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TDMS Study 05037-03 Pathology Tables

NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97
Route: GAVAGE                                                                                                     Time: 11:57:11




       Facility:  Southern Research Institute

       Chemical CAS #:  1825-21-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 004    VEHICLE CONTROL
                               Include 007    40 MG/KG
                               Include 010    40 MG/KG
                               Include 013    20 MG/KG
                               Include 016    20 MG/KG
                               Include 019    10 MG/KG






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           13            4                                                  
    Natural Death                                      4            2            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           35           44                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (1)          (49)                                                
   Intestine Small, Ileum                             (50)         (1)          (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                                                     1 (2%)                                             
   Pancreas                                           (50)                      (50)                                                
      Acinar Cell, Adenoma                             2 (4%)                                                                       
   Pharynx                                            (2)                       (1)                                                 
      Squamous Cell Papilloma                          1 (50%)                                                                      
   Stomach, Forestomach                               (50)         (1)          (50)                                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (100%)                                                        
   Stomach, Glandular                                 (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          3 (6%)       5 (10%)      9 (18%)                                            
      Pheochromocytoma Benign, Multiple                             2 (4%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)                                                
      Pars Distalis, Adenoma                          18 (37%)     21 (42%)     20 (40%)                                            
      Pars Distalis, Carcinoma                         2 (4%)       2 (4%)       3 (6%)                                             
      Pars Distalis, Hamartoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         2 (4%)       2 (4%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (2)          (50)                                                
      C-Cell, Adenoma                                  7 (14%)                   9 (18%)                                            
      C-Cell, Carcinoma                                1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                    1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (8)          (50)                                                
      Adenoma                                          5 (10%)      4 (50%)      3 (6%)                                             
      Carcinoma                                        3 (6%)       1 (13%)      2 (4%)                                             
   Ovary                                              (50)         (5)          (50)                                                
      Granulosa Cell Tumor Malignant                                2 (40%)                                                         
   Uterus                                             (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma In Situ                                1 (2%)                                                                       
      Hemangioma                                                                 1 (2%)                                             
      Polyp Stromal                                   13 (26%)     13 (26%)      7 (14%)                                            
      Sarcoma Stromal                                  2 (4%)       1 (2%)                                                          
   Vagina                                             (2)          (1)          (3)                                                 
      Carcinoma                                                                  1 (33%)                                            
      Leiomyoma                                        1 (50%)                                                                      
      Polyp                                                                      1 (33%)                                            
      Sarcoma Stromal, Metastatic, Uterus                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                                                
   Lymph Node                                         (50)         (11)         (50)                                                
      Renal, Fibrosarcoma, Metastatic, Skin                         1 (9%)                                                          
   Lymph Node, Mandibular                             (50)         (3)          (50)                                                
   Lymph Node, Mesenteric                             (49)         (3)          (50)                                                
   Spleen                                             (50)         (10)         (50)                                                
   Thymus                                             (47)                      (48)                                                
      Thymoma Benign                                                             1 (2%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (21)         (50)                                                
      Adenoma                                          3 (6%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                    16 (33%)     10 (48%)      7 (14%)                                            
   Skin                                               (50)         (3)          (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (33%)                                                         
      Subcutaneous Tissue, Fibrosarcoma                             1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Sarcoma Stromal, Metastatic, Uterus                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (4)          (50)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (7)          (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (14%)      1 (2%)                                             
   Nose                                               (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            11 (22%)     14 (28%)      9 (18%)                                            
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      20 MG/KG     40 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          41          41                                                   
     Total Primary Neoplasms                           98          82          80                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          35          35                                                   
     Total Benign Neoplasms                            75          60          62                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          20          18                                                   
     Total Malignant Neoplasms                         23          22          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           21           14            5                                     
    Natural Death                                      3            5            7           27                                     
    Dosing Accident                                                 4                         2                                     
    Accidently Killed                                                            5            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           20           24           14                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (48)         (50)                                   
   Intestine Large, Colon                             (50)         (50)         (49)         (49)                                   
   Intestine Large, Rectum                            (50)         (50)         (49)         (47)                                   
   Intestine Small, Duodenum                          (50)         (50)         (49)         (49)                                   
   Intestine Small, Ileum                             (50)         (50)         (47)         (50)                                   
   Intestine Small, Jejunum                           (50)         (50)         (47)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Stomach                                1 (2%)                                                          
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)                                             
   Mesentery                                          (11)         (11)         (5)          (9)                                    
      Leiomyosarcoma, Metastatic, Spleen               1 (9%)                                                                       
      Liposarcoma                                      1 (9%)                                                                       
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Stomach                                             1 (2%)                                             
      Acinar Cell, Adenoma                            12 (24%)      1 (2%)       1 (2%)                                             
   Pharynx                                            (1)                       (2)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (50%)                                            
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Tongue                                             (1)          (2)          (4)          (2)                                    
      Squamous Cell Carcinoma                                                    1 (25%)                                            
      Squamous Cell Papilloma                                       1 (50%)                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Schwannoma Benign                                3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)         (50)                                   
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (48)                                   
      Pheochromocytoma Malignant                       3 (6%)       2 (4%)       3 (6%)                                             
      Pheochromocytoma Malignant, Multiple                                       1 (2%)                                             
      Pheochromocytoma Benign                         11 (22%)     12 (24%)     13 (26%)      6 (13%)                               
      Pheochromocytoma Benign, Multiple                1 (2%)       5 (10%)     10 (20%)      9 (19%)                               
   Islets, Pancreatic                                 (49)         (49)         (49)         (50)                                   
      Adenoma                                          8 (16%)      2 (4%)       3 (6%)       6 (12%)                               
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (49)         (50)         (49)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (48)         (50)                                   
      Pars Distalis, Adenoma                          16 (33%)     22 (44%)     14 (29%)     10 (20%)                               
      Pars Distalis, Carcinoma                         4 (8%)       1 (2%)       1 (2%)                                             
      Pars Nervosa, Neoplasm NOS                                    1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      C-Cell, Adenoma                                 12 (24%)      6 (12%)      7 (14%)      5 (10%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (48)         (50)         (50)                                   
      Adenoma                                          2 (4%)       1 (2%)       5 (10%)                                            
      Carcinoma                                        6 (12%)      2 (4%)       1 (2%)       1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Stomach                                             1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                      46 (92%)     45 (90%)     42 (84%)     24 (48%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Bronchial, Carcinoma, Metastatic, Stomach                                  1 (2%)                                             
      Mediastinal, Carcinoma, Metastatic, Stomach                                1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (48)                                   
   Spleen                                             (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Stomach                                             1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
   Thymus                                             (46)         (47)         (47)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (47)                                   
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                     6 (13%)      9 (18%)      2 (4%)       1 (2%)                                
   Skin                                               (50)         (49)         (50)         (50)                                   
      Basal Cell Carcinoma                             2 (4%)                                 2 (4%)                                
      Carcinosarcoma                                   1 (2%)                                                                       
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Squamous Cell Carcinoma                                                    2 (4%)                                             
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                             1 (2%)                                                          
      Sebaceous Gland, Carcinoma                       1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Myxosarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Osteosarcoma                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Pharynx                               1 (2%)                                             
   Skeletal Muscle                                                 (1)                                                              
      Fibroma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Granular Cell Tumor Benign                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       5 (10%)      2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Stomach                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Mediastinum, Hemangiosarcoma                     1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            23 (46%)     22 (44%)     15 (30%)      8 (16%)                               
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                           3 (6%)       4 (8%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05037-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 11:57:11  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          45          26                                       
     Total Primary Neoplasms                          182         154         136          79                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          45          26                                       
     Total Benign Neoplasms                           127         117         104          66                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          33          28          11                                       
     Total Malignant Neoplasms                         55          36          32          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           3                                                   
     Total Metastatic Neoplasm                          5           1           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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