Share This:
https://ntp.niehs.nih.gov/go/3070

TDMS Study 05035-03 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/05/94   
EXP: 05035                  4-HYDROXYACETANILIDE               TIME: 00:31:13   
TEST: 03              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55801    
CONT: N01CP9561902                                             CAS: 103-90-2    
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/05/94  
EXP: 05035                  4-HYDROXYACETANILIDE               TIME: 00:31:13  
TEST: 03              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55801   
CONT: N01CP9561902                                             CAS: 103-90-2   
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                         

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL UM                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 23     CENSORED DEATHS 10   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      460   514   568   568   579   582   612   631   632   632                 |
 |      635   640   641   652   661   661   670   682   703   708                 |
 |      712   714   718                                                           |
 |  CENSORED DEATHS                                                               |
 |      464   464   464   464   464   464   464   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.06%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      506   549   579   585   600   603   613   619   624   635                 |
 |      652   669   670   671   687   687   692   715   718   723                 |
 |      723   725                                                                 |
 |  CENSORED DEATHS                                                               |
 |      464   464   464   464   464   465   465   465   465   465                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.3%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 27     CENSORED DEATHS 10   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      441   471   478   484   521   560   582   620   624   627                 |
 |      627   635   638   642   648   655   661   670   692   698                 |
 |      703   703   710   714   715   719   725                                   |
 |  CENSORED DEATHS                                                               |
 |      464   464   465   465   465   465   465   465   465   465                 |
 |                                                                                |
 ==================================================================================

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.6%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 26     CENSORED DEATHS 10   TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      305   442   533   564   577   577   579   585   586   591                 |
 |      606   613   619   643   644   654   657   669   695   695                 |
 |      701   704   704   718   719   723                                         |
 |  CENSORED DEATHS                                                               |
 |      464   464   464   464   464   464   465   465   465   465                 |
 |                                                                                |
 ==================================================================================

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL UM |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  88.3  68.2  54.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.06%      |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  88.0  78.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3%       |   100.0 100.0 100.0 100.0 100.0  92.3  90.3  86.3  66.2  46.2      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6%       |   100.0 100.0 100.0  98.3  98.3  96.7  94.7  80.6  66.5  48.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL UM   0.06%        0.3%         0.6%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.2%        56.0%        46.2%        48.3%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.348      P=0.846N     P=0.548      P=0.631  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       633.7        647.5        628.3        619.3    |
 |NATURAL DEATHS (C)      |       (13.7)       (13.1)       (16.2)       (18.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       648.4        655.0        639.6        637.4    |
 |(STANDARD ERROR)        |       (13.2)       (13.0)       (13.8)       (14.3)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL UF                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      380   396   501   517   574   575   578   596   607   625                 |
 |      644   652   664   668   668   679   683   697   704   724                 |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   464   464   464   464   464                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.06%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      499   501   562   576   581   618   626   627   644   655                 |
 |      670   689   689   694   710   716                                         |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   464   464   464   464   464                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.3%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      372   456   485   506   519   534   570   590   591   611                 |
 |      613   644   676   689   715   718                                         |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   464   464   464   464   464                 |
 |                                                                                |
 ==================================================================================

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0.6%                                     |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      245   308   354   471   519   554   585   585   611   614                 |
 |      628   639   640   640   652   662   668   672   678   690                 |
 |      693   708                                                                 |
 |  CENSORED DEATHS                                                               |
 |      463   463   463   463   463   464   464   464   464   464                 |
 |                                                                                |
 ==================================================================================

                               4-HYDROXYACETANILIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL UF |   100.0 100.0 100.0 100.0  96.7  96.7  92.6  84.6  74.5  60.4      |
 |           |                                                                    |
 |           |                                                                    |
 |0.06%      |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  90.0  80.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.3%       |   100.0 100.0 100.0 100.0  98.3  94.7  88.6  82.6  76.5  68.5      |
 |           |                                                                    |
 |           |                                                                    |
 |0.6%       |   100.0 100.0  98.3  95.0  95.0  93.0  91.0  84.9  68.7  56.6      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL UF   0.06%        0.3%         0.6%     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.4%        68.0%        68.5%        56.6%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.433      P=0.469N     P=0.590N     P=0.754  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       606.6        628.6        580.6        582.5    |
 |NATURAL DEATHS (C)      |       (21.5)       (17.2)       (24.5)       (27.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       644.0        658.0        645.2        631.1    |
 |(STANDARD ERROR)        |       (14.5)       (13.4)       (14.8)       (16.4)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                        4-HYDROXYACETANILIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL UM       = 1
                                                        0.06%            = 2
                                                        0.3%             = 3
                                                        0.6%             = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                               4                    3   1      2
      |                                                 4                    34  1 33   21   4 2  1
      |                                                                             33       4 2 4 22
      |                                                                              3     3     4112  2
P  90 +                                                                                    3    3  11  22
E     |                                                                                         3  41   213 1
R     |                                                                                                  222
C     |                                                                                             4 4    22
E  80 +                                                                                               4 4   2  2
N     |                                                                                                 444311 2  2
T     |                                                                                                   4  1 1
      |                                                                                                      331 12  2
S  70 +                                                                                                      433
U     |                                                                                                        3 11
R     |                                                                                                          31 1241 2
V     |                                                                                                              331122
I  60 +                                                                                                               33
V     |
A     |                                                                                                                3112 1
L     |                                                                                                                 33
   50 +                                                                                                                  44
      |                                                                                                                  33 4
      |                                                                                                                   3 3
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 38 obs hidden.

                                                        4-HYDROXYACETANILIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL UF       = 1
                                                        0.06%            = 2
                                                        0.3%             = 3
                                                        0.6%             = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                      4                   3 1                 2
      |                                        4        4          3 1 1         3
      |
      |                                                 4       4      1         3   3 1         2
   95 +                                                         4                  4 3 131
      |                                                                                          2 2
      |                                                                            4    31 3      1
      |                                                                                    3 3  4 11
   90 +                                                                                            2      2
      |                                                                                      3  4 3 4
P     |                                                                                                   22
E     |                                                                                           31  31
R  85 +                                                                                             4  114
C     |                                                                                                    2 2
E     |                                                                                               3 13 1 2 2
N     |                                                                                                  4 4
T  80 +                                                                                                    1 1 2  2
      |                                                                                                  3 4 1 1
S     |                                                                                                           2  2
U     |                                                                                                      3 1 1 3
R  75 +                                                                                                          113 3
V     |                                                                                                              22
I     |                                                                                                      4 4     32 23
V     |                                                                                                        4 4
A  70 +                                                                                                           11    22
L     |                                                                                                          4411    3  3
      |                                                                                                                  2  2
      |                                                                                                             1 1
   65 +                                                                                                           44  11
      |
      |                                                                                                            4 4 1  1
      |
   60 +                                                                                                                   1 1
      |                                                                                                              4  4
      |
      |                                                                                                                 4   4
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 29881-29881/29881


--multipart-boundary--