National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2627

TDMS Study 05035-03 Pathology Tables

NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 16:11:14




       Facility:  TSI Mason Research

       Chemical CAS #:  103-90-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     A  +  +  +     +  +     +        +  +  A  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      Parasite Metazoan                    |          4        2     4                       2           2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Parasite Metazoan                    |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     A  +  +  +     +  +     +        A  +  A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Basophilic Focus                     | X  X     X  X     X           X  X     X        X        X  X  X     X   |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change                         |       1                 3  2     1        3              2  1     2      |             
      Granuloma                            | 2        2  3     2           2  2     4        2           3  2         |             
      Hepatodiaphragmatic Nodule           |          X                                                  X            |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic, Focal         |             2                                                            |             
      Necrosis, Focal                      |                                           1                              |             
      Bile Duct, Hyperplasia               |    1  2  1              1     2           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Necrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Acinus, Atrophy, Focal               |    4  3                                                  4     3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |                         3                                                |             
      Hyperplasia, Basal Cell              |             1                                            3               |             
      Ulcer                                |                         4                                                |             
      Epithelium, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      Inflammation, Chronic                |                         3                                            1   |             
      Mineralization                       |                                                 2                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    2     2  1     1     2        2     1  1     2        1  1  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Atrophy                              |                                                                   4      |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |          2  2     2        3                                         2   |             
      Hyperplasia                          | 2                                                                        |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  M  I  +     +  +     +        +  +  +  +  +   |             
      Hyperplasia, Focal                   |                                                                      2   |             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  M  +  M     +  +     +        +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +     +  +  +  +     +  +     +        +  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +  +     M  +     +        +  +  +  +  +   |             
      Pars Distalis, Angiectasis           | 3                                               2                        |             
      Pars Distalis, Cyst                  | X  X  2           X        X     X        X                 X     X      |             
      Pars Distalis, Hemorrhage            |                                                                4         |             
      Pars Distalis, Hyperplasia, Focal    |                         2     1                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      C-Cell, Hyperplasia                  |    2  1  1  1     2        1  1        1        2           1     3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Abscess                              |          2                                               2               |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                           4                              |             
      Inflammation, Acute                  |                                                                   2      |             
      Inflammation, Chronic                |                                  1                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +     +  +  +  +     +  +     M        +  +  +  +  +   |             
      Cyst                                 |    X              X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +  +  +     +  +     M        +  +  +  +  +   |             
      Angiectasis                          |                               2                                          |             
      Atrophy                              |                                                                   3      |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Mineralization, Focal                |                               3                                          |             
      Prolapse                             |                                                                      X   |             
      Thrombosis                           |                                           X                              |             
      Endometrium, Hyperplasia, Cystic     |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +     +     +     +  +     +        +                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Hyperplasia                          |                         2  2              2                 2            |             
      Myelofibrosis                        |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Mediastinal, Congestion              |                                                                          |             
      Pancreatic, Congestion               |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +     +  +  +  M     +  +     +        +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   | 3  3  2  2  3     2        3  2        2        4        3  3     4  4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Granuloma                            | 2  2     2  2     4        2  2        2  2     2           2  2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Granuloma                            |                   4                                                      |             
      Hematopoietic Cell Proliferation     | 2  2     2  2              4     2     2        2        2     2     3   |             
      Pigmentation, Hemosiderin            |    2     2  2                    2     2                 2  3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     +  M  +  +     +  +     +        +  +  +  +  +   |             
      Congestion                           |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +     +  +  +  M     +  +     +        +  +  +  +  +   |             
      Ectasia                              |                                                                   4      |             
      Galactocele                          |    X        X     X           X                          X     X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Abscess                              |                                                                          |             
      Hyperkeratosis                       |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
      Hyperostosis                         |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Myopathy Degenerative                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +     +     +  +     +        +  +  +  +  +   |             
      Hemorrhage                           |                         4                                      2         |             
      Hydrocephalus                        |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|             
                                           | 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Congestion                           |                                                          3               |             
      Hemorrhage, Focal                    |                                                                4         |             
      Infiltration Cellular, Histiocyte    |                   3        4                                             |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Peribronchial, Inflammation, Chronic | 2  2     2  1     1        2                    2           1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  A  +  +   |             
      Fungus                               |                                                                   4      |             
      Hemorrhage                           |                                  4                                       |             
      Inflammation, Acute                  |                                                                   4      |             
      Inflammation, Chronic                |    2  2  2  2                                   2           2            |             
      Metaplasia, Squamous                 | 2     2                                                  2        3      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                 +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     | +                             +  +                          +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                +                          +            |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         | 2                                4                          2            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +  +     +  +     +        +  +  +  +  +   |             
      Abscess, Multiple                    |                                           3                              |             
      Cyst                                 |                            X                                             |             
      Nephropathy                          | 1  2  1  2  1     2     2  2  2  1     1  1     1        1  2  1  3  1   |             
      Renal Tubule, Pigmentation           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     A  +  +  +     +  +     M        A  +  A  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Parasite Metazoan                    |          2        3           3     3                          2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Parasite Metazoan                    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X           X     X        3  X           X  X  X  X  X|             
      Clear Cell Focus                     |                               X                                          |             
      Fatty Change                         |                   1  3  1        1     3                 2              1|             
      Granuloma                            | 1     3  2  2           2     3     2                       3  3  1     2|             
      Hepatodiaphragmatic Nodule           |       X     X                 X  X     X     X                           |             
      Hyperplasia, Focal                   |       2                                                              2  2|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2        1                          2  2        2        2     2  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  +              +                           |             
      Fat, Necrosis                        |                               3              1                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |       2              2  2           2           3           2     2  2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Acanthosis                           |             3                                                            |             
      Diverticulum                         |                      4                                                   |             
      Hyperkeratosis                       |                                                 4                        |             
      Hyperplasia, Basal Cell              |                                                 4                        |             
      Ulcer                                |                                              2           4               |             
      Epithelium, Inflammation, Acute      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                           4                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 3     1              3           1     2                             2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                      4                                                   |             
      Cytoplasmic Alteration, Focal        |             2     2                          2              2            |             
      Hyperplasia                          |                      3                                                   |             
      Necrosis, Focal                      |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  M  +  I  +  +  +  I  +  +  +  A  +  +        I  +  M  I  M  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M        +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                      3                                                   |             
      Pars Distalis, Cyst                  |    X  X              X  X  X                 X           X           X  X|             
      Pars Distalis, Hemorrhage            |                                              3                           |             
      Pars Distalis, Hyperplasia, Focal    |          4        3              1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  2     2           3              1           2  1     2  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +        +                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  M  +  M  +  M  +  +  +        +  +  +  +  +  +|             
      Abscess                              |    3                                                           3         |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                                                                   2      |             
      Inflammation, Chronic                | 2                                            3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Cyst                                 |                                  X                       X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Prolapse                             |                                                                          |             
      Thrombosis                           | X                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +              +              +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Hyperplasia                          |    2                       3                                             |             
      Myelofibrosis                        |                      1                                      2     2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Mediastinal, Congestion              |                            3                                             |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  A  +  M        M  +  M  +  +  +|             
      Congestion                           |                                                             2            |             
      Granuloma                            |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Infiltration Cellular, Plasma Cell   | 2  4     2  4  2  4           2  4  2  2     3                          2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +|             
      Congestion                           |                   4                                                      |             
      Granuloma                            |    2  2  2  3  2  2  2        2  2  4  3                 2  2  2     3  2|             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Granuloma                            |                                                             4            |             
      Hematopoietic Cell Proliferation     | 2  2  2        2     4  2  4  2        2     2  2        2     2  2  2  2|             
      Pigmentation, Hemosiderin            | 3              3  2              3  2  3     2  2              2  2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  M  M  +  +  +  M  +  +  +  +  +  M        M  +  +  +  M  M|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  M  +  +|             
      Ectasia                              | 3           3     4                          3           2     4        4|             
      Galactocele                          |    X  X                          X     X                 X     X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Abscess                              |                   2                                                      |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hyperostosis                         |    X     X                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Myopathy Degenerative                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hemorrhage                           |                            1                                             |             
      Hydrocephalus                        |             2  2                       2                 3     2        3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|             
                                           | 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Congestion                           |                         1     1                                          |             
      Hemorrhage, Focal                    |                                              2  1                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                              3                           |             
      Peribronchial, Inflammation, Chronic | 1                       2  1        2                       1        1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
      Fungus                               | X                    3                                                   |             
      Hemorrhage                           |                                              2                           |             
      Inflammation, Acute                  | 2                    2                                                   |             
      Inflammation, Chronic                |       2        2        3           2           2           2     2  2   |             
      Metaplasia, Squamous                 |                         3  2           2     2                           |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                               2  2                             1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +           +                    +           +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +           +           +                    +           +   |             
      Inflammation, Chronic                |                         2           2                                    |             
      Pigmentation                         |             3                       2                    2           3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Abscess, Multiple                    |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1     1  1  4  3  1  1  1     1  1  1  2  1  1  1        3  2  2  1  1  1|             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |  47        |
      Parasite Metazoan                    | 4     2                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |  48        |
      Parasite Metazoan                    |                                                                          |     10  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +                                                |  49        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A                                                |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |  48        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X                                                |     38  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Fatty Change                         |                                                                          |     15  1.8|
      Granuloma                            | 2  2        1  3  3                                                      |     26  2.3|
      Hepatodiaphragmatic Nodule           | X     X                                                                  |     10     |
      Hyperplasia, Focal                   |          4                                                               |      4  2.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Necrosis, Focal                      |                         2                                                |      2  1.5|
      Bile Duct, Hyperplasia               | 2                                                                        |     15  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                                         |   6        |
      Fat, Necrosis                        | 4              4                                                         |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  M                                                |  47        |
      Acinus, Atrophy, Focal               | 3              1  2                                                      |     15  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Acanthosis                           |                                                                          |      1  3.0|
      Diverticulum                         |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      2  3.5|
      Hyperplasia, Basal Cell              |                   1                                                      |      4  2.3|
      Ulcer                                |                                                                          |      3  3.3|
      Epithelium, Inflammation, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |  49        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Cardiomyopathy                       | 3  2  3  2  2  3  3     2                                                |     27  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +                                                |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Congestion                           |    4                                                                     |      2  4.0|
      Cytoplasmic Alteration, Focal        |          4        2  2                                                   |     12  2.3|
      Hyperplasia                          |                                                                          |      2  2.5|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +                                                |  39        |
      Hyperplasia, Focal                   | 3  2                 3                                                   |      4  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M                                                |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +                                                |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +                                                |  47        |
      Pars Distalis, Angiectasis           |          2        4                                                      |      5  2.8|
      Pars Distalis, Cyst                  | X     X           X  X                                                   |     22  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia, Focal    | 3                                                                        |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  49        |
      C-Cell, Hyperplasia                  |    3     1  2        1                                                   |     25  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +                                                |  43        |
      Abscess                              | 4                                                                        |      5  2.8|
      Cyst                                 |       X                                                                  |      1     |
      Ectasia                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +                                                |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Prolapse                             |                                                                          |      1     |
      Thrombosis                           |                                                                          |      2     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +                                                   |  31        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +                                                |  49        |
      Hyperplasia                          |                                                                          |      6  2.2|
      Myelofibrosis                        | 3                                                                        |      5  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +                                                |  50        |
      Mediastinal, Congestion              | 4                                                                        |      2  3.5|
      Pancreatic, Congestion               | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |  43        |
      Congestion                           |                                                                          |      1  2.0|
      Granuloma                            |    2                                                                     |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   | 2  3  3     3     4  3                                                   |     32  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M                                                |  48        |
      Congestion                           |                                                                          |      1  4.0|
      Granuloma                            | 3  2  2  2  2  2  3  2                                                   |     36  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Granuloma                            | 4                                                                        |      3  4.0|
      Hematopoietic Cell Proliferation     | 2        2  2  2  3  2                                                   |     33  2.2|
      Pigmentation, Hemosiderin            |    2        3     2  3  3                                                |     23  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +                                                |  39        |
      Congestion                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +                                                |  46        |
      Ectasia                              |                                                                          |      8  3.4|
      Galactocele                          |                                                                          |     13     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +                                                |  49        |
      Hyperostosis                         |    X              X  X                                                   |      7     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Myopathy Degenerative                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +                                                |  49        |
      Hemorrhage                           |                                                                          |      3  2.3|
      Hydrocephalus                        |                                                                          |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      3  1.7|
      Hemorrhage, Focal                    |                                                                          |      3  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  3.5|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  3.0|
      Peribronchial, Inflammation, Chronic | 2  2  1  2        2                                                      |     20  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +                                                |  47        |
      Fungus                               |                                                                          |      3  3.5|
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Acute                  | 2                                                                        |      4  2.5|
      Inflammation, Chronic                |    2  2        2                                                         |     17  2.1|
      Metaplasia, Squamous                 | 3     2                                                                  |     10  2.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                      2                                                   |      6  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   8        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      7  2.6|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6|                                            |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    UF                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |  50        |
      Abscess, Multiple                    |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2  1  1  1  3  2  1  2  1                                                |     48  1.5|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A                                                |  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +        +  +  +  +  M        +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  M  +  +|             
      Parasite Metazoan                    |          2                          4                                   3|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  4     2           4              4  3   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X           X  X  X  X  X        X     X     X  X  X   |             
      Fatty Change                         |                      3                                                  3|             
      Granuloma                            | 2     2        2                                   2        4     3      |             
      Hepatodiaphragmatic Nodule           |       X                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |          1        1                                   2                  |             
      Bile Duct, Hyperplasia               |    4     1           4              2              1  2  2               |             
      Hepatocyte, Hyperplasia              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Fat, Necrosis                        |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              | 4  2                 1                                                   |             
      Ulcer                                |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Inflammation, Subacute               |                   4                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  2     2     2        3  3     2  2           3     2     3  2  3|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Congestion                           |                      2                                                   |             
      Cytoplasmic Alteration, Focal        | 2     2                       2  2                             2         |             
      Hypertrophy                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  I        +  +  +  +  +        +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      3   |             
      Pars Distalis, Cyst                  | X              X  X  X        X        X  X              X     X         |             
      Pars Distalis, Hemorrhage            |                                           3                              |             
      Pars Distalis, Hyperplasia, Focal    |                                        2                          4      |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1           1     2        2        1           2     1        4  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Abscess                              |                               4           3                              |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Cyst                                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Dilatation                           |                                  2                                       |             
      Prolapse                             |                                                                          |             
      Thrombosis                           |                                                       X        X         |             
      Endometrium, Cyst                    |                                                       X  X               |             
      Endometrium, Hyperplasia, Cystic     |                2                 2                                       |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
      Cyst                                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +        +  I  +  +  +        +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3  3                    2           2                 3|             
      Myelofibrosis                        |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                4                                                        3|             
      Mediastinal, Granuloma               |                                                                          |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Granuloma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |    2     3     3  3  2        2  3  3  2           3     3  2  2  3  2  3|             
      Lymphatic, Angiectasis               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  A|             
      Congestion                           |                   2                                                      |             
      Granuloma                            | 2     2        2              4  2  2  2  2        2  2  3     2  2  3   |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                   4           2  4  2     2        2     2     2  2  2   |             
      Pigmentation, Hemosiderin            | 3              3                       2           2        3        3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +        +  M  +  +  +        +  +  +  M  M  M  +  A|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  M  +  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Galactocele                          |          X        X                                            X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  M  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Abscess                              |                                  4                                       |             
      Ulcer                                |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                             4            |             
      Choroid Plexus, Perivascular,        |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|             
                                           | 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                3                 1  2                          2         |             
      Peribronchial, Inflammation, Chronic | 2              2  2           2  2  2  1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Abscess                              |                                  4                                       |             
      Fungus                               |                      X                                      X            |             
      Inflammation, Acute                  |                      2              2  2                    3     2      |             
      Inflammation, Chronic                |       1  2        2           2                                          |             
      Metaplasia, Squamous                 |       2  2     2     2           4                             2  2      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
      Inflammation, Chronic                |                                                                3         |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                 +                             +  +     A|             
      Cornea, Inflammation, Acute, Focal   |                                                                2         |             
      Retina, Degeneration                 |                3                                                  2      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                 +                                +      |             
      Inflammation, Chronic                |                                                                   2      |             
      Pigmentation                         |                1                 3                                3      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +        +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1     3  1  1        1  1  4  1  2        1  2  4  1  1  2  1  1|             
      Artery, Inflammation, Subacute       |                   4                                                      |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Pigmentation           |                                                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +        +  +  +  +  A        +  +  +  +  +  +  +  A|             
      Inflammation, Chronic                | 2                                      1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Parasite Metazoan                    |                      2        2                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Parasite Metazoan                    |                                        4        4              2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Parasite Metazoan                    |                                                 2     2                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Basophilic Focus                     | X        X  X  X  X  X  X  X  X     X  X  X  X  X     X     X  X         |             
      Fatty Change                         |                                                          4               |             
      Granuloma                            |          2           2     3                                   2         |             
      Hepatodiaphragmatic Nodule           |             X  X     X        X                             X  X         |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |                   1                 1                                    |             
      Bile Duct, Hyperplasia               |       2           2     2                 2                              |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                             +                  |             
      Fat, Necrosis                        |                         4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  +  +      |             
      Acinus, Atrophy, Focal               |          2           2              2  2  1                    2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Hyperplasia, Basal Cell              |       2                                                  2               |             
      Ulcer                                |             3                             4                              |             
      Perivascular, Inflammation, Chronic  |                                                             2            |             
      Submucosa, Edema                     |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Cardiomyopathy                       | 2        2  2  2              2     2  3  2                 3            |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Hypertrophy                          | 4                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  I  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     M  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  I  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                   X  X                    X     X     X     X            |             
      Pars Distalis, Hemorrhage            |                                                                   4      |             
      Pars Distalis, Hyperplasia, Focal    | 3                                         2                              |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      C-Cell, Hyperplasia                  |          4  3  1  3  1  1  3        1  2        2        2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +  +  +  +  +  +  +  M     +  +  +  +  +     +  +  M  +  +      |             
      Abscess                              |                                           3                              |             
      Cyst                                 |                   X                 X           X     X                  |             
      Inflammation, Acute                  | 4                                                                        |             
      Inflammation, Chronic                |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Atrophy                              |                                                                          |             
      Cyst                                 |             X        X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Atrophy                              |                                                                          |             
      Dilatation                           |                                                                3         |             
      Prolapse                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                    +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Hyperplasia                          |          2                                2              3  2            |             
      Myelofibrosis                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Mediastinal, Congestion              |                                                          2               |             
      Mediastinal, Granuloma               |                                                                          |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Granuloma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  M  +  M      |             
      Congestion                           |             3                                                            |             
      Infiltration Cellular, Plasma Cell   | 4     4  3  2  3     2     4  2     3  3     3  3        2     2         |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  M  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Congestion                           | 4                                                                        |             
      Granuloma                            |       2  2  3  2  2  2        2     3  2  2  2  3     3     2  2         |             
      Lymphatic, Angiectasis               |                2  2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2     2     2  2     2  2           2  2  2  2        2     2  3         |             
      Pigmentation, Hemosiderin            |       2     2  2  2  3  2  2        2        2        2        2  2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  M  +  +  +     +  +  +  +  M     +  +  +  +  +      |             
      Cyst                                 |                3                    X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  M  +  +  M  +     +  +  +  +  +     +  +  +  +  +      |             
      Abscess                              |                                           3                              |             
      Ectasia                              |                                                                   4      |             
      Galactocele                          |       X                       X                 X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +     M  +  +  M  +     +  +  +  M  +      |             
      Abscess                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Hyperostosis                         |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Hydrocephalus                        |             3                                            2        2      |             
      Choroid Plexus, Perivascular,        |                                                                          |             
          Inflammation, Chronic            |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|             
                                           | 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    0.06% LF                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Peribronchial, Inflammation, Chronic |                      2     2        2        2              2  2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Abscess                              |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                            4           2                                 |             
      Inflammation, Chronic                |       3  3     3  3  3  3           3        3  3     2     2            |             
      Metaplasia, Squamous                 |          2                 2                                2            |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                          +        +         |             
      Cornea, Inflammation, Acute, Focal   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +              +                          +                  |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |             2                                         2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +      |             
      Nephropathy                          | 4     1  1  3  2  1  1  2  1  1     1  2  4  2  1        2  1  1  1      |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Renal Tubule, Cyst                   |          X                                                               |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  A      |             
      Inflammation, Chronic                |                               1     1                          2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |  48        |
      Parasite Metazoan                    | 4  2  3                                                                  |      7  2.6|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                   2                                                      |      7  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |             2  4                                                         |      9  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Basophilic Focus                     | X  X  X  X  X  X                                                         |     39     |
      Fatty Change                         |                   3        3                                             |      5  3.2|
      Granuloma                            |       2  4  2        4     2                                             |     15  2.5|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      8     |
      Hyperplasia, Focal                   |                      4  4                                                |      2  4.0|
      Necrosis, Focal                      |                                                                          |      5  1.2|
      Bile Duct, Hyperplasia               | 2  2     2     2                                                         |     15  2.1|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Acinus, Atrophy, Focal               |    1     2  2           3  2                                             |     12  1.9|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Basal Cell              |                                                                          |      5  2.2|
      Ulcer                                |                   4                                                      |      3  3.7|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
      Submucosa, Edema                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Subacute               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 3  2  2     2           2                                                |     29  2.2|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                            2                                             |      7  2.0|
      Hypertrophy                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  46        |
      Hyperplasia                          |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |    X  X     X  X  X                                                      |     20     |
      Pars Distalis, Hemorrhage            |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia, Focal    |    2  2                                                                  |      6  2.5|
      Pars Intermedia, Cyst                | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  | 3     1  2     1  2        4                                             |     26  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +                                             |  47        |
      Abscess                              |                                                                          |      3  3.3|
      Cyst                                 |                      X                                                   |      5     |
      Inflammation, Acute                  |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                   3                                                      |      2  2.5|
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                   3                                                      |      2  3.0|
      Dilatation                           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Prolapse                             |                      X                                                   |      1     |
      Thrombosis                           |                                                                          |      2     |
      Endometrium, Cyst                    |                                                                          |      2     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  2.0|
      Serosa, Inflammation, Acute          |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +              +                                                      |   6        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                   3  2     3                                             |     12  2.5|
      Myelofibrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mediastinal, Congestion              |                                                                          |      3  3.0|
      Mediastinal, Granuloma               |                            3                                             |      1  3.0|
      Renal, Angiectasis                   |                            3                                             |      1  3.0|
      Renal, Granuloma                     |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   | 2     2  2  3     4  4  3  2                                             |     38  2.7|
      Lymphatic, Angiectasis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      2  3.0|
      Granuloma                            | 2  2  2  2  2  3     2  3  3                                             |     38  2.3|
      Lymphatic, Angiectasis               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                         4                                                |      1  4.0|
      Hematopoietic Cell Proliferation     | 2     2  2  2  2     2                                                   |     29  2.2|
      Pigmentation, Hemosiderin            | 2        3     2        2                                                |     22  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +                                             |  42        |
      Cyst                                 |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Abscess                              |                                                                          |      1  3.0|
      Ectasia                              |                         4                                                |      2  4.0|
      Galactocele                          |                   X  X                                                   |      8     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperostosis                         |       X                                                                  |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |                      2                                                   |      5  2.6|
      Choroid Plexus, Perivascular,        |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                         4                                                |      5  2.4|
      Peribronchial, Inflammation, Chronic |       2  2  2  2     2                                                   |     18  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Fungus                               |                                                                          |      2     |
      Inflammation, Acute                  |                                                                          |      7  2.4|
      Inflammation, Chronic                | 2  2  3  3  3  3                                                         |     21  2.6|
      Metaplasia, Squamous                 |          2  3  3        2                                                |     14  2.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +  +                                                         |  11        |
      Cornea, Inflammation, Acute, Focal   |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +     +                                                            |   8        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation                         |       2     2                                                            |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 6| 4| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.06% LF                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 2  3  3  1  1  1  1  1  1  2                                             |     49  1.6|
      Artery, Inflammation, Subacute       |                                                                          |      1  4.0|
      Renal Tubule, Cyst                   |                                                                          |      1     |
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  A  +                                             |  45        |
      Inflammation, Chronic                |                   2                                                      |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        M  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Parasite Metazoan                    |       3                                                        3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +        +  +     +  +  M     +  +     +  +  +     +|             
      Parasite Metazoan                    |             2                                                     2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Parasite Metazoan                    |    2  3           2                                            2  2      |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Basophilic Focus                     | X  X  X     X  X  X  X        X        X     X     X  X     X  X  X      |             
      Cyst                                 |                                                                          |             
      Fatty Change                         |          2                                                              2|             
      Granuloma                            |                                           3        1                     |             
      Hepatodiaphragmatic Nodule           |                X              X  X     X                                 |             
      Hyperplasia, Focal                   |                   3                          2                           |             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Focal                      |       1     1  1                             2                           |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    2     3  2                                      2              2      |             
      Perivascular, Inflammation, Chronic  |                                                       1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +                                                         |             
      Fat, Necrosis                        |          4     4                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Edema                                |          2                                                               |             
      Acinus, Atrophy, Focal               |                               3  2     2                       3        2|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Acanthosis                           |                                                                   3      |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Inflammation, Chronic                |                                  3                                       |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Cardiomyopathy                       |    2     3  2  2  3  3           2        2  3     2        2  1         |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Atrophy                              |                                                                   4      |             
      Cytoplasmic Alteration, Focal        |                                  2                                      2|             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Hyperplasia, Focal                   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  M  +        +  +     M  +  M     +  +     +  +  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Cyst                  |          X     X  X  X        X           X                              |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                       1     1  2         |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      C-Cell, Hyperplasia                  |                2     3           2     1           2  1     1  1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  M  M  +  +  +        +  +     M  +  +     +  +     +  M  M     +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                  X        X                              |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                               2                                          |             
      Inflammation, Chronic                |                               2                             4            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                   4      |             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Atrophy                              |                                                                   3      |             
      Thrombosis                           |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                   +                 +         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +        +  +     +  I  +     +  +     +  +  +     +|             
      Hyperplasia                          |    1                                         1                          3|             
      Myelofibrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +        +  M     +  +  +     +  M     +  M  +     +|             
      Congestion                           |                                           2                              |             
      Infiltration Cellular, Plasma Cell   | 2  3  2  4  2  2  2  3                 2  3  3     2        2     4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Congestion                           |                      2                 2                                 |             
      Granuloma                            | 2  2        2  2  3           2  2        3  2              2  3  2      |             
      Artery, Inflammation, Acute          |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     | 3           2  2                 3        4  2                    2      |             
      Hemorrhage                           |                                                             3            |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            | 2     3     2  2  3  2           2     3  2        3        2     2      |             
      Capsule, Hemorrhage                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +        +  +     M  M  M     +  +     +  M  M     +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +        +  +     M  +  +     +  +     +  +  M     +|             
      Ectasia                              |                                                                          |             
      Galactocele                          |          X        X                                X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Hyperostosis                         |       X  X                                X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Congestion                           |             2                                                            |             
      Fungus                               |                                                                          |             
      Hemorrhage, Focal                    |                                              2                           |             
      Peribronchial, Inflammation, Chronic |             2     2  2        2  2        2        2        2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Inflammation, Chronic                |                3  3  3                 2           2  2     3  2         |             
      Metaplasia, Squamous                 | 2  2  2                                   2           2        2         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Ulcer, Multifocal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +  +        +                  |             
      Retina, Degeneration                 |                                                       3                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +  +                           |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                                           3  2                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Nephropathy                          | 2  1  3  1  2  2  3  1        1  4     1  2  1     2        2  2        1|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +     +  +  +     +  +     +  +  +     +|             
      Inflammation, Chronic                |                                           2                              |             
      Artery, Inflammation, Chronic        |                   4                                                      |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |          3        4                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |    4                       2  2                 4                        |             
      Artery, Inflammation, Chronic        |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     | X  X              X  X  X     X  X  X        X  X  X           X         |             
      Cyst                                 |    X                                                                     |             
      Fatty Change                         |       2  2        2                    3              2           2     2|             
      Granuloma                            |             1           3                    2                           |             
      Hepatodiaphragmatic Nodule           |             X  X                    X                                    |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |       2                                                                  |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Cyst                      |                                        X                                 |             
      Bile Duct, Hyperplasia               |       3                    2                 2  3     2     1     4      |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                   +                 +      |             
      Fat, Necrosis                        |             4                                   4                 4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +|             
      Angiectasis                          |                   2                                                      |             
      Edema                                |                                                                          |             
      Acinus, Atrophy, Focal               |                2                    2           1                        |             
      Artery, Inflammation, Chronic        |                               3                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Acanthosis                           |                            2                                             |             
      Hyperkeratosis                       |                   4                                                      |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |          2                                                               |             
      Artery, Inflammation, Chronic        |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  2  3              2  2        2        2  2  3           2         |             
      Artery, Inflammation, Chronic        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                              2  2  2                     |             
      Necrosis, Focal                      |                                                                         3|             
      Vacuolization Cytoplasmic            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  M  +  +  M  M  +  +     +  +  +  +     I  +  M  +  +|             
      Hyperplasia, Focal                   | 2  2                                               2           2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  M  +  +  +  +  +  +  +  M  +  M  +     M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         4                                                |             
      Pars Distalis, Cyst                  | X     X                          X  X        X        X        X  X      |             
      Pars Distalis, Hemorrhage            |                         4                                                |             
      Pars Distalis, Hyperplasia, Focal    |    4     2                       2  3                             2     2|             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     3  2     1  2        2           3     4  1     1     1  2         |             
      Follicle, Cyst                       |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Abscess                              |          3                                                               |             
      Cyst                                 |                X                    X                                    |             
      Ectasia                              |          4                                                               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                   X        X     X           X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                      2   |             
      Thrombosis                           |                                                 X                        |             
      Endometrium, Cyst                    |                X                    X           X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |       3                                                        2        2|             
      Myelofibrosis                        |                                        3              4        2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Lymphatic, Angiectasis  |                               3                                          |             
      Renal, Congestion                    |          4                                                               |             
      Renal, Pigmentation                  |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Infiltration Cellular, Plasma Cell   | 4  3  3        2  2     2  3  2     2  3     2  2  3        2  3     2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +|             
      Congestion                           |          2                                                               |             
      Granuloma                            | 2  2  2     2  2  2  2  2  2     2  2        2  2  2        3        3   |             
      Artery, Inflammation, Acute          |                               3                                          |             
      Artery, Thrombosis                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Granuloma                            |             2                                                            |             
      Hematopoietic Cell Proliferation     | 2  2                    2     3  2  2        2  2           2  2     2   |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |       3                                                                  |             
      Pigmentation, Hemosiderin            | 2  2     3  3        3  2  3     3  2        3  2  3        3        3   |             
      Capsule, Hemorrhage                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  +  +  +  M  +  M  +  M     +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Ectasia                              |                         2  3                                         4   |             
      Galactocele                          |    X              X              X           X                       X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  I|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperostosis                         |                               X                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                         2                                               2|             
      Hydrocephalus                        |             2     2     2  2                                         3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|             
                                           | 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.3% MF                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Congestion                           |                         4                                                |             
      Fungus                               |                                                       X                  |             
      Hemorrhage, Focal                    |                                                                          |             
      Peribronchial, Inflammation, Chronic |    2     2  2           2        2  2        2  2  2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                         2        2     2     2  2  2                 2   |             
      Metaplasia, Squamous                 | 2  3     2     2  2     3  2                 2     2                    2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Ulcer, Multifocal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                      +                    +      |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                      +                    +      |             
      Inflammation, Chronic                |                                              1                           |             
      Pigmentation                         |       2                                                           2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Nephropathy                          | 3  3  1  4  1  2  3  2  1  3  1  1  1  1     1  2  2  1     2  1  1  2  1|             
      Artery, Inflammation, Chronic        |                               3                                          |             
      Renal Tubule, Degeneration           |                                                                   2      |             
      Renal Tubule, Pigmentation           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |                               2                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      9  2.6|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +                                             |  50        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  A                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Basophilic Focus                     | X  X  X  X        X                                                      |     32     |
      Cyst                                 |                                                                          |      1     |
      Fatty Change                         |                         3  3                                             |     11  2.3|
      Granuloma                            | 2        2                                                               |      7  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      8     |
      Hyperplasia, Focal                   |                                                                          |      2  2.5|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Necrosis, Focal                      |             4                                                            |      5  1.8|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2                                                                        |     13  2.3|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   6        |
      Fat, Necrosis                        |    4                                                                     |      6  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +     +  +                                             |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Acinus, Atrophy, Focal               |                   2                                                      |      9  2.1|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +     +  +                                             |  50        |
      Acanthosis                           |                                                                          |      2  2.5|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +     +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Cardiomyopathy                       | 2  2  2  2        2                                                      |     28  2.2|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Cytoplasmic Alteration, Focal        |    2                                                                     |      6  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +                                             |  44        |
      Hyperplasia, Focal                   |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +     +     +  +                                             |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +     +  +                                             |  50        |
      Pars Distalis, Angiectasis           |    3     2                                                               |      4  2.8|
      Pars Distalis, Cyst                  |       X           X     X                                                |     17     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |     10  2.1|
      Pars Intermedia, Cyst                |    X                                                                     |      1     |
      Pars Intermedia, Hyperplasia         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +     +  +                                             |  50        |
      C-Cell, Hyperplasia                  |          3                                                               |     21  1.9|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +     +     M  +                                             |  43        |
      Abscess                              |       4                                                                  |      2  3.5|
      Cyst                                 |                                                                          |      4     |
      Ectasia                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                         X                                                |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Atrophy                              |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Cyst                    |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +     +  +                                             |  49        |
      Hyperplasia                          |                         3                                                |      7  2.1|
      Myelofibrosis                        |                            4                                             |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +     +  +                                             |  50        |
      Mediastinal, Congestion              |             3                                                            |      1  3.0|
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |      1  3.0|
      Renal, Congestion                    |                                                                          |      1  4.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  +  +  +     +     +  +                                             |  45        |
      Congestion                           |                                                                          |      2  2.5|
      Infiltration Cellular, Plasma Cell   | 3     2  2  2     4                                                      |     35  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +                                             |  49        |
      Congestion                           |                                                                          |      3  2.0|
      Granuloma                            | 2  2  2  2        2     3                                                |     34  2.2|
      Artery, Inflammation, Acute          |                                                                          |      1  3.0|
      Artery, Thrombosis                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Granuloma                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  2     2  4     2                                                      |     23  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |          2        3                                                      |     28  2.5|
      Capsule, Hemorrhage                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +     +     +  M                                             |  36        |
      Congestion                           |             3                                                            |      1  3.0|
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +     +  +                                             |  48        |
      Ectasia                              |                            2                                             |      4  2.8|
      Galactocele                          | X     X                                                                  |     10     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +  +     +     +  +                                             |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Hyperostosis                         |    X                                                                     |      6     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +     +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        |                                                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Congestion                           |                                                                          |      2  3.0|
      Fungus                               |                                                                          |      1     |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Peribronchial, Inflammation, Chronic | 2  3     2  1     2                                                      |     22  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +     +  +                                             |  50        |
      Inflammation, Chronic                | 3                                                                        |     16  2.3|
      Metaplasia, Squamous                 |    2     2                                                               |     18  2.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   1        |
      Ulcer, Multifocal                    |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   7        |
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   5        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 3| 4| 7| 4| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8|                                            |            |
                                           | 5| 5| 5| 9| 2| 4| 5| 3| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.3% MF                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +     +  +                                             |  50        |
      Nephropathy                          | 2  1  2     1     2     1  1                                             |     47  1.7|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Renal Tubule, Degeneration           |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                         2                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +     +  A                                             |  49        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |    2                                                                     |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +     +  M  +  M  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |    2                                         2                       4   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |    4                          3                                      4   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Basophilic Focus                     | X  X  X           X           X  X              X                 X      |             
      Clear Cell Focus                     |                                                                   X      |             
      Fatty Change                         |    3     3  3              1     2  1  2        2     4  2              2|             
      Granuloma                            | 2                                                        4               |             
      Hepatodiaphragmatic Nodule           |                                  X           X                           |             
      Hyperplasia, Focal                   |       4           4     2     1                                      2  2|             
      Necrosis, Focal                      |                            1                                             |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2                       2  1     2  3     2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +        +                       +|             
      Fat, Necrosis                        |                                     3  4        4                       4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                         1                                                |             
      Acinus, Atrophy, Focal               |                               3                 3                    1   |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Acanthosis                           |                         4                                                |             
      Hyperkeratosis                       |                         2                                               4|             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |             1                                            1               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2              2     1     2           2        2     2  3  2  2|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                   2                       2              2        2  4  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |       2  2              2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +     +  M  +  +  +  +  +  +  +  +  M  +     +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |             3                                                            |             
      Pars Distalis, Cyst                  |       X  X                             X  X  X  X  X           X  X      |             
      Pars Distalis, Hyperplasia, Focal    |          2                          2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                                   2  2     2                 1  2  3   |             
      Follicular Cell, Hyperplasia         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +     +     M  +  +  +  M  +  +  +  +  M  +  M     M  +  +  +|             
      Abscess                              |                                        3                                 |             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 | X                                                        X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Metestrus                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +           +     +     +     +        +  +              +  +  +   |             
      Lymphocytosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |          2  2                       2  2  3     2     2                  |             
      Myelofibrosis                        |    4                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Inguinal, Lymphatic, Angiectasis     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  I  +  +  +     M     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                 2                        |             
      Infiltration Cellular, Plasma Cell   | 2     2     3                 3  2     2  2     2  3  2  2        3  4   |             
      Lymphatic, Angiectasis               |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |    4                                                                    4|             
      Granuloma                            | 2     2     3     2           2     2  2     2  2  3     3        1      |             
      Infiltration Cellular, Plasma Cell   |                                                                      4   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Granuloma                            |                                              2                           |             
      Hematopoietic Cell Proliferation     | 3  4              2     2  1  2     2                    2        2  2  2|             
      Infarct                              |                                        4                                 |             
      Pigmentation, Hemosiderin            |                            2        2                    2        2  3  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +     M  +  +  +  M  M  +  +  +  +  +  +     M  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +     +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +|             
      Ectasia                              |                                                                          |             
      Galactocele                          |    X                    X                                X     X  X      |             
      Hypertrophy                          |          2                                                               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperostosis                         |          X              X     X                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
      Hydrocephalus                        |                         2     2  3                    2  2               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                         1                                                |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Peribronchial, Inflammation, Chronic | 2  1                    2  2        2        2                    2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|             
                                           | 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                            3                                             |             
      Inflammation, Chronic                |       2     1           2           2        2                    2      |             
      Metaplasia, Squamous                 |       2     2                    2  2           2  1              3      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                  2                                   2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +  +  +     +              +                  |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +  +     +              +                  |             
      Pigmentation                         |                               4  2     3              2                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Cyst                                 |             X                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 2  2  1  1  1     3     4  1  1  2        1  1  2  1  3  2     1  2  3  4|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |             1                          2  1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Chronic                |       2                                                                  |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Parasite Metazoan                    |       3                    4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Parasite Metazoan                    | 4                       2  2                    2        2  3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Parasite Metazoan                    |                4           3           2        2                    3   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Basophilic Focus                     |       X        X           X     X     X     X        X  X     X  X      |             
      Clear Cell Focus                     | X                                                                        |             
      Fatty Change                         |          2        2  4                                               3   |             
      Granuloma                            | 2              2        3                    1  1                        |             
      Hepatodiaphragmatic Nodule           | X                                X                                   X   |             
      Hyperplasia, Focal                   |          4                                                  2            |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                      3     2     2     2     2        3        1  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +              +            |             
      Fat, Necrosis                        |                                              3              3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  M  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Acinus, Atrophy, Focal               |       1        2                                                         |             
      Duct, Ectasia                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |          3                                3                              |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2     2        2        1        2        1  2        1           2  2   |             
      Artery, Inflammation, Chronic        |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |          2                                   2              3  3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +  M  +  +  +     +     +  +  +  +     M  +  M  +  +  +   |             
      Hyperplasia, Focal                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  M  M  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  M  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +  +  +  +     +     +  +  +  +     M  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                          2           2   |             
      Pars Distalis, Cyst                  |       X        X     X                 X        X              X  X  X   |             
      Pars Distalis, Hyperplasia, Focal    |                                           2     2              3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |                         2                 2     1     1  4        1  1   |             
      Follicular Cell, Hyperplasia         |                                        1                    1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +     +  +  +  +  +     +     +  M  +  +     +  +  M  +  M  +   |             
      Abscess                              | 3                          3                                             |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Congestion                           |                                              2  2                        |             
      Cyst                                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Dilatation                           |          2                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +  +                                                               |             
      Metestrus                            |       X  X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +        +  +              +     +  +  +  +     +  +  +  +  +      |             
      Lymphocytosis                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |          3        2  2                    2     2                    3   |             
      Myelofibrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Inguinal, Lymphatic, Angiectasis     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +  +  +  +  +     +     +  +  M  M     +  +  M  +  +  +   |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |       2  2     2     3  3  2              3           2           3  3   |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Granuloma                            | 2     2        2        2  3     2     2     2  2     2  1  2     2      |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Granuloma                            |                4                 3                                       |             
      Hematopoietic Cell Proliferation     | 2                          2           2     2        2  2        2      |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            | 2                       2  3     3     2        2     2     2     2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +     +  +  +  +  +     +     +  M  +  +     +  +  M  +  M  +   |             
      Cyst                                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +     +  +  +  +  +     +     +  M  +  +     M  M  +  M  +  +   |             
      Ectasia                              |                3        2                                                |             
      Galactocele                          |                X                                X                        |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  M  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                        X                                 |             
      Hemorrhage, Focal                    |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Hyperostosis                         | X                    X                                         X  X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                         2                                                |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
      Degeneration                         |                            2                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                                          2               |             
      Peribronchial, Inflammation, Chronic | 3     2                    2           2     2  2     2  2  2     2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|             
                                           | 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6% HF                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               |                X     3                                                   |             
      Inflammation, Acute                  |       2        2     2                                                   |             
      Inflammation, Chronic                |                            3     2     2     2  2     3           1      |             
      Metaplasia, Squamous                 |                            3                                   2  2      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                                        2                       2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +        +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +  +              +  +                           |             
      Lens, Degeneration                   |                         1                    3                           |             
      Retina, Degeneration                 |                         3                 4  4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Pigmentation                         |                                           3                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Calculus Gross Observation           |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 3     2        1        1  1     3     3  4  1  2     2  2  3  2  2  2   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                   3                                                      |             
      Renal Tubule, Hyperplasia            |                                                       1                  |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +   |             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    | 2  2                                                                     |     10  2.9|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |    X                    X                                                |     20     |
      Clear Cell Focus                     |                                                                          |      2     |
      Fatty Change                         |                1     1                                                   |     17  2.2|
      Granuloma                            |             2                                                            |      8  2.1|
      Hepatodiaphragmatic Nodule           |                         X                                                |      6     |
      Hyperplasia, Focal                   |                                                                          |      8  2.6|
      Necrosis, Focal                      |                1                                                         |      2  1.0|
      Bile Duct, Cyst                      | X                                                                        |      1     |
      Bile Duct, Hyperplasia               |    1     4        3  1                                                   |     19  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +                                                            |   8        |
      Fat, Necrosis                        |          4  4                                                            |      8  3.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +  +  +                                             |  48        |
      Angiectasis                          |                                                                          |      1  1.0|
      Acinus, Atrophy, Focal               |    1     4        3  2                                                   |      9  2.2|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +                                             |  49        |
      Acanthosis                           |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      4  3.0|
      Ulcer                                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |             2        1                                                   |      4  1.3|
      Mineralization                       |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 2  3     4  1  2     2     1                                             |     30  1.9|
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +                                             |  49        |
      Atrophy                              |                   3                                                      |      1  3.0|
      Congestion                           |                            2                                             |      1  2.0|
      Cytoplasmic Alteration, Focal        | 2  2     3                                                               |     13  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +                                             |  47        |
      Hyperplasia, Focal                   |             1                                                            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  M  +  +  +  M  M                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |                      2                                                   |      4  2.3|
      Pars Distalis, Cyst                  | X        X     X        X  X                                             |     22     |
      Pars Distalis, Hyperplasia, Focal    |    3     2  2              2                                             |      9  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |                2                                                         |     15  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +     +  +  +  +  +  M  +                                             |  40        |
      Abscess                              |                                                                          |      3  3.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +  +  +  +  +  M                                             |  49        |
      Congestion                           |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Metestrus                            |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +     +                                                               |  29        |
      Lymphocytosis                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          | 3        2     2  3                                                      |     17  2.3|
      Myelofibrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +  +  +  +                                             |  50        |
      Inguinal, Lymphatic, Angiectasis     | 4                                                                        |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  M                                             |  44        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   | 2  2     2     4        3                                                |     28  2.5|
      Lymphatic, Angiectasis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                3           2                                             |      4  3.3|
      Granuloma                            |          2  2                                                            |     27  2.1|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Granuloma                            |                                                                          |      3  3.0|
      Hematopoietic Cell Proliferation     | 4                                                                        |     19  2.2|
      Infarct                              |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |    2           3        2  4                                             |     19  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +  +  +  +  M                                             |  42        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +  +  +  +  M  M                                             |  43        |
      Ectasia                              |             4                                                            |      3  3.0|
      Galactocele                          |          X                                                               |      8     |
      Hypertrophy                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +  +  +                                             |  48        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hyperostosis                         |             X        X                                                   |     10     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  2.0|
      Peribronchial, Inflammation, Chronic | 2  2                       2                                             |     22  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Fungus                               |                                                                          |      2  3.0|
      Inflammation, Acute                  |                                                                          |      4  2.3|
      Inflammation, Chronic                |                         1                                                |     14  1.9|
      Metaplasia, Squamous                 |    2        2     3  2                                                   |     14  2.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
      Lens, Degeneration                   |                                                                          |      2  2.0|
      Retina, Degeneration                 |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   5        |
      Pigmentation                         |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Calculus Gross Observation           |                            X                                             |      1     |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Nephropathy                          | 1  3     1  4  2  2  1                                                   |     43  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 5| 5| 3| 3|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0|                                            |            |
                                           | 0| 0| 4| 9| 8| 0| 5| 4| 4| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6% HF                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Hyperplasia                     |                            3                                             |      2  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Calculus Gross Observation           |                            X                                             |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                            4                                             |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              2                           |             
      Ulcer                                |                         4                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                2                                   3              4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   2  2                             2              3     2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X                    X            |             
      Clear Cell Focus                     |                                                 X                        |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change                         |          4  1                                         3  2           2   |             
      Granuloma                            |                                                                2         |             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                       X           X      |             
      Hyperplasia, Focal                   |                                           2                             2|             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Focal                      |                                                                1         |             
      Bile Duct, Hyperplasia               | 2     2     2  3  2     2     2        2  4  2  2  3  2  3  2     2  2  2|             
      Subserosa, Thrombosis                |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 3        2  3  4     2        3        2     2  3           2     2      |             
      Artery, Inflammation, Chronic        |                                                    4                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Karyomegaly                          | 2        2  2  2  2  2  3     2        3  3  2  2  2  2  2  3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                              1                           |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Serosa, Inflammation, Chronic        |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3        2  2  3  2  2  3     3        2     2  3  3     2  2  2  2      |             
      Atrium, Inflammation, Chronic        |                2                                                         |             
      Atrium, Thrombosis                   |                      X                                               X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                               2                                         3|             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  I  +|             
      Hyperplasia, Focal                   |                                                                2  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +     +        +  +  +  +  +  M  +  +  +  +  M  I|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                               X                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2  2     2  2  3        3        2  3  2  2        2        4  2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2              4        2              1                 3  2  2  4|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                         X|             
      Ectasia                              |          3                                                               |             
      Inflammation, Acute                  |          3                                                               |             
      Inflammation, Chronic                | 1     2           1  1        1        1  2     2  2     1  1            |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       3        2        3     3              2  3  3     4               |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute                  |                                                       3     1     3     2|             
      Inflammation, Chronic                |                                        2                                 |             
      Metaplasia, Squamous                 |                                                                         2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |       3        4  3     3     4           3  3  4  4  3  3  4     4  4   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          2                                                               |             
      Seminiferous Tubule, Atrophy         |       3        3  4  3  3     3        4  1  4  3  4  3  3  3     4  3   |             
      Seminiferous Tubule, Hypospermia     |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +  +           +        +     +  +  I        +  +  +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3        2  2  3  3                    2                 2        2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                      3                                                   |             
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |             
      Pancreatic, Congestion               |       2                                                                  |             
      Pancreatic, Lymphatic, Angiectasis   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  +     +        +  +  +  +  M  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   | 3     4  4  4  3  3  4  4     3        3     4  2           2  2  2     3|             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3     2                                                                  |             
      Granuloma                            |                2  2  2        2        1     2  2  2        2     2     2|             
      Lymphatic, Angiectasis               |                                                                2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                   3                     |             
      Fibrosis, Focal                      |                      2                                                   |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |             2        3        2        2     2                          2|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +  +  +     M        +  +  M  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  M  +  +  +     +        M  +  M  M  M  M  +  +  +  +  M  +|             
      Ectasia                              |             4                                                            |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|             
                                           | 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |             4                                                            |             
      Hyperkeratosis                       |             4                                                            |             
      Hyperplasia, Basal Cell              |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +     +|             
      Hydrocephalus                        |             2                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                                                                          |             
      Peribronchial, Inflammation, Chronic | 2        2  2  2              2        1     2  2  2        2  2        2|             
      Pleura, Fibrosis                     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |          4                             X                                 |             
      Hemorrhage                           |                                                       3     4            |             
      Inflammation, Acute                  |          3                             3                                 |             
      Inflammation, Chronic                | 2     2     1  2     2                    2        1     2  2     2      |             
      Metaplasia, Squamous                 |       2  2  2  2     2        2        3  2  2     2     2  3  2  3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Lens, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Pigmentation                         |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                          3               |             
      Nephropathy                          | 2     2  2  2  4  3  3  2     2        3  2  2  4  2  3  2  3  2  3  1  2|             
      Renal Tubule, Cyst                   |                                                          X               |             
      Renal Tubule, Hyperplasia            |                                           2                              |             
      Renal Tubule, Pigmentation           |       2                 3                                                |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    | 2  4        3                 3                          3               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |    4           2                 3           3  2     2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |    4  4                       3  3                       4     2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Artery, Inflammation, Chronic        |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Basophilic Focus                     |    X                          X                                X         |             
      Clear Cell Focus                     |                                                                          |             
      Cytoplasmic Alteration, Focal        |    2                                                                     |             
      Fatty Change                         |                         3           2                 2                  |             
      Granuloma                            |                   1                                                      |             
      Hemorrhage, Focal                    |                                        3                                 |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Hyperplasia, Focal                   |                                     1                                    |             
      Hyperplasia, Multifocal              |                                                 3                        |             
      Necrosis, Focal                      |          2                          2                                    |             
      Bile Duct, Hyperplasia               | 2  2  2     1  2  2  1        2  3  3     3  2  3  2  3  2  3  2     2  2|             
      Subserosa, Thrombosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Accessory Spleen                     |                               X                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Acinus, Atrophy, Focal               | 1  4  4     2        2  1           2        2              2  2     4  2|             
      Artery, Inflammation, Chronic        |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Karyomegaly                          | 2  1  2  2  3  3     3  3     2  3  2  2  3  2  2  2  2  3  2  2     3  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Acanthosis                           |                                                 2     2                  |             
      Hyperplasia, Basal Cell              |          2                                                               |             
      Inflammation, Chronic                |                                                                         2|             
      Ulcer                                |                         3                             3                  |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cardiomyopathy                       | 3  4  2  1        2  3  2        1     2  3  3     2  2  3  1  3     3  3|             
      Atrium, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |       X                             3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cytoplasmic Alteration, Focal        |                                                    3                     |             
      Necrosis, Focal                      |          2                                            2                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  I  +  +  M     M  I  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Focal                   |       1              3                 2  2     2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +     +  +  +  +  I  +  +  +  +  +  +  +     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Pars Distalis, Angiectasis           |                                  3                                       |             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia, Focal    |    1     3  3                       4                    3               |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                               2                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  | 2        4                                      3  1  1  4  4            |             
      Follicle, Cyst                       |                                                                         X|             
      Follicular Cell, Hyperplasia         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Abscess                              | 2                             2           1                              |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                         2                                                |             
      Inflammation, Chronic                |       2        1                 1                    1              2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  M  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    3                                                           4     4  4|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute                  |                         4                                                |             
      Inflammation, Chronic                |    2     1           2              2  2  1                              |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Atrophy                              | 4  4           4     4  3     4     3              4  3  2  4  4     4  4|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         | 3  3  3  3     3     3        3  3  3           3  3  3  3  4  3     3  3|             
      Seminiferous Tubule, Hypospermia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +  +        +  +           +  +           +  +     +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |    2  3  2  3                       3     3        3     3  2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mediastinal, Congestion              |                                                    2                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Lymphatic, Angiectasis  |                2                                                         |             
      Pancreatic, Congestion               |                                                                          |             
      Pancreatic, Lymphatic, Angiectasis   |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +     +  +|             
      Infiltration Cellular, Plasma Cell   | 3        3     2     4  2     2  3     2     4           2  2  4     4  4|             
      Lymphatic, Angiectasis               |                                        2     4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            | 2  2        2     2              2     2     2              2  3     2  2|             
      Lymphatic, Angiectasis               |          4     2     3  2                                            3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                    3                     |             
      Granuloma                            |                   2                                                      |             
      Hematopoietic Cell Proliferation     |             3        2  2                    1                       1   |             
      Pigmentation, Hemosiderin            |                   2  2  3                                            2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +     +  +  +  M  M  +  +  +  +  M  +  M     +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +     M  +  +  +  +  +  +  M  +  +  M  +     M  M|             
      Ectasia                              |                         2              3     3                           |             
      Galactocele                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|             
                                           | 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hydrocephalus                        |                   2     2              2     2                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                      2                                                   |             
      Peribronchial, Inflammation, Chronic | 2  2        2  1        2              2                 2     2     2  2|             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Fungus                               | X  X                                                  2        X         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                       3        3         |             
      Inflammation, Chronic                | 3  3  2     3                    2     2     2           1               |             
      Metaplasia, Squamous                 | 3  2  2     3  2     2  2        2  2     2  2  3     2  2  2        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +           +           +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +  +            |             
      Lens, Degeneration                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +           +               |             
      Pigmentation                         |                                              3           3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy, Focal                       |                                                                          |             
      Nephropathy                          | 3  2  2  1  1  2  2  4  3     2  2  2  2  2  3  2  3  1  1  2  3     2  4|             
      Renal Tubule, Cyst                   |                                                    X                     |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                                           2                              |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |       2                                                                 2|             
      Transitional Epithelium, Hyperplasia |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +     +  +|             
      Artery, Inflammation, Chronic        |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +     +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +     +  A     +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      6  2.8|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +     +  +     +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      9  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +     +  +     +                                             |  50        |
      Parasite Metazoan                    |                   2                                                      |     12  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +     +     +  +     +                                             |  50        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    M  +     +     +  +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +     +  +     +                                             |  50        |
      Basophilic Focus                     |    X                                                                     |      6     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Fatty Change                         |                   2                                                      |      9  2.3|
      Granuloma                            |                                                                          |      2  1.5|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Hyperplasia, Focal                   |                                                                          |      3  1.7|
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               |    2  2     3        2                                                   |     42  2.2|
      Subserosa, Thrombosis                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  M     +     +  +     +                                             |  49        |
      Acinus, Atrophy, Focal               |    3                 1     2                                             |     26  2.4|
      Artery, Inflammation, Chronic        |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +     +  +     +                                             |  50        |
      Karyomegaly                          |    2  2           2                                                      |     45  2.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +     +     +  +     +                                             |  49        |
      Acanthosis                           |                                                                          |      2  2.0|
      Hyperplasia, Basal Cell              |             2                                                            |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                   2        3                                             |      4  2.8|
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +     +     +  +     +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +     +  +     +                                             |  50        |
      Cardiomyopathy                       |    4  2     2     3  3     3                                             |     40  2.5|
      Atrium, Inflammation, Chronic        |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +     +  +     +                                             |  50        |
      Cytoplasmic Alteration, Focal        |             2                                                            |      4  2.5|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +     +  +     +                                             |  44        |
      Hyperplasia, Focal                   |    3                                                                     |      8  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  M     +     +  +     +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    I  +     +     +  M     +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     I     +  +     M                                             |  48        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     18  2.5|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +     +  +     +                                             |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     15  2.6|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +     +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  M     +     +  +     +                                             |  48        |
      Abscess                              |                                                                          |      3  1.7|
      Cyst                                 |             X                                                            |      2     |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |    2                                                                     |     17  1.4|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +     +  +     +                                             |  47        |
      Atrophy                              |                   3                                                      |     13  3.2|
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
      Inflammation, Acute                  |                      3                                                   |      6  2.7|
      Inflammation, Chronic                |                                                                          |      7  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +     +  +     +                                             |  48        |
      Atrophy                              |       4           4                                                      |     30  3.6|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +     +     +  +     +                                             |  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |    3  3     3     3                                                      |     37  3.1|
      Seminiferous Tubule, Hypospermia     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +  +                                                                  |  25        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +     +  +     +                                             |  50        |
      Hyperplasia                          |             3     3                                                      |     19  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +     +  +     +                                             |  50        |
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |      1  2.0|
      Pancreatic, Congestion               |                                                                          |      1  2.0|
      Pancreatic, Lymphatic, Angiectasis   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +     +  +     +                                             |  47        |
      Infiltration Cellular, Plasma Cell   |       3     4        2     2                                             |     34  3.0|
      Lymphatic, Angiectasis               |    3                                                                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +     M  +     +                                             |  49        |
      Congestion                           |                            2                                             |      3  2.3|
      Granuloma                            |             2                                                            |     23  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphatic, Angiectasis               |    4                                                                     |      7  2.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +     +  +     +                                             |  50        |
      Congestion                           |                                                                          |      2  3.0|
      Fibrosis, Focal                      |                                                                          |      2  2.5|
      Granuloma                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     11  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +     M  +     +                                             |  40        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  M     +     +  +     +                                             |  36        |
      Ectasia                              |                      4                                                   |      5  3.2|
      Galactocele                          |             X        X                                                   |      3     |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +     +  +     +                                             |  50        |
      Acanthosis                           |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +     +  +     +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +     +  +     +                                             |  49        |
      Hydrocephalus                        |                      2                                                   |      6  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +     +  +     +                                             |  50        |
      Congestion                           |                            3                                             |      1  3.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  2.0|
      Peribronchial, Inflammation, Chronic |    2                 3     2                                             |     25  2.0|
      Pleura, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +     +  +     +                                             |  49        |
      Fungus                               |                                                                          |      6  3.0|
      Hemorrhage                           |                                                                          |      2  3.5|
      Inflammation, Acute                  |                                                                          |      4  3.0|
      Inflammation, Chronic                |       2                    2                                             |     20  2.0|
      Metaplasia, Squamous                 |    1  2     2     2        4                                             |     35  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 4| 7| 4| 7| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6|                                            |            |
                                           | 4| 6| 6| 5| 3| 4| 4| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    UM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +     +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Degeneration                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   4        |
      Pigmentation                         |       3                                                                  |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +     +  +     +                                             |  50        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
      Nephropathy                          |    2  3     2     2  3     1                                             |     50  2.3|
      Renal Tubule, Cyst                   |                                                                          |      2     |
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      3  2.3|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +     +  +     +                                             |  49        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +  +  +        +  +  M  +  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               4  2                    2                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +  +  +        +  +  +  M  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       3                          4                          2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               4  4  2                       3        2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Muscularis, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |             2                          4        2                       1|             
      Granuloma                            |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X     X           X                             X         |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |    1  1                                               4                  |             
      Bile Duct, Hyperplasia               |    3  2        3  4  3        3  2  2     3  2  2        2  2  2     2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +     +                                 |             
      Fibrosis                             |                                        4                                 |             
      Inflammation, Acute                  |                                        3                                 |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Edema                                |                                                                      3   |             
      Pigmentation, Focal, Hemosiderin     |                                                                          |             
      Acinus, Atrophy, Focal               |             2                    2  3        3  4        2  3  2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Karyomegaly                          |    3  2     3  3  3  2        2  3           3  2     2     3  3  2  3  2|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 3                        |             
      Hyperkeratosis                       |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                        4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Mineralization                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  3     3  3     2        3  3  2  2  3  4  3     2  3  3  3  3  2  2|             
      Atrium, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                      2                                      4  2         |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                2  2                                                      |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     M  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                 3                 2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +  +  M        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                     X               |             
      Pars Distalis, Hyperplasia, Focal    |                   2           2  2                    2     4  3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      2                          2           2     4  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |    X                                                                     |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |       1     1                 1                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |       3        2  2              3           3        3        2         |             
      Inflammation, Acute                  |                                                                   2  2  1|             
      Inflammation, Chronic                |                                     2  2                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |    4  4     3  4  4  3        4  4           3  3     4  2  4  4        3|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Interstitial Cell, Hyperplasia       |             3                                                            |             
      Seminiferous Tubule, Atrophy         |    3  4        4     3        4  4           3  3     3  3  4  3     3  3|             
      Seminiferous Tubule, Hypospermia     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                  +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                    2           3  3     2     2   |             
      Myelofibrosis                        |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +  +  +        M  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |       4                                                                  |             
      Infiltration Cellular, Plasma Cell   |    3  3     3  4     3           3  4  2  4  3  4           4  3  2  2  3|             
      Lymphatic, Angiectasis               |                2     3                 3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            |    1        2  2              2  2  2        2  2     2     2  2  2      |             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2     2                                         4     2           2|             
      Pigmentation, Hemosiderin            |                                     2  3        2              2        2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  M  +        +  M  M  M  +  +  +     +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +     +  +  +  +        +  +  +  +  +  +  +     M  +  M  +  M  M  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                   3                 4  4                                 |             
      Galactocele                          |                                              X                           |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|             
                                           | 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                     2                                   3|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fungus                               |                                                                          |             
      Granuloma                            |                                                                          |             
      Inflammation, Focal, Subacute        |                      2                                                   |             
      Alveolar Epithelium, Metaplasia      |    4                                                                     |             
      Peribronchial, Inflammation, Chronic |    2                          2  2  2  2     2  2     3     2  2        2|             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fungus                               |                                  X                                       |             
      Inflammation, Acute                  |                                  3                                      2|             
      Inflammation, Chronic                |    2  2        2  2  2                                   3     2     2   |             
      Metaplasia, Squamous                 |       2           2  4        2  2                    2  4  2  2     2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                       4                  |             
      Nephropathy                          |    2  3     3  3  2  2        3  3  2  3  2  3  4     3  1  3  3  4  2  2|             
      Renal Tubule, Cyst                   |                                                 X                        |             
      Renal Tubule, Hyperplasia            |                                                                   2      |             
      Renal Tubule, Necrosis, Focal        |                                           2                              |             
      Renal Tubule, Pigmentation           |                      2                                   2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +  +  +        +  +  +  +  +  +  +     A  +  +  +  +  +  +|             
      Concretion                           |                                                                   4      |             
      Inflammation, Chronic                |                               1                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Parasite Metazoan                    |                   2                                                      |             
      Ulcer                                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Parasite Metazoan                    |                   3                 2              2              4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Parasite Metazoan                    |                                  2                                   4  2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Muscularis, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Angiectasis                          |                      1                                                   |             
      Basophilic Focus                     |                            X                                X            |             
      Congestion                           |          4                                                               |             
      Fatty Change                         |                         3                 2                              |             
      Granuloma                            |                                           2                              |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Hyperplasia, Focal                   |                                              2                           |             
      Necrosis, Focal                      |                   1                                                      |             
      Bile Duct, Hyperplasia               |       4  2     2  3  2  2  1  2  2  2  2  1  2  2  4        2  3  2  3  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                       +        +            |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +|             
      Edema                                |                                                                          |             
      Pigmentation, Focal, Hemosiderin     |                                                    3                     |             
      Acinus, Atrophy, Focal               |       4           2  3  3                       2           4     3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Karyomegaly                          | 2     2  2     2  2  2  2     2  2  2  3     3  3  2        2  3  2  2  3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                         3                                                |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cardiomyopathy                       | 3     2  3     2  2  3     2  3  3  2  3  3  3                       3  2|             
      Atrium, Inflammation, Chronic        |                      3                                                   |             
      Atrium, Thrombosis                   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                2                    2                                2   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  I        +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2        2                                3     1  2|             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  +  +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +  +  +  +  +  +  I  +  +  +  +  +  M        +  +  M  +  +|             
      Hyperplasia                          |                                     2  2                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Cyst                  |       X                                                     X            |             
      Pars Distalis, Hyperplasia, Focal    |       2        1           1                                      2  2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2              4                       1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Abscess                              |                                  4                                       |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2        2     1  2  1        2              1     2        2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +     +  +  +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +|             
      Atrophy                              | 2     2  3     2  3  3                             3              3      |             
      Inflammation, Acute                  |                                        2                       4         |             
      Inflammation, Chronic                |                                           2                          2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +     +  +  +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +|             
      Atrophy                              | 4                 4  3  4        3  4  3     4  3  4        4  4  4      |             
      Inflammation, Acute                  |                                                                4         |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                                                                   4      |             
      Interstitial Cell, Hyperplasia       |                                                                         3|             
      Seminiferous Tubule, Atrophy         | 4     3        3  4  4     4  4  3  4  4     4  4  4           2  4  3   |             
      Seminiferous Tubule, Hypospermia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                             +  +              +                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |       3  3           2  4  3     2  3           2  3           3     3  3|             
      Myelofibrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mediastinal, Congestion              |          3                                                               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Congestion                    |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |          3     4  2  2     2  2  2  3  4  3     3  2        2  3        3|             
      Lymphatic, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Congestion                           |       2                                                                  |             
      Granuloma                            |                2  3  2     2           2  3     2  3        2  2  2  2   |             
      Lymphatic, Angiectasis               | 3     3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Fibrosis, Focal                      |                                     2  2        1                        |             
      Hematopoietic Cell Proliferation     |                1     3     4           2                                 |             
      Pigmentation, Hemosiderin            |                                        2  2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  M     M  +  +  +  +  +  M  +  M  +  +  +  +        +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M  +     M  M  M  +  M  +  +  +  +  +  +  +  +        +  +  M  +  +|             
      Abscess                              |                                     3                                    |             
      Ectasia                              |                                     4                          4         |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Dermis, Fibrosis                     |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|             
                                           | 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.06% LM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Fungus                               |                         X                                                |             
      Granuloma                            |                                                    2                     |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                         3                                            2   |             
      Peribronchial, Inflammation, Chronic |                      2        2        2  2  2              2     2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Fungus                               | X                                X     X                                 |             
      Inflammation, Acute                  | 2                                2     4                                 |             
      Inflammation, Chronic                |                   3     2           2     2                 3  2  3  1   |             
      Metaplasia, Squamous                 |                3  2     2           3     2     2           3  3  3  3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +  +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +        +  +                                                      |             
      Pigmentation                         |       3        2                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Mineralization, Focal                |                                                                          |             
      Nephropathy                          | 3     2  2     2  2  1  3  1  3  3  4  4  3  2  3  2        1  3  4  2  1|             
      Renal Tubule, Cyst                   |                         X                                                |             
      Renal Tubule, Hyperplasia            |                                  2  2                                2   |             
      Renal Tubule, Necrosis, Focal        |                                                                          |             
      Renal Tubule, Pigmentation           |                      3     2                                            2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  A     +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    | 2                                                                        |      5  2.4|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                         2                                                |      8  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     M  +  M  +  +  +  +  +                                             |  47        |
      Parasite Metazoan                    |                4  3                                                      |     10  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +                                             |  50        |
      Muscularis, Hypertrophy              |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      1  4.0|
      Fatty Change                         |       3                                                                  |      7  2.4|
      Granuloma                            |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                   1                                                      |      5  1.6|
      Bile Duct, Hyperplasia               | 3        2  3  2  2  2  2  2                                             |     44  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +     +                                             |   9        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Fat, Necrosis                        |                      3     4                                             |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +  +  +  +  +                                             |  49        |
      Edema                                |                                                                          |      1  3.0|
      Pigmentation, Focal, Hemosiderin     |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               | 2                          2                                             |     17  2.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +  +  +  +  +                                             |  50        |
      Karyomegaly                          | 2     1  2  2  2  2  2  2  2                                             |     44  2.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Perforation                          |       X                                                                  |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |       4                                                                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 2              3  3  2  3  2                                             |     40  2.6|
      Atrium, Inflammation, Chronic        |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      6  2.3|
      Hyperplasia, Focal                   |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |       1     2                                                            |      9  1.9|
      Necrosis, Focal                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +                                             |  45        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia, Focal    |             2  1        1                                                |     15  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  | 4           1  1        4                                                |     12  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 2                 1     1                                                |     15  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +  +  +  +  +  +                                             |  49        |
      Atrophy                              |                3                                                         |     16  2.6|
      Inflammation, Acute                  |       2                                                                  |      6  2.2|
      Inflammation, Chronic                | 2                                                                        |      6  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +                                             |  49        |
      Atrophy                              | 4     4        4  4  4  4  4                                             |     35  3.7|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  3.0|
      Seminiferous Tubule, Atrophy         |       4     3  4  4     4  4                                             |     36  3.6|
      Seminiferous Tubule, Hypospermia     | X                    X                                                   |      3     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +           +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |             3  3                                                         |     20  2.8|
      Myelofibrosis                        |                            2                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                3                                                         |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |             3                                                            |      1  3.0|
      Renal, Congestion                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  M  +  +  +  I                                             |  45        |
      Congestion                           |                                                                          |      1  4.0|
      Infiltration Cellular, Plasma Cell   | 3     3  3  2     3  3  3                                                |     38  2.9|
      Lymphatic, Angiectasis               | 3        4                                                               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Granuloma                            | 2        3     2  3  3  3                                                |     30  2.2|
      Lymphatic, Angiectasis               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis, Focal                      |                                                                          |      3  1.7|
      Hematopoietic Cell Proliferation     | 1     2              2                                                   |     13  2.2|
      Pigmentation, Hemosiderin            |       2              2                                                   |      9  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M  +  +  +  +  M  +  +                                             |  37        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  M  +  M  +  M  M  M                                             |  34        |
      Abscess                              |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      5  3.8|
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Basal Cell              | 2                                                                        |      1  2.0|
      Dermis, Fibrosis                     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |          2           2                                                   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Fungus                               |                                                                          |      1     |
      Granuloma                            |                            2                                             |      2  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia      |                                                                          |      3  3.0|
      Peribronchial, Inflammation, Chronic | 2     2                                                                  |     20  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
      Fungus                               |                                                                          |      4     |
      Inflammation, Acute                  |                                                                          |      5  2.6|
      Inflammation, Chronic                |       3     2     2  3  2  2                                             |     22  2.2|
      Metaplasia, Squamous                 | 2     3  2  3  2  3  3  3  2                                             |     30  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                                                               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3|                                            |            |
                                           | 8| 4| 3| 8| 4| 2| 2| 2| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.06% LM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +  +                                                               |   5        |
      Pigmentation                         |       3  3                                                               |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization, Focal                |                                                                          |      1  4.0|
      Nephropathy                          | 2     4  3  2  2  2  3  4  2                                             |     50  2.6|
      Renal Tubule, Cyst                   |                                                                          |      2     |
      Renal Tubule, Hyperplasia            |       1                                                                  |      5  1.8|
      Renal Tubule, Necrosis, Focal        |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +                                             |  48        |
      Concretion                           |             4                                                            |      2  4.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  M  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  A  +  +     +   |             
      Parasite Metazoan                    |             3              4  2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Parasite Metazoan                    |       2                 3  4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Parasite Metazoan                    |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Muscularis, Hypertrophy              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  M  +  +  +  +  +     +  +     +  A  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Angiectasis                          |          4                                                               |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |          3                 1           2                                 |             
      Hepatodiaphragmatic Nodule           |       X                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |    1              1  1                                                   |             
      Bile Duct, Hyperplasia               |    1  2  2  3  2  2  2        3  3  2  2     2  3     2  2  3  3     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  M     +  +  +  +     +   |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage, Focal                    |                                                                      3   |             
      Acinus, Atrophy, Focal               |                            3  3        2     3                 3         |             
      Artery, Hypertrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Karyomegaly                          |    2  3  2     2  2  3  2  3  2  2  2        2  2     2  2  2  2     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Acanthosis                           |                      3                                                   |             
      Hyperkeratosis                       |          3                                                               |             
      Hyperplasia, Basal Cell              |          3                                                           2   |             
      Inflammation, Acute                  |          3                                                               |             
      Perforation                          |                                                                          |             
      Ulcer                                |       4              3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Cardiomyopathy                       |    3  2     3     3  3  2  2  3     2        3  2     2  3  2  3     3   |             
      Dilatation                           |                                                          4               |             
      Atrium, Thrombosis                   |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |       2                       2              2                           |             
      Vacuolization Cytoplasmic            |          3                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     I  +     +  +  +  +     +   |             
      Hyperplasia, Focal                   |                   2  2  2        2  2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  M  +  +     +  M     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  M  +     M   |             
      Hyperplasia                          |       2        2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    4     2  4           3              2              3                  |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    3                                                                     |             
      Pars Intermedia, Pigmentation,       |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      C-Cell, Hyperplasia                  |          2     3        4        1  2  2                    1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
      Concretion                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
      Abscess                              |                2           3     1                                       |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          2           1        2     2        2              2            |             
      Inflammation, Subacute               |    2                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    4  4  3     3  3     2     3                                          |             
      Inflammation, Acute                  |                      4                                                   |             
      Inflammation, Chronic                |                                                          2     2         |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Atrophy                              |    4  4  4     3  4  4        4     3        4  2     2        1         |             
      Dilatation                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Hemorrhage                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                          3               |             
      Seminiferous Tubule, Atrophy         |    4  4  4     3  2  4  4     4  4  3        3  3     4                  |             
      Seminiferous Tubule, Hypospermia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +     +        +  +                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Hyperplasia                          |          4  3           3     3        3        3     3                  |             
      Myelofibrosis                        |       1                          3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Mediastinal, Congestion              |                                                          3               |             
      Pancreatic, Congestion               |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  M     +   |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                   3                             3                        |             
      Infiltration Cellular, Plasma Cell   |    2  2           3  4  4  4  4     3        2  4     1     2        3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Congestion                           |                      3                       3           2     3         |             
      Granuloma                            |    2           3     2     2        2                 3     3            |             
      Lymphatic, Angiectasis               |                   3     3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Congestion                           |                                                          4               |             
      Hematopoietic Cell Proliferation     |                2           2                    3     2                  |             
      Pigmentation, Hemosiderin            |       2              3     2                                3  2         |             
      Thrombosis                           |                                                 X                        |             
      Capsule, Fibrosis, Focal             |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M  +  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  M  +     M  +     M  M  +  +     M   |             
      Ectasia                              |                      4     4                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     M  +  +  +     +   |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|             
                             DAY ON TEST   | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|             
                                           | 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Hydrocephalus                        |                                                             4  3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Congestion                           |                                                          4     2         |             
      Hemorrhage, Focal                    |                4                                                         |             
      Alveolar Epithelium, Metaplasia      |                   3                                                      |             
      Peribronchial, Inflammation, Chronic |    2  2           2  2     3                                2            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Fibrosis                             |                2                                                         |             
      Fungus                               |          X                                                               |             
      Inflammation, Acute                  |          3                                                  2            |             
      Inflammation, Chronic                |       2                 2     3        3     3                 3         |             
      Metaplasia, Squamous                 |       2     2     2     2  2  2     2  3     2        2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +     +           +                                             |             
      Anterior Chamber, Fibrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +           +                                             |             
      Inflammation, Chronic                |          2                 1                                             |             
      Pigmentation                         |          4     3           2                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +     +   |             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |       2                                                                  |             
      Nephropathy                          |    2  4  3  2  4  3  4  2  3  3  2  3  1     3  2     1  1  1  3     2   |             
      Cortex, Necrosis, Focal              |                                        2                                 |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       2                                                                  |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  A  +  M     +   |             
      Concretion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Parasite Metazoan                    |       4                       3                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Parasite Metazoan                    |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Parasite Metazoan                    |       3     4                             2        4                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Muscularis, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +  M  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                         X|             
      Congestion                           |                                                                          |             
      Fatty Change                         |                            1  1                          3              2|             
      Hepatodiaphragmatic Nodule           |                                                                X        X|             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |       1                          1                                       |             
      Bile Duct, Hyperplasia               | 3  3  2     2        2  2  2  2  2  3  2  1  3     2           3        2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +                              |             
      Fat, Necrosis                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  M  +     +     +  +  +  +  +  +  +     +  +     +     +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Acinus, Atrophy, Focal               | 2                    2     2        2     3        2                    2|             
      Artery, Hypertrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Karyomegaly                          | 2  3  3     3     3  2  2  2  2  2  3  3  3  2     3     1  2  2     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     M     +  +  M     +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                               3           2                              |             
      Inflammation, Acute                  |                                                                          |             
      Perforation                          |                                                          X               |             
      Ulcer                                |                                                          4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Mineralization                       | 2                                                                        |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Cardiomyopathy                       | 2  2  2     2        2  2  2  2     2  2  1  2     2     3  3  3     2  1|             
      Dilatation                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Congestion                           |                                                    2                     |             
      Cytoplasmic Alteration, Focal        |                                  2        2        3                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hyperplasia, Focal                   |       3                                            2     3               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +     +     +  +  +  +  +  +  +  M  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  M  +     +  +|             
      Hyperplasia                          |                   2                          2     2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Pars Distalis, Angiectasis           |             2                                                            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 3  3  4           1  3                       2                           |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Intermedia, Pigmentation,       |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      C-Cell, Hyperplasia                  | 1     2                       2  4     2  2  2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                         +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1                    2        2     2     1     2     2               |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    3  2           3                 3  4           3     3  2            |             
      Inflammation, Acute                  |                      2                    2  4                          2|             
      Inflammation, Chronic                |                         2        2                                       |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Atrophy                              | 4  4  4           4  4  4           4  4     3     4     3  4        4   |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hemorrhage                           |                                              4                           |             
      Interstitial Cell, Hyperplasia       |                                                          2              4|             
      Seminiferous Tubule, Atrophy         | 4  4  4     3        4  4        2  2  4  3  4              4  3         |             
      Seminiferous Tubule, Hypospermia     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                   +  +     +     +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hyperplasia                          | 2  3                       2     2  1  3     3     2           3     2   |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Angiectasis                          |                                           4                              |             
      Congestion                           |                                                                         3|             
      Infiltration Cellular, Plasma Cell   | 2  2  4     4     4  2  2  4  4  4  2     3  2     4     2           2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            | 2     3           2  2  2        2  2     2  2     2     2           2   |             
      Lymphatic, Angiectasis               |                               4        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |       2     1        2     3     3        2                              |             
      Pigmentation, Hemosiderin            |                         2                                4               |             
      Thrombosis                           |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M     +     +  +  +  +  +  +  +  M  +  M     +     M  +  M     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +     M  M  +  +  +  M  M  +  M  +     +     +  M  +     +  +|             
      Ectasia                              |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +  +  +  +  +  M  +     +     +  +  +     +  +|             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|             
                                           | 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.3% MM                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hydrocephalus                        |                            2                                            2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Congestion                           |                                                          2               |             
      Hemorrhage, Focal                    |                                                                          |             
      Alveolar Epithelium, Metaplasia      |                      2                                                   |             
      Peribronchial, Inflammation, Chronic |       2     1        2  2  2  2                                         3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Fibrosis                             |                                                                          |             
      Fungus                               |                                        X                 X               |             
      Inflammation, Acute                  |                                        3           2     3               |             
      Inflammation, Chronic                |       2     2           2        2        1  2                       1   |             
      Metaplasia, Squamous                 |       2     4     2  2  3  2  2     2     2  2                          2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                +  +  +        +|             
      Anterior Chamber, Fibrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                +  +  +        +|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         |                         2                                4  2  2        2|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +              +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Cyst                                 |                   X                                                      |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  3  2     1     4  3  3  2  4  3  3  3  1  4     4     4  1  3     3  2|             
      Cortex, Necrosis, Focal              |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            |                      1                                                   |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Concretion                           |                                           2                              |             
      Inflammation, Chronic                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |          3                                                               |      7  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                4                                                         |      5  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +                                             |  47        |
      Parasite Metazoan                    |    2                    4                                                |      7  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Muscularis, Hypertrophy              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      1     |
      Congestion                           |       2  1                                                               |      2  1.5|
      Fatty Change                         |                2        2                                                |      9  1.9|
      Hepatodiaphragmatic Nodule           |    X     X                                                               |      5     |
      Hyperplasia, Focal                   | 3                                                                        |      1  3.0|
      Necrosis, Focal                      |                            3                                             |      6  1.3|
      Bile Duct, Hyperplasia               | 2  2  3     2  2  3  3  3  2                                             |     43  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Congestion                           |                2                                                         |      1  2.0|
      Edema                                | 3                                                                        |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |    2        1        3  3                                                |     16  2.4|
      Artery, Hypertrophy                  |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Karyomegaly                          | 2  2  2  2  3  3  3  3  2                                                |     46  2.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  M  M  +  +  +  +  +  +                                             |  46        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Basal Cell              |                                                                          |      4  2.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                                                                          |      1     |
      Ulcer                                |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 3  2  2  2  2  3        3  2                                             |     42  2.3|
      Dilatation                           |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        | 3     2        2                                                         |      9  2.2|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Focal                   |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +                                             |  46        |
      Hyperplasia                          |                2                                                         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |       2                                                                  |      2  2.0|
      Pars Distalis, Cyst                  |    X                                                                     |      1     |
      Pars Distalis, Hyperplasia, Focal    |       2              2     4                                             |     15  2.8|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
      Pars Intermedia, Pigmentation,       |                                                                          |            |
          Hemosiderin                      |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |    4  2           1                                                      |     17  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Abscess                              |       4              4                                                   |      5  2.8|
      Hyperplasia                          | 1                                                                        |      2  1.5|
      Inflammation, Acute                  |                2                                                         |      1  2.0|
      Inflammation, Chronic                |                                                                          |     13  1.8|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              | 3  3                                                                     |     17  3.0|
      Inflammation, Acute                  |                                                                          |      5  2.8|
      Inflammation, Chronic                |                         2                                                |      5  2.0|
      Inflammation, Subacute               |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              | 3  4     4     4  4  4  4                                                |     32  3.6|
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |             3              3                                             |      5  3.0|
      Seminiferous Tubule, Atrophy         | 4  4  3  3        4  4  3                                                |     33  3.5|
      Seminiferous Tubule, Hypospermia     |                3                                                         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                                                                     |  10        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          | 3                    2  2                                                |     20  2.6|
      Myelofibrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Pancreatic, Congestion               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Angiectasis                          |                                                                          |      1  4.0|
      Congestion                           |                2                                                         |      4  2.8|
      Infiltration Cellular, Plasma Cell   | 4  3     2  4  4  4  2     2                                             |     38  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      4  2.8|
      Granuloma                            | 2     2  1     1  1  1                                                   |     25  2.0|
      Lymphatic, Angiectasis               |    4                                                                     |      5  3.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |       2  2  2  2     2                                                   |     15  2.1|
      Pigmentation, Hemosiderin            |                   2                                                      |      8  2.5|
      Thrombosis                           |                                                                          |      1     |
      Capsule, Fibrosis, Focal             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +                                             |  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  +  M  +  +  +  M                                             |  35        |
      Ectasia                              |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Dilatation                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hydrocephalus                        |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      3  2.7|
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
      Alveolar Epithelium, Metaplasia      |                2        2                                                |      4  2.3|
      Peribronchial, Inflammation, Chronic |          2  2                                                            |     15  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Fungus                               |                                                                          |      3     |
      Inflammation, Acute                  |                         2                                                |      6  2.5|
      Inflammation, Chronic                |          2  1  2     3                                                   |     17  2.1|
      Metaplasia, Squamous                 | 2  2     2  2  3  2  2  3  2                                             |     30  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +     +     +                                                   |  11        |
      Anterior Chamber, Fibrosis           |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6|                                            |            |
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.3% MM                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                I     +                                                   |   9        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Pigmentation                         |                      3                                                   |      9  2.7|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy                          | 3  2  2  3  3  3  3  3  3  2                                             |     50  2.6|
      Cortex, Necrosis, Focal              |                                                                          |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Cyst                   |                X                                                         |      1     |
      Renal Tubule, Hyperplasia            |          1           2                                                   |      3  1.3|
      Renal Tubule, Pigmentation           | 2                       1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Concretion                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +        +  +  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
      Parasite Metazoan                    |          2                                2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Parasite Metazoan                    |                                     2     2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Parasite Metazoan                    |                   4                       2     2  4                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +        +  A  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Ulcer                                |                                                                         4|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Basophilic Focus                     |                   1                                                      |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                  1                                       |             
      Eosinophilic Focus                   |                                                                      3   |             
      Fatty Change                         |                                        1                                 |             
      Hepatodiaphragmatic Nodule           |    X                                                     X               |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2  2           2  3  2  2  1  2     2  2     2  2  3     1     2  3|             
      Centrilobular, Necrosis              |                      3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                            +                     |             
      Edema                                |                                                    3                     |             
      Fat, Necrosis                        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +        +  A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy, Focal               |       1  2                       3     2  1     1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Karyomegaly                          |    2  2  2        2  2  2  2  2  2  1  2  2  2  2  2  2  2     2     2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Acanthosis                           |                                                                      3   |             
      Bulla                                |                                                                          |             
      Hyperkeratosis                       |          1                                                               |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Chronic                |                                     2                                    |             
      Mineralization                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Cardiomyopathy                       |    2  2           2  2     1  1  2  2  2  2  2        1              2   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration, Focal        |                   2                                                     2|             
      Hemorrhage, Focal                    |                                     3                                    |             
      Vacuolization Cytoplasmic            |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  M  +     +     +  +|             
      Hyperplasia, Focal                   |          2              2                                                |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +        +  M  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +        +  I  +  +  +  +  +  I  +  +  +  +  M  +     +     +  +|             
      Hyperplasia                          |                   2                          4     2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                     4     2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      C-Cell, Hyperplasia                  |       1                 1                    4                           |             
      Follicle, Cyst                       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Degeneration, Focal                  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  M     +     +  +|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1                    2  1     1     2        2              2        1|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +        +  +  +  +  M  +  +  +  +  +  +  +  +  +     +     +  +|             
      Abscess                              |                                                                          |             
      Atrophy                              |       4  4                                   3                           |             
      Hyperplasia, Focal                   |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                         2                                            2   |             
      Inflammation, Chronic                |                                  2  2  2           2     2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Atrophy                              |       4  4        3        3           4     3  4  4  3  3     3     4   |             
      Dilatation                           |                               4     4                                    |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hypospermia                          |                                  X                                       |             
      Interstitial Cell, Hyperplasia       |                                           1                          2   |             
      Seminiferous Tubule, Atrophy         |       4           3           3     2           3        3               |             
      Seminiferous Tubule, Hypospermia     |                            3                                   3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +           +           +  +  +        +                 +         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +        +  A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia                          |    3  2                 3                 2        2     3              3|             
      Myelofibrosis                        |                                              3        3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                           4                              |             
      Renal, Lymphatic, Angiectasis        |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  M     M     +  +|             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Plasma Cell   |    3     4        3  4        3  2     4  3  3     4                 4  3|             
      Lymphatic, Angiectasis               |    4                                            4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  +     +     M  +|             
      Congestion                           |          2                                                               |             
      Granuloma                            |    2  2              2        2     2  2  2        2     2     2         |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Lymphatic, Angiectasis               |                   2                                                     4|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                    2                     |             
      Hematopoietic Cell Proliferation     |       2  2        1        2  1              2  2              2     2  3|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M        +  +  +  M  +  +  +  +  +  +  +  M  +  +     M     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +        M  +  +  +  M  M  M  M  M  +  +  +  +  +     M     +  +|             
      Ectasia                              |          2                                         3                 3   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperkeratosis                       |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hydrocephalus                        |                            2                       2                    2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                               1        2                                 |             
      Alveolar Epithelium, Metaplasia      |                            3                                             |             
      Alveolus, Inflammation, Acute, Focal |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                      3   |             
      Peribronchial, Inflammation, Chronic |       1  2        1        2  1        2     2           2              2|             
      Pleura, Inflammation, Chronic, Focal |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Fungus                               |                      X                                                   |             
      Hemorrhage                           |                                        4                                 |             
      Inflammation, Acute                  |                      4                 4                                 |             
      Inflammation, Chronic                |                   2        2                             2               |             
      Metaplasia, Squamous                 |                         2  2     2  3           2     2        2     2  2|             
      Parasite Metazoan                    |                                        4                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +        +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                 +|             
      Anterior Chamber, Inflammation, Acute|                                                       4                  |             
      Lens, Degeneration                   |                                                                         2|             
      Retina, Degeneration                 |                                                                         3|             
      Retrobulbar, Hemorrhage              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Pigmentation                         |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|             
                                           | 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                          2               |             
      Mineralization, Focal                |                                                                          |             
      Nephropathy                          |    2  2  4        4  3  2  3  3  3  3  3  4  4  3  4  3  2     3     4  1|             
      Cortex, Necrosis, Focal              |                                        3                                 |             
      Interstitial Tissue, Hyperplasia     |                                                                          |             
      Renal Tubule, Cyst                   |                   X                                                      |             
      Renal Tubule, Hyperplasia            |                                           2        2                     |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                 3                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +        +  A  +  +  +  +  +  A  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +  +|             
      Parasite Metazoan                    |       3        3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                2                                2           4            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |    3                                      2                          4  3|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Clear Cell Focus                     |          X                                   X                           |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |          3                                                               |             
      Hepatodiaphragmatic Nodule           |                X                                                  X      |             
      Hyperplasia, Focal                   |                                                             2     2      |             
      Necrosis, Focal                      |                                                       1                  |             
      Bile Duct, Hyperplasia               | 2  2  3     2  2  2  2  2  1  1  2  2  2     2  2  2  3     2     2  3  1|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Edema                                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Ectopic Tissue                       |                                                                      X   |             
      Acinus, Atrophy, Focal               | 2           3  1  1           2        2     1  2           4     1  1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Karyomegaly                          | 2  2  2  2  2  2  2  2  1  2  1  2  2  2     2  2  2  2     2     2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Acanthosis                           |                                                                          |             
      Bulla                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |    1                                                                     |             
      Inflammation, Chronic                |                         2                                                |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 2  2  2  3     3  2  2  2  3  2  4  2  3  1     3  2        2           3|             
      Atrium, Thrombosis                   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                      3                                                   |             
      Cytoplasmic Alteration, Focal        |                            3                                             |             
      Hemorrhage, Focal                    |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +|             
      Hyperplasia, Focal                   |    2                                                  3                  |             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M     +  +  +|             
      Hyperplasia                          |                   2     1  4  2                                   2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Cyst                  |                                                                      X   |             
      Pars Distalis, Hyperplasia, Focal    |    2           2                    3     2        1  2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |    2     3              2  3                    4                 2     3|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Degeneration, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
      Concretion                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +     +  +  +|             
      Abscess                              |                               3     2                                    |             
      Ectasia                              |                                                                         3|             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |    1  1        1                 2              2                 2     2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Abscess                              |                                                       4                  |             
      Atrophy                              |    3  4  3                    3                 4  2                 4  3|             
      Hyperplasia, Focal                   | 2                                                                 3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                      3  3  1                                             |             
      Inflammation, Chronic                | 4                                                                 1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              | 4  3  4  3                 4  4        2     4  4  4                 4  4|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hypospermia                          |                                                                          |             
      Interstitial Cell, Hyperplasia       |          2                                                               |             
      Seminiferous Tubule, Atrophy         | 4  3  4        3  3           3        3     3  3           3     2  3  3|             
      Seminiferous Tubule, Hypospermia     |          3                                         3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +     +     +              +  +           I     +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |             3                 2  3  2  3        3     3  2  3        2  2|             
      Myelofibrosis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                        4                                 |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                       4                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                         2                                                |             
      Mediastinal, Lymphatic, Angiectasis  |                         3                                                |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                       4                  |             
      Renal, Lymphatic, Angiectasis        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +     +  +  +|             
      Granuloma                            | 2                                                                        |             
      Hyperplasia, Lymphoid                |                            4                                             |             
      Infiltration Cellular, Plasma Cell   | 4     4  2     4     4  3        2              2  4  2           3      |             
      Lymphatic, Angiectasis               |    3                                                                    4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |          3                                2                              |             
      Granuloma                            |    2  2              2  2  2                    2           2     2  2  2|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Lymphatic, Angiectasis               |             4     3                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                3  4                          2  3                 2      |             
      Hematopoietic Cell Proliferation     |                               2        2     2     2  3                 2|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            |    2     3           2                    2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +|             
      Ectasia                              |          4              2                                                |             
      Hypertrophy                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hydrocephalus                        |          1                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                           2                              |             
      Alveolar Epithelium, Metaplasia      |                   2              2                                       |             
      Alveolus, Inflammation, Acute, Focal |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Peribronchial, Inflammation, Chronic | 2  1           2           2           2  2  1                          2|             
      Pleura, Inflammation, Chronic, Focal |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fungus                               |                                                                         X|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                         4|             
      Inflammation, Chronic                |                                  2           2  2  2  1                  |             
      Metaplasia, Squamous                 |    2        2     2        2  2  2              3  2  2           2     3|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                +           +     +                  |             
      Anterior Chamber, Inflammation, Acute|                                                                          |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Retrobulbar, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +     +                          +           +                        |             
      Pigmentation                         |    2     2                          3           2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|             
                                           | 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6% HM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |                                           3                              |             
      Fibrosis, Focal                      |                                                                          |             
      Mineralization, Focal                |                            3                                             |             
      Nephropathy                          | 3  3  3  3  2  3  3  2  4  4  4  3  2  2     3  4  1  1  1  2     4  2  3|             
      Cortex, Necrosis, Focal              |                                                                          |             
      Interstitial Tissue, Hyperplasia     |                                                                          |             
      Renal Tubule, Cyst                   |                         X                       X                        |             
      Renal Tubule, Hyperplasia            |                         3     1                                          |             
      Renal Tubule, Pigmentation           |             2                                                            |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +  +  +  +     +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +  +  +  +     +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +  +  +  +     +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      8  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +  +  +  +     +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +  +  +  +     +                                             |  49        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |       +     +  +  +  +     +                                             |  50        |
      Basophilic Focus                     |                                                                          |      2  1.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Fatty Change                         |                            1                                             |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Hyperplasia, Focal                   |                2  2                                                      |      4  2.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |       2     1  2  1        2                                             |     43  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Edema                                |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +  +  +  M     +                                             |  47        |
      Ectopic Tissue                       |                                                                          |      1     |
      Acinus, Atrophy, Focal               |       4     3     2                                                      |     20  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +  +  +  +     +                                             |  50        |
      Karyomegaly                          |       2     2  2  2  2     2                                             |     48  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +  +  +  +     +                                             |  50        |
      Acanthosis                           |             2                                                            |      2  2.5|
      Bulla                                |             4                                                            |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +  +  +  +     +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +  +  +  +     +                                             |  50        |
      Cardiomyopathy                       |       3        2     1     3                                             |     35  2.1|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +     +  +  +  +     +                                             |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      3  2.3|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +     +  +  +  +     +                                             |  46        |
      Hyperplasia, Focal                   |                2                                                         |      5  2.2|
      Hyperplasia                          |                   2                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +  +  +  M     +                                             |  48        |
      Hyperplasia                          |                1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +  +  +  +     +                                             |  45        |
      Hyperplasia                          |                                                                          |      8  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +     +  +  +  +     +                                             |  48        |
      Pars Distalis, Cyst                  |                   X                                                      |      2     |
      Pars Distalis, Hyperplasia, Focal    |             2  3                                                         |     10  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +  +  +  +     +                                             |  50        |
      C-Cell, Hyperplasia                  |       4           2  2                                                   |     13  2.5|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +     +  +  +  +     +                                             |  50        |
      Degeneration, Focal                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +     +  +  +  +     +                                             |  47        |
      Abscess                              |                2                                                         |      3  2.3|
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |     15  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +  +  +  +     +                                             |  49        |
      Abscess                              |                                                                          |      1  4.0|
      Atrophy                              |       4     4                                                            |     13  3.5|
      Hyperplasia, Focal                   |                                                                          |      3  2.3|
      Inflammation, Acute                  |                                                                          |      5  2.2|
      Inflammation, Chronic                |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +     +  +  +  +     +                                             |  50        |
      Atrophy                              |       4     4  3  3        4                                             |     29  3.6|
      Dilatation                           |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |       +     +  +  +  +     +                                             |  50        |
      Hypospermia                          |                                                                          |      1     |
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.7|
      Seminiferous Tubule, Atrophy         |       3     3  3  3  2     3                                             |     25  3.0|
      Seminiferous Tubule, Hypospermia     |                                                                          |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +     +  +  +                                                      |  23        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +  +  +  +     +                                             |  49        |
      Hyperplasia                          |             3     3                                                      |     20  2.6|
      Myelofibrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +  +  +  +     +                                             |  49        |
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Mediastinal, Lymphatic, Angiectasis  |                                                                          |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      2  4.0|
      Renal, Lymphatic, Angiectasis        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +  +  +  +     +                                             |  45        |
      Granuloma                            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Plasma Cell   |       2     2  3  2                                                      |     27  3.1|
      Lymphatic, Angiectasis               |                   4                                                      |      5  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +     +  +  +  +     +                                             |  48        |
      Congestion                           |                                                                          |      3  2.3|
      Granuloma                            |                2  2                                                      |     22  2.0|
      Infiltration Cellular, Plasma Cell   |                      3                                                   |      1  3.0|
      Lymphatic, Angiectasis               |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +  +  +     +                                             |  50        |
      Congestion                           |                2                                                         |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      6  2.7|
      Hematopoietic Cell Proliferation     |       2           2  4     2                                             |     20  2.1|
      Necrosis, Focal                      |                      4                                                   |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     M  M  +  +     +                                             |  42        |
      Congestion                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +  M  +  M     M                                             |  36        |
      Ectasia                              |                                                                          |      5  2.8|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +  +  +  +     M                                             |  49        |
      Hyperkeratosis                       |                      4                                                   |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +  +  +  +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +  +  +  +     +                                             |  49        |
      Hydrocephalus                        |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +  +  +  +     +                                             |  50        |
      Congestion                           |                                                                          |      3  1.7|
      Alveolar Epithelium, Metaplasia      |                                                                          |      3  2.3|
      Alveolus, Inflammation, Acute, Focal |                            4                                             |      1  4.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05035-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        4-HYDROXYACETANILIDE                                   Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 16:11:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 6| 4| 6|                                            |            |
                             DAY ON TEST   | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0|                                            |            |
                                           | 5| 4| 0| 4| 0| 0| 0| 9| 4| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.6% HM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Peribronchial, Inflammation, Chronic |                2                                                         |     18  1.7|
      Pleura, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +  +  +  +     +                                             |  49        |
      Fungus                               |                      4                                                   |      3  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Acute                  |                   4                                                      |      4  4.0|
      Inflammation, Chronic                |       2              3                                                   |     10  2.0|
      Metaplasia, Squamous                 |       2              3                                                   |     22  2.2|
      Parasite Metazoan                    |                   2                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +  +  +  +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                                                         |   8        |
      Anterior Chamber, Inflammation, Acute|                                                                          |      1  4.0|
      Lens, Degeneration                   |                2                                                         |      2  2.0|
      Retina, Degeneration                 |                3                                                         |      2  3.0|
      Retrobulbar, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   6        |
      Pigmentation                         |       2                                                                  |      6  2.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +  +  +     +                                             |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Nephropathy                          |       2     3  3  3  2     4                                             |     49  2.8|
      Cortex, Necrosis, Focal              |                                                                          |      1  3.0|
      Interstitial Tissue, Hyperplasia     |                   2                                                      |      1  2.0|
      Renal Tubule, Cyst                   |                X                                                         |      4     |
      Renal Tubule, Hyperplasia            |             1                                                            |      5  1.8|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +  +  +  +     +                                             |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.