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TDMS Study 05037-04 Pathology Tables

NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97
Route: GAVAGE                                                                                                     Time: 12:31:18




       Facility:  Southern Research Institute

       Chemical CAS #:  1825-21-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 004    VEHICLE CONTROL
                               Include 007    40 MG/KG
                               Include 010    40 MG/KG
                               Include 013    20 MG/KG
                               Include 016    20 MG/KG































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           18           29                                                  
    Natural Death                                      8            6            5                                                  
    Accidently Killed                                  1                                                                            
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           25           16                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (43)         (21)         (49)                                                
   Intestine Small, Duodenum                          (48)         (21)         (49)                                                
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (23)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         4 (8%)       2 (4%)       2 (4%)                                             
      Hepatocellular Adenoma                           8 (16%)      6 (12%)     10 (20%)                                            
      Hepatocellular Adenoma, Multiple                              2 (4%)       2 (4%)                                             
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Mesentery                                          (25)         (18)         (24)                                                
      Cholangiocarcinoma, Metastatic, Liver                                      1 (4%)                                             
      Fibrosarcoma                                                               1 (4%)                                             
      Hemangiosarcoma                                  1 (4%)                    2 (8%)                                             
      Sarcoma                                          1 (4%)       2 (11%)                                                         
   Pancreas                                           (50)         (28)         (50)                                                
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
   Salivary Glands                                    (50)         (25)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (45)         (50)                                                
      Sarcoma                                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Stomach, Glandular                                 (50)         (44)         (50)                                                
      Carcinoid Tumor Malignant                        1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Tooth                                                           (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
   Adrenal Gland, Medulla                             (50)         (49)         (48)                                                
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (25)         (50)                                                
   Pituitary Gland                                    (47)         (49)         (50)                                                
      Pars Distalis, Adenoma                           7 (15%)      5 (10%)      3 (6%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (36)         (50)                                                
      Cystadenoma, Papillary                           1 (2%)                    2 (4%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Luteoma                                                       1 (3%)                                                          
      Sarcoma                                                       1 (3%)                                                          
      Teratoma Malignant                               1 (2%)                                                                       
      Teratoma NOS                                                  1 (3%)                                                          
   Uterus                                             (46)         (43)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Fibrous Histiocytoma Malignant                                1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
      Sarcoma                                                       2 (5%)       1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma Stromal                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (25)         (50)                                                
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Bronchial, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (2%)                                             
      Iliac, Sarcoma                                                1 (2%)                                                          
      Mediastinal, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                 1 (2%)                                             
      Renal, Neoplasm NOS, Metastatic, Ovary           1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)         (47)         (49)                                                
      Mast Cell Tumor Benign                           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)       3 (6%)                                                          
   Thymus                                             (48)         (24)         (47)                                                
      Fibrosarcoma                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (23)         (50)                                                
      Adenocarcinoma                                   1 (2%)       1 (4%)                                                          
   Skin                                               (50)         (26)         (50)                                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (3)                                                 
      Fibrosarcoma                                                  1 (100%)     1 (33%)                                            
      Rhabdomyosarcoma                                                           1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (26)         (50)                                                
      Meningioma Benign                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (27)         (50)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                   2 (7%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (4%)       1 (2%)                                             
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                                             
      Mediastinum, Fibrosarcoma                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (1)          (1)                                                 
      Fibrosarcoma                                                  1 (100%)                                                        
   Harderian Gland                                    (6)          (2)          (4)                                                 
      Adenocarcinoma                                                2 (100%)                                                        
      Adenoma                                          3 (50%)                   4 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (25)         (50)                                                
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
   Urinary Bladder                                    (49)         (26)         (47)                                                
      Hemangioma                                                    1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                       1 (4%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   2 (4%)       1 (2%)       8 (16%)                                            
      Lymphoma Malignant Mixed                         4 (8%)       7 (14%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          31          30                                                   
     Total Primary Neoplasms                           52          56          58                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          19          18                                                   
     Total Benign Neoplasms                            24          22          25                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          20          23                                                   
     Total Malignant Neoplasms                         28          33          33                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           1                                                   
     Total Metastatic Neoplasm                          2           2           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      2            2                                                               
    Moribund Sacrifice                                17           20           22                                                  
    Accidently Killed                                  1                                                                            
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           27                                                  
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (50)         (22)         (49)                                                
   Intestine Small, Jejunum                           (50)         (23)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)       5 (10%)      3 (6%)                                             
      Hemangiosarcoma, Multiple                                     3 (6%)       7 (14%)                                            
      Hepatocellular Carcinoma                         7 (14%)     14 (28%)      9 (18%)                                            
      Hepatocellular Carcinoma, Multiple               2 (4%)       2 (4%)       3 (6%)                                             
      Hepatocellular Adenoma                          18 (36%)     18 (36%)     13 (26%)                                            
      Hepatocellular Adenoma, Multiple                 2 (4%)       6 (12%)      1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (2)          (9)          (4)                                                 
      Fibrous Histiocytoma Malignant                                1 (11%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (25%)                                            
   Pancreas                                           (50)         (23)         (50)                                                
      Fibrous Histiocytoma Malignant                                1 (4%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Salivary Glands                                    (50)         (23)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Fibrous Histiocytoma Malignant                                1 (2%)                                                          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (49)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (49)                                                
      Capsule, Spindle Cell, Adenoma                   4 (8%)                    2 (4%)                                             
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Capsule, Fibrous Histiocytoma Malignant                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (48)                                                
      Pheochromocytoma Benign                                       4 (8%)       7 (15%)                                            
   Islets, Pancreatic                                 (50)         (23)         (49)                                                
      Adenoma                                                       1 (4%)                                                          
      Fibrous Histiocytoma Malignant                                1 (4%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)                                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Mediastinum, Fibrosarcoma                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (24)         (50)                                                
      Fibrous Histiocytoma Malignant                                1 (4%)                                                          
   Prostate                                           (50)         (23)         (50)                                                
      Fibrous Histiocytoma Malignant                                1 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (4%)                                                          
   Seminal Vesicle                                    (50)         (24)         (50)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Testes                                             (50)         (23)         (50)                                                
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (23)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Fibrous Histiocytoma Malignant                   1 (2%)                                                          
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach                                                    1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (49)         (49)                                                
   Lymph Node, Mesenteric                             (50)         (49)         (50)                                                
      Fibrous Histiocytoma Malignant                                1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  3 (6%)       1 (2%)       5 (10%)                                            
   Thymus                                             (49)         (22)         (50)                                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (29)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                               1 (3%)                                                          
      Keratoacanthoma                                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                               2 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (24)         (50)                                                
      Osteosarcoma                                                  2 (8%)                                                          
   Skeletal Muscle                                                              (2)                                                 
      Fibrosarcoma                                                               1 (50%)                                            
      Hemangiosarcoma                                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     6 (12%)      7 (22%)      4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       4 (13%)      5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       1 (3%)                                                          
                                                             Page   9                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                                         2 (6%)       2 (4%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (3%)       2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
   Harderian Gland                                    (2)          (6)          (4)                                                 
      Adenoma                                          2 (100%)     6 (100%)     4 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (25)         (50)                                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (4%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant Histiocytic                   2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         2 (4%)       4 (8%)       8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05037-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:31:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          47          46                                                   
     Total Primary Neoplasms                           64          94          82                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          36          25                                                   
     Total Benign Neoplasms                            37          46          32                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          30          35                                                   
     Total Malignant Neoplasms                         27          48          50                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           5                                                   
     Total Metastatic Neoplasm                          2           5           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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