National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3408

TDMS Study 05037-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 06/23/97       
EXPERIMENT: 05037 TEST: 04                                                                                     TIME: 09:58:45       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NOI-ES-28024                              ROUTE: GAVAGE                                                  NTP C#: 56520        
PATHOLOGIST: T. MAKOVEC                      S. EUSTIS                                                         CAS: 1825-21-4       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 004    VEHICLE CONTROL                                                               
                                       INCLUDE 007    40 MG/KG                                                                      
                                       INCLUDE 010    40 MG/KG                                                                      
                                       INCLUDE 013    20 MG/KG                                                                      
                                       INCLUDE 016    20 MG/KG                                                                      
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 06/23/97      
EXPERIMENT: 05037 TEST: 04                                                                                     TIME: 09:58:45      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NOI-ES-28024                              ROUTE: GAVAGE                                                  NTP C#: 56520       
PATHOLOGIST: T. MAKOVEC                      S. EUSTIS                                                         CAS: 1825-21-4      
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 1    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      424   491   529   589   599   617   617   675   691   691                 |
 |      691   691   701   701   705   708   710   712   717                       |
 |  CENSORED DEATHS                                                               |
 |      9                                                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 1    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      592   676   682   690   691   691   696   701   701   702                 |
 |      702   702   704   704   705   711   715   716   716   717                 |
 |      717   717                                                                 |
 |  CENSORED DEATHS                                                               |
 |      651                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 40 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      467   548   550   596   596   596   599   610   611   612                 |
 |      677   691   691   698   701   701   702   705   705   705                 |
 |      715   715                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  98.0  93.9  89.8  85.7  61.2      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  55.1      |
 |           |                                                                    |
 |           |                                                                    |
 |40 MG/KG   |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  86.0  80.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          20 MG/KG         40 MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       61.2%            55.1%            56.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.607          P=0.937          P=0.682       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       645.2            697.6            645.0         |
 |NATURAL DEATHS (C)      |       (19.5)           ( 5.6)           (14.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       682.8            713.6            692.1         |
 |(STANDARD ERROR)        |       (16.6)           ( 3.5)           ( 8.8)        |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 1    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      72    81    400   410   411   428   474   477   477   505                 |
 |      517   576   583   605   611   624   633   639   674   674                 |
 |      675   687   702   704   705                                               |
 |  CENSORED DEATHS                                                               |
 |      560                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 1    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      318   333   365   415   428   434   438   444   472   499                 |
 |      526   531   549   549   564   583   583   598   598   647                 |
 |      652   661   687   704                                                     |
 |  CENSORED DEATHS                                                               |
 |      11                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 40 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      291   323   365   375   376   381   386   389   389   414                 |
 |      470   472   499   499   519   527   551   563   571   576                 |
 |      583   597   612   632   653   661   677   677   690   702                 |
 |      704   704   704   710                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    96.0  96.0  96.0  96.0  90.0  82.0  78.0  71.8  63.6  49.3      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0  93.9  91.8  81.6  75.5  61.2  55.1  51.0      |
 |           |                                                                    |
 |           |                                                                    |
 |40 MG/KG   |   100.0 100.0 100.0  94.0  80.0  76.0  68.0  56.0  48.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          20 MG/KG         40 MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       49.3%            51.0%            32.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.085          P=1.000          P=0.097       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       533.8            524.1            536.5         |
 |NATURAL DEATHS (C)      |       (34.2)           (22.5)           (22.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       628.0            616.3            598.1         |
 |(STANDARD ERROR)        |       (21.9)           (21.8)           (19.9)        |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                         PENTACHLOROANISOLE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        20 MG/KG         = 2
                                                        40 MG/KG         = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                  1      3                   2
      |
      |                                                                    1      3   1        3      2            2
      |                                                                               1     1                      22
   95 +
      |                                                                                     1  3      13            22
      |
      |                                                                                               11
   90 +                                                                                                1  1
      |
P     |                                                                                                              22
E     |                                                                                                3 31        1  22
R  85 +
C     |                                                                                                            1 1
E     |
N     |
T  80 +                                                                                                  3         3
      |
S     |                                                                                                            3 3
U     |
R  75 +                                                                                                              1 1
V     |                                                                                                              33
I     |                                                                                                               33
V     |
A  70 +                                                                                                                11
L     |
      |                                                                                                                 22
      |
   65 +
      |                                                                                                                 11
      |
      |                                                                                                                  1  1
   60 +                                                                                                                3 3
      |
      |
      |                                                                                                                  3  3
   55 +                                                                                                                  2  2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.
                                                         PENTACHLOROANISOLE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        20 MG/KG         = 2
                                                        40 MG/KG         = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1           1                                 3    2
      |             11                                3    232
      |              1                                      32    23    112
      |                                                                   2 2
   90 +                                                            3 3   1  1
      |                                                              33     12     1
P     |                                                                      22    11
E     |                                                               3   3   2    21  21
R  80 +                                                                   3        3   211  2
C     |                                                                                  1         1
E     |                                                                            3   3    2  2   11   1
N     |                                                                                3   3   2 2      11
T  70 +                                                                                    33    2  2    1 1
      |                                                                                     3  3           11
S     |                                                                                        3 33 2  2    11
U     |                                                                                           33         1     1
R  60 +                                                                                            33  2      22
V     |                                                                                             3  3       2 2 1 1
I     |                                                                                                3 3  3    2   1 1
V     |                                                                                                     3  3     2 2
A  50 +                                                                                                        3 3     1    1
L     |                                                                                                          3 3
      |                                                                                                            3 3
      |                                                                                                              3 3
   40 +
      |
      |                                                                                                                33
      |                                                                                                                 3   3
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.