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TDMS Study 05035-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        4-HYDROXYACETANILIDE


NTP Experiment-Test: 05035-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: DOSED FEED                                                                                                 Time: 00:14:46




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dead                                               6            4            3                                                  
    Moribund                                          14           12           13           22                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           34           34           27                                     
    Dead                                               1                                                                            
    Moribund                                           1                                      1                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (48)         (50)         (50)                                   
   Intestine Large, Colon                             (48)         (49)         (49)         (49)                                   
   Intestine Small, Duodenum                          (48)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (43)         (46)         (48)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
   Mesentery                                          (6)          (3)          (6)          (8)                                    
      Sarcoma                                          1 (17%)                                                                      
   Pancreas                                           (47)         (49)         (49)         (48)                                   
   Pharynx                                                                                   (1)                                    
      Palate, Squamous Cell Papilloma                                                         1 (100%)                              
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
   Tooth                                              (1)          (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (39)         (47)         (44)         (47)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                          3 (8%)       6 (13%)      6 (14%)      4 (9%)                                
   Islets, Pancreatic                                 (46)         (49)         (48)         (47)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (47)         (50)         (50)         (49)                                   
      Pars Distalis, Adenoma                          23 (49%)     31 (62%)     27 (54%)     24 (49%)                               
      Pars Distalis, Carcinoma                         1 (2%)                    2 (4%)       1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  9 (18%)      4 (8%)       6 (12%)      7 (14%)                               
      C-Cell, Carcinoma                                1 (2%)       3 (6%)       3 (6%)       1 (2%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (1)                                                              
      Sarcoma                                          1 (50%)      1 (100%)                                                        
      Squamous Cell Carcinoma                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (47)         (43)         (40)                                   
      Adenoma                                          3 (7%)       1 (2%)       6 (14%)      5 (13%)                               
      Carcinoma                                        4 (9%)       5 (11%)      3 (7%)       2 (5%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Bilateral, Adenoma                               2 (5%)                                                                       
   Ovary                                              (49)         (50)         (50)         (49)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                   1 (2%)       1 (2%)                                                          
      Polyp Stromal                                   15 (31%)     12 (24%)     14 (28%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (31)         (6)          (4)          (29)                                   
   Bone Marrow                                        (49)         (49)         (49)         (50)                                   
   Lymph Node                                         (50)         (49)         (50)         (50)                                   
   Lymph Node, Mandibular                             (43)         (46)         (45)         (44)                                   
   Lymph Node, Mesenteric                             (48)         (48)         (49)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
   Thymus                                             (39)         (42)         (36)         (42)                                   
      Thymoma Benign                                   1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (47)         (48)         (43)                                   
      Adenocarcinoma                                                1 (2%)       1 (2%)       2 (5%)                                
      Fibroadenoma                                    19 (41%)     23 (49%)     20 (42%)     18 (42%)                               
      Fibroadenoma, Multiple                                        1 (2%)                                                          
   Skin                                               (50)         (46)         (48)         (48)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                 2 (4%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Carcinoma Adenosquamous                          1 (2%)                                                                       
   Nose                                               (47)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                    (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                    1 (2%)                                             
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (44)         (45)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                             9 (18%)     17 (34%)     15 (30%)     24 (48%)                               
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.06% LF     0.3% MF      0.6% HF                                   
                                                   UF                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          46          49          46                                       
     Total Primary Neoplasms                          108         117         106         111                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          44          45          40                                       
     Total Benign Neoplasms                            83          88          81          73                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          23          21          33                                       
     Total Malignant Neoplasms                         25          29          25          38                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           2                                       
     Total Metastatic Neoplasm                          1                       1           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          22           20           25           22                                     
    Dead                                               1            2            2            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           28           23           24                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (49)         (49)         (48)                                   
   Intestine Large, Colon                             (48)         (49)         (50)         (50)                                   
   Intestine Large, Rectum                            (50)         (47)         (47)         (49)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (49)         (48)         (48)         (46)                                   
   Intestine Small, Jejunum                           (50)         (48)         (49)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                          (3)          (9)          (3)          (2)                                    
      Liposarcoma                                                                1 (33%)                                            
   Pancreas                                           (49)         (49)         (47)         (47)                                   
      Acinus, Adenoma                                                                         1 (2%)                                
      Acinus, Carcinoma                                                                       1 (2%)                                
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (46)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (44)         (49)         (49)         (46)                                   
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Pheochromocytoma Benign                         11 (25%)     17 (35%)     13 (27%)     16 (35%)                               
      Bilateral, Pheochromocytoma Benign               5 (11%)      3 (6%)       4 (8%)       3 (7%)                                
   Islets, Pancreatic                                 (49)         (49)         (46)         (48)                                   
      Adenoma                                          2 (4%)       4 (8%)       2 (4%)       1 (2%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (48)         (49)         (49)         (48)                                   
      Pars Distalis, Adenoma                          16 (33%)     27 (55%)     19 (39%)     19 (40%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Carcinoma                                                            1 (2%)                                
      C-Cell, Adenoma                                  4 (8%)       8 (16%)      1 (2%)       6 (12%)                               
      C-Cell, Carcinoma                                3 (6%)       3 (6%)       1 (2%)       2 (4%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (48)         (50)         (49)         (47)                                   
      Adenoma                                          2 (4%)       6 (12%)      2 (4%)       5 (11%)                               
      Carcinoma                                        3 (6%)       6 (12%)      3 (6%)       5 (11%)                               
   Prostate                                           (47)         (49)         (50)         (49)                                   
   Seminal Vesicle                                    (48)         (49)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Liposarcoma, Metastatic                                                    1 (2%)                                             
      Bilateral, Interstitial Cell, Adenoma           29 (58%)     36 (72%)     35 (70%)     33 (66%)                               
      Bilateral, Interstitial Cell, Carcinoma          1 (2%)                                                                       
      Interstitial Cell, Adenoma                      13 (26%)      9 (18%)     13 (26%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (25)         (8)          (10)         (23)                                   
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Mediastinal, Histiocytic Sarcoma                                                        1 (2%)                                
   Lymph Node, Mandibular                             (47)         (45)         (49)         (45)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (48)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (40)         (37)         (40)         (42)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (34)         (35)         (36)                                   
      Fibroadenoma                                     4 (11%)      5 (15%)      1 (3%)       1 (3%)                                
   Skin                                               (50)         (50)         (48)         (49)                                   
      Basal Cell Adenoma                               1 (2%)                                 1 (2%)                                
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Keratoacanthoma                                  3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                 1 (2%)                                
      Squamous Cell Papilloma                          2 (4%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     6 (12%)      4 (8%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Osteoma                                                                                 1 (2%)                                
   Skeletal Muscle                                                 (1)                       (1)                                    
      Hemangiosarcoma                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (49)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                 1 (2%)                                
      Glioma Malignant                                                                        1 (2%)                                
      Granular Cell Tumor NOS                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Adrenal Gland                                       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Pheochromocytoma Malignant, Metastatic                        1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (2%)                                
   Nose                                               (49)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)          (2)                       (3)                                    
      Squamous Cell Papilloma                                                                 1 (33%)                               
   Eye                                                (3)          (5)          (11)         (8)                                    
      Carcinoma, Metastatic, Harderian Gland                        1 (20%)                                                         
   Harderian Gland                                    (4)          (5)          (9)          (6)                                    
      Carcinoma                                                     1 (20%)                                                         
   Zymbal's Gland                                                               (4)          (2)                                    
      Carcinoma                                                                  4 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hamartoma                                                                               1 (2%)                                
      Lipoma                                                                                  1 (2%)                                
      Renal Tubule, Adenoma                            3 (6%)                    3 (6%)       3 (6%)                                
   Urinary Bladder                                    (49)         (48)         (47)         (46)                                   
                                                             Page  10                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            27 (54%)     26 (52%)     24 (48%)     20 (40%)                               
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                           2 (4%)       5 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05035-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 09/05/94  
Route: DOSED FEED                                                                                                 Time: 00:14:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.06% LM     0.3% MM      0.6% HM                                   
                                                   UM                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          145         178         141         152                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          50          49                                       
     Total Benign Neoplasms                           103         128         102         109                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          34          34          35                                       
     Total Malignant Neoplasms                         42          50          39          42                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           3           2                                       
     Total Metastatic Neoplasm                          3           4           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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