National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3049

TDMS Study 05035-02 Pathology Tables

NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97
Route: DOSED FEED                                                                                                 Time: 12:24:19




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  M      |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  M  +     +  +  +      |             
      Adenocarcinoma                       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hepatocellular Adenoma               |                                        X  X                              |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Mixed             | X                       X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                             +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             | X                       X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  M     +  M  M  +  +  +  +  M  +     I  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Pars Distalis, Adenoma               | X        X           X                    X  X     X           X  X      |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Intermedia, Adenoma             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hemangiosarcoma                      |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Polyp Stromal                        |                                                                          |             
      Endometrium, Adenocarcinoma          |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Lumbar, Lymphoma Malignant Mixed     | X                       X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Mediastinal, Lymphoma Malignant Mixed|                         X                                                |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |    X                                         X                           |             
      Renal, Lymphoma Malignant Lymphocytic|    X                                         X                           |             
      Renal, Lymphoma Malignant Mixed      | X                       X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  M  +     M  +  M  +  +  +  +  +  +     +  M  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  M  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             | X                       X                             X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Mixed             | X                 X     X                             X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  M  M  M  +  +     M  M  +  M  +  M  +  +  +     M  +  M      |             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  M  +  +     M  M  +  +  M  M  M  +  M     M  M  +      |             
      Adenocarcinoma                       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
      Hemangiosarcoma                      |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Mixed             | X                       X                             X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  M      |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             | X                       X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Mixed             | X                       X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                         X                           |             
      Lymphoma Malignant Mixed             | X                 X     X                             X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M     +  +  +  +  M  +  +  +  +        +  +  +        +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hepatocellular Adenoma               |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     M  M  +  +  +  M  +  M  M        +  M  +        +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  I|             
      Pars Distalis, Adenoma               |                X                    X                       X     X      |             
      Pars Distalis, Carcinoma             |                                                 X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        I  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                      X                                                   |             
      Endometrium, Adenocarcinoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                            X                                             |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  M        +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  M|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X  X                    X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  +  M  M  +  M  +  M  M        +  +  +        +  M  M  M  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     M  +  M  +  M  +  M  M  +        M  +  M        +  +  M  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +              +  +   |             
      Adenoma                              |                                                    X              X  X   |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X  X                    X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M     M  +  +  M  +                                             |  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M     +  +  +  A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  A  +                                             |  47        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  A  +                                             |  49        |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  M  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  M                                             |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  M  M                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  M  M                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  M  M                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Leukemia                             |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  A  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +     M  +  M  A  +                                             |  46        |
      Pheochromocytoma Malignant           |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  M  +                                             |  48        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M     M  +  M  M  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  M  +  +                                             |  46        |
      Pars Distalis, Adenoma               | X                 X                                                      |         14 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  A  +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Endometrium, Adenocarcinoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  A  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  A  +                                             |  49        |
      Axillary, Lymphoma Malignant Mixed   |                            X                                             |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                            X                                             |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                            X                                             |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  M  +  A  +                                             |  41        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +     +  +  +  M  +                                             |  44        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M     M  +  M  M  +                                             |  23        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M     +  +  M  M  +                                             |  25        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  47        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia                             |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  A  +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   5        |
      Adenoma                              |                X                                                         |          4 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  A  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  M     +  +  M  M  M  M  +  +  M        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  M  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Intestine Small                  |                                              X                           |             
      Hepatocellular Adenoma               | X                                                                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     M  +  M     M  +  +  +  +  +  +  M  M        M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +     +  M  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X              X  X  X        X  X           X     X      |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cystadenoma                          |                X              X                                          |             
      Hemangioma                           |                                                             X            |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hemangiosarcoma                      |                                     X                                    |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed| X                                                                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Renal, Lymphoma Malignant Lymphocytic|                                                                         X|             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M     M  A  +     +  M  M  +  +  M  +  +  +        +  M  M  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hemangioma                           |                                     X                                    |             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  A  +     M  +  M  M  +  +  M  +  +        +  +  M  I  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X           X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     +  M  +     +  M  M  M  M  M  +  M  M        M  M  M  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M     +  M  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X  X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X           X|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X           X|             
      Lymphoma Malignant Mixed             | X                                      X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +     +  M  +     +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  M  A  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  M  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +     M  +  +  +  +  A  +  +  +  M  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +     +  +  +  M  +  A  +  +  +  A  +  +  M  +  A  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  M  A  A  +  +  +  A  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +     +  +  M  +  +  A  +  +  +  A  A  +  +  +  A  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Intestine Small                  |                                                                          |             
      Hepatocellular Adenoma               |                                                                   X      |             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +        +                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +     M  +  +     M  +  M  M  +  M  M  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  M  +  +  +  M  +  I  +|             
      Pars Distalis, Adenoma               |          X     X              X  X                          X     X      |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                           X                              |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +     +  M  M     +  M  M  M  M  +  M  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +     M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                       X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                             X            |             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |    X     X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +     +  M  +     M  M  M  +  +  +  +  +  M  M  +  +  M  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +     M  +  +     +  +  M  M  M  +  M  M  M  M  +  M  +  M  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                   X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant                   |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X     X                       X                                X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +                                                   |  39        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +  +                                                   |  45        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +                                                   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +                                                   |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +                                                   |  44        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +                                                   |  43        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        M  M  +                                                   |  42        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +                                                   |  50        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Intestine Small                  |                                                                          |          1 |
      Hepatocellular Adenoma               | X  X                                                                     |          4 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +                                                   |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +                                                   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +                                                   |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +                                                   |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +                                                   |  47        |
      Adenoma                              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  M                                                   |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +        +  +  +                                                   |  43        |
      Pars Distalis, Adenoma               |                   X                                                      |         16 |
      Pars Distalis, Carcinoma             |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +                                                   |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +                                                   |  49        |
      Cystadenoma                          |                                                                          |          2 |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +                                                   |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +                                                   |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +                                                   |  47        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                      X                                                   |          2 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M        +  M  +                                                   |  26        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +                                                   |  45        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +                                                   |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M        +  M  +                                                   |  30        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M        +  +  +                                                   |  20        |
      Adenoacanthoma                       |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +                                                   |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  M  +                                                   |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +                                                   |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +        +  M  +                                                   |  44        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
      Adenoma                              | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +                                                   |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  M  +                                                   |  46        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +                                                   |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +     M  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  M      |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        M  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Hemangiosarcoma                      |                                              X                           |             
      Hepatocellular Adenoma               | X                                                           X            |             
      Lymphoma Malignant Mixed             |       X           X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                          +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |       X                                      X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                   X                          X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  I        +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  M  +     +  M  M  M  +     M  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  +        +  +  +      |             
      Pars Distalis, Adenoma               | X                                X                 X           X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | I  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Cystadenoma                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Polyp Stromal                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        M  +  +      |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lumbar, Lymphoma Malignant Mixed     |                   X                          X                           |             
      Mediastinal, Lymphoma Malignant Mixed|                   X                                                      |             
      Pancreatic, Lymphoma Malignant Mixed |                   X                                                      |             
      Renal, Lymphoma Malignant Mixed      |       X           X                          X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +     M  +  M  M  +     +  M  +        M  +  +      |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |       X           X                 X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |       X           X                 X        X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  +  +     +  +  +  M  M     +  M  M        +  +  +      |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  +  +  +  M     +  +  M  M  +     M  M  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic                |                                                 X                        |             
      Lymphoma Malignant Mixed             |                   X                          X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  M  +  +  +     M  +  +  M  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Carcinoma, Metastatic                |                                                 X                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                +                        |             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |       X           X                          X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +     +  +  +  +  M     +  +  +        +  +  +      |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Mixed             |       X           X                 X        X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Sarcoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Adenoma               | X                                      X                          X  X   |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  M  +  +     +  +  +  +  +  +  M  +  M     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  M  +  M  +     +  M  M  M  +  +  M  M  +     +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  M  +  M  M  +  +     +  +  +  +  +  M  +  M  +     +  +  +  +   |             
      Pars Distalis, Adenoma               | X                                                              X  X      |             
      Pars Distalis, Carcinoma             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Follicular Cell, Adenoma             |                                  X                                       |             
      Follicular Cell, Carcinoma           | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Cystadenoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  M     M  M  M  M  M  M  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                 X                 X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  M  +  M  +     +  M  +  +  M  +  +  +  +     +  +  M  M   |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  +  M  M  +  +     M  M  +  +  M  M  +  +  M     M  +  M  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                            +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                        X     X  X           X            |             
      Carcinoma, Metastatic                |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     M  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +              +                       +  +                       +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Carcinoma, Metastatic                |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                 X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  A  A  A  M                                             |  44        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +                                             |  49        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  M  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +     +  A  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  M                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  A  A  A  +                                             |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Adenoma               |    X                                                                     |          7 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  M  M     +  +  +  +  +                                             |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +                                             |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  M  M     +  +  +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M     +  M  +  +  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +     +  +  +  +  +                                             |  42        |
      Pars Distalis, Adenoma               |                                                                          |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +                                             |  49        |
      Cystadenoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  M                                             |  49        |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|       X                                                                  |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M     M  +  +  M  M                                             |  29        |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M     +  A  M  +  M                                             |  45        |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |       X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M     +  M  +  M  M                                             |  30        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M     +  +  M  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  49        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Carcinoma, Metastatic                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  A  A  A  A                                             |  44        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                      X                                                   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                     X                    X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +        +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                   X     X                                            X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                          X        X      |             
      Pancreatic, Lymphoma Malignant Mixed |                                     X                                    |             
      Renal, Lymphoma Malignant Mixed      |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        I  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Mixed             |                                     X                    X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                    X        X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                     X                    X  X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M        +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +        M  +  M  +  M  M  M  +  +  M  M  +  +  +  +  M  M  M  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Melanoma Malignant                   |                                                                         X|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                             X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +        +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +              +                                          |             
      Adenoma                              |                X              X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                          X  X     X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia                             |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                     X                    X  X     X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +  +  M        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  M  +        M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Adenoma               |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                            X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  I  M  +  +  M  M     +  +  +        M  M  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +     M  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X              X     X  X        X  X        X                       X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  I  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          +               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                     X                                    |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                      X              X                             X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                               X            |             
      Lymphoma Malignant Mixed             |       X              X              X                             X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  M  M  M  +  +     +  M  +        +  M  +  +  M  +  M  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                      X              X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M     M  M  +        M  M  M  +  +  M  M  M  M  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  M  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Melanoma Malignant                   |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X              X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                     X                                    |             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  M  +  +  M  M     M  +  +        +  +  M  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                               X            |             
      Lymphoma Malignant Mixed             |                      X                                            X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                          X               |             
      Leukemia                             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                               X            |             
      Lymphoma Malignant Mixed             |       X              X              X                             X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M        M  +                                                      |  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +                                                      |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +                                                      |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +                                                      |  48        |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +        +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +        +                                             |  50        |
      Lymphoma Malignant Mixed             |                   X        X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +                                                      |  47        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +                                                      |  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X              X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +                                                      |  49        |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +                                                      |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +                                                      |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +                                                      |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +                                                      |  50        |
      Leukemia                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +                                                      |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +                                                      |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +                                                      |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +                                                      |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M        M  M                                                      |  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +                                                      |  45        |
      Pars Distalis, Adenoma               |    X           X  X                                                      |         14 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +        +                                             |  50        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +                                                      |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  M                                                      |  49        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +                                                      |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +                                                      |  49        |
      Bronchial, Lymphoma Malignant Mixed  | X                                                                        |          1 |
      Lumbar, Lymphoma Malignant Mixed     | X                                                                        |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed | X                                                                        |          2 |
      Renal, Lymphoma Malignant Mixed      | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +  +                                                      |  44        |
      Lymphoma Malignant Mixed             | X     X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +                                                      |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X     X        X                                                         |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +                                                      |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X     X        X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  M                                                      |  34        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X              X                                                         |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +        M  M                                                      |  17        |
      Adenocarcinoma                       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +                                                      |  48        |
      Melanoma Malignant                   |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +                                                      |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +                                                      |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +                                                      |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X     X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  M                                                      |  38        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        M  +                                                      |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +                                                      |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X              X                                                         |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +                                                      |  46        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +        +                                             |  51        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia                             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X     X        X  X        X                                             |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |             X                                                            |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                    X  X           X      |             
      Hepatocellular Adenoma               |          X                    X                    X              X  X   |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  +  +  +  +  +  +  +  +  M     M  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Follicular Cell, Adenoma             |                                              X                           |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                 +              M     +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Axillary, Fibrosarcoma, Metastatic   |                            X                                             |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +     +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                      X              X           X              X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                      X                                         X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  +  M  M  M  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +     M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                X                                                         |             
      Subcutaneous Tissue, Fibrosarcoma    |          X     X           X           X                             X   |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Meninges, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X  X                                                   |             
      Cholangiocarcinoma, Metastatic, Liver|             X                                                            |             
      Fibrosarcoma, Metastatic, Skin       |                            X                                             |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                       +  +                                             |             
      Adenoma                              | X                       X  X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                      X              X           X              X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  M     +  +     M     +  +  +  +     +  M         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +     A     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Cholangiocarcinoma                   |                                                                          |             
      Hemangiosarcoma                      | X                                                                        |             
      Hepatocellular Carcinoma             |             X           X                       X  X                     |             
      Hepatocellular Adenoma               | X              X              X                       X                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                          +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  M     M     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  M     M     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  M     +  +     M     +  +  +  +     M  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  I     +  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +  +  +              +        +     +     +                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Axillary, Fibrosarcoma, Metastatic   |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +     M     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  M  +  M  M  M  +     M  +     M     M  M  +  +     M  M         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M     M  M     M     M  M  M  M     M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     M  +         |             
      Squamous Cell Papilloma              | X                                                                        |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Meninges, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Alveolar/Bronchiolar Adenoma         |                X     X                          X  X  X                  |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |             X           X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  M  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  +  +                                                   |  41        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +                                                   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  M  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +                                                   |  48        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +                                                   |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  M  +  M  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hemangiosarcoma                      |       X                                                                  |          2 |
      Hepatocellular Carcinoma             |                                                                          |          7 |
      Hepatocellular Adenoma               |                X  X                                                      |         11 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +                                                   |  47        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  49        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Pericardium, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  M  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  M  M                                                   |  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +  +  +                                                   |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             | X                                                                        |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |  17        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +                                                   |  48        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  49        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +                                                   |  49        |
      Axillary, Fibrosarcoma, Metastatic   |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |    X                                                                     |          1 |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |    X                                                                     |          1 |
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |          1 |
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +                                                   |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  M  +  M  +                                                   |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  50        |
      Hemangiosarcoma                      |                   X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  M  M  M  M  M                                                   |  11        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          5 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
      Meninges, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  50        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          8 |
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +                                                   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   4        |
      Adenoma                              |                X                                                         |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +                                                   |  47        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +                                                   |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  +  A           +  +     A  M  +  +  M  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  A           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  A           +  +     M  M  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  A           M  +     A  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  A           +  +     A  A  +  +  +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |    X                                                                     |             
      Hepatocellular Adenoma               |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +           +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Capsule, Adenoma                     |                                              X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                            X                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +     +  +  +  +  +  +  M           +  +     +  +  M  M  M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  M  +  M     +  +  +  +  +  +  +           M  +     M  +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +        +        +  +  +                 +           +  +  +      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +     +  +  +  +  +  +  M           +  +     +  M  +  +  +  +   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +     M  M  M  M  M  +  M           +  M     +  M  M  M  M  M   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +     +  +  +  +  +  +  M           +  +     +  M  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M     M  +  M  +  M  M  M           +  +     +  M  +  +  M  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  +  M  M           M  M     M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Basal Cell Carcinoma                 |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                   X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |       X                                      X                       X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |    X                                                                     |             
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +     +  +  M  +  +  M  +           +  +     +  +  +  +  +  M   |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     A  +  +  +  +  +   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  A           +  +     A  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |       X  X        X  X                    X                       X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
      Pheochromocytoma Malignant           |                                                                X         |             
      Pheochromocytoma Benign              | X                                                           X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +     +        +        +                 +  +           +      |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  M  M  M  +  M  M  M  M      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemangioma                           |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  M  M  +  +  M  M  +  +  M  M  M  M  +  M  M  M  M  +  +      |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |             
      Basal Cell Carcinoma                 |                                                                X         |             
      Hemangiosarcoma                      |                               X                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X     X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         | X                                            X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +      |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +           +  +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +           +  +                                 |             
      Adenoma                              |                         X              X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  M  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +     +  +  +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     M     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  A                                             |  42        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +  +                                             |  45        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  A                                             |  43        |
      Adenocarcinoma                       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +                                             |  50        |
      Hemangiosarcoma                      |                         X                                                |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                      X                                                   |          8 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     M     +  +  +  +  +                                             |  48        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     M     +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     M     +  +  +  +  +                                             |  48        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     +     M  +  +  +  +                                             |  37        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     I  +  +  +  M                                             |  39        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +  +                                             |  49        |
      Follicular Cell, Adenoma             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +     +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +              +  +     +                                             |  22        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     M     +  M  +  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +  +  +  +  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +  M                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +  +  +                                             |  47        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |          X                                                               |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |          X                                                               |          1 |
      Renal, Lymphoma Malignant Lymphocytic|          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M     +     M  M  M  +  M                                             |  20        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +                                             |  45        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +  +                                             |  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     M     M  M  M  M  M                                             |  18        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M     M     M  M  M  M  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +  M                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  M  +  +  M                                             |  40        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +                                             |  49        |
      Renal Tubule, Adenoma                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +  +                                             |  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +     +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  M     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +     +  +  +  +     +  +  +        M  +  +  M     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
      Adenocarcinoma                       | X                 X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |       X                                                           X      |             
      Hepatocellular Adenoma               |       X  X                          X                                    |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Subcapsular, Adenoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Pheochromocytoma Benign              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  M  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M     +  +  +  M     +  M  M        M  M  M  M     M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  I  +     +  M  +        +  +  M  +     I  M  +  M  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +              +              +        +              +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +     +  +  +  +     +  +  +        M  +  +  +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  M  M  +|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +     M  +  M  M     M  +  M        M  M  +  M     +  M  M  M  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  M  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     M  +  M  I     +  +  +        M  +  +  M     +  M  M  M  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     +  M  M  M     M  M  M        M  M  M  M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |                X     X                                                   |             
      Subcutaneous Tissue, Lipoma          |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Neurofibroma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +              +   |             
      Adenoma                              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  M  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A     +  +  M        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  M  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                     X              X                     |             
      Hepatocellular Carcinoma             |          X                                            X              X   |             
      Hepatocellular Adenoma               |                X  X                                                      |             
      Histiocytic Sarcoma                  |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              | X                    X                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Adenoma                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  M  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M     M  M  +  M     +  +  +        +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  M  M     +  M  +        +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |       X                                                                  |             
      Follicular Cell, Carcinoma           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                             +                 +                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                   X      |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                   X      |             
      Renal, Histiocytic Sarcoma           |                         X                                                |             
      Renal, Lymphoma Malignant Mixed      |                                                                   X      |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M     +  M  +  M     +  M  M        M  M  M  M  M  M  M  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  M  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  +  +  M     M  M  M        M  +  M  M  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M     M  M  M        M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                   X            |             
      Fibrosarcoma, Metastatic, Skin       | X                                                                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  M  +  +  M  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
      Neurofibroma                         |                                                          X               |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
      Adenoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  47        |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatocellular Carcinoma             |                      X                                                   |          6 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Squamous Cell Papilloma              |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
      Subcapsular, Adenoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  48        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +  +  +  +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +                                                |  39        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |          X                                                               |          1 |
      Follicular Cell, Adenoma, Multiple   |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +     +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +                                                |  47        |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  +  M  M  +  M  +                                                |  17        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +                                                |  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  M  M  M                                                |  28        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hemangioma                           |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          3 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +                                                      |   1        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Alveolar/Bronchiolar Adenoma         |       X           X                                                      |          5 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                      X                                                   |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  +  +  +  M  +                                                |  46        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Neurofibroma                         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   4        |
      Adenoma                              |                   X                                                      |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A                                                |  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  +           A  +  +  A  A  A  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  M  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  M  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +           A  +  +  M  +  +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +           +  +  +  M  A  +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
      Adenocarcinoma                       |                                              X                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                        +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  I  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +     +  M  +  M  M  +           +  M  +  +  M  +  M  M  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +           +  +                 M        +        +  +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                    X                     |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +           M  +  +  +  M  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +     +  M  M  M  M  +           M  M  +  M  +  M  M  M  M  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M     M  M  M  M  M  M           M  M  M  M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |       X                                      X  X           X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  M  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +     +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  A  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     A  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Hepatocellular Carcinoma             |                                                 X                       X|             
      Hepatocellular Adenoma               |                         X     X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               M                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  M  M  M     +  +  M        +  +  M  M     M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +     +  +  M  +     +  +  +        M  +  +  +     +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                                     +           +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |             
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M     A  +  +  M     +  +  +        +  +  M  +     M  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +     A  +  +  +     +  +  M        +  +  +  +     +  +  +  +  M|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +     M  M  M  +     M  +  +        M  M  +  +     +  M  M  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  +     M  M  M        M  M  M  +     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                   X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                       X           X                          X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Hemangiosarcoma, Metastatic, Liver   |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  M  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                               +   |             
      Adenoma                              |                      X                                               X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  A                                             |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X                                                                  |          3 |
      Hepatocellular Adenoma               | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  M  +  +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  M  +  M                                             |  40        |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M                                             |  42        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  +  +  +  M  +                                             |  22        |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M                                             |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Subcutaneous Tissue, Fibrosarcoma    |          X  X           X                                                |          6 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05035-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 12:24:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          9 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |       X                                                                  |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  M  M  +  M  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
      Adenoma                              |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Renal Tubule, Adenoma                |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A                                             |  45        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.