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https://ntp.niehs.nih.gov/go/3047

TDMS Study 05035-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        4-HYDROXYACETANILIDE


NTP Experiment-Test: 05035-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 22:25:07




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          21            9           21            8                                     
    Dead                                               2            9                         4                                     
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           32           25           38                                     
  Animals Examined Microscopically                    50           50           50           51                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (45)         (44)         (46)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Serosa, Inflammation, Chronic                                                           1 (2%)                                
   Intestine Large, Cecum                             (49)         (45)         (49)         (48)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Intestine Large, Colon                             (47)         (44)         (47)         (48)                                   
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (46)         (49)         (48)                                   
      Artery, Inflammation                                          1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (43)         (48)         (47)                                   
      Amyloid Deposition                                            1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (42)         (46)         (48)                                   
      Amyloid Deposition                                                                      1 (2%)                                
   Liver                                              (49)         (50)         (50)         (49)                                   
      Angiectasis, Focal                               2 (4%)                                                                       
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                                                                      1 (2%)                                
      Fatty Change                                     9 (18%)      4 (8%)       4 (8%)       3 (6%)                                
      Hematopoietic Cell Proliferation                 6 (12%)      3 (6%)       5 (10%)      5 (10%)                               
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Focal, Granulomatous                                                      1 (2%)                                
      Mixed Cell Focus                                              1 (2%)                    1 (2%)                                
      Necrosis, Focal                                 14 (29%)      3 (6%)       6 (12%)      9 (18%)                               
      Artery, Mineralization                                        1 (2%)                                                          
      Centrilobular, Necrosis                                                    1 (2%)                                             
      Hepatocyte, Hyperplasia, Focal                                                          1 (2%)                                
      Periductular, Fibrosis                                                     1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Perivascular, Inflammation, Chronic              9 (18%)      9 (18%)     13 (26%)     12 (24%)                               
   Mesentery                                          (4)          (4)          (3)          (1)                                    
      Hemorrhage                                                    1 (25%)                                                         
      Inflammation, Acute                              1 (25%)      1 (25%)      2 (67%)                                            
      Fat, Necrosis                                    3 (75%)      2 (50%)      1 (33%)      1 (100%)                              
   Pancreas                                           (49)         (48)         (47)         (49)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                    21 (43%)     17 (35%)     14 (30%)     19 (39%)                               
      Acinus, Atrophy                                  4 (8%)       1 (2%)                                                          
      Acinus, Hyperplasia                              1 (2%)                                                                       
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Duct, Ectasia                                    2 (4%)       1 (2%)                                                          
   Salivary Glands                                    (46)         (49)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    2 (4%)                                
      Hypoplasia                                                                 1 (2%)                                             
      Inflammation, Chronic, Focal                    33 (72%)     32 (65%)     29 (58%)     31 (62%)                               
   Stomach, Forestomach                               (48)         (49)         (49)         (48)                                   
      Acanthosis                                       3 (6%)                                                                       
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hyperkeratosis                                   4 (8%)       2 (4%)                                                          
      Hyperplasia, Squamous                                         1 (2%)       1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
   Stomach, Glandular                                 (47)         (47)         (50)         (48)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            9 (19%)      9 (19%)      6 (12%)      5 (10%)                               
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Mineralization, Focal                                                      2 (4%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
   Tooth                                                           (1)          (1)          (1)                                    
      Abscess                                                                    1 (100%)                                           
      Inflammation, Acute                                           1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   1 (2%)       1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic, Focal                     3 (6%)                                                                       
      Mineralization, Focal                                                                   1 (2%)                                
      Atrium, Thrombosis                                            1 (2%)                                                          
      Coronary Artery, Inflammation, Acute             1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic                                                  1 (2%)                                
      Pericardium, Inflammation, Acute                 2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (49)         (46)         (49)                                   
      Capsule, Hyperplasia                             2 (4%)       2 (4%)                    1 (2%)                                
      Subcapsular, Hyperplasia                                                                1 (2%)                                
   Adrenal Gland, Cortex                              (49)         (49)         (46)         (49)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                 1 (2%)                                
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                                       2 (4%)                                                          
      Congestion                                                    1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (46)         (46)         (45)         (47)                                   
      Congestion                                       1 (2%)                    3 (7%)       1 (2%)                                
      Hyperplasia                                                   1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (47)         (43)         (49)                                   
      Hyperplasia                                      7 (15%)      2 (4%)       2 (5%)       6 (12%)                               
   Pituitary Gland                                    (46)         (43)         (42)         (45)                                   
      Congestion                                                                              1 (2%)                                
      Pars Distalis, Angiectasis                       1 (2%)                                 1 (2%)                                
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                       2 (4%)                    2 (5%)                                             
      Pars Distalis, Hyperplasia, Focal               13 (28%)      6 (14%)     13 (31%)     13 (29%)                               
   Thyroid Gland                                      (48)         (50)         (50)         (50)                                   
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Inflammation, Chronic                                         2 (4%)                                                          
      Inflammation, Chronic, Focal                     4 (8%)       5 (10%)      2 (4%)      11 (22%)                               
      Follicular Cell, Cyst                                                                   1 (2%)                                
      Follicular Cell, Hyperplasia, Focal              2 (4%)       8 (16%)     11 (22%)     25 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                                            (1)                                    
      Dilatation                                                                              1 (100%)                              
   Ovary                                              (47)         (49)         (49)         (50)                                   
      Abscess                                          5 (11%)      8 (16%)      8 (16%)      3 (6%)                                
      Congestion                                                    2 (4%)                    1 (2%)                                
      Cyst                                            17 (36%)     20 (41%)     12 (24%)     10 (20%)                               
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Granulomatous                                                             1 (2%)                                
      Thrombosis                                                                 2 (4%)                                             
      Corpus Luteum, Hypertrophy                       1 (2%)                                                                       
      Follicle, Hemorrhage                                          2 (4%)                                                          
   Uterus                                             (49)         (50)         (50)         (49)                                   
      Abscess                                          3 (6%)                    2 (4%)                                             
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                                       1 (2%)                                                          
      Dilatation                                       3 (6%)       1 (2%)       1 (2%)       5 (10%)                               
      Inflammation, Acute                              2 (4%)       5 (10%)      3 (6%)       1 (2%)                                
      Thrombosis                                                                 1 (2%)       1 (2%)                                
      Endometrium, Angiectasis                         2 (4%)                                                                       
      Endometrium, Cyst                                                          1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                33 (67%)     33 (66%)     35 (70%)     31 (63%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (49)         (49)                                   
      Angiectasis                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Hyperplasia, Neutrophil                          8 (16%)     10 (20%)     13 (27%)      2 (4%)                                
      Myelofibrosis                                   30 (61%)     27 (55%)     21 (43%)     35 (71%)                               
   Lymph Node                                         (49)         (47)         (49)         (49)                                   
      Axillary, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Lumbar, Congestion                               1 (2%)       2 (4%)                                                          
      Lumbar, Infiltration Cellular, Plasma Cell       4 (8%)       2 (4%)       1 (2%)                                             
      Lumbar, Inflammation, Acute                      1 (2%)       1 (2%)                                                          
      Lymphatic, Angiectasis                                                     1 (2%)                                             
      Mediastinal, Abscess                             1 (2%)                    1 (2%)       1 (2%)                                
      Mediastinal, Congestion                                       1 (2%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)       5 (11%)      2 (4%)                                             
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      1 (2%)                                                          
      Renal, Angiectasis                               1 (2%)                                                                       
      Renal, Congestion                                             2 (4%)                                                          
      Renal, Infiltration Cellular, Plasma Cell        3 (6%)       3 (6%)       3 (6%)       1 (2%)                                
      Renal, Necrosis                                               1 (2%)                                                          
      Renal, Lymphatic, Angiectasis                                 1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (41)         (26)         (29)         (44)                                   
      Congestion                                                    1 (4%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (4%)                                                          
      Hyperplasia, Lymphoid                            2 (5%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Plasma Cell               6 (15%)      6 (23%)      7 (24%)      9 (20%)                               
      Inflammation, Acute                                           1 (4%)                                                          
   Lymph Node, Mesenteric                             (44)         (45)         (45)         (43)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Congestion                                       4 (9%)       2 (4%)       3 (7%)       2 (5%)                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (5%)                    3 (7%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell               1 (2%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Acute                              2 (5%)                                                                       
   Spleen                                             (49)         (50)         (50)         (49)                                   
      Congestion                                                                              1 (2%)                                
      Hematopoietic Cell Proliferation                31 (63%)     37 (74%)     32 (64%)     36 (73%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                           11 (22%)      8 (16%)      5 (10%)      8 (16%)                               
      Inflammation, Acute                                                        1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)       4 (8%)                                             
   Thymus                                             (23)         (30)         (30)         (34)                                   
      Congestion                                                                              1 (3%)                                
      Hyperplasia, Lymphoid                            2 (9%)                                                                       
      Infiltration Cellular, Plasma Cell               1 (4%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (47)         (48)         (49)         (48)                                   
      Ulcer                                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)                                   
      Sternum, Necrosis                                             1 (2%)                                                          
      Tarsal, Hyperostosis                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Congestion                                                                 2 (4%)                                             
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hydrocephalus                                    1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Mineralization, Focal                           24 (48%)     31 (62%)     28 (56%)     31 (62%)                               
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Choroid Plexus, Inflammation, Chronic, Focal     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)       1 (2%)       5 (10%)      1 (2%)                                
      Giant Cell                                                    1 (2%)                                                          
      Granuloma                                                     2 (4%)                                                          
      Hemorrhage, Focal                                1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Alveolar Epithelium, Metaplasia                                            1 (2%)       1 (2%)                                
      Perivascular, Inflammation, Chronic             33 (66%)     27 (54%)     22 (44%)     32 (64%)                               
      Pleura, Inflammation, Acute                      2 (4%)                                 1 (2%)                                
      Pleura, Inflammation, Chronic                    1 (2%)                                                                       
   Nose                                               (47)         (44)         (45)         (38)                                   
      Inflammation, Chronic                            4 (9%)       1 (2%)       5 (11%)                                            
      Metaplasia, Squamous                            18 (38%)     15 (34%)     10 (22%)      6 (16%)                               
      Respiratory Epithelium, Degeneration, Hyaline   28 (60%)     30 (68%)     27 (60%)     22 (58%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (6)                                                 
      Inflammation, Chronic                                                      1 (17%)                                            
   Eye                                                (1)          (1)          (1)                                                 
      Degeneration                                                  1 (100%)                                                        
      Retina, Degeneration                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Atrophy, Focal                                                1 (2%)       1 (2%)                                             
      Congestion                                       3 (6%)                                 1 (2%)                                
      Glomerulosclerosis                              13 (27%)      5 (10%)      8 (16%)      8 (16%)                               
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Inflammation, Chronic, Focal                    25 (51%)     22 (45%)     26 (52%)     26 (53%)                               
      Mineralization                                                             1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Cortex, Degeneration                                                                    1 (2%)                                
      Cortex, Necrosis, Focal                          1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Interstitial Tissue, Inflammation                             1 (2%)                                                          
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
      Renal Tubule, Regeneration                       6 (12%)                   1 (2%)       2 (4%)                                
   Urinary Bladder                                    (49)         (46)         (44)         (46)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic, Focal                    37 (76%)     30 (65%)     35 (80%)     36 (78%)                               
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Transitional Epithelium, Hyperplasia, Focal                   2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          13            3           16           10                                     
    Dead                                               5            7            3            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           40           31           31                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (48)         (48)         (49)                                   
      Acanthosis                                                                              1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Hyperkeratosis                                                                          1 (2%)                                
   Gallbladder                                        (41)         (43)         (47)         (40)                                   
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
   Intestine Large, Cecum                             (49)         (50)         (48)         (47)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Large, Colon                             (48)         (46)         (49)         (47)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Large, Rectum                            (49)         (47)         (47)         (47)                                   
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Small, Ileum                             (48)         (45)         (48)         (44)                                   
      Amyloid Deposition                                            1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (43)         (47)         (45)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Abscess                                          1 (2%)                                 1 (2%)                                
      Abscess, Multiple                                1 (2%)                                                                       
      Basophilic Focus                                              1 (2%)       2 (4%)                                             
      Cytoplasmic Alteration, Focal                                 4 (8%)                                                          
      Fatty Change                                     2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)                                             
      Hepatodiaphragmatic Nodule                       2 (4%)                                                                       
      Infarct                                                                                 1 (2%)                                
      Mineralization, Focal                            1 (2%)                                                                       
      Necrosis, Focal                                  3 (6%)       3 (6%)       6 (12%)      3 (6%)                                
      Thrombosis                                                                 1 (2%)                                             
      Hepatocyte, Hyperplasia, Focal                   1 (2%)       1 (2%)       2 (4%)                                             
      Perivascular, Inflammation, Chronic              2 (4%)       1 (2%)                    5 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (4)          (2)                       (1)                                    
      Hemorrhage                                                    1 (50%)                                                         
      Fat, Necrosis                                    4 (100%)     1 (50%)                                                         
   Pancreas                                           (47)         (49)         (50)         (48)                                   
      Congestion                                                                 2 (4%)                                             
      Edema                                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                     4 (9%)      10 (20%)      5 (10%)      9 (19%)                               
      Acinus, Atrophy                                  3 (6%)                    1 (2%)                                             
      Acinus, Hyperplasia                              1 (2%)                                                                       
      Acinus, Vacuolization Cytoplasmic                                          1 (2%)                                             
      Duct, Ectasia                                                              1 (2%)                                             
      Periductular, Inflammation, Acute                1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (50)         (49)                                   
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                    38 (76%)     36 (73%)     35 (70%)     31 (63%)                               
      Karyomegaly                                                   1 (2%)                                                          
   Stomach, Forestomach                               (49)         (49)         (50)         (49)                                   
      Acanthosis                                                    1 (2%)       2 (4%)                                             
      Cyst                                             1 (2%)                                                                       
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)                    1 (2%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (47)         (49)         (48)                                   
      Inflammation, Acute                              1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            7 (14%)      2 (4%)       5 (10%)      4 (8%)                                
      Mineralization                                                1 (2%)       1 (2%)       1 (2%)                                
      Mineralization, Focal                                         1 (2%)                                                          
   Tooth                                              (2)          (1)          (1)          (2)                                    
      Abscess                                          2 (100%)     1 (100%)     1 (100%)     1 (50%)                               
      Inflammation, Acute                                                                     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                1 (2%)                    2 (4%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Karyomegaly                                                                             1 (2%)                                
      Atrium, Thrombosis                                                                      1 (2%)                                
      Coronary Artery, Inflammation, Acute                                                    1 (2%)                                
      Coronary Artery, Inflammation, Chronic           1 (2%)                                 2 (4%)                                
      Myocardium, Inflammation, Acute, Focal                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (48)         (49)         (49)                                   
      Capsule, Hyperplasia                             1 (2%)                                                                       
   Adrenal Gland, Cortex                              (50)         (48)         (49)         (49)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Cytoplasmic Alteration, Focal                    5 (10%)     10 (21%)      5 (10%)      6 (12%)                               
      Hypertrophy                                                                             1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (47)         (48)         (48)         (48)                                   
      Congestion                                                                              1 (2%)                                
      Hyperplasia                                      8 (17%)      7 (15%)      5 (10%)      5 (10%)                               
      Inflammation, Acute                                                                     1 (2%)                                
   Islets, Pancreatic                                 (47)         (48)         (48)         (48)                                   
      Hyperplasia                                     11 (23%)      4 (8%)       9 (19%)      7 (15%)                               
   Pituitary Gland                                    (48)         (39)         (39)         (46)                                   
      Pars Distalis, Congestion                                                  2 (5%)       1 (2%)                                
      Pars Distalis, Cyst                              3 (6%)       1 (3%)       3 (8%)       1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                             1 (3%)                                                          
   Thyroid Gland                                      (49)         (49)         (50)         (50)                                   
      Congestion                                                                 1 (2%)                                             
      Inflammation, Chronic, Focal                     5 (10%)                   2 (4%)       3 (6%)                                
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicle, Cyst                                                             1 (2%)                                             
      Follicle, Inflammation, Acute, Focal                                                    1 (2%)                                
      Follicular Cell, Hyperplasia, Focal                           6 (12%)     12 (24%)     15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Abscess                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Inflammation, Chronic                                         3 (6%)                    1 (2%)                                
      Spermatocele                                                  1 (2%)                                                          
      Duct, Dilatation                                              1 (2%)                                                          
   Penis                                              (2)          (2)          (1)          (1)                                    
      Abscess                                                       1 (50%)      1 (100%)                                           
      Inflammation, Acute                              1 (50%)                                1 (100%)                              
      Inflammation, Subacute                                        1 (50%)                                                         
      Necrosis                                         1 (50%)                                1 (100%)                              
   Preputial Gland                                    (17)         (22)         (12)         (11)                                   
      Abscess                                          4 (24%)      8 (36%)      6 (50%)      3 (27%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Ectasia                                          4 (24%)      3 (14%)      3 (25%)      1 (9%)                                
      Inflammation, Chronic                           11 (65%)     13 (59%)      4 (33%)      6 (55%)                               
   Prostate                                           (48)         (42)         (47)         (48)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                                                                       
      Inflammation, Chronic                            9 (19%)     10 (24%)      5 (11%)      7 (15%)                               
      Inflammation, Subacute                                        1 (2%)                                                          
   Seminal Vesicle                                    (49)         (49)         (49)         (50)                                   
      Abscess                                                                                 1 (2%)                                
      Atrophy                                          3 (6%)                    1 (2%)       1 (2%)                                
      Dilatation                                       4 (8%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hypospermia, Focal                               1 (2%)                    1 (2%)                                             
      Mineralization                                                4 (8%)                    2 (4%)                                
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
      Seminiferous Tubule, Atrophy                     5 (10%)      6 (12%)      2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
      Hypochromasia                                    1 (100%)                                                                     
   Bone Marrow                                        (50)         (49)         (50)         (49)                                   
      Hyperplasia, Neutrophil                          4 (8%)       7 (14%)      6 (12%)      4 (8%)                                
   Lymph Node                                         (49)         (47)         (47)         (47)                                   
      Axillary, Hyperplasia, Lymphoid                                                         1 (2%)                                
      Axillary, Infiltration Cellular, Plasma Cell                                            2 (4%)                                
      Inguinal, Congestion                                          1 (2%)                                                          
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Inguinal, Infiltration Cellular, Plasma Cell     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Lumbar, Hyperplasia, Lymphoid                    2 (4%)       1 (2%)                                                          
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)       1 (2%)       2 (4%)                                             
      Lumbar, Inflammation, Acute                                                             1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   1 (2%)       1 (2%)                                
      Pancreatic, Congestion                                                                  1 (2%)                                
      Renal, Congestion                                             1 (2%)       1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                     2 (4%)                                                                       
      Renal, Infiltration Cellular, Plasma Cell        1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (43)         (20)         (17)         (40)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)                    1 (6%)                                             
      Infiltration Cellular, Plasma Cell              19 (44%)     15 (75%)     11 (65%)     31 (78%)                               
   Lymph Node, Mesenteric                             (43)         (45)         (47)         (42)                                   
      Congestion                                      14 (33%)     18 (40%)     13 (28%)     17 (40%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Lymphatic, Angiectasis                                                                  1 (2%)                                
   Spleen                                             (50)         (50)         (49)         (48)                                   
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                                 2 (4%)                                             
      Depletion Lymphoid                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                19 (38%)     18 (36%)     16 (33%)     17 (35%)                               
      Hyperplasia, Lymphoid                            6 (12%)      2 (4%)       5 (10%)      1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
   Thymus                                             (11)         (18)         (28)         (22)                                   
      Hyperplasia, Lymphoid                                         1 (6%)       1 (4%)                                             
      Infiltration Cellular, Plasma Cell                                                      1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (49)         (50)         (50)                                   
      Alopecia                                                                                1 (2%)                                
      Fibrosis                                         1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                            6 (13%)      3 (6%)                    3 (6%)                                
      Dermis, Inflammation, Chronic                    2 (4%)                                 1 (2%)                                
      Epidermis, Inflammation, Acute                   1 (2%)                                                                       
      Perivascular, Inflammation                                                              1 (2%)                                
      Scrotal, Subcutaneous Tissue, Thrombosis                                   1 (2%)                                             
      Scrotal, Subcutaneous Tissue, Lymphatic,                                                                                      
           Dilatation                                                                         1 (2%)                                
      Subcutaneous Tissue, Abscess                                                            1 (2%)                                
      Subcutaneous Tissue, Hyperplasia, Lymphoid       1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Plasma Cell                                                                        1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute                                                1 (2%)                                
      Subcutaneous Tissue, Mineralization, Focal                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)                                   
      Hyperostosis                                     1 (2%)                                                                       
      Cranium, Fibrous Osteodystrophy                  1 (2%)                                                                       
      Tarsal, Fibrosis                                                           1 (2%)                                             
      Tarsal, Hyperostosis                            44 (88%)     35 (71%)     41 (82%)     39 (78%)                               
      Tarsal, Inflammation, Acute                                                1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage, Focal                                             1 (2%)                                                          
      Mineralization, Focal                           19 (38%)     23 (46%)     19 (38%)     18 (36%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)       3 (6%)                    2 (4%)                                
      Granuloma                                                     1 (2%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       6 (12%)      1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Metaplasia                                            1 (2%)       2 (4%)                                
      Bronchiole, Epithelium, Hyperplasia                           1 (2%)       1 (2%)                                             
      Bronchus, Foreign Body                                        1 (2%)                                                          
      Perivascular, Inflammation, Chronic             22 (44%)     24 (48%)      9 (18%)     21 (42%)                               
      Pleura, Inflammation, Chronic                    1 (2%)                                 1 (2%)                                
   Nose                                               (47)         (40)         (46)         (44)                                   
      Inflammation, Chronic                            1 (2%)       7 (18%)      5 (11%)      2 (5%)                                
      Metaplasia, Squamous                            17 (36%)     20 (50%)     19 (41%)     13 (30%)                               
      Respiratory Epithelium, Degeneration, Hyaline   21 (45%)     25 (63%)     30 (65%)     19 (43%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)          (1)                                                 
      Cornea, Degeneration                                          1 (33%)                                                         
      Cornea, Inflammation, Acute                                   1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05035-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:07  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Abscess                                                       1 (2%)                                                          
      Congestion                                       2 (4%)       3 (6%)       4 (8%)       4 (8%)                                
      Cyst                                                                       1 (2%)       2 (4%)                                
      Fibrosis, Focal                                               2 (4%)                                                          
      Glomerulosclerosis                               7 (14%)      1 (2%)       3 (6%)       6 (12%)                               
      Hydronephrosis                                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic, Focal                    26 (52%)     18 (37%)     22 (44%)     28 (56%)                               
      Inflammation, Subacute                                        1 (2%)                                                          
      Mineralization                                   1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
      Necrosis, Focal                                                            1 (2%)       4 (8%)                                
      Nephropathy, Focal                                                                      1 (2%)                                
      Capsule, Fibrosis                                1 (2%)                                                                       
      Papilla, Necrosis                                             2 (4%)                    1 (2%)                                
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Renal Tubule, Atrophy, Focal                                               1 (2%)                                             
      Renal Tubule, Casts                                           1 (2%)                    1 (2%)                                
      Renal Tubule, Degeneration                                                 1 (2%)       1 (2%)                                
      Renal Tubule, Dilatation                                                   1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                              1 (2%)                    2 (4%)                                
      Renal Tubule, Necrosis                                                     1 (2%)                                             
      Renal Tubule, Regeneration                      25 (50%)     15 (31%)     16 (32%)     25 (50%)                               
   Urethra                                                                                   (2)                                    
      Hemorrhage                                                                              1 (50%)                               
      Inflammation, Acute                                                                     2 (100%)                              
   Urinary Bladder                                    (47)         (46)         (46)         (45)                                   
      Calculus Gross Observation                       1 (2%)       1 (2%)                                                          
      Calculus Micro Observation Only                               1 (2%)                                                          
      Concretion                                       1 (2%)       1 (2%)                    2 (4%)                                
      Ectasia                                                                    1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic, Focal                    23 (49%)     25 (54%)     18 (39%)     19 (42%)                               
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Inflammation, Subacute                                        1 (2%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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