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TDMS Study 05035-03 Pathology Tables

NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97
Route: DOSED FEED                                                                                                 Time: 12:32:01




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     A  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     A  +  +  +     +  +     +        A  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |       X                       X           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Moderate       |                                           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  M  I  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Pheochromocytoma Benign              |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  M  +  M     +  +     +        +  +  +  +  +   |             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +     +  +  +  +     +  +     +        +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +  +     M  +     +        +  +  +  +  +   |             
      Pars Distalis, Adenoma               |    X     X        X        X     X                       X     X  X      |             
      Pars Distalis, Carcinoma             |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      C-Cell, Adenoma                      | X                       X                 X                              |             
      C-Cell, Carcinoma                    |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X                              |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Bilateral, Adenoma                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +     +  +  +  +     +  +     M        +  +  +  +  +   |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Luteoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +  +  +     +  +     M        +  +  +  +  +   |             
      Leiomyosarcoma                       |                                                                          |             
      Polyp Stromal                        | X  X        X                                               X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +     +     +     +  +     +        +                        |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |       X                       X                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +     +  +  +  M     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |       X                       X           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |       X                       X           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |       X                       X           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Thymoma Benign                       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +     +  +  +  M     +  +     +        +  +  +  +  +   |             
      Fibroadenoma                         |             X     X        X  X           X              X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma Adenosquamous              | X                                                                        |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |       X                       X           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                 +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     | +                             +  +                          +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                +                          +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     A  +  +  +     +  +     M        A  +  A  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                           X                              |             
      Leukemia Mononuclear, Mild           |                                                          X               |             
      Leukemia Mononuclear, Moderate       |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  +              +                           |             
      Sarcoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  M  +  I  +  +  +  I  +  +  +  A  +  +        I  +  M  I  M  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M        +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X           X  X              X     X  X        X        X     X  X     X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                X  X  X                       X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +        +                                             |             
      Sarcoma                              |                            X                                             |             
      Squamous Cell Carcinoma              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  M  +  M  +  M  +  +  +        +  +  +  +  +  +|             
      Adenoma                              |    X                                                           X         |             
      Carcinoma                            | X                                                                    X   |             
      Squamous Cell Papilloma              |                                                                          |             
      Bilateral, Adenoma                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Luteoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Leiomyosarcoma                       |                      X                                                   |             
      Polyp Stromal                        | X           X  X              X     X        X           X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +              +              +  +           +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |             X                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  A  +  M        M  +  M  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                           X                              |             
      Leukemia Mononuclear, Mild           |                                                          X               |             
      Leukemia Mononuclear, Moderate       |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  M  M  +  +  +  M  +  +  +  +  +  M        M  +  +  +  M  M|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  M  +  +|             
      Fibroadenoma                         |    X  X           X           X  X     X                 X     X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                     X                                    |             
      Subcutaneous Tissue, Fibroma         |                                              X                           |             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Carcinoma Adenosquamous              |                                                                          |             
      Leukemia Mononuclear, Marked         |                                           X                              |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +           +                    +           +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +           +           +                    +           +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A                                                |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Leukemia Mononuclear, Mild           |       X                                                                  |          2 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                                         |   6        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  M                                                |  47        |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  39        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Pheochromocytoma Benign              |       X        X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M                                                |  46        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +                                                |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +                                                |  47        |
      Pars Distalis, Adenoma               |       X     X  X     X                                                   |         23 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
      C-Cell, Adenoma                      |                X                                                         |          9 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Sarcoma                              |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +                                                |  43        |
      Adenoma                              | X                                                                        |          3 |
      Carcinoma                            |          X                                                               |          4 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Granulosa Cell Tumor Benign          |          X                                                               |          1 |
      Luteoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +                                                |  49        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Polyp Stromal                        |    X     X  X           X                                                |         15 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +                                                   |  31        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Mild           |       X                                                                  |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +                                                |  50        |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |  43        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M                                                |  48        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear, Mild           |       X                                                                  |          2 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +                                                |  39        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +                                                |  46        |
      Fibroadenoma                         | X        X     X                                                         |         19 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |       X                                                                  |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A                                                |  44        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +        +  +  +  +  M        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                                                  X|             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |    X     X                                            X  X     X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Adenoma                              |                                           X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  I        +  +  +  +  +        +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Pars Distalis, Adenoma               | X     X  X     X              X  X  X              X  X     X           X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                     X                                    |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
      Sarcoma                              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                       X        X        X|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                    X                     |             
      Leiomyosarcoma                       |    X                                                                     |             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Polyp Stromal                        |                X     X              X                             X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                                               |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |    X     X                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +        +  I  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Lumbar, Leukemia Mononuclear, Marked |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                      X                                                  X|             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear, Moderate|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                                                  X|             
      Leukemia Mononuclear, Moderate       |    X                                                  X  X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Leukemia Mononuclear, Moderate       |    X     X                                            X  X     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                                                  X|             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |    X     X                                            X  X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +        +  M  +  +  +        +  +  +  M  M  M  +  A|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |          X        X           X                       X        X     X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  M  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Squamous Cell Papilloma              |                X                                                         |             
      Subcutaneous Tissue, Fibroma         | X     X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear, Marked         |                      X                                                  X|             
      Leukemia Mononuclear, Moderate       |    X     X                                            X  X     X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                 +                             +  +     A|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                 +                                +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Mild           |                         X           X                                    |             
      Leukemia Mononuclear, Moderate       |          X                    X        X        X        X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                             +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  I  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X           X     X           X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  +  +      |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  I  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Pars Distalis, Adenoma               |       X  X  X  X  X     X     X     X  X     X  X        X     X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                                           X  X                           |             
      C-Cell, Carcinoma                    | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  M  +  +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leiomyoma                            |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Polyp Stromal                        | X              X  X                       X  X              X            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                    +                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Lumbar, Leukemia Mononuclear, Marked |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear, Moderate|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  M  +  M      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |          X                             X        X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |          X                    X        X        X        X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Mild           |                         X           X                                    |             
      Leukemia Mononuclear, Moderate       |          X                    X        X        X        X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  M  +  +  +     +  +  +  +  M     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  M  +  +  M  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                        X                                 |             
      Fibroadenoma                         | X     X  X     X        X     X        X  X  X  X     X        X         |             
      Fibroadenoma, Multiple               |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +     M  +  +  M  +     +  +  +  M  +      |             
      Basal Cell Adenoma                   |                         X                                                |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |          X                    X        X        X        X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                          +        +         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +              +                          +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          3 |
      Leukemia Mononuclear, Mild           |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |    X                       X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          2 |
      Pheochromocytoma Malignant           |                      X                                                   |          1 |
      Pheochromocytoma Benign              |       X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          1 |
      Pars Distalis, Adenoma               |          X  X  X     X  X  X                                             |         31 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Bilateral, C-Cell, Adenoma           |                      X                                                   |          1 |
      C-Cell, Adenoma                      |    X                       X                                             |          4 |
      C-Cell, Carcinoma                    |                         X                                                |          3 |
      Follicular Cell, Adenoma             |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +                                             |  47        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |    X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leiomyoma                            |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Polyp Stromal                        |    X           X                                                         |         12 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +              +                                                      |   6        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          1 |
      Leukemia Mononuclear, Moderate       |    X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Lumbar, Leukemia Mononuclear, Marked |                   X                                                      |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                   X                                                      |          3 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Moderate                        |                            X                                             |          1 |
      Renal, Leukemia Mononuclear, Moderate|                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          3 |
      Leukemia Mononuclear, Moderate       |    X                       X                                             |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear, Marked         |                   X                                                      |          2 |
      Leukemia Mononuclear, Moderate       |    X                       X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |                   X                                                      |          3 |
      Leukemia Mononuclear, Mild           |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |    X                       X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +                                             |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |    X        X  X  X  X                                                   |         23 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                   X                                                      |          3 |
      Leukemia Mononuclear, Moderate       |    X                       X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +  +                                                         |  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +     +                                                            |   8        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         | +  +  +  +  +  M  +  +  A  +                                             |  45        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        M  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +        +  +     +  +  M     +  +     +  +  +     +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Mild           |                               X                                          |             
      Leukemia Mononuclear, Moderate       |    X                                         X                 X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +                                                         |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Pheochromocytoma Benign              |    X  X                                            X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  M  +        +  +     M  +  M     +  +     +  +  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X        X  X  X  X        X  X        X  X     X              X     X|             
      Pars Distalis, Carcinoma             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      C-Cell, Adenoma                      |             X                                                            |             
      C-Cell, Carcinoma                    |                               X              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  M  M  +  +  +        +  +     M  +  +     +  +     +  M  M     +|             
      Adenoma                              | X                                            X                           |             
      Carcinoma                            |    X                 X                       X                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Polyp Stromal                        |    X                                   X     X              X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                   +                 +         |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Moderate       |    X                                         X                 X         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +        +  +     +  I  +     +  +     +  +  +     +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Mediastinal, Leukemia Mononuclear    |                                                                         X|             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |          X                                                               |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                         X|             
      Renal, Leukemia Mononuclear, Marked  |                                                                          |             
      Renal, Leukemia Mononuclear, Moderate|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +        +  M     +  +  +     +  M     +  M  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Moderate       |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                         X|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Moderate       |    X                                         X                 X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Mild           |                               X                                          |             
      Leukemia Mononuclear, Moderate       |    X                                         X                 X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +        +  +     M  M  M     +  +     +  M  M     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +        +  +     M  +  +     +  +     +  +  M     +|             
      Adenocarcinoma                       |             X                                                            |             
      Fibroadenoma                         |          X  X     X  X                       X        X                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Moderate       |    X                                         X                 X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +  +        +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +  +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Sarcoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X     X|             
      Leukemia Mononuclear, Mild           |                X                                   X                     |             
      Leukemia Mononuclear, Moderate       |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                   +                 +      |             
      Leukemia Mononuclear, Marked         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  M  +  +  M  M  +  +     +  +  +  +     I  +  M  +  +|             
      Leukemia Mononuclear, Marked         |                                                                         X|             
      Pheochromocytoma Benign              |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +|             
      Adenoma                              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  M  +  +  +  +  +  +  +  M  +  M  +     M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pars Distalis, Adenoma               | X           X  X     X     X  X                 X  X        X  X     X   |             
      Pars Distalis, Carcinoma             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      C-Cell, Adenoma                      |                                     X                             X      |             
      C-Cell, Carcinoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenoma                              | X        X           X                                         X         |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X      |             
      Polyp Stromal                        |          X     X           X  X  X                 X                 X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                   X      |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                   X     X|             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Moderate                        |                                        X                                 |             
      Renal, Leukemia Mononuclear          |                                                                          |             
      Renal, Leukemia Mononuclear, Marked  |                                                                          |             
      Renal, Leukemia Mononuclear, Moderate|                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X     X|             
      Leukemia Mononuclear, Moderate       |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                         X|             
      Leukemia Mononuclear, Moderate       |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X     X|             
      Leukemia Mononuclear, Mild           |                X                                   X                     |             
      Leukemia Mononuclear, Moderate       |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  +  +  +  M  +  M  +  M     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X     X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |    X     X        X  X           X           X  X           X  X        X|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  I|             
      Squamous Cell Papilloma              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                   X                                                      |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Leukemia Mononuclear, Marked         |                                                                   X     X|             
      Leukemia Mononuclear, Moderate       |       X                                X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                      +                    +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                      +                    +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  A                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                         X  X                                             |          5 |
      Leukemia Mononuclear, Mild           |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   6        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +                                             |  44        |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Pheochromocytoma Benign              |                   X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +                                             |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +     +     +  +                                             |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X                 X        X                                             |         27 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +     +  +                                             |  50        |
      C-Cell, Adenoma                      | X     X           X                                                      |          6 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +     +     M  +                                             |  43        |
      Adenoma                              |                                                                          |          6 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Polyp Stromal                        |    X        X                                                            |         14 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +     +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +     +  +                                             |  50        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Marked                          |                         X  X                                             |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Moderate                        |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
      Renal, Leukemia Mononuclear, Marked  |                         X                                                |          1 |
      Renal, Leukemia Mononuclear, Moderate|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  +  +  +     +     +  +                                             |  45        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                         X  X                                             |          5 |
      Leukemia Mononuclear, Moderate       |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                         X  X                                             |          4 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                         X  X                                             |          5 |
      Leukemia Mononuclear, Mild           |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +     +     +  M                                             |  36        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                         X                                                |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +     +  +                                             |  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         | X  X  X  X                                                               |         20 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +  +     +     +  +                                             |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                         X  X                                             |          5 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +     +  A                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  M  +  M  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |             X                    X              X  X                     |             
      Leukemia Mononuclear, Moderate       |       X  X                             X  X  X        X        X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +        +                       +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
      Palate, Squamous Cell Papilloma      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                  X                 X                     |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Pheochromocytoma Benign              |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +     +  M  +  +  +  +  +  +  +  +  M  +     +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X     X           X     X     X  X           X  X     X  X     X  X  X  X|             
      Pars Distalis, Carcinoma             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |          X                    X                 X                        |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +     +     M  +  +  +  M  +  +  +  +  M  +  M     M  +  +  +|             
      Adenoma                              |       X                                X  X                              |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                    X                     |             
      Polyp Stromal                        |       X                                      X     X                    X|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +           +     +     +     +        +  +              +  +  +   |             
      Leukemia Mononuclear, Marked         |                                                 X                        |             
      Leukemia Mononuclear, Moderate       |       X                                      X                 X         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  I  +  +  +     M     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |             X                    X              X  X                     |             
      Leukemia Mononuclear, Moderate       |       X  X                             X  X  X                 X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |             X                    X              X  X                     |             
      Leukemia Mononuclear, Moderate       |       X  X                             X  X  X        X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |             X                    X              X  X                     |             
      Leukemia Mononuclear, Moderate       |       X  X                             X  X  X        X        X         |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     M  +  +  +  M  M  +  +  +  +  +  +     M  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         | X  X                    X     X           X        X     X     X  X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Astrocytoma Malignant                |                            X                                             |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |             X                    X              X  X                     |             
      Leukemia Mononuclear, Moderate       |       X  X                             X  X           X        X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +  +  +     +              +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +  +     +              +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                               X   |             
      Leukemia Mononuclear, Moderate       |                X                 X        X                    X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +              +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  M  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Moderate       |                                                                X         |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Leukemia Mononuclear, Moderate       |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +  M  +  +  +     +     +  +  +  +     M  +  M  +  +  +   |             
      Pheochromocytoma Benign              | X                                               X              X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  M  M  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Adenoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  M  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Pars Distalis, Adenoma               | X     X  X     X        X  X     X     X     X              X            |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      C-Cell, Adenoma                      |       X        X                                                         |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                      X           X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +     +  +  +  +  +     +     +  M  +  +     +  +  M  +  M  +   |             
      Adenoma                              | X                                X                                       |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Polyp Stromal                        | X                    X           X        X                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +  +                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +        +  +              +     +  +  +  +     +  +  +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                X                 X        X                    X         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Mediastinal, Leukemia Mononuclear    |          X                                                               |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                      X   |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +  +  +  +  +     +     +  +  M  M     +  +  M  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Leukemia Mononuclear, Moderate       |                X                          X                    X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                               X   |             
      Leukemia Mononuclear, Moderate       |                X                          X                    X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                               X   |             
      Leukemia Mononuclear, Moderate       |                X                 X        X                    X         |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +     +  +  +  +  +     +     +  M  +  +     +  +  M  +  M  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +     +  +  +  +  +     +     +  M  +  +     M  M  +  M  +  +   |             
      Adenocarcinoma                       |                         X                                                |             
      Fibroadenoma                         | X     X        X  X        X                    X           X        X   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  M  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Squamous Cell Papilloma              |       X                                                                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Leukemia Mononuclear, Marked         |                      X                                               X   |             
      Leukemia Mononuclear, Moderate       |                X                 X        X                    X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +        +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +  +              +  +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X        X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                      X                                                   |          7 |
      Leukemia Mononuclear, Moderate       |          X  X  X                                                         |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                                                            |   8        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +                                             |  47        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  M  +  +  +  M  M                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Pars Distalis, Adenoma               |                                                                          |         24 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      | X        X                                                               |          7 |
      C-Cell, Carcinoma                    |             X                                                            |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +     +  +  +  +  +  M  +                                             |  40        |
      Adenoma                              |                                                                          |          5 |
      Carcinoma                            | X                          X                                             |          2 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +  +  +  +  +  M                                             |  49        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Polyp Stromal                        |                   X  X                                                   |         10 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +     +                                                               |  29        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |          X                                                               |          8 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Moderate                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  M                                             |  44        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                      X                                                   |          6 |
      Leukemia Mononuclear, Moderate       |          X                                                               |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                      X                                                   |          7 |
      Leukemia Mononuclear, Moderate       |          X                                                               |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                      X                                                   |          7 |
      Leukemia Mononuclear, Moderate       |          X  X  X                                                         |         14 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +  +  +  +  M                                             |  42        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +  +  +  +  M  M                                             |  43        |
      Adenocarcinoma                       |                X                                                         |          2 |
      Fibroadenoma                         |          X                                                               |         18 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +  +  +                                             |  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |             X                                                            |          1 |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Leukemia Mononuclear, Marked         |                      X                                                   |          7 |
      Leukemia Mononuclear, Moderate       |          X     X                                                         |         12 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   1        |
      Carcinoma                            |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
      Renal Tubule, Adenoma                |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |       X                 X                             X  X               |             
      Leukemia Mononuclear, Mild           |                                                             X            |             
      Leukemia Mononuclear, Moderate       |                   X  X                                         X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Leukemia Mononuclear, Marked         |       X                                                                  |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  I  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X     X        X                             X                          X|             
      Bilateral, Pheochromocytoma Benign   |                      X        X        X  X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  M  I|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X        X                                                  X  X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Carcinoma             |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                                                        |             
      C-Cell, Carcinoma                    |                X                                X                        |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                               X                 X                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                               X                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X  X  X     X        X     X  X     X  X  X        X   |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Carcinoma                        |                                                                          |             
      Interstitial Cell, Adenoma           |                                           X        X           X  X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +  +           +        +     +  +  I        +  +  +      |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Mild           |                                                             X            |             
      Leukemia Mononuclear, Moderate       |                   X                                            X  X      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |                                                       X  X               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Mediastinal, Leukemia Mononuclear    |                                           X                          X   |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |       X                                               X                  |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |       X                 X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  +     +        +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |       X                 X                             X  X               |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |       X                 X                             X  X               |             
      Leukemia Mononuclear, Moderate       |                   X  X                                            X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |       X                 X                             X  X               |             
      Leukemia Mononuclear, Mild           |                                                             X            |             
      Leukemia Mononuclear, Moderate       |                   X  X                                         X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +  +  +     M        +  +  M  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Leukemia Mononuclear, Marked         |       X                                                  X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  M  +  +  +     +        M  +  M  M  M  M  +  +  +  +  M  +|             
      Fibroadenoma                         | X                             X                                   X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                           X                              |             
      Squamous Cell Carcinoma              |                      X                                                   |             
      Squamous Cell Papilloma              |                   X  X                                                   |             
      Subcutaneous Tissue, Fibroma         |                         X                                X              X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                X                                                         |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Leukemia Mononuclear                 |                                           X                          X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear, Marked         |       X                 X                             X  X               |             
      Leukemia Mononuclear, Moderate       |                   X                                            X  X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Leukemia Mononuclear, Marked         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                          X   |             
      Mesothelioma Malignant               |                               X                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                     X           X     X                  |             
      Leukemia Mononuclear, Mild           | X  X                          X                                          |             
      Leukemia Mononuclear, Moderate       |          X                       X        X        X     X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                                 X                        |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  I  +  +  M     M  I  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear, Marked         |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                                         X|             
      Pheochromocytoma Benign              | X                 X                                X           X         |             
      Bilateral, Pheochromocytoma Benign   |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +     +  +  +  +  I  +  +  +  +  +  +  +     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Pars Distalis, Adenoma               |       X        X  X  X  X              X     X     X     X           X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                      X                                                   |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |    X                                                                    X|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  M  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X                    X     X     X  X        X        X  X|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Carcinoma                        |                                                       X                  |             
      Interstitial Cell, Adenoma           |          X        X           X  X           X           X     X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +  +        +  +           +  +           +  +     +  +|             
      Leukemia Mononuclear, Marked         |                                                 X                        |             
      Leukemia Mononuclear, Mild           | X  X                          X                                          |             
      Leukemia Mononuclear, Moderate       |                                  X                          X            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                     X           X                        |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |       X                                                                  |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                     X           X     X                  |             
      Leukemia Mononuclear, Moderate       |                                  X        X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                     X                 X                  |             
      Leukemia Mononuclear, Moderate       |          X                       X        X        X     X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hemangiosarcoma                      |                                           X                              |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                     X           X     X                  |             
      Leukemia Mononuclear, Mild           | X  X                          X                                          |             
      Leukemia Mononuclear, Moderate       |          X                       X        X        X     X  X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +     +  +  +  M  M  +  +  +  +  M  +  M     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +     M  +  +  +  +  +  +  M  +  +  M  +     M  M|             
      Fibroadenoma                         |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |          X              X                                                |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X                       X              X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                   X   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear, Marked         |                                     X           X     X                  |             
      Leukemia Mononuclear, Moderate       |          X                       X        X        X     X  X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear, Marked         |                                                 X                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +           +           +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +  +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +           +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Renal Tubule, Adenoma                |       X              X                                                  X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +     +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +     +  A     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +     +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    M  +     +     +  +     +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                   X                                                      |          8 |
      Leukemia Mononuclear, Mild           |    X                                                                     |          5 |
      Leukemia Mononuclear, Moderate       |             X                                                            |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  M     +     +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +     +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +     +  +     +                                             |  44        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X     X                                                            |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  M     +     +  +     +                                             |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    I  +     +     +  M     +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     I     +  +     M                                             |  48        |
      Pars Distalis, Adenoma               |                      X                                                   |         16 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +     +  +     +                                             |  50        |
      C-Cell, Adenoma                      |                   X  X                                                   |          4 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +     +  +     +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  M     +     +  +     +                                             |  48        |
      Adenoma                              |                      X                                                   |          2 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +     +  +     +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +     +  +     +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +     +     +  +     +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X           X                                                      |         29 |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |             X        X                                                   |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +  +                                                                  |  25        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Mild           |    X                                                                     |          5 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                                                                          |          4 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Moderate                        |             X                                                            |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Marked                          |                   X                                                      |          3 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +     +  +     +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                   X                                                      |          8 |
      Leukemia Mononuclear, Moderate       |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +     M  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          6 |
      Leukemia Mononuclear, Moderate       |             X                                                            |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +     +  +     +                                             |  50        |
      Hemangiosarcoma                      |             X                                                            |          2 |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                   X                                                      |          8 |
      Leukemia Mononuclear, Mild           |    X                                                                     |          5 |
      Leukemia Mononuclear, Moderate       |             X                                                            |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +     M  +     +                                             |  40        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  M     +     +  +     +                                             |  36        |
      Fibroadenoma                         |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +     +  +     +                                             |  50        |
      Basal Cell Adenoma                   |             X                                                            |          1 |
      Keratoacanthoma                      |                                                                          |          3 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +     +  +     +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +     +  +     +                                             |  49        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +     +  +     +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |             X                                                            |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                   X                                                      |          8 |
      Leukemia Mononuclear, Moderate       |             X                                                            |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +     +  +     +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +     +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Renal Tubule, Adenoma                |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +     +  +     +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +     +     +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +  +  +        +  +  M  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +  +  +        +  +  +  M  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear, Marked         |                   X  X                    X                              |             
      Leukemia Mononuclear, Mild           |                                  X                                       |             
      Leukemia Mononuclear, Moderate       |                X                                         X        X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +                                 |             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                   X  X                                                   |             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
      Squamous Cell Papilloma              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                   X                                                      |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                      X                    X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X  X     X                 X                 X           X     X      |             
      Bilateral, Pheochromocytoma Benign   |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                          X      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     M  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +  +  M        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X     X  X                    X  X  X  X  X                 X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                             X  X                                    |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                       X     X            |             
      Leukemia Mononuclear, Marked         |                      X                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X        X  X        X  X  X     X  X  X        X   |             
      Interstitial Cell, Adenoma           |             X                                                  X        X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                  +   |             
      Leukemia Mononuclear, Marked         |                   X                                                      |             
      Leukemia Mononuclear, Moderate       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                   X  X                    X                              |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Moderate                        |                                                          X               |             
      Renal, Leukemia Mononuclear, Moderate|                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +  +  +        M  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                   X  X                                                   |             
      Leukemia Mononuclear, Moderate       |                                                          X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                   X  X                    X                              |             
      Leukemia Mononuclear, Moderate       |                X                                         X           X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear, Marked         |                   X  X                    X                              |             
      Leukemia Mononuclear, Mild           |                                  X                                       |             
      Leukemia Mononuclear, Moderate       |                X                                         X        X  X   |             
      Sarcoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  M  +        +  M  M  M  +  +  +     +  +  +  +  +  M  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +     +  +  +  +        +  +  +  +  +  +  +     M  +  M  +  M  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                   X      |             
      Leukemia Mononuclear, Marked         |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                                        X     X        X                  |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear, Marked         |                   X  X                    X                              |             
      Leukemia Mononuclear, Moderate       |                X                                         X        X  X   |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                   X                                                      |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Benign                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Benign                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                             X            |             
      Leukemia Mononuclear, Marked         |       X  X              X                                                |             
      Leukemia Mononuclear, Mild           |                                                                   X      |             
      Leukemia Mononuclear, Moderate       | X                             X  X  X           X  X           X     X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                       +        +            |             
      Mesothelioma Malignant               |                      X     X                       X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Mesothelioma Malignant               |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Malignant               |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                    X                     |             
      Schwannoma Malignant                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  I        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |       X                             X  X  X     X           X  X        X|             
      Bilateral, Pheochromocytoma Benign   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +  +  +  +  +  +  I  +  +  +  +  +  M        +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X        X  X  X        X  X  X  X  X     X           X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                       X                                 |             
      C-Cell, Carcinoma                    |                               X                                   X      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Malignant               |                      X     X                       X                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Adenoma                              |                                                 X              X     X   |             
      Carcinoma                            | X     X                             X                                   X|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +     +  +  +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +     +  +  +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Malignant               |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Malignant               |                      X     X                       X                     |             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X        X  X  X     X     X  X           X  X  X  X   |             
      Interstitial Cell, Adenoma           |          X           X  X           X              X                    X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                             +  +              +                        |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       | X                             X  X              X                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |          X              X                                                |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                     X                                   X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear, Moderate|                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Leukemia Mononuclear, Marked         |       X                 X                                                |             
      Leukemia Mononuclear, Moderate       |                                                    X                 X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |       X  X              X                                                |             
      Leukemia Mononuclear, Moderate       | X                             X  X  X           X  X           X     X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hemangiosarcoma                      |       X                                                                  |             
      Leukemia Mononuclear, Marked         |       X  X              X                                                |             
      Leukemia Mononuclear, Mild           |                                                                   X      |             
      Leukemia Mononuclear, Moderate       | X                             X  X  X           X  X           X     X  X|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  M     M  +  +  +  +  +  M  +  M  +  +  +  +        +  M  +  +  +|             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |                                                                      X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M  +     M  M  M  +  M  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Fibroadenoma                         |                                                 X  X           X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Keratoacanthoma                      |                                                                X         |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                X         |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Mesothelioma Malignant               |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear, Marked         |       X  X              X                                                |             
      Leukemia Mononuclear, Moderate       | X                             X  X  X           X  X           X     X  X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +  +                                                      |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +        +  +                                                      |             
      Carcinoma                            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Mesothelioma Malignant               |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mesothelioma Benign                  |                      X                                                   |             
      Mesothelioma Malignant               |                      X     X                       X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +                                             |  49        |
      Mesothelioma Benign                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     M  +  M  +  +  +  +  +                                             |  47        |
      Mesothelioma Benign                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |             X                                                            |          7 |
      Leukemia Mononuclear, Mild           |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |                X        X  X                                             |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +     +                                             |   9        |
      Mesothelioma Malignant               |                   X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  66                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                            X                                             |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Pheochromocytoma Malignant           |                X        X                                                |          2 |
      Pheochromocytoma Benign              | X        X                                                               |         17 |
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                X        X                                                |          4 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Adenoma               | X     X  X        X  X                                                   |         27 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |          X        X        X                                             |          8 |
      C-Cell, Carcinoma                    |                      X                                                   |          3 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +  +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                   X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                      X     X                                             |          6 |
      Carcinoma                            |                                                                          |          6 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +                                             |  49        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          4 |
      Bilateral, Interstitial Cell, Adenoma| X     X     X  X  X  X  X  X                                             |         36 |
      Interstitial Cell, Adenoma           |                                                                          |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +           +                                             |   8        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                X           X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +                                             |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |             X                                                            |          6 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Moderate                        |                X                                                         |          3 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Marked                          |             X                                                            |          1 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Moderate                        |                                                                          |          1 |
      Renal, Leukemia Mononuclear, Moderate|                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  M  +  +  +  I                                             |  45        |
      Leukemia Mononuclear, Marked         |             X                                                            |          5 |
      Leukemia Mononuclear, Moderate       |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |             X                                                            |          7 |
      Leukemia Mononuclear, Moderate       |                X        X  X                                             |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |             X                                                            |          7 |
      Leukemia Mononuclear, Mild           |          X                                                               |          3 |
      Leukemia Mononuclear, Moderate       |                X        X  X                                             |         16 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M  +  +  +  +  M  +  +                                             |  37        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  M  +  M  +  M  M  M                                             |  34        |
      Fibroadenoma                         | X     X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Keratoacanthoma                      |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          4 |
      Subcutaneous Tissue, Hemangiosarcoma |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Sarcoma         |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |          1 |
      Leukemia Mononuclear, Marked         |             X                                                            |          7 |
      Leukemia Mononuclear, Moderate       |                X        X  X                                             |         16 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic                       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                                                               |   5        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +  +                                                               |   5        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                   X                                                      |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  M  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  M  +  +  +  +  +     +  +     +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                             X                                 |             
      Leukemia Mononuclear, Moderate       |             X           X     X     X        X  X              X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Liposarcoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  M     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
      Palate, Squamous Cell Papilloma      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     I  +     +  +  +  +     +   |             
      Ganglioneuroma                       |                                                          X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |       X  X                 X     X  X           X     X                  |             
      Bilateral, Pheochromocytoma Benign   |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  M  +  +     +  M     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  M  +     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Pars Distalis, Adenoma               |                X  X  X     X        X                       X  X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Adenoma                              |             X                 X                                          |             
      Carcinoma                            |                         X                             X                  |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Liposarcoma, Metastatic              |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X     X  X  X  X  X  X     X     X        X  X                    X   |             
      Interstitial Cell, Adenoma           |       X                          X     X              X  X  X  X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +     +        +  +                        |             
      Leukemia Mononuclear, Moderate       |                               X     X        X  X                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                      X   |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |          X                                                               |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                      X   |             
      Renal, Leukemia Mononuclear, Marked  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  M     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                             X                                 |             
      Leukemia Mononuclear, Moderate       |             X                 X              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                             X                                 |             
      Leukemia Mononuclear, Moderate       |             X           X     X     X        X  X              X         |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                             X                                 |             
      Leukemia Mononuclear, Moderate       |             X           X     X     X        X  X              X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                                                               |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  M  +     M  +     M  M  +  +     M   |             
      Fibroadenoma                         |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     M  +  +  +     +   |             
      Keratoacanthoma                      |                                                                      X   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Astrocytoma Malignant                |                            X                                             |             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Leukemia Mononuclear, Marked         |          X                             X                                 |             
      Leukemia Mononuclear, Moderate       |             X           X     X     X        X  X              X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +     +           +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +           +                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
      Renal Tubule, Adenoma                |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  A  +  M     +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                  X                                   X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +  M  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hepatocellular Adenoma               |                                                             X            |             
      Leukemia Mononuclear                 |                                                             X            |             
      Leukemia Mononuclear, Marked         |                                                                X         |             
      Leukemia Mononuclear, Moderate       | X  X                                X  X     X     X                 X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +                              |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Liposarcoma                          |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  M  +     +     +  +  +  +  +  +  +     +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     M     +  +  M     +  +|             
      Leukemia Mononuclear, Moderate       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Carcinoma                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Ganglioneuroma                       |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                              X              X            |             
      Bilateral, Pheochromocytoma Benign   |                   X              X     X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +     +     +  +  +  +  +  +  +  M  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                         X  X  X  X  X              X     X     X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                         +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Liposarcoma, Metastatic              |                                           X                              |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X           X  X  X     X     X  X  X  X              X  X     X   |             
      Interstitial Cell, Adenoma           |             X                    X                 X     X              X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                   +  +     +     +                     |             
      Leukemia Mononuclear, Moderate       | X                                   X  X     X     X                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Axillary, Leukemia Mononuclear       |                                                             X            |             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
      Lumbar, Leukemia Mononuclear         |                                                             X            |             
      Mediastinal, Leukemia Mononuclear    |                                                             X            |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                X         |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
           Marked                          |                                                                          |             
      Pancreatic, Leukemia Mononuclear,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Moderate                        |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                             X            |             
      Renal, Leukemia Mononuclear, Marked  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Leukemia Mononuclear, Marked         |                                                                X         |             
      Leukemia Mononuclear, Moderate       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Leukemia Mononuclear, Marked         |                                                                X         |             
      Leukemia Mononuclear, Moderate       | X  X                                X  X     X     X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Leukemia Mononuclear, Marked         |                                                                X         |             
      Leukemia Mononuclear, Moderate       | X  X                                X  X     X     X                 X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M     +     +  +  +  +  +  +  +  M  +  M     +     M  +  M     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     M  M  +  +  +  M  M  +  M  +     +     +  M  +     +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +  +  +  +  +  M  +     +     +  +  +     +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                        X         |             
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Carcinoma, Metastatic, Adrenal Gland |                               X                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                            X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                X         |             
      Leukemia Mononuclear, Moderate       | X  X                                X  X     X     X                 X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                +  +  +        +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                +  +  +        +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +              +     +                                       |             
      Carcinoma                            |             X              X     X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Renal Tubule, Adenoma                |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       | X  X                    X  X                                             |         18 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Liposarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  M  M  +  +  +  +  +  +                                             |  46        |
      Leukemia Mononuclear, Moderate       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ganglioneuroma                       |                                                                          |          1 |
      Pheochromocytoma Malignant           | X        X                                                               |          2 |
      Pheochromocytoma Benign              |    X           X  X  X                                                   |         13 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Adenoma                              |    X                                                                     |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |          X        X                                                      |         19 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |                X                                                         |          1 |
      C-Cell, Carcinoma                    |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Liposarcoma, Metastatic              |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X     X  X  X  X                                             |         35 |
      Interstitial Cell, Adenoma           |                X                                                         |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                                                                     |  10        |
      Leukemia Mononuclear, Moderate       |    X                                                                     |         10 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Marked                          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear,    |                                                                          |            |
           Moderate                        |                            X                                             |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
      Renal, Leukemia Mononuclear, Marked  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       |    X                    X  X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       | X  X                    X  X                                             |         17 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       | X  X                    X  X                                             |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +                                             |  40        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  +  M  +  +  +  M                                             |  35        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Keratoacanthoma                      | X                                                                        |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
      Leukemia Mononuclear, Moderate       | X  X                    X  X                                             |         18 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +     +     +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                I     +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                            |   4        |
      Carcinoma                            |             X                                                            |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Renal Tubule, Adenoma                | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +        +  +  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +        +  A  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Mild           |                                     X                                    |             
      Leukemia Mononuclear, Moderate       |    X                 X                    X        X  X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                            +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +        +  A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Acinus, Adenoma                      |                                                                X         |             
      Acinus, Carcinoma                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  M  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                               X                                          |             
      Pheochromocytoma Benign              |                   X  X           X        X  X  X              X     X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +        +  M  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Adenoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +  I  +  +  +  +  +  I  +  +  +  +  M  +     +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Pars Distalis, Adenoma               |          X        X        X  X  X                 X  X        X     X  X|             
      Pars Distalis, Carcinoma             |    X                                                                     |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Carcinoma         |                                                                          |             
      C-Cell, Adenoma                      |    X     X        X                                X                     |             
      C-Cell, Carcinoma                    |                                           X                              |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  M     +     +  +|             
      Adenoma                              |                   X                                                      |             
      Carcinoma                            |       X                                                                  |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +  +  +  +  M  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Bilateral, Interstitial Cell, Adenoma|       X           X     X  X  X  X     X     X  X        X     X         |             
      Interstitial Cell, Adenoma           |          X           X              X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +           +           +  +  +        +                 +         |             
      Leukemia Mononuclear, Marked         |                                                                          |             
      Leukemia Mononuclear, Mild           |                                     X                                    |             
      Leukemia Mononuclear, Moderate       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +  A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                                                          |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  M     M     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  +     +     M  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |    X                                                  X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Mild           |                                     X                                    |             
      Leukemia Mononuclear, Moderate       |    X                                      X        X  X  X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M        +  +  +  M  +  +  +  +  +  +  +  M  +  +     M     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +        M  +  +  +  M  M  M  M  M  +  +  +  +  +     M     +  +|             
      Fibroadenoma                         |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Basal Cell Adenoma                   |       X                                                                  |             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                           X                              |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Osteoma                              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |    X                                                                     |             
      Glioma Malignant                     |                                                                          |             
      Granular Cell Tumor NOS              |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Leukemia Mononuclear, Marked         |                         X                                                |             
      Leukemia Mononuclear, Moderate       |    X                 X                    X        X  X  X               |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +        +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                 +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
      Carcinoma                            |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hamartoma                            |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Lipoma                               |       X                                                                  |             
      Renal Tubule, Adenoma                |                                     X        X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +  A  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear, Moderate       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  +|             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X  X           X                        |             
      Leukemia Mononuclear, Mild           |                                                                          |             
      Leukemia Mononuclear, Moderate       |       X     X                                               X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Carcinoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Pheochromocytoma Malignant           |          X                                                               |             
      Pheochromocytoma Benign              | X              X           X                    X  X                 X   |             
      Bilateral, Pheochromocytoma Benign   |       X              X        X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |          X        X     X        X  X  X     X              X           X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Nervosa, Leukemia Mononuclear   |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Bilateral, C-Cell, Carcinoma         |                                                                          |             
      C-Cell, Adenoma                      |             X                                         X                  |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +     +  +  +|             
      Adenoma                              |                   X     X           X                                X   |             
      Carcinoma                            |                               X        X              X     X            |             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X     X  X  X  X  X        X  X  X        X     X  X  X|             
      Interstitial Cell, Adenoma           |    X        X        X                 X              X  X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +     +     +              +  +           I     +  +  +|             
      Leukemia Mononuclear, Marked         |                                                 X                        |             
      Leukemia Mononuclear, Mild           | X                                                                        |             
      Leukemia Mononuclear, Moderate       |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                          X               |             
      Lumbar, Leukemia Mononuclear         |                                                          X               |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                          X               |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Marked                          |                                  X                                       |             
      Mediastinal, Leukemia Mononuclear,   |                                                                          |             
           Moderate                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X  X           X                        |             
      Leukemia Mononuclear, Moderate       |                                                             X     X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X  X           X                        |             
      Leukemia Mononuclear, Moderate       |       X     X                                               X     X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X  X           X                        |             
      Leukemia Mononuclear, Mild           | X                                                                        |             
      Leukemia Mononuclear, Moderate       |       X     X                                               X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                     X           X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |    X                                                                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Osteoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Hemangiosarcoma                      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Glioma Malignant                     |                                           X                              |             
      Granular Cell Tumor NOS              |                                                                         X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Leukemia Mononuclear, Marked         |                                  X  X           X                        |             
      Leukemia Mononuclear, Moderate       |       X     X                                               X     X  X   |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                +           +     +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +     +                          +           +                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
      Carcinoma                            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hamartoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Lipoma                               |                                                                          |             
      Renal Tubule, Adenoma                |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +     +  +  +|             
      Leukemia Mononuclear, Moderate       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +  +  +     +                                             |  48        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +  +  +     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +  +  +     +                                             |  49        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +  +  +  +     +                                             |  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Leukemia Mononuclear, Mild           |                                                                          |          1 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +  +  M     +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
      Acinus, Adenoma                      |                                                                          |          1 |
      Acinus, Carcinoma                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  91                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +     +  +  +  +     +                                             |  46        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |       X     X                                                            |         16 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +  +  M     +                                             |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +  +  +     +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +  +  +     +                                             |  48        |
      Pars Distalis, Adenoma               |                                                                          |         19 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, C-Cell, Carcinoma         |                            X                                             |          1 |
      C-Cell, Adenoma                      |                                                                          |          6 |
      C-Cell, Carcinoma                    |                            X                                             |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +  +  +  +     +                                             |  47        |
      Adenoma                              |                                                                          |          5 |
      Carcinoma                            |                                                                          |          5 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +  +  +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +  +  +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell, Adenoma|       X     X  X  X  X     X                                             |         33 |
      Interstitial Cell, Adenoma           |                            X                                             |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +     +  +  +                                                      |  23        |
      Leukemia Mononuclear, Marked         |                                                                          |          1 |
      Leukemia Mononuclear, Mild           |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +  +  +     +                                             |  49        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +  +     +                                             |  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     |                      X                                                   |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Marked                          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear,   |                                                                          |            |
           Moderate                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +  +  +     +                                             |  45        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +  +  +     +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +  +  +     +                                             |  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Leukemia Mononuclear, Mild           |                                                                          |          2 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     M  M  +  +     +                                             |  42        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +  M  +  M     M                                             |  36        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +  +  +     M                                             |  49        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Basal Cell Carcinoma                 |       X                                                                  |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +  +  +     +                                             |  50        |
      Osteoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +  +  +     +                                             |  49        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Glioma Malignant                     |                                                                          |          1 |
      Granular Cell Tumor NOS              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +  +  +  +     +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Leukemia Mononuclear, Marked         |                                                                          |          4 |
      Leukemia Mononuclear, Moderate       |             X     X                                                      |         13 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +  +  +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +  +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  94                                                               
NTP Experiment-Test: 05035-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 12:32:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                                                         |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +  +  +     +                                             |  50        |
      Hamartoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lipoma                               |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +  +  +     +                                             |  46        |
      Leukemia Mononuclear, Moderate       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +     +  +  +  +     +                                             |  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  95                                                               
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