   191   191   191   191   193   193   193   193   193                 |
 |      464   464   464   466   466   466   466   466   466   466                 |
 |                                                                                |
 ==================================================================================

                                     QUERCETIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 723 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   723 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL UF |   100.0 100.0 100.0 100.0  98.3  98.3  98.3  96.3  80.3  60.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1%       |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  82.0  74.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0%       |   100.0 100.0 100.0  98.3  98.3  96.7  94.7  86.6  84.6  70.5      |
 |           |                                                                    |
 |           |                                                                    |
 |4.0%       |   100.0 100.0 100.0  98.3  98.3  96.7  94.7  84.6  74.5  56.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL UF   0.1%         1.0%         4.0%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.2%        56.0%        70.5%        56.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.704      P=0.614      P=0.455N     P=0.656  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       651.7        622.6        609.5        613.6    |
 |NATURAL DEATHS (C)      |       (14.9)       (14.5)       (29.0)       (21.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       589.9        578.7        586.0        576.0    |
 |(STANDARD ERROR)        |       (22.4)       (22.0)       (22.9)       (22.5)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             QUERCETIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL UM       = 1
                                                        0.1%             = 2
                                                        1.0%             = 3
                                                        4.0%             = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                   1             4               3      2
      |                                     1             4 4             33     1      2  1  23
      |                                                                    4               1  2321
      |                                                                                         211
P  90 +                                                                                         3211      4
E     |                                                                                           212 123 14
R     |                                                                                                23 141    4
C     |                                                                                                   33     44
E  80 +                                                                                                    311    44
N     |                                                                                                   2  1 1   3
T     |                                                                                                        2  2
      |                                                                                                        1 1224
S  70 +                                                                                                          1 124
U     |                                                                                                            11 2
R     |                                                                                                             1122 2
V     |                                                                                                              1 1
I  60 +                                                                                                              331 1
V     |                                                                                                               33 22
A     |                                                                                                                44 2
L     |                                                                                                                 411
   50 +                                                                                                                3 43
      |                                                                                                                   4
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 47 obs hidden.

                                                             QUERCETIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL UF       = 1
                                                        0.1%             = 2
                                                        1.0%             = 3
                                                        4.0%             = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                            4        3            1          2
      |                                              4        3            1 3   4                     1
      |                                                                               22
      |                                                                      3   4    42 2 3           11
   95 +                                                                               4    3   3
      |                                                                                  2    2         11
      |                                                                                       22         11
      |                                                                                        34       3
   90 +                                                                                        2       2  11
      |                                                                                         4     4    11
P     |
E     |                                                                                               422   11   3
R  85 +                                                                                                4  4      33
C     |                                                                                                      1   1
E     |                                                                                                 2244      3 3
N     |
T  80 +                                                                                                    44    11 3 3
      |
S     |                                                                                                  2 2
U     |                                                                                                    24 2  41 1 33
R  75 +                                                                                                          44    33
V     |                                                                                                       2   2 11
I     |                                                                                                           22    33
V     |
A  70 +                                                                                                           42211  33
L     |                                                                                                             44
      |
      |                                                                                                               1  1
   65 +
      |                                                                                                             22
      |                                                                                                              22  4
      |
   60 +                                                                                                               22 11
      |
      |                                                                                                                2 2
      |                                                                                                                  22
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.