National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3055

TDMS Study 05035-02 Pathology Tables

NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 16:11:20




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  M      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  M  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Angiectasis, Focal                   |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |             3                                                            |             
      Cytoplasmic Alteration, Focal        |       3                                                                  |             
      Fatty Change                         |       3  2  2                    2                             2         |             
      Hematopoietic Cell Proliferation     |             3                                         3                  |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Focal                      |    4        3                 1        2                       1         |             
      Perivascular, Inflammation, Chronic  |                2  1           1                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                             +                              |             
      Inflammation, Acute                  |             3                                                            |             
      Fat, Necrosis                        |          3                                4                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Inflammation, Chronic, Focal         |                1  2           2  2     2  2        2        1  2         |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                           2                              |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 2        3  2  2     3        2  3  2  2        3  2           1  2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Acanthosis                           |                               3        2                                 |             
      Hyperkeratosis                       |          3                    3                    2                     |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +     +  +  +      |             
      Inflammation, Chronic                |                   1              1              2              1         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation, Acute |                                                                          |             
      Pericardium, Inflammation, Acute     |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Capsule, Hyperplasia                 |                                        4                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hematopoietic Cell Proliferation     |             3                                                            |             
      Vacuolization Cytoplasmic            |                                                                4         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Congestion                           |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hyperplasia                          |                1                 2                    3        1         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  M     +  M  M  +  +  +  +  M  +     I  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Pars Distalis, Angiectasis           |    3                                                                     |             
      Pars Distalis, Hyperplasia, Focal    |             2                    3              4                        |             
      Pars Distalis, Hyperplasia           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Inflammation, Chronic, Focal         |                                  1  1              1                     |             
      Follicular Cell, Hyperplasia, Focal  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +      |             
      Abscess                              |             4                                                            |             
      Cyst                                 | X        X        X     X           X                          X         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Corpus Luteum, Hypertrophy           |                2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Abscess                              | 2           4                                                            |             
      Dilatation                           | 4                                                  3                     |             
      Inflammation, Acute                  |                                                    2                     |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2           2  2  3        2  3  2  4  4  3  3           1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |          2                                      2  2                     |             
      Myelofibrosis                        | 2  1  3        2  2           2  2  2  2  3  2     1        1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lumbar, Congestion                   |                                                       1                  |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                   3                                                      |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                        4                                 |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Angiectasis                   |                                              2                           |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  M  +     M  +  M  +  +  +  +  +  +     +  M  +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   | 1                                               4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  M  +     +  +  +      |             
      Congestion                           |                2                                                  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hematopoietic Cell Proliferation     |    3        4  4     3           2  2     2     3  2        2  2  4      |             
      Hyperplasia, Lymphoid                |                               4  3  2  2                    2  4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  M  M  M  +  +     M  M  +  M  +  M  +  +  +     M  +  M      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  M  +  +     M  M  +  +  M  M  M  +  M     M  M  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hydrocephalus                        |                                                                          |             
      Mineralization, Focal                |    2  1  2     2     1           2     2  2  2     1           1         |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Choroid Plexus, Inflammation,        |                                                                          |             
          Chronic, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|             
                                           | 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |          2                                                               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Perivascular, Inflammation, Chronic  |                3  2  2        2  2  2  2  2     3  2        2  2  1      |             
      Pleura, Inflammation, Acute          |             4                                                            |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  M      |             
      Inflammation, Chronic                |                   2                                                      |             
      Metaplasia, Squamous                 |       3           2     2              2  2  2  2                        |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2              2              2  2  2  2  2  2  2     1        2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Congestion                           |       2                          2  1                                    |             
      Glomerulosclerosis                   |             3           4     3                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |          2     2  2  3                 2        2  2        3  2  1      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Cortex, Necrosis, Focal              |                                  2                                       |             
      Renal Tubule, Regeneration           |                               3  2     1  1                 2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Inflammation, Chronic, Focal         |       3  2  1  2  2  2        2  2  2  2  1     2  2        3  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M     +  +  +  +  M  +  +  +  +        +  +  +        +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Angiectasis, Focal                   |                3              2                                          |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change                         |       1     2              1                                         3   |             
      Hematopoietic Cell Proliferation     |    4                       1                                      4  2   |             
      Inflammation, Acute                  |       2                                                                  |             
      Necrosis, Focal                      | 1                                2  1        3                 1     3   |             
      Perivascular, Inflammation, Chronic  |             2  2  2                                                     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Focal         |    2           3              1  3                             3  2  1  3|             
      Acinus, Atrophy                      |       2                 4                                      3         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               1                                          |             
      Inflammation, Chronic, Focal         | 2  2  3     3  1  2  3  2  1                 2                 2  1  3  3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Acanthosis                           |                                              4                           |             
      Hyperkeratosis                       |                                              3                           |             
      Inflammation, Acute                  |                                              4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2     2   |             
      Inflammation, Chronic Active         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       |    3                                                                     |             
      Inflammation, Chronic, Focal         |                   1           1  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation, Acute |                                              4                           |             
      Pericardium, Inflammation, Acute     |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                   4      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X                           |             
      Cytoplasmic Alteration, Focal        |                                                                1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hyperplasia                          | 2                                                                 2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     M  M  +  +  +  M  +  M  M        +  M  +        +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  I|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                   3  2     1     1           4     3                     |             
      Pars Distalis, Hyperplasia           |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        I  +  +  +  +|             
      Abscess                              |    4  4                          4  3                                    |             
      Cyst                                 |       X              X        X                    X           X     X   |             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia, Lymphoid                |                                                                4         |             
      Corpus Luteum, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Abscess                              |                               3                                          |             
      Dilatation                           |                                                             4            |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Angiectasis             |                3                                                     4   |             
      Endometrium, Hyperplasia, Cystic     |    2        1  3  3     1  2  2  2           3     2        4  4  3     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |    4  4                          3  4        2                           |             
      Myelofibrosis                        | 2              3  2  2  1     2              1     1        1  3  3     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Lumbar, Congestion                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |    4                                2                                3   |             
      Lumbar, Inflammation, Acute          |                                     2                                    |             
      Mediastinal, Abscess                 |                                     3                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                     4                                    |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |    4                             4  3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  M        +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |    3                             3           3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        M  +  +  +  M|             
      Congestion                           |       3              1                                                   |             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Infiltration Cellular, Plasma Cell   |    2                                                                     |             
      Infiltration Cellular, Histiocyte    |                                  3                                       |             
      Inflammation, Acute                  |    3                                3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  4        2  2  2           4  3        4  2           2  2  4  4  4|             
      Hyperplasia, Lymphoid                |                               1                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  +  M  M  +  M  +  M  M        +  +  +        +  M  M  M  M|             
      Hyperplasia, Lymphoid                |                               1                                          |             
      Infiltration Cellular, Plasma Cell   |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     M  +  M  +  M  +  M  M  +        M  +  M        +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Hydrocephalus                        |                                                 3                        |             
      Mineralization, Focal                | 2                          2     1                 1           2  2      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Choroid Plexus, Inflammation,        |                                                                          |             
          Chronic, Focal                   |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|             
                                           | 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Congestion                           |                                                                   2      |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                      2                                                   |             
      Perivascular, Inflammation, Chronic  | 2     2     2  1  2  2  2     3  2  2        3              2  3        4|             
      Pleura, Inflammation, Acute          |                                     3                                    |             
      Pleura, Inflammation, Chronic        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |       1                                                                  |             
      Metaplasia, Squamous                 | 2  3  2        2                                   2           2     2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2              2  2     2        2  2        2  1              2  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Retina, Degeneration                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Glomerulosclerosis                   |    4  3                          3  3        4  3                 3      |             
      Hyperplasia, Lymphoid                |                               1                                          |             
      Inflammation, Chronic, Focal         |       3     2  2  1  2           2  2        1                 4     3  2|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Cortex, Necrosis, Focal              |                                                                          |             
      Renal Tubule, Regeneration           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +        +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Focal         | 2  3  3        2  2  2  2     2  2  2        2              2  2  2  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M     M  +  +  M  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M     +  +  +  A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  A  +                                             |  49        |
      Angiectasis, Focal                   |                                                                          |      2  2.5|
      Clear Cell Focus                     |          3                                                               |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Fatty Change                         |                                                                          |      9  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      6  2.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis, Focal                      |                1  2        1                                             |     14  1.9|
      Perivascular, Inflammation, Chronic  |                      4                                                   |      9  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  M  +                                             |  49        |
      Inflammation, Chronic, Focal         |    1     2        2  2                                                   |     21  2.0|
      Acinus, Atrophy                      |                            2                                             |      4  2.8|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Ectasia                        | 4                                                                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  M                                             |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         | 2  2     1        2  1  2                                                |     33  2.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  M  M                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  M  M                                             |  48        |
      Acanthosis                           |                                                                          |      3  3.0|
      Hyperkeratosis                       |                                                                          |      4  2.8|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  M  M                                             |  47        |
      Inflammation, Chronic                |    2           2     2                                                   |      9  1.7|
      Inflammation, Chronic Active         |                   2                                                      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      3  1.0|
      Coronary Artery, Inflammation, Acute |                                                                          |      1  4.0|
      Pericardium, Inflammation, Acute     |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  A  +                                             |  49        |
      Capsule, Hyperplasia                 |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  A  +                                             |  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +     M  +  M  A  +                                             |  46        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  M  +                                             |  48        |
      Hyperplasia                          |                   2                                                      |      7  1.9|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M     M  +  M  M  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  M  +  +                                             |  46        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |    2  2  2     4                                                         |     13  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  48        |
      Inflammation, Chronic, Focal         |                   1                                                      |      4  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  A  +                                             |  47        |
      Abscess                              |                                                                          |      5  3.8|
      Cyst                                 | X  X     X        X        X                                             |     17     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Corpus Luteum, Hypertrophy           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Abscess                              |                                                                          |      3  3.0|
      Dilatation                           |                                                                          |      3  3.7|
      Inflammation, Acute                  |                      3                                                   |      2  2.5|
      Endometrium, Angiectasis             |                                                                          |      2  3.5|
      Endometrium, Hyperplasia, Cystic     |    2  2        1  2  3     2                                             |     33  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  A  +                                             |  49        |
      Hyperplasia, Neutrophil              |                                                                          |      8  2.9|
      Myelofibrosis                        | 2  2     1     1  3                                                      |     30  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  A  +                                             |  49        |
      Lumbar, Congestion                   |                                                                          |      1  1.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      4  3.0|
      Lumbar, Inflammation, Acute          |                                                                          |      1  2.0|
      Mediastinal, Abscess                 |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  M  +  A  +                                             |  41        |
      Hyperplasia, Lymphoid                |          2           4                                                   |      2  3.0|
      Infiltration Cellular, Plasma Cell   |                3                                                         |      6  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +     +  +  +  M  +                                             |  44        |
      Congestion                           |                                                                          |      4  2.0|
      Hyperplasia, Lymphoid                |          4                                                               |      2  3.5|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Hematopoietic Cell Proliferation     | 2              2  3  2     2                                             |     31  2.8|
      Hyperplasia, Lymphoid                | 3        4           3                                                   |     11  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M     M  +  M  M  +                                             |  23        |
      Hyperplasia, Lymphoid                |    3                                                                     |      2  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M     +  +  M  M  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Mineralization, Focal                |    2  2  2     2  2  1     2                                             |     24  1.7|
      Artery, Inflammation, Chronic        |          3                                                               |      1  3.0|
      Choroid Plexus, Inflammation,        |                                                                          |            |
          Chronic, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  | 2     1  2     2  1  3                                                   |     33  2.1|
      Pleura, Inflammation, Acute          |                                                                          |      2  3.5|
      Pleura, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  A  +                                             |  47        |
      Inflammation, Chronic                | 2                          2                                             |      4  1.8|
      Metaplasia, Squamous                 | 2  2                       2                                             |     18  2.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2  2  2  2        2                                                      |     28  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3|                                            |            |
                                           | 3| 3| 3| 5| 7| 3| 3| 3| 2| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  A  +                                             |  49        |
      Congestion                           |                                                                          |      3  1.7|
      Glomerulosclerosis                   | 3        4                 3                                             |     13  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |       2  3     3     3                                                   |     25  2.2|
      Artery, Inflammation, Chronic        |                   2                                                      |      1  2.0|
      Cortex, Necrosis, Focal              |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  A  +                                             |  49        |
      Inflammation, Chronic, Focal         | 1  2  2        2  2  2                                                   |     37  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  M     +  +  M  M  M  M  +  +  M        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Artery, Inflammation                 |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  M  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Fatty Change                         |                      1                                                  2|             
      Hematopoietic Cell Proliferation     |          4                                                               |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                      3                 2  1                              |             
      Artery, Mineralization               |                                                                   4      |             
      Perivascular, Inflammation, Chronic  |    3                                               3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                            2     2  2     2  2  2                 2      |             
      Acinus, Atrophy                      |                                     4                                    |             
      Duct, Ectasia                        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Inflammation, Chronic, Focal         |    2  2        3           2  1  2  2  1  2  3     1           2  2  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |       2                             2                             2      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |          4                                                               |             
      Atrium, Thrombosis                   |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Atrophy                              | 2                                                                 2      |             
      Congestion                           |                                                                         1|             
      Cyst                                 |                                  X                                       |             
      Cytoplasmic Alteration, Focal        | 2                                                                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     M  +  M     M  +  +  +  +  +  +  M  M        M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +     +  M  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                        2           3                 3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Acute, Focal           |                1                                                         |             
      Inflammation, Chronic, Focal         |                                              1              1            |             
      Inflammation, Chronic                |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |       1                       1                             3     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Abscess                              |          4        4                                                      |             
      Congestion                           |                                                                          |             
      Cyst                                 |    X  X                       X  X  X              X        X     X      |             
      Follicle, Hemorrhage                 |                                                                      3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic     | 2  3  3              3        3  2     4  2  3  3  4        4  3     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia, Neutrophil              |          4                                   2                          3|             
      Myelofibrosis                        | 2     3        2              2  3  2  2  3     3  2        2  2  1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Lumbar, Congestion                   |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                   4                                                      |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |          4           4                                                   |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |          4        4                                                      |             
      Renal, Necrosis                      |                                                                          |             
      Renal, Lymphatic, Angiectasis        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M     M  A  +     +  M  M  +  +  M  +  +  +        +  M  M  M  +|             
      Congestion                           |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                        2     2  2                       3|             
      Inflammation, Acute                  |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |          4                                                               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  2  4        4  3        4  2  3  2  2  4  1  2              3  2  4|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2              3  4                          3  3         |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  A  +     M  +  M  M  +  +  M  +  +        +  +  M  I  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     +  M  +     +  M  M  M  M  M  +  M  M        M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M     +  M  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Sternum, Necrosis                    |                                                                          |             
      Tarsal, Hyperostosis                 |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|             
                                           | 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |          3                                                               |             
      Hydrocephalus                        |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Mineralization, Focal                | 2  2  2        1     2           1  2     2  1                 2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Giant Cell                           |       2                                                                  |             
      Granuloma                            |                                              2     1                     |             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Perivascular, Inflammation, Chronic  |    3  2                       2  2  2  1  2     2                 2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        M  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 | 2                                2           2     4           2     2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2  1        2              2  2  2  2  2  2  2  2           2     2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  A  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Glomerulosclerosis                   |          4           4     4                                             |             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Infiltration Cellular, Plasma Cell   |                            3                                             |             
      Inflammation, Chronic, Focal         |    3  2        1              3     2           1                 2      |             
      Cortex, Necrosis, Focal              |                                                                          |             
      Interstitial Tissue, Inflammation    |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic, Focal         |    3  2  3        2        2     3  2     2  2  3              2  3  1   |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +     +  M  +     +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  M  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  M  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +     M  +  +  +  +  A  +  +  +  M  A  +  +  +  A  +|             
      Parasite Metazoan                    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +     +  +  +  M  +  A  +  +  +  A  +  +  M  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  M  A  A  +  +  +  A  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +     +  +  M  +  +  A  +  +  +  A  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                            4                                            3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Perivascular, Inflammation, Chronic  | 2     1        2  1                                1           1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +        +                                             |             
      Hemorrhage                           |                3                                                         |             
      Inflammation, Acute                  |                            4                                             |             
      Fat, Necrosis                        |                   3        4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic, Focal         | 2     2                    3  2                    2     2     2        2|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 2     2        3     3        2  3  3  2     2  1  2     2  3     2     3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperkeratosis                       |                2           3                                             |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +  A  +  +  +  +  A  +  +  +  M  +|             
      Inflammation, Chronic                |                1     1        1     2  1                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Inflammation, Acute                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |          3                                                              2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                    2              1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +     M  +  +     M  +  M  M  +  M  M  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  M  +  +  +  M  +  I  +|             
      Pars Distalis, Hyperplasia, Focal    |                                              4  3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |                                              1     1                     |             
      Inflammation, Chronic                |       1                          1                                       |             
      Follicular Cell, Hyperplasia, Focal  |    2  1                          1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       4  4     4  4  4  4|             
      Congestion                           |                                              2                           |             
      Cyst                                 |    X     X     X  X  X        X  X  X  X  X  X              X            |             
      Follicle, Hemorrhage                 |       2                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                            4                 2        4     2            |             
      Endometrium, Hyperplasia, Cystic     | 3  3  2        3     2           1  2  3     1  2  2        2  2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia, Neutrophil              |                            4                 3        2  2        1     3|             
      Myelofibrosis                        | 3  2  2        2  2  2        2        2        1              1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Congestion                   |                                                       4           4      |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                         4|             
      Lumbar, Inflammation, Acute          |                                                       3                  |             
      Mediastinal, Congestion              |                                                       3                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                            4                          3                 4|             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                   4      |             
      Renal, Congestion                    |                                                       4           4      |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                         4|             
      Renal, Necrosis                      |                                                       3                  |             
      Renal, Lymphatic, Angiectasis        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +     +  M  M     +  M  M  M  M  +  M  +  +  M  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Infiltration Cellular, Plasma Cell   |                2                                                         |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +     M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   4      |             
      Hemorrhage                           |                                        3                                 |             
      Infiltration Cellular, Plasma Cell   |                                                                         4|             
      Infiltration Cellular, Histiocyte    |                                                          3               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2        3           4  2  3     2     2  2  2  4  3     4  3  4  4|             
      Hemorrhage                           |          4                                                               |             
      Hyperplasia, Lymphoid                |                                     3  2        3                        |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +     +  M  +     M  M  M  +  +  +  +  +  M  M  +  +  M  +  M  +|             
      Infiltration Cellular, Plasma Cell   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +     M  +  +     +  +  M  M  M  +  M  M  M  M  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Necrosis                    |                            2                                             |             
      Tarsal, Hyperostosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|             
                                           | 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization, Focal                | 2  2     1     2     2     2        1  2     2     2     2        2  1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Giant Cell                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
      Inflammation, Acute, Focal           |                                                                2         |             
      Perivascular, Inflammation, Chronic  | 2  2  2        2  1  1        2  2  1  2        1  2     2  2           2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
      Metaplasia, Squamous                 | 2  3  3  2           2                       3                           |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2           2  2  2        2  2  2        2     2  2     2  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                      2                                                   |             
      Glomerulosclerosis                   |                                                          3               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Inflammation, Chronic, Focal         | 2     2        2  1  2        2  2  2  1           1        1     2     2|             
      Cortex, Necrosis, Focal              |                                                       3           1      |             
      Interstitial Tissue, Inflammation    |                                                                3         |             
      Papilla, Necrosis                    |                                                                      4   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +|             
      Inflammation, Chronic, Focal         |    2  1        3  1  3        2     3        3  2        2  1  2  2      |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +                                                   |  39        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +  +                                                   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +                                                   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +                                                   |  44        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +                                                   |  46        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +                                                   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +                                                   |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +                                                   |  43        |
      Amyloid Deposition                   |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        M  M  +                                                   |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +                                                   |  50        |
      Fatty Change                         |                   1                                                      |      4  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mixed Cell Focus                     |       2                                                                  |      1  2.0|
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Artery, Mineralization               |                                                                          |      1  4.0|
      Perivascular, Inflammation, Chronic  |    3                                                                     |      9  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +                                                   |  48        |
      Inflammation, Chronic, Focal         | 2     2                                                                  |     17  2.1|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +                                                   |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 3     2           2                                                      |     32  2.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +                                                   |  49        |
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Hyperplasia, Squamous                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +                                                   |  47        |
      Inflammation, Chronic                | 2                                                                        |      9  1.6|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +                                                   |  50        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +                                                   |  49        |
      Capsule, Hyperplasia                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +                                                   |  49        |
      Atrophy                              |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +                                                   |  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +                                                   |  47        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  M                                                   |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +        +  +  +                                                   |  43        |
      Pars Distalis, Hyperplasia, Focal    |                4                                                         |      6  3.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +                                                   |  50        |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                      2                                                   |      5  1.2|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Follicular Cell, Hyperplasia, Focal  |                      4                                                   |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +                                                   |  49        |
      Abscess                              |                                                                          |      8  4.0|
      Congestion                           |                      1                                                   |      2  1.5|
      Cyst                                 |                                                                          |     20     |
      Follicle, Hemorrhage                 |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +                                                   |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Dilatation                           |                      3                                                   |      1  3.0|
      Inflammation, Acute                  |                                                                          |      5  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  3           2  2                                                   |     33  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +                                                   |  49        |
      Hyperplasia, Neutrophil              | 3                                                                        |     10  2.7|
      Myelofibrosis                        |    3           3  3                                                      |     27  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +                                                   |  47        |
      Lumbar, Congestion                   |                                                                          |      2  4.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      2  4.0|
      Lumbar, Inflammation, Acute          |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      5  3.8|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Renal, Congestion                    |                                                                          |      2  4.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      3  4.0|
      Renal, Necrosis                      |                                                                          |      1  3.0|
      Renal, Lymphatic, Angiectasis        | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M        +  M  +                                                   |  26        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   | 4                                                                        |      6  2.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +                                                   |  45        |
      Congestion                           |                2                                                         |      2  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  4.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +                                                   |  50        |
      Hematopoietic Cell Proliferation     | 3  1  2        2                                                         |     37  2.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      8  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M        +  M  +                                                   |  30        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M        +  +  +                                                   |  20        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +                                                   |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  M  +                                                   |  49        |
      Sternum, Necrosis                    |                                                                          |      1  2.0|
      Tarsal, Hyperostosis                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +                                                   |  50        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Hydrocephalus                        |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mineralization, Focal                |    2  2        2  2  2                                                   |     31  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +                                                   |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Giant Cell                           |                                                                          |      1  2.0|
      Granuloma                            |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  | 2  3                                                                     |     27  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +        +  M  +                                                   |  44        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |    2           3                                                         |     15  2.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    2  2        2                                                         |     30  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 6| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5|                                            |            |
                                           | 2| 2| 2| 8| 7| 2| 1| 9| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +                                                   |  49        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                      4                                                   |      5  3.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 3                 2                                                      |     22  1.9|
      Cortex, Necrosis, Focal              |                                                                          |      2  2.0|
      Interstitial Tissue, Inflammation    |                                                                          |      1  3.0|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  M  +                                                   |  46        |
      Inflammation, Chronic, Focal         | 3  2  2        1                                                         |     30  2.2|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +     M  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  M      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        M  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Cytoplasmic Alteration, Focal        |                                                                3         |             
      Fatty Change                         |             3                                                            |             
      Hematopoietic Cell Proliferation     |                                     2  4           2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis, Focal                      |                      1                                                   |             
      Centrilobular, Necrosis              |             4                                                            |             
      Periductular, Fibrosis               | 1                                                                        |             
      Perivascular, Inflammation, Chronic  | 2                          2     1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                          +      |             
      Inflammation, Acute                  |                                        3                          2      |             
      Fat, Necrosis                        |             3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic, Focal         |                2           2                                   1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Hypoplasia                           |                                                                          |             
      Inflammation, Chronic, Focal         |    2  2  2     2     2     2     3     2        2  2           3         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Cyst Epithelial Inclusion            |             X                                                            |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Acute                  |                                                                   1      |             
      Inflammation, Chronic                |                                        1                       2         |             
      Mineralization, Focal                |          1                                                               |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Abscess                              |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  +        +  +  +      |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  M     +  +  +  +  +     +  M  I        +  +  +      |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  M  +     +  M  M  M  +     M  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  +        +  +  +      |             
      Pars Distalis, Cyst                  |                                     X                                    |             
      Pars Distalis, Hyperplasia, Focal    |    2  4           2                          1              2            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |    2              3              2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | I  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Abscess                              |                                  4     4           4        4     4      |             
      Cyst                                 |       X        X  X                 X           X                        |             
      Inflammation, Acute                  |                               4                                          |             
      Inflammation, Chronic                |                                                    3                     |             
      Thrombosis                           |             4                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Abscess                              |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                      3           3                                       |             
      Thrombosis                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  4  3  3  2  1  3  3     4  2  2     2           2        2  1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        M  +  +      |             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Neutrophil              |                   2  2           4  3  2           4                     |             
      Myelofibrosis                        | 2  3  1  3     2  3           2                 2  2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Axillary, Hyperplasia, Lymphoid      |                                        2                                 |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Plasma Cell                      |                                        4                                 |             
      Lymphatic, Angiectasis               |                                                                          |             
      Mediastinal, Abscess                 |                                                                   4      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                        4                    4            |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                        4                    4            |             
      Renal, Lymphatic, Angiectasis        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +     M  +  M  M  +     +  M  +        M  +  +      |             
      Infiltration Cellular, Plasma Cell   |                2     4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Congestion                           |                                              4                           |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Hematopoietic Cell Proliferation     | 2  2     2  4        1     2  3  2  4  4     3  4  4        4     3      |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  +  +     +  +  +  M  M     +  M  M        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  +  +  +  M     +  +  M  M  +     M  M  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Congestion                           |                                                                          |             
      Hydrocephalus                        |                                                                2         |             
      Mineralization, Focal                |    2  1  1     1  2  2        2  2  2  1        2  2           2  2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Congestion                           |                                                                   2      |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Perivascular, Inflammation, Chronic  | 1  2     2                 2           2                    2  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|             
                                           | 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  M  +  +  +     M  +  +  M  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                |       2  2                                                     2         |             
      Metaplasia, Squamous                 |       3  3           2                                         3         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2           2  2  2        2  2           2                    2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +        +  +  +      |             
      Atrophy, Focal                       |                                                                          |             
      Glomerulosclerosis                   |                                        4           4        4  2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 1  2           1           2     2     3                    2  2         |             
      Mineralization                       |                                                                          |             
      Cortex, Necrosis, Focal              |             4                                                            |             
      Renal Tubule, Pigmentation           |             3                                                            |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +     +  +  +  +  M     +  +  +        +  +  +      |             
      Inflammation, Chronic, Focal         |       2        2     2        2  2           1  1  2        3  3  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +  +   |             
      Amyloid Deposition                   | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change                         |          2                                2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Necrosis, Focal                      |    1        1           1                          2                     |             
      Centrilobular, Necrosis              |                                                                          |             
      Periductular, Fibrosis               |                                                                          |             
      Perivascular, Inflammation, Chronic  |       1  2     2  3           1  2  1                       2     2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic, Focal         | 2              2  2     1              2  1                 2  2  2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hypoplasia                           |                                           2                              |             
      Inflammation, Chronic, Focal         |       2  2     2  2     2        2  2  2           2  2     3  2  2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2                          2                             2            |             
      Mineralization, Focal                |    2                                                                     |             
      Artery, Inflammation                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +   |             
      Congestion                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  M  +  +     +  +  +  +  +  +  M  +  M     +  +  +  +   |             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  M  +  M  +     +  M  M  M  +  +  M  M  +     +  +  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  M  +  M  M  +  +     +  +  +  +  +  M  +  M  +     +  +  +  +   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |             2                    4  3           3           3            |             
      Pars Distalis, Hyperplasia           |       2                       2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic, Focal         |                                        1                       2         |             
      Follicular Cell, Hyperplasia, Focal  |    2  2                          2              2  2        2  3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Abscess                              |                         4                                                |             
      Cyst                                 |    X  X        X                                X  X        X            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis                           |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Abscess                              |                                                                          |             
      Dilatation                           |                      4                                                   |             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Cyst                    |                                                                      X   |             
      Endometrium, Hyperplasia, Cystic     | 3  3     3  2  3  2           4  3  3        3  3  2  1     4  3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Neutrophil              |             2                                                     2  3   |             
      Myelofibrosis                        |       2     2  3  1              1  2        2  2  3        2  3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Lymphatic, Angiectasis               |                                                                          |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
      Renal, Lymphatic, Angiectasis        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  M     M  M  M  M  M  M  +  +  +     +  +  +  +   |             
      Infiltration Cellular, Plasma Cell   |    2              3                                               2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Congestion                           | 4              2                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                2     3                                      3            |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Hematopoietic Cell Proliferation     | 2  2        4  2        2     2  2  3              2        2  2     4   |             
      Hyperplasia, Lymphoid                | 3                 4  4                                      4            |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                           3                    2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  M  +  M  +     +  M  +  +  M  +  +  +  +     +  +  M  M   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  +  M  M  +  +     M  M  +  +  M  M  +  +  M     M  +  M  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +   |             
      Ulcer                                |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization, Focal                |          2        2           2  2        2  2  2  2        2  2     2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                            +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |                   2                                                      |             
      Infiltration Cellular, Histiocyte    |                3                                                         |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Perivascular, Inflammation, Chronic  |    2        1     2  2        2  2  2  2           2  3     3  2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|             
                                           | 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +     M  +  +  +   |             
      Inflammation, Chronic                |                                           3                              |             
      Metaplasia, Squamous                 |             2                                   2                 2  4   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2  2  2     2  2           2  2  2           2  2  2        2  2  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +              +                       +  +                       +      |             
      Inflammation, Chronic                |                                           3                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Atrophy, Focal                       |                                                                1         |             
      Glomerulosclerosis                   |             2           3                             3                  |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Inflammation, Chronic, Focal         | 1  1  2  1  2     2              2  2  2  2        2  2     3     2  2   |             
      Mineralization                       |                                              2                           |             
      Cortex, Necrosis, Focal              |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic, Focal         | 2  2  1  1  1  2  1  2  2     2     2     2  2  1  2  2     4  2  1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  A  A  A  M                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  M  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +     +  A  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  M                                             |  48        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  A  A  A  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Fatty Change                         |                1                                                         |      4  2.0|
      Hematopoietic Cell Proliferation     |       2        3                                                         |      5  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis, Focal                      |    2                                                                     |      6  1.3|
      Centrilobular, Necrosis              |                                                                          |      1  4.0|
      Periductular, Fibrosis               |                                                                          |      1  1.0|
      Perivascular, Inflammation, Chronic  | 2                                                                        |     13  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  M  M     +  +  +  +  +                                             |  47        |
      Inflammation, Chronic, Focal         | 2  2                                                                     |     14  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hypoplasia                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         | 2  2  2        2                                                         |     29  2.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +                                             |  49        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2                                                                        |      6  1.8|
      Mineralization, Focal                |                                                                          |      2  1.5|
      Artery, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +                                             |  46        |
      Congestion                           |                   3        3                                             |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +                                             |  45        |
      Congestion                           |                   3        3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  M  M     +  +  +  +  +                                             |  43        |
      Hyperplasia                          | 2                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M     +  M  +  +  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +     +  +  +  +  +                                             |  42        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |    2  3  2                                                               |     13  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Chronic, Focal         |                                                                          |      2  1.5|
      Follicular Cell, Hyperplasia, Focal  |          2                                                               |     11  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +                                             |  49        |
      Abscess                              |    4     3                                                               |      8  3.9|
      Cyst                                 |    X                                                                     |     12     |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Abscess                              |       3  3                                                               |      2  3.0|
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |    2                                                                     |      3  2.7|
      Thrombosis                           |       X                                                                  |      1     |
      Endometrium, Cyst                    |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     | 1  3  2  3     3                                                         |     35  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +                                             |  49        |
      Angiectasis                          |                   3                                                      |      1  3.0|
      Hyperplasia, Neutrophil              |    3  2  3     2                                                         |     13  2.6|
      Myelofibrosis                        |       2                                                                  |     21  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  M                                             |  49        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  4.0|
      Lymphatic, Angiectasis               |          4                                                               |      1  4.0|
      Mediastinal, Abscess                 |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  4.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                4                                                         |      3  4.0|
      Renal, Lymphatic, Angiectasis        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M     M  +  +  M  M                                             |  29        |
      Infiltration Cellular, Plasma Cell   |    2                                                                     |      7  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M     +  A  M  +  M                                             |  45        |
      Congestion                           |                                                                          |      3  3.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     | 2  3  2  3     3                                                         |     32  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      5  3.6|
      Inflammation, Acute                  |                4                                                         |      1  4.0|
      Pigmentation, Hemosiderin            | 2        2                                                               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M     +  M  +  M  M                                             |  30        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M     +  +  M  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  49        |
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 5| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0|                                            |            |
                                           | 1| 1| 1| 1| 7| 1| 9| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                   3  3                                                   |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization, Focal                |    1     2     1                                                         |     28  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |                   4  4  4  4                                             |      5  3.6|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          2                                                               |      2  2.5|
      Alveolar Epithelium, Metaplasia      |                2                                                         |      1  2.0|
      Perivascular, Inflammation, Chronic  | 3  2                                                                     |     22  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +                                             |  45        |
      Inflammation, Chronic                |                         2                                                |      5  2.2|
      Metaplasia, Squamous                 | 2  2                                                                     |     10  2.5|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2  2  2  2                                                               |     27  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   6        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
      Glomerulosclerosis                   |                3                                                         |      8  3.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 3  3     2                                                               |     26  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Cortex, Necrosis, Focal              |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  A  A  A  A                                             |  44        |
      Inflammation, Chronic, Focal         | 2     2  2     1                                                         |     35  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  M|             
      Degeneration, Hyaline                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                2         |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                      3   |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       3              4   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                    3                     |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |       1        1  1           1        1                                 |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                      2  1  1                 1                 2  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Fat, Necrosis                        |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 1                 1  2     2  3              2                    1      |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |    1           2  2  2  1  2  1        1     2     2        3  3         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
      Subcapsular, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                      X   |             
      Angiectasis                          |                                                       3                  |             
      Congestion                           |                                        2                                 |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  M|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +        +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Congestion                           |                                        1                                 |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    1                 4     2  4                 3        3              4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                         1|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                   2     2  2  1  2              2  2        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                        4              4                  |             
      Congestion                           |                                                                          |             
      Cyst                                 |                      X     X     X                       X              X|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |                                  4                                   4   |             
      Inflammation, Acute                  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  4  1        1     4     3  4  2           3  3  3  2  2     3        3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Neutrophil              |                                                       3                  |             
      Myelofibrosis                        | 2  2           2  1     2  2  2  2           3  2  2           2        3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Abscess                 |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        I  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                         2                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                 2           2  2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hematopoietic Cell Proliferation     | 2  2  2           2  2  2     2        3        2     4     2     2  3   |             
      Hyperplasia, Lymphoid                |                                              2  4              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M        +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
      Congestion                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +        M  +  M  +  M  M  M  +  +  M  M  +  +  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                | 2  2  1              2        1  1  2        2           1  1     2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                                 |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Perivascular, Inflammation, Chronic  | 2  2           1  2  2  2  2        2        2     2  2     2  2  2     1|             
      Pleura, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +        +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                         2  2                       2                     |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2  2                 2                       1  2        2  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +              +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Glomerulosclerosis                   | 3                       3           2                                3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 2  2  2        2  2  2  2                          2  2        2        2|             
      Cortex, Degeneration                 |                                                                          |             
      Cortex, Necrosis, Focal              |                                                                          |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         | 2     2        2  2  2  2  2                 2  2  2     2  2  2  2     3|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +  +  M        +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                       2                  |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  M  +        M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                  4                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                      2        1                                      2   |             
      Hematopoietic Cell Proliferation     |                                                                4         |             
      Hyperplasia, Lymphoid                | 3                                                                        |             
      Inflammation, Acute                  |                                                                         4|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Mixed Cell Focus                     |             2                                                            |             
      Necrosis, Focal                      |                                                 1  1              1      |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Perivascular, Inflammation, Chronic  |    2                                            1     2     2        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Inflammation, Chronic, Focal         | 2              2              2              2  2  2        2  1     2   |             
      Artery, Inflammation, Chronic        |                                                       4                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                   3                                    |             
      Inflammation, Chronic, Focal         |    2     2  2  1  2           3  2           2  1  1  3  2     3  1  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1                 1                       2                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization, Focal                |                      1                                                   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                      4   |             
      Subcapsular, Hyperplasia             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |          3                                                               |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                          1     1        1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  I  M  +  +  M  M     +  +  +        M  M  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +     M  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                             4            |             
      Pars Distalis, Hyperplasia, Focal    |       2  2                       3              4  3  4                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +        +  I  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         | 3     2                          1           3              2            |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 4  2  1     3  1  2  2  4        3           4     3  1        2  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          +               |             
      Dilatation                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Congestion                           |                                                                          |             
      Cyst                                 |       X     X                                      X     X  X            |             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Granulomatous          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                                   |             
      Dilatation                           |    3                             4                 4                     |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       3  4     3  3     3     2  2           3  3     4     4  2  3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                                                        |             
      Hyperplasia, Neutrophil              |                                                                         2|             
      Myelofibrosis                        | 2  1  3  2  2  2  3  2  3     2  3  2        1  3  1        3     1  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Abscess                 |                                                                         3|             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 3                                                                        |             
      Infiltration Cellular, Plasma Cell   |          2  2                                2        2     3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  M|             
      Amyloid Deposition                   |                                  3                                       |             
      Congestion                           |             3                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2  2     2  2  1  2     2  2  2              2  2  4  2  2  2  2  4|             
      Hyperplasia, Lymphoid                | 3                                            2  2              4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  M  M  M  +  +     +  M  +        +  M  +  +  M  +  M  M  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M     M  M  +        M  M  M  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  M  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |       1  2  1  2  2  2  2     2  2           1  2  2  1  2  2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      |             2                                                            |             
      Perivascular, Inflammation, Chronic  | 3  2  2  3     2  2  2  2     2  2  2        2     2        2  1     1   |             
      Pleura, Inflammation, Acute          |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  M  +  +  M  M     M  +  +        +  +  M  +  +  +  +  +  M  M|             
      Metaplasia, Squamous                 |                                     2           2                        |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2     2  2     2  2              2           1  2     2     2  2  3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Glomerulosclerosis                   |             3                                                  3        3|             
      Hyperplasia, Lymphoid                | 3                                                              3         |             
      Inflammation, Chronic, Focal         |    2  2  2        2     2     2  1           2  3  2  2              2   |             
      Cortex, Degeneration                 |                                                          4               |             
      Cortex, Necrosis, Focal              |       3                                                                  |             
      Renal Tubule, Regeneration           |                      1        2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic, Focal         | 3  2  2  1  2  2  2  2        1  2  3        3  2  2     2  2  2     2   |             
      Artery, Inflammation, Chronic        |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M        M  +                                                      |  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +                                                      |  46        |
      Degeneration, Hyaline                |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +                                                      |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +                                                      |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +        +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +        +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +                                                      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +                                                      |  48        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +                                                      |  49        |
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Fatty Change                         |                                                                          |      3  1.7|
      Hematopoietic Cell Proliferation     | 3     2                                                                  |      5  3.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis, Focal                      |                   1                                                      |      9  1.0|
      Hepatocyte, Hyperplasia, Focal       |    3                                                                     |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |     12  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +                                                      |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    1           2  2                                                      |     19  1.8|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +                                                      |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Chronic, Focal         |    2  2        2                                                         |     31  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +                                                      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +                                                      |  48        |
      Inflammation, Chronic                |                                                                          |      5  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
      Inflammation, Acute                  |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +                                                      |  50        |
      Mineralization, Focal                |                                                                          |      1  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +                                                      |  49        |
      Capsule, Hyperplasia                 |                                                                          |      1  4.0|
      Subcapsular, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +                                                      |  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +                                                      |  47        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +                                                      |  49        |
      Hyperplasia                          |                                                                          |      6  1.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M        M  M                                                      |  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +                                                      |  45        |
      Congestion                           |                                                                          |      1  1.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     13  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +        +                                             |  50        |
      Inflammation, Chronic, Focal         |    2  1        2  1        1                                             |     11  1.7|
      Follicular Cell, Cyst                | X                                                                        |      1     |
      Follicular Cell, Hyperplasia, Focal  |    4           4  4                                                      |     25  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +                                                      |  50        |
      Abscess                              |                                                                          |      3  4.0|
      Congestion                           |       1                                                                  |      1  1.0|
      Cyst                                 |                                                                          |     10     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  M                                                      |  49        |
      Angiectasis                          |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      5  3.8|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Thrombosis                           |    2                                                                     |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2              3                                                         |     31  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +                                                      |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Neutrophil              |                                                                          |      2  2.5|
      Myelofibrosis                        | 2  3           2  2                                                      |     35  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +                                                      |  49        |
      Mediastinal, Abscess                 |                                                                          |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +  +                                                      |  44        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                   3                                                      |      9  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +                                                      |  43        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Congestion                           |                   4                                                      |      2  3.5|
      Hyperplasia, Lymphoid                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +                                                      |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  3  2        2  2                                                      |     36  2.2|
      Hyperplasia, Lymphoid                |                   3                                                      |      8  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  M                                                      |  34        |
      Congestion                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +        M  M                                                      |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 4| 7| 7| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5|                                            |            |
                                           | 2| 1| 3| 8| 8| 1| 1| 8| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +                                                      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +                                                      |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +                                                      |  50        |
      Mineralization, Focal                |                1  2                                                      |     31  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +                                                      |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |    2                                                                     |     32  1.9|
      Pleura, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  M                                                      |  38        |
      Metaplasia, Squamous                 |    2                                                                     |      6  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    2  2        2                                                         |     22  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        M  +                                                      |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +                                                      |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                3                                                         |      8  2.9|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Chronic, Focal         |    2  3           1                                                      |     26  2.0|
      Cortex, Degeneration                 |                                                                          |      1  4.0|
      Cortex, Necrosis, Focal              |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +                                                      |  46        |
      Inflammation, Chronic, Focal         |    2           2  2                                                      |     36  2.1|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  M|             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Abscess, Multiple                    |                                        4                                 |             
      Fatty Change                         |                   3                                                      |             
      Hematopoietic Cell Proliferation     |                                        4                                 |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Mineralization, Focal                |                                                                          |             
      Necrosis, Focal                      |       1                                                                  |             
      Hepatocyte, Hyperplasia, Focal       |                                                                2         |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         | 1                                                        2               |             
      Acinus, Atrophy                      |                   1                                                      |             
      Acinus, Hyperplasia                  |                                                                          |             
      Periductular, Inflammation, Acute    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        4                                 |             
      Inflammation, Chronic, Focal         |    2  2  2  1  2  2  2  2  1  2  2  1        3  2  2  2  2  1  2  2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperkeratosis                       |                                                                   3      |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                        2                                 |             
      Inflammation, Chronic                |                1                                1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        | 2     2                                               2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  2                    1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     4                                               4           4      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  +  +  +  +  +  +  +  +  M     M  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |       1        1                                                         |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                          3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                 +              M     +  +     +  +        +     +|             
      Abscess                              |                                                          4               |             
      Ectasia                              |       4                                                           3     3|             
      Inflammation, Chronic                |       3                 2                    3  2     4           3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1                                                  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                          2                                 |             
      Dilatation                           |       3                    3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hypospermia, Focal                   |                                                                          |             
      Seminiferous Tubule, Atrophy         |    1        1  1                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Hypochromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                        4                 2           3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                          4               |             
      Lumbar, Hyperplasia, Lymphoid        |                                        3        4                        |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |       3                                                                  |             
      Renal, Hyperplasia, Lymphoid         |                                        3                          2      |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Infiltration Cellular, Plasma Cell   |             3     2     3     3  2              2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +     +  +  +  +  M  +  +  +  +  +|             
      Congestion                           | 3  3              2                                   3                  |             
      Hematopoietic Cell Proliferation     |                                                                      4   |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Infiltration Cellular, Histiocyte    |                                                                   3      |             
      Inflammation, Acute                  |                                        4                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 2        3                 4        3  4           3  2  2        4  4   |             
      Hyperplasia, Lymphoid                |    4              2                    2                                 |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  +  M  M  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +     M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Ulcer                                |          4           2                                            2      |             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Epidermis, Inflammation, Acute       |                                                                          |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                      3   |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Tarsal, Hyperostosis                 | 4  4  4  4  4  3  4  4  3  4  3     4        3  3  4  4  3     4  4     3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |       2  2  2  2  2  2     2                             2  2     2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Perivascular, Inflammation, Chronic  |       2  2  2  2     2           2     2           2  2  2               |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |          2     2        2  3  2     1        2  3     2  1               |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    3     3  2  2  2     2  2  2  2                    2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                       +  +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    1                     |             
      Glomerulosclerosis                   |                                                                   2  3   |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         | 2  1  2  2     2  1     1     1     2                       2  1     2   |             
      Mineralization                       |       1                                                                  |             
      Capsule, Fibrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Regeneration           | 1  1  1  3        1  1        1  1  1                 1     1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  A|             
      Calculus Gross Observation           |                                                                          |             
      Concretion                           |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|             
                                           | 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |          2     3  1  1  1     1  1     2     2  2  1     1  1  2     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  M     +  +     M     +  +  +  +     +  M         |             
      Inflammation, Chronic, Focal         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +     A     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Abscess                              |                                                                          |             
      Abscess, Multiple                    |                                                                          |             
      Fatty Change                         |                                                                1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Mineralization, Focal                |                                  2                                       |             
      Necrosis, Focal                      |             2  3                                                         |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                             1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                          +            |             
      Fat, Necrosis                        |                                  4                          4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  M     M     +  +  +  +     +  +         |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Acinus, Atrophy                      |                               2                       1                  |             
      Acinus, Hyperplasia                  |                                                                          |             
      Periductular, Inflammation, Acute    |                         3                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Inflammation, Chronic, Focal         | 1        2     2  1  2  2     1              2  3  2  2     2  3         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Cyst                                 |          X                                                               |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       1  1        1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Abscess                              |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Cytoplasmic Alteration, Focal        |                   2                                            2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia                          |       2                       1  3                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  M     M     +  +  +  +     +  +         |             
      Hyperplasia                          |                2  3     2                       2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  M     +  +     M     +  +  +  +     M  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  I     +  +         |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Inflammation, Chronic, Focal         |                1  1                          1                           |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Abscess                              |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
      Inflammation, Acute                  |                                        4                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +  +  +              +        +     +     +                     |             
      Abscess                              |          4                    3              4                           |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                | 4           3  3                       2           2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                        4                                 |             
      Inflammation, Chronic                |                2                 1           1  2              1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Atrophy                              |                         1                                                |             
      Dilatation                           |                                  2     3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hypospermia, Focal                   |                         3                                                |             
      Seminiferous Tubule, Atrophy         |                               2                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Hypochromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Neutrophil              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   | 2           2     2           2  2           2  2  1  2     3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +     M     +  +  +  +     +  +         |             
      Congestion                           |    2  2  2        3     4                    2        4     4  2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 3           4           4     2  2     3     4     2                     |             
      Hyperplasia, Lymphoid                |    3                                            2                        |             
      Inflammation, Acute                  |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  M  +  M  M  M  +     M  +     M     M  M  +  +     M  M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M     M  M     M     M  M  M  M     M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     M  +         |             
      Fibrosis                             |                                                                          |             
      Ulcer                                |                               3                       2                  |             
      Dermis, Inflammation, Chronic        | 3                                2                                       |             
      Epidermis, Inflammation, Acute       |                                  3                                       |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Hyperostosis                         |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |             X                                                            |             
      Tarsal, Hyperostosis                 | 3  4  4  4  X  4  4     4     4  4     4     4  3  3  4     4  4         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Mineralization, Focal                |    2  1  2     2     2                 2        2  2                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                4                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Perivascular, Inflammation, Chronic  | 2  2  2        3  2                    2     2  2  2  2        2         |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Inflammation, Chronic                |             3                                                            |             
      Metaplasia, Squamous                 | 2           4     2                          2        3                  |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2     2     2  3           2              2     2  2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Congestion                           |                         2                                                |             
      Glomerulosclerosis                   |                         3        3                                       |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Inflammation, Acute, Focal           |                                        4                                 |             
      Inflammation, Chronic, Focal         | 1        1  2  3  2  2        2              2  2  2  1     1  1         |             
      Mineralization                       |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Regeneration           |    1  2  1  1        1  2     1                 1  1           1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +     +     +  +  +  +     +  +         |             
      Calculus Gross Observation           |                                                                          |             
      Concretion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|             
                                           | 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |    3        2     2           1                 1  1           2         |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Artery, Inflammation, Chronic        |                                                             3            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  M  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  +  +                                                   |  41        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +                                                   |  49        |
      Hyperplasia, Lymphoid                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +                                                   |  48        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +                                                   |  49        |
      Artery, Inflammation, Chronic        |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  M  +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +                                                   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +                                                   |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  M  +  M  +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Abscess                              |                   3                                                      |      1  3.0|
      Abscess, Multiple                    |                                                                          |      1  4.0|
      Fatty Change                         |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mineralization, Focal                |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |          1                                                               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
      Fat, Necrosis                        |                      3                                                   |      4  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +                                                   |  47        |
      Inflammation, Chronic, Focal         |       2           2                                                      |      4  1.8|
      Acinus, Atrophy                      |                                                                          |      3  1.3|
      Acinus, Hyperplasia                  |          3                                                               |      1  3.0|
      Periductular, Inflammation, Acute    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +                                                   |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Chronic, Focal         | 2              2  2  1                                                   |     38  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +                                                   |  49        |
      Cyst                                 |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +                                                   |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1     1                                                                  |      7  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   2        |
      Abscess                              |                   3                                                      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +                                                   |  50        |
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  M  +                                                   |  47        |
      Hyperplasia                          |       2        4                                                         |      8  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +                                                   |  47        |
      Hyperplasia                          |       2        2  2                                                      |     11  2.6|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  M  M                                                   |  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +                                                   |  48        |
      Pars Distalis, Cyst                  |       2        X                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +  +  +                                                   |  49        |
      Inflammation, Chronic, Focal         |                                                                          |      5  1.0|
      C-Cell, Hyperplasia                  |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |                                                                          |      4  3.8|
      Ectasia                              |       3                                                                  |      4  3.3|
      Inflammation, Chronic                |                                                                          |     11  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +                                                   |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Acute                  |             3                                                            |      2  3.5|
      Inflammation, Chronic                | 2        2                                                               |      9  1.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +                                                   |  49        |
      Atrophy                              |                                                                          |      3  1.3|
      Dilatation                           |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +                                                   |  50        |
      Hypospermia, Focal                   |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                                                                     |   1        |
      Hypochromasia                        |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +                                                   |  50        |
      Hyperplasia, Neutrophil              |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +                                                   |  49        |
      Inguinal, Hyperplasia, Lymphoid      |                4                                                         |      1  4.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      2  3.5|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +                                                   |  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                4  2  3                                                   |     19  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  M  +  M  +                                                   |  43        |
      Congestion                           |                4                                                         |     14  2.9|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +                                                   |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |          4                                                               |      1  4.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |     19  3.0|
      Hyperplasia, Lymphoid                |                4                                                         |      6  2.8|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  M  M  M  M  M                                                   |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +                                                   |  48        |
      Fibrosis                             |          3                                                               |      1  3.0|
      Ulcer                                |                4                                                         |      6  2.8|
      Dermis, Inflammation, Chronic        |                                                                          |      2  2.5|
      Epidermis, Inflammation, Acute       |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +                                                   |  50        |
      Hyperostosis                         |                                                                          |      1  3.0|
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1     |
      Tarsal, Hyperostosis                 | 4  3  4  4     4  3  3                                                   |     44  3.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +                                                   |  50        |
      Mineralization, Focal                |       2                                                                  |     19  1.9|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |  50        |
      Congestion                           |          2                                                               |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                   2                                                      |     22  2.0|
      Pleura, Inflammation, Chronic        |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +                                                   |  47        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                   3  3                                                   |     17  2.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |       2        2  2                                                      |     21  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 1| 7| 7| 7| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5|                                            |            |
                                           | 7| 8| 1| 9| 6| 7| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +                                                   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  50        |
      Congestion                           |                                                                          |      2  1.5|
      Glomerulosclerosis                   |          4     3  3                                                      |      7  3.0|
      Hydronephrosis                       |             3                                                            |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         | 1                                                                        |     26  1.6|
      Mineralization                       |                                                                          |      1  1.0|
      Capsule, Fibrosis                    |       2                                                                  |      1  2.0|
      Pelvis, Inflammation, Acute          |             3                                                            |      1  3.0|
      Renal Tubule, Regeneration           | 1     1  4        1                                                      |     25  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +                                                   |  47        |
      Calculus Gross Observation           |          X                                                               |      1     |
      Concretion                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                      2                                                   |     23  1.6|
      Inflammation, Chronic Active         |          3                                                               |      2  3.5|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  +  A           +  +     A  M  +  +  M  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  A           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  A           +  +     M  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  A           M  +     A  +  +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  A           +  +     A  A  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change                         |                   1                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Focal                      |                                  4                                       |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
      Inflammation, Chronic, Focal         |                                                 2           2  1     1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
      Inflammation, Chronic, Focal         | 1  2  2  2     1  2  2  2  1  3  2           1  2           3  2  2      |             
      Karyomegaly                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Acanthosis                           |    4                                                                     |             
      Cyst Epithelial Inclusion            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +           +  +     M  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Mineralization                       |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Cytoplasmic Alteration, Focal        |    2                                         2                 2  2      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  M  +  +   |             
      Hyperplasia                          |                   2        1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +     +  +  +  +  +  +  M           +  +     +  +  M  M  M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  M  +  M     +  +  +  +  +  +  +           M  +     M  +  M  +  +  +   |             
      Pars Distalis, Cyst                  |                            X                                             |             
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Follicular Cell, Hyperplasia, Focal  |    1                                            2              1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Spermatocele                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +        +        +  +  +                 +           +  +  +      |             
      Abscess                              |                4                                4                        |             
      Ectasia                              | 4                                                                        |             
      Inflammation, Chronic                | 2     4                 3  4  3                             2  2  2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
      Inflammation, Chronic                | 2                 2           2                             2     2      |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +           +  +     +  M  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Mineralization                       |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                             2            |             
      Seminiferous Tubule, Atrophy         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                         2  3                             4               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +     +  +  +  +  +  +  M           +  +     +  M  +  +  +  +   |             
      Inguinal, Congestion                 |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                              4                           |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +     M  M  M  M  M  +  M           +  M     +  M  M  M  M  M   |             
      Infiltration Cellular, Plasma Cell   |    2  2                       3              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +     +  +  +  +  +  +  M           +  +     +  M  +  +  +  +   |             
      Congestion                           |    4  2        2           2  2                 1                        |             
      Hematopoietic Cell Proliferation     |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |    3     2              1  4                 2        3  4               |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M     M  +  M  +  M  M  M           +  +     +  M  +  +  M  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  +  M  M           M  M     M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Tarsal, Hyperostosis                 | 4  4  4  4     4        4  4  4              4  4           4  4     4   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Hemorrhage, Focal                    |                                  1                                       |             
      Mineralization, Focal                | 2     2  2     2     1     2                 2  2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
      Congestion                           |                                  2                       4               |             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|             
                                           | 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    4                          4                                      4   |             
      Bronchiole, Epithelium, Hyperplasia  |                         4                                                |             
      Bronchus, Foreign Body               |                                  3                                       |             
      Perivascular, Inflammation, Chronic  | 1     2        2  1     2        2           2              2  1         |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +     +  +  M  +  +  M  +           +  +     +  +  +  +  +  M   |             
      Inflammation, Chronic                |                   3                                      2               |             
      Metaplasia, Squamous                 |          3     2                             2                    2      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2  2  2     2  2     2  2                 2  2           2  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +           +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Degeneration                 |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +           +  +     A  +  +  +  +  +   |             
      Abscess                              |                                                          4               |             
      Congestion                           |                         1                                      1         |             
      Fibrosis, Focal                      |                      2                                                   |             
      Glomerulosclerosis                   |                                  3                                       |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |                      1        1  1                          2            |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                                                                   1      |             
      Papilla, Necrosis                    |                                                          4               |             
      Renal Tubule, Casts                  |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Regeneration           |    1                 1        1  1           1  1                 1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  A           +  +     A  +  +  +  +  +   |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           |                            3                                             |             
      Inflammation, Chronic, Focal         |    2           1  3  1                       2  2        2  2  1  1      |             
      Inflammation, Subacute               |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Amyloid Deposition                   |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Hyperplasia, Lymphoid                |                               4                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Basophilic Focus                     |                         X                                                |             
      Cytoplasmic Alteration, Focal        | 2                             4                             4            |             
      Fatty Change                         |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Necrosis, Focal                      |                                                       1                  |             
      Hepatocyte, Hyperplasia, Focal       |    3                                                                     |             
      Perivascular, Inflammation, Chronic  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +                              |             
      Hemorrhage                           |                                  2                                       |             
      Fat, Necrosis                        |                                           4                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic, Focal         |                            2           2  3        2           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic, Focal         | 2  2  1        2     2           2  2  3  1     2  2  2        3  2      |             
      Karyomegaly                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +      |             
      Inflammation, Acute                  |                                     2                                    |             
      Inflammation, Chronic                |                                  1                          2            |             
      Mineralization, Focal                |                                        2                                 |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy                       |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
      Cytoplasmic Alteration, Focal        |    2  2                       2                 2  2                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                   1                 2  2              1        2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Follicular Cell, Hyperplasia, Focal  |                1                          2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |       2        1                                                         |             
      Spermatocele                         |       X                                                                  |             
      Duct, Dilatation                     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
      Abscess                              |             4                                                            |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +     +        +        +                 +  +           +      |             
      Abscess                              |    4     4              3        4                    4                  |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                4                                                  2      |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |             
      Inflammation, Chronic                |          1                                2  2        2                  |             
      Inflammation, Subacute               |                            4                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mineralization                       |       3        2        2                             2                  |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       1        2              3                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                                     2                    3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inguinal, Congestion                 |             3                                                            |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                       3                  |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                            4                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                               4                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  M  M  M  +  M  M  M  M      |             
      Infiltration Cellular, Plasma Cell   |       1  2     2     2  2           4  2  2           3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |          3              3        2        2        3        3  4         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hematopoietic Cell Proliferation     |             3              3        3                 4  3               |             
      Hyperplasia, Lymphoid                |                               4                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  M  M  +  +  M  M  +  +  M  M  M  M  +  M  M  M  M  +  +      |             
      Hyperplasia, Lymphoid                |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic, Focal         |                            3                                             |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Tarsal, Hyperostosis                 | 4  4     4     4  4  4  4     4  4  4     4  4     4  4        4  4      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemorrhage, Focal                    |                                                                          |             
      Mineralization, Focal                | 2  2  2                 2     2        2     2     2  2        2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                                          4               |             
      Granuloma                            |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|             
                                           | 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 4                                                                        |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Bronchus, Foreign Body               |                                                                          |             
      Perivascular, Inflammation, Chronic  | 3     2        2     2  1        2  3  2        1  2        2  2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +      |             
      Inflammation, Chronic                |                   3                    2  3     2              3         |             
      Metaplasia, Squamous                 |                3  3        3     2     3  3  2  4  3  2        3  3      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2  2        2  2  2        2                 2  2        2  2  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +           +  +                                 |             
      Cornea, Degeneration                 |                                     3                                    |             
      Cornea, Inflammation, Acute          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +           +  +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Abscess                              |                                                                          |             
      Congestion                           | 1                                                                        |             
      Fibrosis, Focal                      |                                                                2         |             
      Glomerulosclerosis                   |                                                                          |             
      Inflammation, Acute, Focal           |                                                          2               |             
      Inflammation, Chronic, Focal         |          2     2              2  2  3  2     2  2                 2      |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                            2                                             |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts                  |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                               3                                          |             
      Renal Tubule, Regeneration           |                         1                    1     1        1  1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Calculus Gross Observation           |                                                          X               |             
      Calculus Micro Observation Only      |                                                          X               |             
      Concretion                           |                                                                          |             
      Inflammation, Chronic, Focal         |       2        1  2  2           2  2  2     1     1        1  1  2      |             
      Inflammation, Subacute               |                                                          3               |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  M  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +     +  +  +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     M     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  A                                             |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +  +                                             |  45        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  A                                             |  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |    4                                                                     |      4  3.5|
      Fatty Change                         |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis, Focal                      | 1                                                                        |      3  2.0|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +  +                                             |  49        |
      Inflammation, Chronic, Focal         |                2                                                         |     10  1.9|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +  +                                             |  49        |
      Inflammation, Chronic, Focal         | 2  3           2  1  2  2                                                |     36  1.9|
      Karyomegaly                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +  +                                             |  49        |
      Acanthosis                           |                                                                          |      1  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +  +                                             |  47        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Mineralization, Focal                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     M     +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     M     +  +  +  +  +                                             |  48        |
      Cytoplasmic Alteration, Focal        |                   2                                                      |     10  2.0|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     M     +  +  +  +  +                                             |  48        |
      Hyperplasia                          |                   2                                                      |      7  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +  +                                             |  48        |
      Hyperplasia                          |                      1                                                   |      4  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     +     M  +  +  +  +                                             |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     I  +  +  +  M                                             |  39        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +  +                                             |  49        |
      Follicular Cell, Hyperplasia, Focal  |    2                                                                     |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +     +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                         2                                                |      3  1.7|
      Spermatocele                         |                                                                          |      1     |
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                            +                                             |   2        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Subacute               |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +              +  +     +                                             |  22        |
      Abscess                              |                      4                                                   |      8  3.9|
      Ectasia                              |    4                 3                                                   |      3  3.7|
      Inflammation, Chronic                |    2              1        2                                             |     13  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     M     +  M  +  +  +                                             |  42        |
      Inflammation, Chronic                |                            3                                             |     10  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +     +  +  +  +  +                                             |  50        |
      Mineralization                       |                                                                          |      4  2.3|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         | 2                                                                        |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +  M                                             |  49        |
      Hyperplasia, Neutrophil              |          3        2                                                      |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +  +  +                                             |  47        |
      Inguinal, Congestion                 |                                                                          |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  3.5|
      Lumbar, Hyperplasia, Lymphoid        |                2                                                         |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Renal, Congestion                    |                            4                                             |      1  4.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M     +     M  M  M  +  M                                             |  20        |
      Infiltration Cellular, Plasma Cell   | 2                       2                                                |     15  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +  +                                             |  45        |
      Congestion                           |    3           1  4  2     4                                             |     18  2.6|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    4                                                                     |      1  4.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |    3     4     3  2     3  4                                             |     18  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     M     M  M  M  M  M                                             |  18        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M     M     M  M  M  M  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +  +  +                                             |  49        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                   4     2                                                |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +  M                                             |  49        |
      Tarsal, Hyperostosis                 | 4  4     4        4  4  4                                                |     35  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +  +                                             |  50        |
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Mineralization, Focal                | 2  2     2     2  1                                                      |     23  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      3  3.3|
      Granuloma                            |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          2        2                                                      |      6  3.3|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  4.0|
      Bronchus, Foreign Body               |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  | 2  2           2                                                         |     24  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  M  +  +  M                                             |  40        |
      Inflammation, Chronic                |                                                                          |      7  2.6|
      Metaplasia, Squamous                 | 2  2           3        3                                                |     20  2.7|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                2     2  2                                                |     25  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cornea, Degeneration                 |                                                                          |      1  3.0|
      Cornea, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +                                             |  49        |
      Abscess                              |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      3  1.0|
      Fibrosis, Focal                      |                                                                          |      2  2.0|
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 4| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2|                                            |            |
                                           | 6| 6| 7| 1| 6| 6| 6| 6| 6| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         | 2              2  1  2  2                                                |     18  1.8|
      Inflammation, Subacute               |                            4                                             |      1  4.0|
      Mineralization                       |                            4                                             |      3  2.3|
      Papilla, Necrosis                    |                            4                                             |      2  4.0|
      Renal Tubule, Casts                  |                            4                                             |      1  4.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |    1              1     1                                                |     15  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +  +                                             |  46        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Concretion                           |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 2              2           3                                             |     25  1.7|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  M     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +     +  +  +  +     +  +  +        M  +  +  M     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                                              X                           |             
      Fatty Change                         |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Necrosis, Focal                      |                         3                                                |             
      Thrombosis                           |                                                                          |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic, Focal         |                2                                                         |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 2     3  1     2     2        2  1  2        2              2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Acanthosis                           |       3                                                                  |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Acute                  |       3                             2                                    |             
      Inflammation, Chronic                |                      1           2              1                        |             
      Mineralization                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Abscess                              |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |       2  2                                      3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  M  +     +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M     +  +  +  M     +  M  M        M  M  M  M     M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  I  +     +  M  +        +  +  M  +     I  M  +  M  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                   1      |             
      Follicle, Cyst                       |                                              X                           |             
      Follicular Cell, Hyperplasia, Focal  |       2  3                    2                 1  2           1  3  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +              +              +        +              +   |             
      Abscess                              |                                                       4                  |             
      Ectasia                              |       3        3                             4                           |             
      Inflammation, Chronic                |                               3              3                       1   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +     +  +  +  +     +  +  +        M  +  +  +     +  +  M  +  +|             
      Inflammation, Chronic                |                               2                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        M  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                2         |             
      Hypospermia, Focal                   |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
      Seminiferous Tubule, Atrophy         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  M  M  +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Plasma Cell                     |                                                       4                  |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                         4|             
      Renal, Congestion                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +     M  +  M  M     M  +  M        M  M  +  M     +  M  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   | 2        1        2              2                          2           3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  M  M  +|             
      Congestion                           | 2  2           4  1           2  3           2        2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 3              2  4     4                             2           2  2   |             
      Hyperplasia, Lymphoid                |       4                                                     4           3|             
      Infiltration Cellular, Plasma Cell   |                                                                         2|             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     M  +  M  I     +  +  +        M  +  +  M     +  M  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     +  M  M  M     M  M  M        M  M  M  M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
      Scrotal, Subcutaneous Tissue,        |                                                                          |             
          Thrombosis                       |                                                                          |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Tarsal, Fibrosis                     |                                                                         4|             
      Tarsal, Hyperostosis                 |    4  4  4     4  4     4     4  4           4  4  4  4     4  4  4  4  X|             
      Tarsal, Inflammation, Acute          |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Mineralization, Focal                | 2        2        2                 2        1     2              2  2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|             
                                           | 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                       4                  |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |       3                                                                  |             
      Perivascular, Inflammation, Chronic  |                2                                      2                 2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |    2                 2  2        2           2  2              2  2      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2  2  3     2  2  2  2                                   2  2  2  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +              +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                         2                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                      3   |             
      Inflammation, Chronic, Focal         |       2  1           1        2  2  2                             2     1|             
      Mineralization                       |                                                                      2   |             
      Necrosis, Focal                      |                         2                                                |             
      Renal Tubule, Atrophy, Focal         |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Dilatation             |                                                                      3   |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           | 1  2                                1                                   1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |                   2  2  1     2  2           2        2                 1|             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  M  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A     +  +  M        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  M  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Focal                      |                         3           4              4                     |             
      Thrombosis                           |                                                    X                     |             
      Hepatocyte, Hyperplasia, Focal       |                                              2              2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                            2                  |             
      Inflammation, Chronic, Focal         |                                                       2  2               |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                  3                                       |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          1               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         | 1  1  2  2     1     1  2     2  2           2  2           2  2  1  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                3                                                         |             
      Hyperkeratosis                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1                                                  1   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                     2        2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  M  +        +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |          1                                   3           2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |    2  2              2                                2     1           2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M     M  M  +  M     +  +  +        +  +  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  M  M     +  M  +        +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Congestion            |                                                       3                  |             
      Pars Distalis, Cyst                  |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                2                             1  1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
      Abscess                              |                                  4                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                             +                 +                  |             
      Abscess                              |       4                                               4                  |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      1                       2              2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Dilatation                           |                                                                         2|             
      Hemorrhage                           |                                                                         4|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hypospermia, Focal                   |                                                                          |             
      Capsule, Fibrosis                    |                                                                   3      |             
      Seminiferous Tubule, Atrophy         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                  2                                      2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                              4                           |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Congestion                    |                         4                                                |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M     +  M  +  M     +  M  M        M  M  M  M  M  M  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |       2        2     2        2                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       4                             4              4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  M  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2  2                                       |             
      Hematopoietic Cell Proliferation     | 4        2                          4              4  4              2  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  +  +  M     M  M  M        M  +  M  M  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M     M  M  M        M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Scrotal, Subcutaneous Tissue,        |                                                                          |             
          Thrombosis                       |                                                                         X|             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Fibrosis                     |                                                                          |             
      Tarsal, Hyperostosis                 | 4  4           4  4     4     4  4  4        4  4     4  X  4  4  4     4|             
      Tarsal, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |    2  2  2           2                          2  2     1  2  2     2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|             
                                           | 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                                          2               |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Perivascular, Inflammation, Chronic  |    2                 1                          2           2  2     2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  M  +  +  M  +  +|             
      Inflammation, Chronic                |                      2              3                       3  3         |             
      Metaplasia, Squamous                 | 2  2              4  3              3        3     2        3  3         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2     2  2     2        2     2  2  2        2  2  2  2     2  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              1           2               |             
      Cyst                                 |       X                                                                  |             
      Glomerulosclerosis                   |                                  4                                      4|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |    1  2  2     2     2        2                    2  2  2  1  1         |             
      Mineralization                       |                                                                         3|             
      Necrosis, Focal                      |                                                                          |             
      Renal Tubule, Atrophy, Focal         |                                                                          |             
      Renal Tubule, Degeneration           |                                                                   4      |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |                                                                         2|             
      Renal Tubule, Regeneration           |          1     1     1           2           1        2  1           3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +     +  +  +  A     +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |          2                    2  2              3           2           2|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Basophilic Focus                     |    X                                                                     |      2     |
      Fatty Change                         |                         2                                                |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis, Focal                      | 1                 1                                                      |      6  2.7|
      Thrombosis                           |                                                                          |      1     |
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |             2           1                                                |      5  1.8|
      Acinus, Atrophy                      | 4                                                                        |      1  4.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
      Duct, Ectasia                        | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Inflammation, Chronic, Focal         | 1  2  1     2  2     1                                                   |     35  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Acanthosis                           |                                                                          |      2  3.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  49        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      5  1.2|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Cytoplasmic Alteration, Focal        |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  48        |
      Hyperplasia                          |             1                                                            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |  48        |
      Hyperplasia                          | 1        2                                                               |      9  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +  +  +  +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +                                                |  39        |
      Pars Distalis, Congestion            |                         4                                                |      2  3.5|
      Pars Distalis, Cyst                  |    X                                                                     |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                      1                                                   |      1  1.0|
      Inflammation, Chronic, Focal         |             1                                                            |      2  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Focal  |                1                                                         |     12  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +     +                                                   |  12        |
      Abscess                              |          4     4     4                                                   |      6  4.0|
      Ectasia                              |                                                                          |      3  3.3|
      Inflammation, Chronic                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +                                                |  47        |
      Inflammation, Chronic                |       2                                                                  |      5  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +                                                |  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hypospermia, Focal                   |       1                                                                  |      1  1.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hyperplasia, Neutrophil              |          3        3  2  3                                                |      6  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +                                                |  47        |
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                   4                                                      |      2  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |          1                                                               |      1  1.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Renal, Congestion                    |                                                                          |      1  4.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  +  M  M  +  M  +                                                |  17        |
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |     11  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +                                                |  47        |
      Congestion                           |       2        2                                                         |     13  2.6|
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  49        |
      Congestion                           |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                      3  4                                                |     16  3.1|
      Hyperplasia, Lymphoid                |          1  2                                                            |      5  2.8|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  M  M  M                                                |  28        |
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Scrotal, Subcutaneous Tissue,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Thrombosis                       |                                                                          |      1     |
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Tarsal, Fibrosis                     |                                                                          |      1  4.0|
      Tarsal, Hyperostosis                 | 4  4  4  4     4  4  4  4                                                |     41  4.0|
      Tarsal, Inflammation, Acute          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Mineralization, Focal                |    2                                                                     |     19  1.9|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Hemorrhage, Focal                    |                         3                                                |      1  3.0|
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  2.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  +  +  +  M  +                                                |  46        |
      Inflammation, Chronic                |                         2                                                |      5  2.6|
      Metaplasia, Squamous                 | 2     2                                                                  |     19  2.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2     2     2  2                                                         |     30  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |             1                                                            |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 7| 1| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
      Glomerulosclerosis                   |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                |          3                                                               |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 2           2        2                                                   |     22  1.7|
      Mineralization                       |                                                                          |      2  2.5|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Renal Tubule, Atrophy, Focal         |    2                                                                     |      1  2.0|
      Renal Tubule, Degeneration           |                                                                          |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |    1     1     1                                                         |     16  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A                                                |  46        |
      Ectasia                              |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|
      Inflammation, Chronic, Focal         | 2     1     2        2                                                   |     18  1.9|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  M   |             
      Acanthosis                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  +           A  +  +  A  A  A  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  M  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  M  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +           A  +  +  M  +  +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +           +  +  +  M  A  +  +  A  +  +   |             
      Amyloid Deposition                   |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                                          |             
      Fatty Change                         |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |       1  1           1  2                                   2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Edema                                |                                                                          |             
      Inflammation, Chronic, Focal         | 1     1        2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Inflammation, Chronic, Focal         | 2  2  1  2     2     2  2     2              1  1  2              2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                        +            |             
      Abscess                              |    3                                                                     |             
      Inflammation, Acute                  |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation, Acute |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |          3                                                               |             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
      Accessory Adrenal Cortical Nodule    | 2                                                                        |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  I  +  +  M           +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |          2                                      2                 1      |             
      Inflammation, Acute                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                               1              2                       1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +     +  M  +  M  M  +           +  M  +  +  M  +  M  M  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Congestion            |                                           1                              |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic, Focal         | 1  2                                                                     |             
      Follicle, Inflammation, Acute, Focal |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 2                             3              1  1                    3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +           +  +                 M        +        +  +         |             
      Abscess                              |          4                                                  4            |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |       4              1  2                          4           2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  M  +  +  +   |             
      Inflammation, Chronic                |          3           2        1                       3                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                            2                                             |             
      Inflammation, Chronic                |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  +  +  +   |             
      Hyperplasia, Neutrophil              |          3              2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Axillary, Hyperplasia, Lymphoid      |                            2                                             |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |       4                       4                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                               4                                          |             
      Lumbar, Inflammation, Acute          |          4                                                               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |          2                                                               |             
      Pancreatic, Congestion               |          3                                                               |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +           M  +  +  +  M  +  +  +  +  +   |             
      Infiltration Cellular, Plasma Cell   | 2  3  3  2     2  3  1  3  4  2              4  2  2     2        3  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Congestion                           |       2  4     2  4  2        2                 3  4        2            |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  M  +  +  +  +  +   |             
      Depletion Lymphoid                   |                                           3                              |             
      Hematopoietic Cell Proliferation     |          3              4     2              4  2  2     4               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +     +  M  M  M  M  +           M  M  +  M  +  M  M  M  M  +   |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M     M  M  M  M  M  M           M  M  M  M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Alopecia                             |                                                                   3      |             
      Fibrosis                             |                                                                          |             
      Ulcer                                |                                                                   2      |             
      Dermis, Inflammation, Chronic        |                                           4                              |             
      Perivascular, Inflammation           |                                                                          |             
      Scrotal, Subcutaneous Tissue,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Lymphatic, Dilatation            |                                                 4                        |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                          |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Plasma Cell            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Tarsal, Hyperostosis                 | 4  4  4  4     4  4  4  3                 3     3  3  3     4     4  4   |             
      Tarsal, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Mineralization, Focal                |    2                       1  1                             2     2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Perivascular, Inflammation, Chronic  | 2  2  2        1     1        1                 2  2     1  2     2      |             
      Pleura, Inflammation, Chronic        |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  M  +           +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |                   2                                                  2   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2  2  2     2  2  2  2     1                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                           2                              |             
      Cyst                                 |          X                                                  2            |             
      Glomerulosclerosis                   | 3        3                                                               |             
      Inflammation, Acute, Focal           |                                                       4                  |             
      Inflammation, Chronic, Focal         | 3  3  2  4     2  2  3  2  2  1              2  2  1        4     2  1   |             
      Mineralization                       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|             
                             DAY ON TEST   | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|             
                                           | 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis, Focal                      |                                                          3               |             
      Nephropathy, Focal                   |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts                  |                                                                3         |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Regeneration           | 2  1              1  1        2              2  1           2        2   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +     +         |             
      Hemorrhage                           |                                                          3               |             
      Inflammation, Acute                  |                                                          3     4         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +           +  +  +  +  A  +  +  A  +  +   |             
      Concretion                           |                                                             2            |             
      Ectasia                              |                                                          4               |             
      Inflammation, Chronic, Focal         | 2  2  1  4     2     2  1     1                             4            |             
      Transitional Epithelium, Hyperplasia |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Acanthosis                           | 4                                                                        |             
      Cyst                                 | X                                                                        |             
      Hyperkeratosis                       | 4                                                                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     A  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     M  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Abscess                              |                                                 3                        |             
      Fatty Change                         |                                                                          |             
      Infarct                              |                         4                                                |             
      Necrosis, Focal                      |                                              2  4                        |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               M                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
      Edema                                |                                                    3                     |             
      Inflammation, Chronic, Focal         |    1                                                                    2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic, Focal         |    2  2           2  1        2     2        2        2        1  2     2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                |       2                                                        1         |             
      Mineralization                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Cardiomyopathy                       |                                                             2            |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Karyomegaly                          |                                                       3                  |             
      Atrium, Thrombosis                   |                                                 X                        |             
      Coronary Artery, Inflammation, Acute |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |    2  3                                                           2  2   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hyperplasia                          |                                     1                                    |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  M  M  M     +  +  M        +  +  M  M     M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +     +  +  M  +     +  +  +        M  +  +  +     +  +  +  M  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                   2      |             
      Follicle, Inflammation, Acute, Focal |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                      3              2                          3  3  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                                     +           +|             
      Abscess                              |                                                                         4|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     M  +  +  +  +|             
      Inflammation, Chronic                |          1        1                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Mineralization                       |       3                                                                  |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Lumbar, Inflammation, Acute          |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M     A  +  +  M     +  +  +        +  +  M  +     M  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |    2              2  4        2  2  3        2  4              4        2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +     A  +  +  +     +  +  M        +  +  +  +     +  +  +  +  M|             
      Congestion                           | 3                             2                 4     2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphatic, Angiectasis               |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     4           4     3     3           3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +     M  M  M  +     M  +  +        M  M  +  +     +  M  M  +  M|             
      Infiltration Cellular, Plasma Cell   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  +     M  M  M        M  M  M  +     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Fibrosis                             |                                                                          |             
      Ulcer                                |                               4     4                                    |             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Perivascular, Inflammation           |                                                                          |             
      Scrotal, Subcutaneous Tissue,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Lymphatic, Dilatation            |                                                                          |             
      Subcutaneous Tissue, Abscess         | 3                                                                        |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        | 3                                                                        |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Plasma Cell            | 4                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Tarsal, Hyperostosis                 | 4  4  4  4     3  3  4  3     4  4  4        4  X     X        4  3  4  4|             
      Tarsal, Inflammation, Acute          |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Mineralization, Focal                |    2  2        2  2  2                       1     2           2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                    4                     |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                               2                                          |             
      Perivascular, Inflammation, Chronic  |       2                       2  2  2        2                 2  2     3|             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +        +  +  M  +     +  +  +  +  +|             
      Inflammation, Chronic                |       3                                                                  |             
      Metaplasia, Squamous                 | 2     3  2           3                                3           2  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  2     2        2  2  3                    2                    2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                               +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +        +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                              1                       1   |             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                 3     3                 3|             
      Inflammation, Acute, Focal           |                                                 4                        |             
      Inflammation, Chronic, Focal         |       2              2  1     2     2                             2  2  3|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|             
                                           | 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Nephropathy, Focal                   |                                  1                                       |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts                  |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |       2                                                        1         |             
      Renal Tubule, Regeneration           |       2  1        2           1  1  1        1                 2  2     3|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     A  +  +  +     +  +  +        +  +  +  +     A  +  +  +  +|             
      Concretion                           |                                                 3                        |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic, Focal         |       2  2        2  1                                            3      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Acanthosis                           |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  A                                             |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  44        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Fatty Change                         |                            2                                             |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Necrosis, Focal                      |                1                                                         |      3  2.3|
      Perivascular, Inflammation, Chronic  |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    1  2  1        2                                                      |      9  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic, Focal         | 1  1     1  2  2  1  2                                                   |     31  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                1  1                                                      |      4  1.3|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                      2                                                   |      2  2.0|
      Inflammation, Chronic, Focal         |                1                                                         |      1  1.0|
      Karyomegaly                          |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Coronary Artery, Inflammation, Acute |                                                                          |      1  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |    1                                                                     |      2  2.0|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        | 2        1                                                               |      6  2.0|
      Hypertrophy                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |    2                                                                     |      5  1.6|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Hyperplasia                          | 1     1              2                                                   |      7  1.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  M  +  +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Pars Distalis, Congestion            |                                                                          |      1  1.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic, Focal         |                                                                          |      3  1.7|
      Follicle, Inflammation, Acute, Focal |             2                                                            |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  | 1     4  2        2                                                      |     15  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ectopic Tissue                       |                   X                                                      |      1     |
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +                                                   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                      4                                                   |      1  4.0|
      Necrosis                             |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |  11        |
      Abscess                              |                                                                          |      3  4.0|
      Ectasia                              |                      3                                                   |      1  3.0|
      Inflammation, Chronic                |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Inflammation, Chronic                |                1                                                         |      7  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Mineralization                       |       4                                                                  |      2  3.5|
      Seminiferous Tubule, Atrophy         |       3           1                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Neutrophil              |                         2                                                |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  4.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Lumbar, Inflammation, Acute          |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Pancreatic, Congestion               |                                                                          |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  M  +  M                                             |  40        |
      Infiltration Cellular, Plasma Cell   | 2  2  2        3  2                                                      |     31  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M                                             |  42        |
      Congestion                           |    4        2  4  2                                                      |     17  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Lymphatic, Angiectasis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     3  3  4        3                                                   |     17  3.1|
      Hyperplasia, Lymphoid                |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  +  +  +  M  +                                             |  22        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M                                             |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alopecia                             |                                                                          |      1  3.0|
      Fibrosis                             | 3                                                                        |      1  3.0|
      Ulcer                                |                                                                          |      3  3.3|
      Dermis, Inflammation, Chronic        |                                                                          |      1  4.0|
      Perivascular, Inflammation           |                      2                                                   |      1  2.0|
      Scrotal, Subcutaneous Tissue,        |                                                                          |            |
          Lymphatic, Dilatation            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Plasma Cell            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Tarsal, Hyperostosis                 | 4  4  4  4  4  4                                                         |     39  3.8|
      Tarsal, Inflammation, Acute          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization, Focal                | 2     2  2     2  2                                                      |     18  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                         3                                                |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                      2                                                   |      1  2.0|
      Alveolar Epithelium, Metaplasia      |             2                                                            |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05035-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 5| 0|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0|                                            |            |
                                           | 1| 1| 1| 1| 5| 1| 1| 3| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Perivascular, Inflammation, Chronic  | 1              2                                                         |     21  1.8|
      Pleura, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  M  M  +  M  +  +  +  +                                             |  44        |
      Inflammation, Chronic                |                            2                                             |      2  2.5|
      Metaplasia, Squamous                 |             2     2  2                                                   |     13  2.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                   2                                                      |     19  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                   2                                                      |      4  1.5|
      Cyst                                 |                                                                          |      2  2.0|
      Glomerulosclerosis                   |                      3                                                   |      6  3.0|
      Inflammation, Acute, Focal           |                                                                          |      2  4.0|
      Inflammation, Chronic, Focal         |    2  3  3     2                                                         |     28  2.2|
      Mineralization                       |                         3                                                |      2  2.5|
      Necrosis, Focal                      |    2  1           2                                                      |      4  2.0|
      Nephropathy, Focal                   |                                                                          |      1  1.0|
      Papilla, Necrosis                    |                         4                                                |      1  4.0|
      Renal Tubule, Casts                  |                                                                          |      1  3.0|
      Renal Tubule, Degeneration           |                            1                                             |      1  1.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      2  1.5|
      Renal Tubule, Regeneration           | 1  2  2  2     1  2                                                      |     25  1.6|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A                                             |  45        |
      Concretion                           |                                                                          |      2  2.5|
      Ectasia                              |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |    2  2  2  1  2                                                         |     19  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.