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TDMS Study 05037-03 Pathology Tables

NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97
Route: GAVAGE                                                                                                     Time: 11:29:25




       Facility:  Southern Research Institute

       Chemical CAS #:  1825-21-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 004    VEHICLE CONTROL
                               Include 007    40 MG/KG
                               Include 010    40 MG/KG
                               Include 013    20 MG/KG
                               Include 016    20 MG/KG
                               Include 019    10 MG/KG






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           13            4                                                  
    Natural Death                                      4            2            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           35           44                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (1)          (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Large, Colon                             (49)         (1)          (49)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Parasite Metazoan                                2 (4%)                    2 (4%)                                             
   Intestine Large, Rectum                            (50)         (1)          (49)                                                
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
      Parasite Metazoan                                7 (14%)                   9 (18%)                                            
   Intestine Small, Ileum                             (50)         (1)          (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (1)          (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   4 (8%)       2 (4%)                                             
      Basophilic Focus                                42 (84%)     44 (88%)     45 (90%)                                            
      Clear Cell Focus                                 5 (10%)      3 (6%)       2 (4%)                                             
      Developmental Malformation                                    1 (2%)       5 (10%)                                            
      Eosinophilic Focus                               1 (2%)                    2 (4%)                                             
      Granuloma                                       29 (58%)     19 (38%)     24 (48%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       4 (8%)       3 (6%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       7 (14%)      5 (10%)                                            
      Hyperplasia, Focal                               4 (8%)       6 (12%)      5 (10%)                                            
      Inflammation, Chronic                           11 (22%)     10 (20%)     12 (24%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mixed Cell Focus                                              4 (8%)       4 (8%)                                             
      Bile Duct, Hyperplasia                          31 (62%)     27 (54%)     17 (34%)                                            
      Centrilobular, Atrophy                           1 (2%)       1 (2%)                                                          
      Centrilobular, Necrosis                          1 (2%)       1 (2%)       1 (2%)                                             
      Hepatocyte, Pigmentation                                     18 (36%)     24 (48%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            4 (8%)       3 (6%)       1 (2%)                                             
      Kupffer Cell, Pigmentation                       3 (6%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Lobules, Necrosis                                2 (4%)       3 (6%)       1 (2%)                                             
      Oval Cell, Hyperplasia                           1 (2%)                    1 (2%)                                             
      Portal, Necrosis                                                           1 (2%)                                             
   Mesentery                                          (13)         (3)          (7)                                                 
      Cyst                                             1 (8%)                                                                       
      Necrosis                                                                   1 (14%)                                            
      Fat, Inflammation, Chronic Active                2 (15%)                                                                      
      Fat, Necrosis                                   10 (77%)      3 (100%)     6 (86%)                                            
   Pancreas                                           (50)                      (50)                                                
      Atrophy                                         11 (22%)                  10 (20%)                                            
      Cytoplasmic Alteration                           2 (4%)                                                                       
      Hyperplasia, Focal                               3 (6%)                                                                       
      Inflammation, Chronic                                                      3 (6%)                                             
      Duct, Hyperplasia                                1 (2%)                                                                       
   Salivary Glands                                    (50)                      (50)                                                
      Atrophy                                                                    3 (6%)                                             
      Duct, Dilatation                                 1 (2%)                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (1)          (50)                                                
      Edema                                            3 (6%)                    1 (2%)                                             
      Foreign Body                                                  1 (100%)                                                        
      Inflammation, Chronic Active                     1 (2%)       1 (100%)     1 (2%)                                             
      Ulcer                                            2 (4%)                    1 (2%)                                             
      Mucosa, Hyperplasia                              3 (6%)       1 (100%)     3 (6%)                                             
   Stomach, Glandular                                 (50)         (1)          (50)                                                
      Erosion                                          2 (4%)                                                                       
      Mineralization                                   3 (6%)                                                                       
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Tooth                                              (2)                       (1)                                                 
      Developmental Malformation                                                 1 (100%)                                           
      Inflammation, Suppurative                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                                                
      Cardiomyopathy                                  20 (40%)                  31 (62%)                                            
      Myocardium, Inflammation, Chronic                4 (8%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Hypertrophy, Focal                                            1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                9 (18%)     13 (26%)     13 (26%)                                            
      Angiectasis                                     24 (48%)     30 (60%)     27 (54%)                                            
      Clear Cell Focus                                 4 (8%)       4 (8%)       4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                                                       1 (2%)                                             
      Degeneration, Fatty                                           1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia, Focal                              12 (24%)     13 (26%)     12 (24%)                                            
      Hypertrophy, Focal                               1 (2%)       3 (6%)       4 (8%)                                             
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse                                         1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia                                     10 (20%)     18 (36%)     25 (50%)                                            
   Islets, Pancreatic                                 (50)                      (50)                                                
      Hyperplasia                                      2 (4%)                                                                       
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Pars Distalis, Angiectasis                       4 (8%)       7 (14%)      8 (16%)                                            
      Pars Distalis, Cyst                             20 (41%)     27 (54%)     20 (40%)                                            
      Pars Distalis, Hyperplasia                       9 (18%)      8 (16%)      8 (16%)                                            
      Pars Distalis, Pigmentation                      9 (18%)     10 (20%)      9 (18%)                                            
      Pars Intermedia, Angiectasis                                  1 (2%)       1 (2%)                                             
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Pigmentation                                 1 (2%)                                                          
      Pars Nervosa, Cyst                               1 (2%)                                                                       
   Thyroid Gland                                      (50)         (2)          (50)                                                
      Ultimobranchial Cyst                             3 (6%)                    1 (2%)                                             
      C-Cell, Hyperplasia                              5 (10%)                  13 (26%)                                            
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (8)          (50)                                                
      Ectasia                                          4 (8%)       2 (25%)      2 (4%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       1 (13%)      5 (10%)                                            
      Inflammation, Suppurative                        3 (6%)                    4 (8%)                                             
   Ovary                                              (50)         (5)          (50)                                                
      Cyst                                             1 (2%)       1 (20%)      6 (12%)                                            
   Uterus                                             (50)         (50)         (50)                                                
      Abscess                                          2 (4%)       1 (2%)       2 (4%)                                             
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)                    2 (4%)                                             
      Hemorrhage                                                    3 (6%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       7 (14%)      2 (4%)       6 (12%)                                            
      Hyperplasia, Cystic                             13 (26%)     13 (26%)     20 (40%)                                            
      Inflammation, Suppurative                                                  2 (4%)                                             
      Necrosis                                                      1 (2%)                                                          
      Myometrium, Hyperplasia                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                                                
      Hypercellularity                                 1 (2%)                    2 (4%)                                             
      Hyperplasia, Reticulum Cell                      3 (6%)                    3 (6%)                                             
   Lymph Node                                         (50)         (11)         (50)                                                
      Bronchial, Hemorrhage                                                      1 (2%)                                             
      Bronchial, Pigmentation                                                    1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)       1 (9%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                              1 (9%)                                                          
      Lumbar, Lymphatic, Dilatation                                 1 (9%)                                                          
      Mediastinal, Hemorrhage                          7 (14%)                   2 (4%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                         1 (9%)       2 (4%)                                             
      Mediastinal, Pigmentation                       10 (20%)      1 (9%)       7 (14%)                                            
      Pancreatic, Hemorrhage                                        1 (9%)                                                          
      Pancreatic, Hyperplasia, Plasma Cell             1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte                              1 (2%)                                             
      Pancreatic, Lymphatic, Dilatation                1 (2%)                                                                       
      Renal, Hemorrhage                                                          1 (2%)                                             
      Renal, Pigmentation                                           1 (9%)       1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (3)          (50)                                                
      Hemorrhage                                                    1 (33%)      1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (33%)      2 (4%)                                             
      Hyperplasia, Plasma Cell                        14 (28%)      1 (33%)     20 (40%)                                            
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Pigmentation                                                               1 (2%)                                             
      Lymphatic, Dilatation                            1 (2%)       1 (33%)      5 (10%)                                            
   Lymph Node, Mesenteric                             (49)         (3)          (50)                                                
      Hemorrhage                                       2 (4%)       1 (33%)      1 (2%)                                             
      Hyperplasia, Lymphoid                                                      3 (6%)                                             
      Lymphatic, Dilatation                                                      1 (2%)                                             
   Spleen                                             (50)         (10)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Developmental Malformation                                    1 (10%)                                                         
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                15 (30%)      4 (40%)      6 (12%)                                            
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (10%)                                                         
      Pigmentation, Hemosiderin                        5 (10%)      2 (20%)      7 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lymphoid Follicle, Hyperplasia                                             2 (4%)                                             
   Thymus                                             (47)                      (48)                                                
      Cyst                                             3 (6%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (21)         (50)                                                
      Hyperplasia, Cystic                             38 (79%)     15 (71%)     33 (66%)                                            
      Hyperplasia, Lobular                             4 (8%)       2 (10%)      2 (4%)                                             
   Skin                                               (50)         (3)          (50)                                                
      Hemorrhage                                                    1 (33%)                                                         
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (6)          (50)                                                
      Calvarium, Osteopetrosis                         5 (10%)      6 (100%)                                                        
      Femur, Osteopetrosis                             6 (12%)                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (4)          (50)                                                
      Compression                                      6 (12%)      3 (75%)      4 (8%)                                             
      Degeneration, Focal                              1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hydrocephalus                                    4 (8%)       1 (25%)      4 (8%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Meninges, Fibrosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (50)                                                
      Congestion                                       2 (4%)       1 (14%)      1 (2%)                                             
      Edema                                            2 (4%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               24 (48%)      4 (57%)     31 (62%)                                            
      Inflammation, Chronic                           12 (24%)      1 (14%)     18 (36%)                                            
      Inflammation, Suppurative                                     1 (14%)      1 (2%)                                             
      Pigmentation, Cholesterol                        1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       2 (29%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Smooth Muscle, Hyperplasia                       1 (2%)                                                                       
   Nose                                               (49)         (50)         (50)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Exudate                                          3 (6%)       8 (16%)      7 (14%)                                            
      Foreign Body                                     1 (2%)       3 (6%)       1 (2%)                                             
      Fungus                                           1 (2%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic                            5 (10%)     13 (26%)     11 (22%)                                            
      Glands, Hyperplasia                              1 (2%)                                                                       
      Glands, Necrosis                                 1 (2%)                                                                       
      Mucosa, Hyperplasia                                           5 (10%)      2 (4%)                                             
      Mucosa, Metaplasia, Squamous                                  4 (8%)                                                          
      Olfactory Epithelium, Pigmentation                           46 (92%)     50 (100%)                                           
   Trachea                                            (50)                      (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (4)          (8)                                                 
      Cataract                                         1 (100%)     3 (75%)      8 (100%)                                           
      Phthisis Bulbi                                                1 (25%)                                                         
      Cornea, Inflammation, Chronic Active                                       1 (13%)                                            
      Cornea, Mineralization                                                     1 (13%)                                            
      Retina, Atrophy                                  1 (100%)     3 (75%)      8 (100%)                                           
      Sclera, Mineralization                                                     2 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Hydronephrosis                                   1 (2%)                    1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            7 (14%)     11 (22%)     10 (20%)                                            
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                  21 (42%)     24 (48%)     15 (30%)                                            
      Nephropathy                                     41 (82%)     48 (96%)     42 (84%)                                            
      Renal Tubule, Atrophy                                                      1 (2%)                                             
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)       1 (2%)       1 (2%)                                             
      Renal Tubule, Pigmentation                                   43 (86%)     45 (90%)                                            
      Transitional Epithelium, Hyperplasia             4 (8%)                    2 (4%)                                             
   Urethra                                            (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
      Necrosis                                         1 (100%)                                                                     
   Urinary Bladder                                    (50)         (1)          (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Subacute                                                     2 (4%)                                             
      Mucosa, Hyperplasia                              1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           21           14            5                                     
    Natural Death                                      3            5            7           27                                     
    Dosing Accident                                                 4                         2                                     
    Accidently Killed                                                            5            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           20           24           14                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (49)         (48)         (50)                                   
      Edema                                            1 (2%)                    1 (2%)       1 (2%)                                
      Parasite Metazoan                                2 (4%)                    3 (6%)                                             
      Ulcer                                            2 (4%)                    1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (49)         (49)                                   
      Parasite Metazoan                                5 (10%)                   2 (4%)       5 (10%)                               
   Intestine Large, Rectum                            (50)         (50)         (49)         (47)                                   
      Edema                                                                                   1 (2%)                                
      Parasite Metazoan                                5 (10%)      6 (12%)      3 (6%)       3 (6%)                                
      Lymphatic, Dilatation                                                                   1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   4 (8%)       1 (2%)       2 (4%)                                
      Basophilic Focus                                27 (54%)     27 (54%)     26 (52%)      8 (16%)                               
      Clear Cell Focus                                14 (28%)      7 (14%)      6 (12%)      4 (8%)                                
      Congestion                                                    2 (4%)       2 (4%)      13 (26%)                               
      Degeneration, Cystic                             2 (4%)       5 (10%)      9 (18%)      6 (12%)                               
      Eosinophilic Focus                               3 (6%)       9 (18%)      9 (18%)      1 (2%)                                
      Granuloma                                       19 (38%)     10 (20%)      6 (12%)      8 (16%)                               
      Hematopoietic Cell Proliferation                 4 (8%)       2 (4%)       2 (4%)                                             
      Hepatodiaphragmatic Nodule                                    2 (4%)       2 (4%)       1 (2%)                                
      Hyperplasia, Focal                               7 (14%)      5 (10%)                   2 (4%)                                
      Inflammation, Chronic                            6 (12%)      8 (16%)      9 (18%)      4 (8%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       3 (6%)                    1 (2%)                                
      Bile Duct, Hyperplasia                          45 (90%)     45 (90%)     44 (88%)     26 (52%)                               
      Centrilobular, Atrophy                           2 (4%)                    5 (10%)                                            
      Centrilobular, Necrosis                                       6 (12%)      6 (12%)     17 (34%)                               
      Hepatocyte, Pigmentation                                                   1 (2%)       4 (8%)                                
      Hepatocyte, Vacuolization Cytoplasmic            8 (16%)      2 (4%)       1 (2%)       2 (4%)                                
      Kupffer Cell, Hyperplasia                        3 (6%)       1 (2%)       4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Pigmentation                                    1 (2%)                                                          
      Lobules, Necrosis                                2 (4%)       4 (8%)       1 (2%)       1 (2%)                                
      Periportal, Inflammation, Chronic Active                                                1 (2%)                                
      Portal, Necrosis                                                                        1 (2%)                                
   Mesentery                                          (11)         (11)         (5)          (9)                                    
      Accessory Spleen                                 1 (9%)       1 (9%)                                                          
      Fat, Inflammation, Pyogranulomatous              1 (9%)                                                                       
      Fat, Necrosis                                    6 (55%)      5 (45%)      4 (80%)      3 (33%)                               
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Atrophy                                         14 (29%)     17 (35%)     19 (39%)      9 (18%)                               
      Cytoplasmic Alteration                                        3 (6%)       2 (4%)       1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Focal Cellular Change                            1 (2%)                    3 (6%)                                             
      Hyperplasia, Focal                              19 (39%)     17 (35%)      8 (16%)      1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Dysplasia                                                                  1 (2%)                                             
      Edema                                            1 (2%)       2 (4%)       4 (8%)                                             
      Erosion                                          2 (4%)                    2 (4%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Ulcer                                            3 (6%)       4 (8%)       2 (4%)                                             
      Mucosa, Hyperplasia                              6 (12%)      7 (14%)      5 (10%)                                            
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)       1 (2%)                                             
      Erosion                                          3 (6%)       1 (2%)       2 (4%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Mineralization                                   4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Ulcer                                            3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Tooth                                              (2)          (1)                                                              
      Developmental Malformation                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (4)          (4)          (5)          (5)                                    
      Polyarteritis                                    4 (100%)     4 (100%)     4 (80%)      5 (100%)                              
   Heart                                              (50)         (50)         (49)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Cardiomyopathy                                  33 (66%)     37 (74%)     36 (73%)     21 (42%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                2 (4%)       3 (6%)       3 (6%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule               14 (29%)     11 (22%)      8 (16%)      6 (12%)                               
      Angiectasis                                      4 (8%)       2 (4%)       2 (4%)       4 (8%)                                
      Clear Cell Focus                                 4 (8%)       5 (10%)      5 (10%)      3 (6%)                                
      Congestion                                                                 2 (4%)       2 (4%)                                
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)                                             
      Hemorrhage                                                                              5 (10%)                               
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Hyperplasia, Focal                               7 (14%)     10 (20%)      7 (14%)      2 (4%)                                
      Necrosis                                                      2 (4%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (48)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                     23 (46%)     26 (52%)     16 (32%)      9 (19%)                               
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (49)         (49)         (50)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      8 (16%)      7 (14%)      8 (16%)      3 (6%)                                
   Pituitary Gland                                    (49)         (50)         (48)         (50)                                   
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Pars Distalis, Cyst                              5 (10%)      2 (4%)       4 (8%)       2 (4%)                                
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)      5 (10%)      2 (4%)                                
      Pars Distalis, Necrosis                                       1 (2%)                                                          
      Pars Distalis, Pigmentation                      2 (4%)                    1 (2%)                                             
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)                    1 (2%)                                
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Ultimobranchial Cyst                                          3 (6%)                                                          
      C-Cell, Hyperplasia                              9 (18%)     12 (24%)      5 (10%)      4 (8%)                                
      Follicle, Cyst                                   4 (8%)       6 (12%)      1 (2%)       2 (4%)                                
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Preputial Gland                                    (50)         (48)         (50)         (50)                                   
      Ectasia                                          4 (8%)       1 (2%)       1 (2%)                                             
      Foreign Body                                     1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           28 (56%)     23 (48%)     29 (58%)     15 (30%)                               
      Inflammation, Suppurative                       11 (22%)      7 (15%)      7 (14%)      3 (6%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)       1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Fibrosis                                         2 (4%)                    1 (2%)                                             
      Inflammation, Chronic                            7 (14%)      2 (4%)       5 (10%)      4 (8%)                                
      Inflammation, Suppurative                       25 (50%)     26 (52%)     20 (40%)     15 (30%)                               
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
      Edema                                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization                                  26 (52%)     21 (42%)     29 (58%)     14 (28%)                               
      Interstitial Cell, Hyperplasia                   2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Seminiferous Tubule, Atrophy                     5 (10%)      4 (8%)       7 (14%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hypercellularity                                 2 (4%)       3 (6%)       6 (12%)                                            
      Hyperplasia, Reticulum Cell                      1 (2%)       1 (2%)                                                          
      Hypocellularity                                  1 (2%)       1 (2%)       2 (4%)                                             
      Myelofibrosis                                                 2 (4%)                                                          
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Inguinal, Hyperplasia, Lymphoid                               1 (2%)                                                          
      Inguinal, Hyperplasia, Plasma Cell                            1 (2%)       1 (2%)                                             
      Inguinal, Lymphatic, Dilatation                  1 (2%)                                                                       
      Mediastinal, Congestion                                                                 1 (2%)                                
      Mediastinal, Hemorrhage                          8 (16%)      6 (12%)     10 (20%)      1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                         5 (10%)      1 (2%)       1 (2%)                                
      Mediastinal, Pigmentation                        4 (8%)       8 (16%)      2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Hemorrhage                           1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                2 (4%)                                                                       
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Renal, Lymphatic, Dilatation                     1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (49)         (49)         (49)                                   
      Congestion                                       1 (2%)                    2 (4%)       5 (10%)                               
      Hemorrhage                                                                 2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       4 (8%)       2 (4%)       3 (6%)                                
      Hyperplasia, Plasma Cell                        19 (38%)     18 (37%)     17 (35%)      5 (10%)                               
      Hyperplasia, Reticulum Cell                                                             1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Lymphatic, Dilatation                            2 (4%)       6 (12%)     10 (20%)      2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (48)                                   
      Congestion                                                                              1 (2%)                                
      Erythrophagocytosis                              1 (2%)       2 (4%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       6 (12%)      2 (4%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Pigmentation                                                               1 (2%)                                             
      Lymphatic, Dilatation                                         1 (2%)                    1 (2%)                                
   Spleen                                             (50)         (49)         (50)         (50)                                   
      Congestion                                       2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Degeneration, Fatty                                                        1 (2%)                                             
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis                                         2 (4%)                    3 (6%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 9 (18%)      6 (12%)      7 (14%)      2 (4%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Mononuclear Cell                                              1 (2%)                                             
      Hyperplasia, Re Cell                                          2 (4%)       2 (4%)                                             
      Necrosis                                         1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Pigmentation, Hemosiderin                        5 (10%)      7 (14%)      8 (16%)                                            
      Lymphoid Follicle, Atrophy                                    1 (2%)                                                          
      Red Pulp, Hyperplasia                                         1 (2%)                                                          
   Thymus                                             (46)         (47)         (47)         (47)                                   
      Congestion                                       1 (2%)                    5 (11%)     13 (28%)                               
      Cyst                                             3 (7%)       4 (9%)       1 (2%)       1 (2%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Hemorrhage                                                                 5 (11%)     21 (45%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (47)                                   
      Hyperplasia, Cystic                             17 (35%)     13 (27%)     11 (22%)      4 (9%)                                
      Hyperplasia, Lobular                                          2 (4%)       2 (4%)                                             
   Skin                                               (50)         (49)         (50)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Acanthosis                                       2 (4%)                    1 (2%)       1 (2%)                                
      Angiectasis                                                                1 (2%)                                             
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Exudate                                          1 (2%)                                 1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                    1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
      Lip, Hemorrhage                                                            1 (2%)                                             
      Scrotum, Congestion                                                        1 (2%)      13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Femur, Osteopetrosis                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      6 (12%)      4 (8%)       3 (6%)       2 (4%)                                
      Congestion                                                    1 (2%)       4 (8%)      21 (42%)                               
      Degeneration, Focal                                                        1 (2%)                                             
      Hemorrhage                                       1 (2%)       2 (4%)       4 (8%)                                             
      Hydrocephalus                                    1 (2%)       4 (8%)       1 (2%)                                             
      Mineralization                                                1 (2%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Atelectasis                                      1 (2%)                                                                       
      Congestion                                       2 (4%)       3 (6%)       6 (12%)     30 (60%)                               
      Edema                                            3 (6%)       2 (4%)       1 (2%)       5 (10%)                               
      Foreign Body                                                  3 (6%)                    2 (4%)                                
      Hemorrhage                                       1 (2%)       3 (6%)       2 (4%)       2 (4%)                                
      Infiltration Cellular, Histiocyte               33 (66%)     30 (60%)     28 (56%)     23 (46%)                               
      Inflammation, Chronic                            7 (14%)     14 (28%)     10 (20%)      6 (12%)                               
      Inflammation, Subacute                                                                  1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       2 (4%)                    1 (2%)                                
      Leukocytosis                                                  4 (8%)                                                          
      Metaplasia, Osseous                                                                     1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05037-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:29:25  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 6 (12%)      3 (6%)                    1 (2%)                                
      Mediastinum, Inflammation, Granulomatous         1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                              3 (6%)                                
      Exudate                                         17 (34%)     17 (34%)     12 (24%)      9 (18%)                               
      Foreign Body                                     8 (16%)      6 (12%)      5 (10%)      2 (4%)                                
      Fungus                                          14 (28%)     15 (30%)     11 (22%)      6 (12%)                               
      Inflammation, Chronic                            2 (4%)       7 (14%)     11 (22%)      5 (10%)                               
      Pigmentation                                                  1 (2%)                                                          
      Mucosa, Erosion                                                                         1 (2%)                                
      Mucosa, Hyperplasia                              8 (16%)      7 (14%)      7 (14%)      3 (6%)                                
      Mucosa, Metaplasia, Squamous                     5 (10%)      8 (16%)      9 (18%)      5 (10%)                               
      Nerve, Hypertrophy                               1 (2%)       1 (2%)                                                          
      Olfactory Epithelium, Pigmentation                           29 (58%)     40 (80%)     25 (50%)                               
   Trachea                                            (50)         (49)         (50)         (50)                                   
      Exudate                                                                                 1 (2%)                                
      Mucosa, Hyperplasia                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (7)          (2)          (2)                                    
      Cataract                                         1 (50%)      6 (86%)      1 (50%)      1 (50%)                               
      Phthisis Bulbi                                                                          1 (50%)                               
      Cornea, Hyperplasia                                           1 (14%)                                                         
      Retina, Atrophy                                  2 (100%)     6 (86%)      1 (50%)      1 (50%)                               
      Sclera, Mineralization                           1 (50%)      4 (57%)                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                             2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           38 (76%)     35 (70%)     30 (60%)     20 (40%)                               
      Inflammation, Suppurative                       10 (20%)     15 (30%)     20 (40%)     14 (28%)                               
      Mineralization                                  20 (40%)     13 (26%)     15 (30%)      8 (16%)                               
      Nephropathy                                     49 (98%)     49 (98%)     46 (92%)     27 (54%)                               
      Artery, Hypertrophy                                                                     1 (2%)                                
      Renal Tubule, Pigmentation                       1 (2%)      23 (46%)     22 (44%)     16 (32%)                               
      Transitional Epithelium, Hyperplasia             2 (4%)       2 (4%)       1 (2%)                                             
   Urethra                                            (2)                                                                           
      Bulbourethral Gland, Ectasia                     1 (50%)                                                                      
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)                    1 (2%)                                
      Mucosa, Hyperplasia                              1 (2%)  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------