TDMS Study 05037-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 06/23/97
EXPERIMENT: 05037 TEST: 04 TIME: 09:58:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: T. MAKOVEC S. EUSTIS CAS: 1825-21-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 004 VEHICLE CONTROL
INCLUDE 007 40 MG/KG
INCLUDE 010 40 MG/KG
INCLUDE 013 20 MG/KG
INCLUDE 016 20 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 06/23/97
EXPERIMENT: 05037 TEST: 04 TIME: 09:58:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: T. MAKOVEC S. EUSTIS CAS: 1825-21-4
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 1 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 424 491 529 589 599 617 617 675 691 691 |
| 691 691 701 701 705 708 710 712 717 |
| CENSORED DEATHS |
| 9 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 1 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 592 676 682 690 691 691 696 701 701 702 |
| 702 702 704 704 705 711 715 716 716 717 |
| 717 717 |
| CENSORED DEATHS |
| 651 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 467 548 550 596 596 596 599 610 611 612 |
| 677 691 691 698 701 701 702 705 705 705 |
| 715 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.0 98.0 93.9 89.8 85.7 61.2 |
|CONTROL | |
| | |
|20 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 55.1 |
| | |
| | |
|40 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 86.0 80.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 20 MG/KG 40 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.2% 55.1% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.607 P=0.937 P=0.682 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 645.2 697.6 645.0 |
|NATURAL DEATHS (C) | (19.5) ( 5.6) (14.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.8 713.6 692.1 |
|(STANDARD ERROR) | (16.6) ( 3.5) ( 8.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 72 81 400 410 411 428 474 477 477 505 |
| 517 576 583 605 611 624 633 639 674 674 |
| 675 687 702 704 705 |
| CENSORED DEATHS |
| 560 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 1 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 318 333 365 415 428 434 438 444 472 499 |
| 526 531 549 549 564 583 583 598 598 647 |
| 652 661 687 704 |
| CENSORED DEATHS |
| 11 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 291 323 365 375 376 381 386 389 389 414 |
| 470 472 499 499 519 527 551 563 571 576 |
| 583 597 612 632 653 661 677 677 690 702 |
| 704 704 704 710 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 96.0 96.0 96.0 96.0 90.0 82.0 78.0 71.8 63.6 49.3 |
|CONTROL | |
| | |
|20 MG/KG | 100.0 100.0 100.0 93.9 91.8 81.6 75.5 61.2 55.1 51.0 |
| | |
| | |
|40 MG/KG | 100.0 100.0 100.0 94.0 80.0 76.0 68.0 56.0 48.0 32.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 20 MG/KG 40 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 49.3% 51.0% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.085 P=1.000 P=0.097 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 533.8 524.1 536.5 |
|NATURAL DEATHS (C) | (34.2) (22.5) (22.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 628.0 616.3 598.1 |
|(STANDARD ERROR) | (21.9) (21.8) (19.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
20 MG/KG = 2
40 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 1 3 2 2
| 1 1 22
95 +
| 1 3 13 22
|
| 11
90 + 1 1
|
P | 22
E | 3 31 1 22
R 85 +
C | 1 1
E |
N |
T 80 + 3 3
|
S | 3 3
U |
R 75 + 1 1
V | 33
I | 33
V |
A 70 + 11
L |
| 22
|
65 +
| 11
|
| 1 1
60 + 3 3
|
|
| 3 3
55 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
PENTACHLOROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
20 MG/KG = 2
40 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 11 3 232
| 1 32 23 112
| 2 2
90 + 3 3 1 1
| 33 12 1
P | 22 11
E | 3 3 2 21 21
R 80 + 3 3 211 2
C | 1 1
E | 3 3 2 2 11 1
N | 3 3 2 2 11
T 70 + 33 2 2 1 1
| 3 3 11
S | 3 33 2 2 11
U | 33 1 1
R 60 + 33 2 22
V | 3 3 2 2 1 1
I | 3 3 3 2 1 1
V | 3 3 2 2
A 50 + 3 3 1 1
L | 3 3
| 3 3
| 3 3
40 +
|
| 33
| 3 3
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.