National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3051

TDMS Study 05035-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        4-HYDROXYACETANILIDE


NTP Experiment-Test: 05035-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 22:25:10




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          21            9           21            8                                     
    Dead                                               2            9                         4                                     
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           32           25           38                                     
  Animals Examined Microscopically                    50           50           50           51                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (45)         (44)         (46)                                   
   Intestine Large, Cecum                             (49)         (45)         (49)         (48)                                   
      Sarcoma                                                                    1 (2%)                                             
   Intestine Small, Duodenum                          (48)         (44)         (47)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (43)         (48)         (47)                                   
   Intestine Small, Jejunum                           (47)         (42)         (46)         (48)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (49)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Intestine Small                  1 (2%)                                                          
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                           3 (6%)       4 (8%)       7 (14%)      2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Mesentery                                          (4)          (4)          (3)          (1)                                    
   Pancreas                                           (49)         (48)         (47)         (49)                                   
   Salivary Glands                                    (46)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (48)         (49)         (49)         (48)                                   
   Stomach, Glandular                                 (47)         (47)         (50)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (49)         (46)         (49)                                   
   Adrenal Gland, Medulla                             (46)         (46)         (45)         (47)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (47)         (43)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (46)         (43)         (42)         (45)                                   
      Pars Distalis, Adenoma                          14 (30%)     16 (37%)      7 (17%)     14 (31%)                               
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)       1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (48)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       2 (4%)                                
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (49)         (49)         (50)                                   
      Cystadenoma                                                   2 (4%)       1 (2%)                                             
      Hemangioma                                                    1 (2%)                                                          
   Uterus                                             (49)         (50)         (50)         (49)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Polyp Stromal                                    1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Adenocarcinoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (49)         (49)                                   
   Lymph Node                                         (49)         (47)         (49)         (49)                                   
   Lymph Node, Mandibular                             (41)         (26)         (29)         (44)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (44)         (45)         (45)         (43)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Spleen                                             (49)         (50)         (50)         (49)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (23)         (30)         (30)         (34)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (25)         (20)         (28)         (17)                                   
      Adenoacanthoma                                                1 (5%)                                                          
      Adenocarcinoma                                   1 (4%)                                 1 (6%)                                
   Skin                                               (47)         (48)         (49)         (48)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Melanoma Malignant                                                                      1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       4 (8%)       4 (8%)       4 (8%)                                
      Carcinoma, Metastatic                                                      1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Nose                                               (47)         (44)         (45)         (38)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)                                                 
      Carcinoma, Metastatic                                                      1 (100%)                                           
   Harderian Gland                                    (5)          (2)          (2)          (2)                                    
      Adenoma                                          4 (80%)      2 (100%)     1 (50%)      2 (100%)                              
      Carcinoma                                        1 (20%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (49)         (46)         (44)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(51)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Leukemia                                         1 (2%)                                 1 (2%)                                
      Lymphoma Malignant                                            1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                   2 (4%)       3 (6%)                    3 (6%)                                
      Lymphoma Malignant Mixed                         8 (16%)      6 (12%)      7 (14%)     13 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          28          24          35                                       
     Total Primary Neoplasms                           45          48          37          49                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 22          22          17          22                                       
     Total Benign Neoplasms                            24          32          22          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          15          14          19                                       
     Total Malignant Neoplasms                         21          16          15          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           2           1                                       
     Total Metastatic Neoplasm                          1           1           3           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          13            3           16           10                                     
    Dead                                               5            7            3            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           40           31           31                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (43)         (47)         (40)                                   
   Intestine Small, Duodenum                          (48)         (42)         (49)         (45)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (48)         (45)         (48)         (44)                                   
   Intestine Small, Jejunum                           (47)         (43)         (47)         (45)                                   
      Adenocarcinoma                                                1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Hepatocellular Carcinoma                         7 (14%)      1 (2%)       6 (12%)      3 (6%)                                
      Hepatocellular Adenoma                          11 (22%)      8 (16%)      5 (10%)      4 (8%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Pancreas                                           (47)         (49)         (50)         (48)                                   
   Salivary Glands                                    (50)         (49)         (50)         (49)                                   
   Stomach, Forestomach                               (49)         (49)         (50)         (49)                                   
      Squamous Cell Papilloma                          1 (2%)                    3 (6%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (47)         (49)         (48)                                   
      Adenocarcinoma                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (48)         (49)         (49)                                   
      Capsule, Adenoma                                              1 (2%)                                                          
      Subcapsular, Adenoma                                                       1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (48)         (49)         (49)                                   
   Adrenal Gland, Medulla                             (47)         (48)         (48)         (48)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                                       4 (8%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (48)         (39)         (39)         (46)                                   
   Thyroid Gland                                      (49)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Prostate                                           (48)         (42)         (47)         (48)                                   
   Seminal Vesicle                                    (49)         (49)         (49)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (49)                                   
   Lymph Node                                         (49)         (47)         (47)         (47)                                   
      Axillary, Fibrosarcoma, Metastatic               1 (2%)                                                                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (2%)                                
      Renal, Histiocytic Sarcoma                                                 1 (2%)                                             
   Lymph Node, Mandibular                             (43)         (20)         (17)         (40)                                   
   Lymph Node, Mesenteric                             (43)         (45)         (47)         (42)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (49)         (48)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (11)         (18)         (28)         (22)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (49)         (50)         (50)                                   
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                    2 (4%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                5 (10%)      5 (10%)      3 (6%)       6 (12%)                               
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
   Peripheral Nerve                                                             (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)      5 (10%)      5 (10%)      9 (18%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    2 (4%)                                
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                    1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    2 (4%)       2 (4%)                                
   Nose                                               (47)         (40)         (46)         (44)                                   
      Squamous Cell Papilloma                                       1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Neurofibroma                                                               1 (100%)                                           
   Harderian Gland                                    (4)          (3)          (4)          (3)                                    
      Adenoma                                          4 (100%)     2 (67%)      3 (75%)      3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)                    1 (2%)                                
   Urinary Bladder                                    (47)         (46)         (46)         (45)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         6 (12%)      3 (6%)       2 (4%)       2 (4%)                                
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05035-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 22:25:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          29          31          28                                       
     Total Primary Neoplasms                           56          41          46          37                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          22          21          20                                       
     Total Benign Neoplasms                            29          25          28          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          14          17          13                                       
     Total Malignant Neoplasms                         27          16          18          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       3           6                                       
     Total Metastatic Neoplasm                          5                       3           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.