National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3084

TDMS Study 05037-04 Pathology Tables

NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97
Route: GAVAGE                                                                                                     Time: 12:43:25




       Facility:  Southern Research Institute

       Chemical CAS #:  1825-21-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 004    VEHICLE CONTROL
                               Include 007    40 MG/KG
                               Include 010    40 MG/KG
                               Include 013    20 MG/KG
                               Include 016    20 MG/KG































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           18           29                                                  
    Natural Death                                      8            6            5                                                  
    Accidently Killed                                  1                                                                            
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           25           16                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (23)         (49)                                                
      Dilatation                                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Basophilic Focus                                 2 (4%)       1 (2%)                                                          
      Cytologic Alterations                            1 (2%)      34 (68%)     39 (78%)                                            
      Eosinophilic Focus                               5 (10%)      1 (2%)       1 (2%)                                             
      Eosinophilic Focus, Multiple                                               3 (6%)                                             
      Hematopoietic Cell Proliferation                 9 (18%)      6 (12%)      9 (18%)                                            
      Inflammation, Subacute                           1 (2%)      28 (56%)     32 (64%)                                            
      Mixed Cell Focus                                              2 (4%)       2 (4%)                                             
      Mixed Cell Focus, Multiple                                                 5 (10%)                                            
      Necrosis                                         1 (2%)       2 (4%)       2 (4%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Biliary Tract, Dilatation                                                  1 (2%)                                             
      Biliary Tract, Hyperplasia                       1 (2%)      16 (32%)     30 (60%)                                            
      Kupffer Cell, Pigmentation                                   37 (74%)     48 (96%)                                            
   Mesentery                                          (25)         (18)         (24)                                                
      Hemorrhage                                                    1 (6%)                                                          
      Inflammation, Suppurative                        8 (32%)      7 (39%)      8 (33%)                                            
      Fat, Necrosis                                   14 (56%)      8 (44%)      8 (33%)                                            
   Pancreas                                           (50)         (28)         (50)                                                
      Acinar Cell, Atrophy                             4 (8%)       3 (11%)      2 (4%)                                             
      Duct, Dilatation                                 1 (2%)       1 (4%)       2 (4%)                                             
   Salivary Glands                                    (50)         (25)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (45)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Hyperplasia                                     12 (24%)      7 (16%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (49)                                                
      Capsule, Spindle Cell, Hyperplasia                            1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Accessory Adrenal Cortical Nodule                2 (4%)       1 (2%)                                                          
      Hypertrophy, Focal                                                         1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
   Parathyroid Gland                                  (47)         (25)         (48)                                                
      Cyst                                                          1 (4%)                                                          
   Pituitary Gland                                    (47)         (49)         (50)                                                
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                      12 (26%)      8 (16%)      4 (8%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     5 (10%)      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                  (1)          (1)                                                 
      Duct, Cyst                                                    1 (100%)     1 (100%)                                           
   Ovary                                              (45)         (36)         (50)                                                
      Abscess                                         12 (27%)     14 (39%)     18 (36%)                                            
      Cyst                                             3 (7%)       8 (22%)      5 (10%)                                            
      Hemorrhage                                                    3 (8%)                                                          
   Uterus                                             (46)         (43)         (50)                                                
      Dilatation                                       9 (20%)                   4 (8%)                                             
      Hyperplasia, Cystic                             42 (91%)     36 (84%)     46 (92%)                                            
      Inflammation, Suppurative                        5 (11%)      6 (14%)     10 (20%)                                            
      Mucosa, Cyst                                     2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (25)         (50)                                                
      Myeloid Cell, Hypercellularity                  17 (34%)     11 (44%)     21 (42%)                                            
   Lymph Node                                         (50)         (50)         (50)                                                
      Iliac, Hyperplasia, Lymphoid                     1 (2%)       1 (2%)       2 (4%)                                             
      Iliac, Inflammation, Suppurative                 1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Inflammation, Suppurative           2 (4%)                    1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                     1 (2%)       1 (2%)       4 (8%)                                             
      Renal, Inflammation, Suppurative                                           1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (47)         (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (49)         (50)                                                
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                21 (42%)     18 (36%)     28 (56%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (23)         (50)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Skin                                               (50)         (26)         (50)                                                
      Inflammation                                                  1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (25)         (50)                                                
      Hypertrophy                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (26)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (27)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)       2 (7%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Suppurative                                     1 (4%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (7%)                                                          
      Mediastinum, Inflammation, Suppurative           5 (10%)      5 (19%)      3 (6%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     7 (14%)     15 (30%)     19 (38%)                                            
      Fungus                                                                     1 (2%)                                             
      Inflammation, Suppurative                        5 (10%)     13 (26%)     21 (42%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (2)          (4)                                                 
      Hyperplasia                                      2 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (25)         (50)                                                
      Amyloid Deposition                               2 (4%)                                                                       
      Hydronephrosis                                   1 (2%)       2 (8%)                                                          
      Nephropathy                                     12 (24%)      3 (12%)      8 (16%)                                            
      Cortex, Cyst                                     1 (2%)                                                                       
      Glomerulus, Inflammation                                      2 (8%)                                                          
      Transitional Epithelium, Hyperplasia                          1 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      2            2                                                               
    Moribund Sacrifice                                17           20           22                                                  
    Accidently Killed                                  1                                                                            
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           27                                                  
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (23)         (50)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Large, Rectum                            (50)         (23)         (50)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Ileum                             (50)         (22)         (49)                                                
      Hyperplasia                                                   1 (5%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       3 (6%)                                                          
      Basophilic Focus                                 5 (10%)      1 (2%)       1 (2%)                                             
      Basophilic Focus, Multiple                                    1 (2%)                                                          
      Clear Cell Focus                                 2 (4%)       1 (2%)       2 (4%)                                             
      Clear Cell Focus, Multiple                                    3 (6%)       3 (6%)                                             
      Cytologic Alterations                                        50 (100%)    50 (100%)                                           
      Eosinophilic Focus                               8 (16%)      1 (2%)                                                          
      Eosinophilic Focus, Multiple                     2 (4%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (4%)                                             
      Inflammation, Subacute                                       49 (98%)     49 (98%)                                            
      Mixed Cell Focus                                 7 (14%)      4 (8%)       5 (10%)                                            
      Mixed Cell Focus, Multiple                       2 (4%)      11 (22%)     22 (44%)                                            
      Necrosis                                         2 (4%)                    1 (2%)                                             
      Biliary Tract, Dilatation                                     1 (2%)       2 (4%)                                             
      Biliary Tract, Fibrosis                                                    1 (2%)                                             
      Biliary Tract, Hyperplasia                                   47 (94%)     48 (96%)                                            
      Kupffer Cell, Pigmentation                       1 (2%)      50 (100%)    50 (100%)                                           
   Mesentery                                          (2)          (9)          (4)                                                 
      Hemorrhage                                                    2 (22%)                                                         
      Fat, Necrosis                                    2 (100%)     5 (56%)      2 (50%)                                            
   Pancreas                                           (50)         (23)         (50)                                                
      Acinar Cell, Atrophy                             5 (10%)      4 (17%)      3 (6%)                                             
      Duct, Dilatation                                                           3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperplasia                                     19 (38%)     23 (46%)     24 (48%)                                            
   Stomach, Glandular                                 (50)         (48)         (49)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Tooth                                              (36)         (10)         (24)                                                
      Dysplasia                                       35 (97%)     10 (100%)    23 (96%)                                            
      Foreign Body                                     1 (3%)                                                                       
      Inflammation, Chronic                                                      1 (4%)                                             
      Inflammation, Subacute                           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (23)         (50)                                                
      Inflammation, Subacute                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (49)                                                
      Capsule, Spindle Cell, Hyperplasia               4 (8%)       2 (4%)       3 (6%)                                             
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    1 (2%)                                             
      Hypertrophy, Focal                               9 (18%)      4 (8%)       7 (14%)                                            
   Adrenal Gland, Medulla                             (50)         (50)         (48)                                                
      Hyperplasia                                                  13 (26%)     29 (60%)                                            
      Hypertrophy                                                   3 (6%)      36 (75%)                                            
   Parathyroid Gland                                  (49)         (22)         (50)                                                
      Cyst                                             2 (4%)                                                                       
   Pituitary Gland                                    (44)         (50)         (47)                                                
      Pars Distalis, Cyst                              3 (7%)       1 (2%)       4 (9%)                                             
      Pars Distalis, Hyperplasia                       1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (24)         (50)                                                
      Granuloma Sperm                                                            1 (2%)                                             
   Preputial Gland                                    (22)         (32)         (26)                                                
      Inflammation, Subacute                           3 (14%)      5 (16%)      2 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Cyst                                      20 (91%)     26 (81%)     26 (100%)                                           
   Seminal Vesicle                                    (50)         (24)         (50)                                                
      Inflammation, Subacute                                        1 (4%)                                                          
   Testes                                             (50)         (23)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (23)         (50)                                                
      Myeloid Cell, Hypercellularity                                             2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Hyperplasia, Lymphoid                               1 (2%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                 7 (14%)      8 (16%)     10 (20%)                                            
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (29)         (50)                                                
      Inflammation, Suppurative                                     1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (24)         (50)                                                
      Hypertrophy                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (23)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05037-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:43:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Foreign Body                                                  1 (3%)                                                          
      Hemorrhage                                                    1 (3%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                7 (14%)      3 (9%)       5 (10%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 7 (14%)      4 (13%)      2 (4%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Exudate, Serous                                  1 (2%)                                                                       
      Foreign Body                                     2 (4%)      14 (28%)     10 (20%)                                            
      Inflammation, Suppurative                        5 (10%)     12 (24%)     10 (20%)                                            
      Mucosa, Atrophy                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (25)         (50)                                                
      Inflammation, Subacute                                        1 (4%)                                                          
      Nephropathy                                     21 (42%)     12 (48%)     17 (34%)                                            
      Cortex, Cyst                                     4 (8%)       3 (12%)      4 (8%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
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