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TDMS Study 05037-03 Pathology Tables

NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97
Route: GAVAGE                                                                                                     Time: 12:05:45




       Facility:  Southern Research Institute

       Chemical CAS #:  1825-21-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 004    VEHICLE CONTROL
                               Include 007    40 MG/KG
                               Include 010    40 MG/KG
                               Include 013    20 MG/KG
                               Include 016    20 MG/KG
                               Include 019    10 MG/KG
































                                                              Page   1

NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|             
                                           | 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |             X                                                  X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                                                                        |             
      Parasite Metazoan                    |       X  X              X                 X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X     X  X  X        X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X        X                 X                                             |             
      Eosinophilic Focus                   |                      X                                                   |             
      Granuloma                            |          2  1        3     1  1  2  1  2  2        1     3  3     2      |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                                                                         2|             
      Inflammation, Chronic                |                      1                    3                       1      |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Bile Duct, Hyperplasia               | 1  1  1  1     1  2     1  1  1        1  2        1  1  1           1  3|             
      Centrilobular, Atrophy               |                                                                2         |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                             2  2                        |             
      Kupffer Cell, Pigmentation           |                1                                                         |             
      Lobules, Necrosis                    |                                                                2         |             
      Oval Cell, Hyperplasia               |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +        +                                +     +  +  +        +|             
      Cyst                                 |                                                          X               |             
      Fat, Inflammation, Chronic Active    | 3                 3                                                      |             
      Fat, Necrosis                        |          3                                         4        3  3        3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                       3           2     1     1     1                  |             
      Cytoplasmic Alteration               |                                              4                           |             
      Hyperplasia, Focal                   |       2                                            1     2               |             
      Duct, Hyperplasia                    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Dilatation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|             
                                           | 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                3                                                         |             
      Mucosa, Hyperplasia                  |                3  3                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 1                                                                        |             
      Mineralization                       |       2           1                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  2              2  1  1        2  1        1     2        2  2  3|             
      Myocardium, Inflammation, Chronic    |       1     1                                   1  1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X     X                    X                                   X|             
      Angiectasis                          |       1  1  2        2  2  1  1  1              1        2  1  1  2      |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                            3     1     3  3        1  1  2              2|             
      Hypertrophy, Focal                   |                                                                   1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                      1     1              1  1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2                                                                     |             
      Pars Distalis, Cyst                  | X           X                 X     X        X     X  X  X               |             
      Pars Distalis, Hyperplasia           |                                     1              3     2        2      |             
      Pars Distalis, Pigmentation          |    2           2                 2                             2        3|             
      Pars Intermedia, Cyst                |             X                                                            |             
      Pars Nervosa, Cyst                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                       X           X      |             
      C-Cell, Hyperplasia                  |                                                    2     2           3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|             
                                           | 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            3           2                          3      |             
      Inflammation, Chronic                |                                                          3               |             
      Inflammation, Suppurative            |                            2                             3               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       3        3         |             
      Cyst                                 |                                                                          |             
      Hydrometra                           |                                                    2  2                  |             
      Hyperplasia, Cystic                  |                                  1     1  1        2  1        2  2     1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                      2                                                   |             
      Mediastinal, Hemorrhage              |          3  2                                         3     2            |             
      Mediastinal, Pigmentation            |          3  3                                         3     4     3      |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Lymphatic, Dilatation    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Hyperplasia, Plasma Cell             |    2                       3              2                       2     3|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Lymphatic, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                    2     2              2           2  2  2        2   |             
      Hyperplasia, Re Cell                 | 2                                                                        |             
      Necrosis                             |                                                                2         |             
      Pigmentation, Hemosiderin            |                3  3              2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  2     1  2  2  2  1  3  1  4     2  1     3     2  2        2  4  3|             
      Hyperplasia, Lobular                 |       2                                            3           2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|             
                                           | 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteopetrosis             |             2                                                           2|             
      Femur, Osteopetrosis                 |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X        X  X              X                                      X|             
      Degeneration, Focal                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                 2                        |             
      Pigmentation                         |                                                                          |             
      Meninges, Fibrosis                   |                                                 4                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1  1  1        1     1     1     1  1        1     1        1  1   |             
      Inflammation, Chronic                |       1        1              1                       1              1   |             
      Pigmentation, Cholesterol            |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Smooth Muscle, Hyperplasia           |                                                                3         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       X                                                                  |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
      Glands, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|             
                                           | 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    1  3                    1     1                                2      |             
      Inflammation, Suppurative            |                                              2                           |             
      Mineralization                       | 1                 1     2  1           2  1  2     2  2        1     1  2|             
      Nephropathy                          | 1  1  1  1  1  1  2     1  1     2  1  1  1  2  1  1  1  2     1  2  1  1|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Dilatation             |                                              3                           |             
      Transitional Epithelium, Hyperplasia |                               1              3                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
      Inflammation, Chronic                |                                              4                           |             
      Necrosis                             |                                              4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              2                           |             
      Mucosa, Hyperplasia                  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7|            |
                             DAY ON TEST   | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3|            |
                                           | 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Parasite Metazoan                    |                      X  X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                              2                           |      2  2.0|
      Parasite Metazoan                    |                                     X     X                             X|      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X        X  X  X|     42     |
      Clear Cell Focus                     |    X                                X                                    |      5     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Granuloma                            |    1  2     1     1  2     3  2     2  3  3     2  3  1  2  1     2      |     29  1.9|
      Hematopoietic Cell Proliferation     |       3                                                                  |      2  2.0|
      Hepatodiaphragmatic Nodule           |             X           X  X                                             |      3     |
      Hyperplasia, Focal                   | 3                       2  1                                             |      4  2.0|
      Inflammation, Chronic                |             1     2  1           1  1           2  2     2               |     11  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  1     2  1        1  2  1  1  2  1  1        1     1              1  1|     31  1.2|
      Centrilobular, Atrophy               |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                              2                           |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                4                                                         |      4  2.5|
      Kupffer Cell, Pigmentation           |                         3                             1                  |      3  1.7|
      Lobules, Necrosis                    |                                                                2         |      2  2.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +     +  +              +                             +|  13        |
      Cyst                                 |                                                                          |      1     |
      Fat, Inflammation, Chronic Active    |                                                                          |      2  3.0|
      Fat, Necrosis                        |                   3     3  3              3                             1|     10  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1     2  2                    2     2                        |     11  1.8|
      Cytoplasmic Alteration               |                4                                                         |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7|            |
                             DAY ON TEST   | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3|            |
                                           | 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                          |      3  1.7|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Dilatation                     |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |    1           2                                                         |      3  1.7|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Ulcer                                |    2                                                                     |      2  2.5|
      Mucosa, Hyperplasia                  |                                                 3                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                2         |      2  1.5|
      Mineralization                       |                                                                         2|      3  1.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   2        |
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1              2           1        1              1  2  1  1|     20  1.5|
      Myocardium, Inflammation, Chronic    |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    | X        X           X  X  X                                             |      9     |
      Angiectasis                          |                1  2  2     2  1  1  2              1  1  2              2|     24  1.5|
      Clear Cell Focus                     |          X                    X                 X     X                  |      4     |
      Hematopoietic Cell Proliferation     |       2                 1                                                |      2  1.5|
      Hyperplasia, Focal                   |                         1     1           3        2                     |     12  1.9|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         2|      1  2.0|
      Hyperplasia                          |                               2  1              2     1              1  2|     10  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7|            |
                             DAY ON TEST   | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3|            |
                                           | 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |                            2        3              3                     |      4  2.5|
      Pars Distalis, Cyst                  | X           X     X  X        X  X     X           X        X  X  X  X   |     20     |
      Pars Distalis, Hyperplasia           |                   1  2           1     1           2                     |      9  1.7|
      Pars Distalis, Pigmentation          |          2                 1                       2                    2|      9  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                             X            |      3     |
      C-Cell, Hyperplasia                  |       1                 2                                                |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                            3                                             |      4  2.8|
      Inflammation, Chronic                |                                        1           2                     |      3  2.0|
      Inflammation, Suppurative            |                            3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      2  3.0|
      Cyst                                 |             X                                                            |      1     |
      Hydrometra                           |             3        2        3                          2           2   |      7  2.3|
      Hyperplasia, Cystic                  |          2  2        1        1                                         2|     13  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       M                                                              +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |       4                                                                  |      1  4.0|
      Hyperplasia, Reticulum Cell          |                2           1                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |          3                          2                                2   |      7  2.4|
      Mediastinal, Pigmentation            |             3  3        3           2                                3   |     10  3.0|
      Pancreatic, Hyperplasia, Plasma Cell |       2                                                                  |      1  2.0|
      Pancreatic, Lymphatic, Dilatation    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7|            |
                             DAY ON TEST   | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3|            |
                                           | 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Plasma Cell             |          2  2  2  3  2           2        2     2                       2|     14  2.2|
      Infiltration Cellular, Mast Cell     |                      3                                                   |      1  3.0|
      Lymphatic, Dilatation                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Hemorrhage                           |          2                          3                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       4              2                       3        2     3        2  2|     15  2.3|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                3                          2                              |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                               X     X                                    |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  |    2  2  1  1  3     4  2  3     2  2  1  4     1  1  1  2        2  2  2|     38  2.1|
      Hyperplasia, Lobular                 |                                                       1                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Osteopetrosis             |             3     3  3                                                   |      5  2.6|
      Femur, Osteopetrosis                 |             3     2  4                 2           3                     |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                X                                                         |      6     |
      Degeneration, Focal                  |                         2                                                |      1  2.0|
      Hemorrhage                           |                                                                4         |      1  4.0|
      Hydrocephalus                        |                2        3                       2                        |      4  2.3|
      Pigmentation                         |                         1                                                |      1  1.0|
      Meninges, Fibrosis                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          3                                                               |      2  3.0|
      Edema                                |          1                                                  2            |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7|            |
                             DAY ON TEST   | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3|            |
                                           | 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1  1  1  1  1  1        1        1  1        1     1  3            |     24  1.1|
      Inflammation, Chronic                | 1              1  1              1                    1           1     1|     12  1.0|
      Pigmentation, Cholesterol            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             3     2           3                                          |      3  2.7|
      Smooth Muscle, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Exudate                              |    X                                                        X            |      3     |
      Foreign Body                         |    2                                                                     |      1  2.0|
      Fungus                               |    X                                                                     |      1     |
      Inflammation, Chronic                |                         2  2  2     2  2                                 |      5  2.0|
      Glands, Hyperplasia                  |    3                                                                     |      1  3.0|
      Glands, Necrosis                     |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   1        |
      Cataract                             |                                           3                              |      1  3.0|
      Retina, Atrophy                      |                                           4                              |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         X|      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                   1                       2                              |      7  1.6|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 1     2           1                 1  2        1        1     2        2|     21  1.5|
      Nephropathy                          |    1  1  1  1  2  1  1  2  1     1  1  1  2     1  1     1        1  1  1|     41  1.2|
      Renal Tubule, Degeneration           |    4                                                                     |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |       2                                                        1         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    40 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2                           |             
      Parasite Metazoan                    |       X              X                                         X     X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                      2                        |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                           X                 X            |             
      Developmental Malformation           |                   X                 X  X                    X            |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |             2           1  3     1        2     1  1              1     1|             
      Hematopoietic Cell Proliferation     | 3                                            1                           |             
      Hepatodiaphragmatic Nodule           |          X                             X                          X     X|             
      Hyperplasia, Focal                   |                3                          3        4        3            |             
      Inflammation, Chronic                |                                           1                    1  1  1   |             
      Mixed Cell Focus                     |       3                                   X                              |             
      Bile Duct, Hyperplasia               |    1           1              2  1     1        1  1  1                  |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Pigmentation             | 1  1     1  1  1     1     1     1  1  1        1                 1  1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                                                       1                  |             
      Lobules, Necrosis                    |                               1                                          |             
      Oval Cell, Hyperplasia               |                               2                                          |             
      Portal, Necrosis                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                                                      |             
      Necrosis                             |                                                                          |             
      Fat, Necrosis                        |          4        3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                   1           1              1         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                    1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    40 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                   1  1        2  2  1     2        2  2  2  1  1  2  2  2|             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X     X     X                          X  X     X        X  X      |             
      Angiectasis                          | 2  1  2           2     2        2  2           3        1  2  2     3   |             
      Clear Cell Focus                     |                                  X                          X            |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   | 3                 2     3           1           1  1  1                  |             
      Hypertrophy, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 2  1  1        1  2  1     1              1              1        1  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 1              4                       1  2                       2      |             
      Pars Distalis, Cyst                  |                      X        X     X  X  X                 X  X  X      |             
      Pars Distalis, Hyperplasia           | 1                             1        3           3           2  2      |             
      Pars Distalis, Pigmentation          |       2     1  1                                2        2  2            |             
      Pars Intermedia, Angiectasis         |                                  3                                       |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  | 2  1        1  1     3              2     2                          2   |             
      Follicle, Cyst                       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    40 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                3         |             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X              X  X           X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Hemorrhage                           |          3                                                               |             
      Hydrometra                           |                                                                   2      |             
      Hyperplasia, Cystic                  |                   1  1  1  1     1     2  1                 3        1   |             
      Inflammation, Suppurative            |                      1                                                   |             
      Myometrium, Hyperplasia              |                                              3                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     | 4                                                                        |             
      Hyperplasia, Reticulum Cell          |                2           2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hemorrhage                |                                                                   2      |             
      Bronchial, Pigmentation              |                                                                   3      |             
      Mediastinal, Hemorrhage              |                               4  2                                       |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                    3                     |             
      Mediastinal, Pigmentation            | 3                    3           3     3        3                        |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Renal, Hemorrhage                    |                                           3                              |             
      Renal, Pigmentation                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          3               |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Hyperplasia, Plasma Cell             | 2     2     2           3     3  2     3        2              2  2  3   |             
      Pigmentation                         |                                                          3               |             
      Lymphatic, Dilatation                | 3                       2                       2  2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    40 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2     3  3|             
      Lymphatic, Dilatation                |                                                                2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      1   |             
      Fibrosis                             |                                                 1                        |             
      Hematopoietic Cell Proliferation     | 4              2                             3                           |             
      Pigmentation, Hemosiderin            |       3                          3              3        3               |             
      Lymphoid Follicle, Hyperplasia       |                            2              3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  3  1  1     1  1           2     2     3  1     1  2  2     2  2   |             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X                                                  X               |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                          2               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Infiltration Cellular, Histiocyte    |       1  1     1     1        1     1  1  1  1  1  1     1  1     1     1|             
      Inflammation, Chronic                | 1  1     1              1  1     1  1           1  2           1  1  1  1|             
      Inflammation, Suppurative            |                                                             1            |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Exudate                              |                            X                             X               |             
      Foreign Body                         |                                                          2               |             
      Fungus                               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    40 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                      2        2        2  2           2  3               |             
      Mucosa, Hyperplasia                  |                                                          2               |             
      Olfactory Epithelium, Pigmentation   | 1  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  1  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                +              +   |             
      Cataract                             |                      3                                2              2   |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                       1                  |             
      Retina, Atrophy                      |                      3                                3              3   |             
      Sclera, Mineralization               |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Hydronephrosis                       |                                              3                           |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                | 1        1                       1                    2  1        2      |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             2     1                       1                 1  1         |             
      Nephropathy                          | 1  1  2  2  1     1  1           1  1  1     1  2  1  2  3  2  1  1  1  1|             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Dilatation             |                                              3                           |             
      Renal Tubule, Pigmentation           | 2  2  2  3  2  2  3  1  2  3     2  2  3  1     1  1  2     2  3  3  3  3|             
      Transitional Epithelium, Hyperplasia |                                                                   1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              1                           |             
      Inflammation, Subacute               |                                              1              2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    | X        X        X        X  X                                          |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                 3                        |      1  3.0|
      Necrosis                             |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X     X  X  X  X     X     X  X  X   |     45     |
      Clear Cell Focus                     |                                                                          |      2     |
      Developmental Malformation           |    X                                                                     |      5     |
      Eosinophilic Focus                   |                                                          X        X      |      2     |
      Granuloma                            |    2  1  1  1     1        2     2  3  1  1     2     2  2     1  2      |     24  1.5|
      Hematopoietic Cell Proliferation     |                      2                                                   |      3  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      5     |
      Hyperplasia, Focal                   |                                                    2                     |      5  3.0|
      Inflammation, Chronic                |                   1                 2     1  1  1     1        1  2      |     12  1.2|
      Mixed Cell Focus                     |                               X  X                                       |      4  3.0|
      Bile Duct, Hyperplasia               |       1  1           1  1     1                       1           2  1  1|     17  1.1|
      Centrilobular, Necrosis              |                1                                                         |      1  1.0|
      Hepatocyte, Pigmentation             |                1           1  1  1        1     1        1     1  2  1  1|     24  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                         3|      1  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  1.0|
      Lobules, Necrosis                    |                                                                          |      1  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  2.0|
      Portal, Necrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                +        +        +        +|   7        |
      Necrosis                             |                                                                         4|      1  4.0|
      Fat, Necrosis                        |             3                                3        3        2         |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                               1           2              2     1     1  3|     10  1.4|
      Inflammation, Chronic                |    1                 1                    2                              |      3  1.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      2                                                   |      3  1.7|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                         3|      1  3.0|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
      Ulcer                                |                                                                         2|      1  2.0|
      Mucosa, Hyperplasia                  |                                                       1                 2|      3  1.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                +         |   1        |
      Developmental Malformation           |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  1  1           1  1           1  1  2     1  3     1  2  1  2  2|     31  1.6|
      Myocardium, Inflammation, Chronic    |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       X     X     X           X                                   X      |     13     |
      Angiectasis                          | 3  2     2  2        2  2           3  2  1  2  2  2     2  2        1   |     27  2.0|
      Clear Cell Focus                     |                                                 X              X         |      4     |
      Cyst                                 |                               X                                          |      1     |
      Hyperplasia, Focal                   |                      1  2           2              1              2      |     12  1.7|
      Hypertrophy, Focal                   | 1  2                                               1              1      |      4  1.3|
      Vacuolization Cytoplasmic, Diffuse   |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    3                                                                     |      1  3.0|
      Hyperplasia                          |          1        2  2  1  2           1  1  2           1  1     2  1  1|     25  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           | 3                    3                    2                              |      8  2.3|
      Pars Distalis, Cyst                  |          X  X     X  X  X  X  X           X  X        X  X              X|     20     |
      Pars Distalis, Hyperplasia           |                      1                                               1   |      8  1.8|
      Pars Distalis, Pigmentation          | 1                                                  2        1            |      9  1.6|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                               2           1           2     2        1   |     13  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                         2|      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                  2  2              2                    2|      5  2.0|
      Inflammation, Suppurative            |          3        2        3        1                                    |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              X                    X      |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                3                                         3               |      2  3.0|
      Cyst                                 |                      X                                                   |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrometra                           |                4        3  3                             2  3            |      6  2.8|
      Hyperplasia, Cystic                  | 2        1  1                 1  1     1     2  1     2              1  2|     20  1.4|
      Inflammation, Suppurative            |                                              1                           |      2  1.0|
      Myometrium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         +                          +                    M|   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                      3                                                   |      2  3.5|
      Hyperplasia, Reticulum Cell          |                                  3                                       |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Hemorrhage                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Bronchial, Pigmentation              |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|       2                                                                  |      2  2.5|
      Mediastinal, Pigmentation            |       2                          3                                       |      7  2.9|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |    3                                                                     |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                           3                              |      2  2.5|
      Hyperplasia, Plasma Cell             | 2  3     3  3                 2  2     2                 2     3         |     20  2.4|
      Pigmentation                         |                                                                          |      1  3.0|
      Lymphatic, Dilatation                |                                        2                                 |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                            2                                             |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.7|
      Lymphatic, Dilatation                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3                                                                        |      2  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |    2                 4                                         2         |      6  2.8|
      Pigmentation, Hemosiderin            |       3           3                                               3      |      7  3.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                    X                     |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    4  2  1  2  1  2  1  1  2  2        2     1  1  2     1  2  2         |     33  1.7|
      Hyperplasia, Lobular                 |          1                                                        3      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteopetrosis                 |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    X              X                                                      |      4     |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Hydrocephalus                        |    1              2                                2                     |      4  1.8|
      Necrosis                             |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1  1  1        1  1  1  1  1  1  2  1     1           1  1        1  1|     31  1.0|
      Inflammation, Chronic                |       1  1                                               1     1  1      |     18  1.1|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Thrombosis                           |                                                       1                  |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                  X                                       |      1     |
      Exudate                              |                               X  X              X                 X     X|      7     |
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic                |             2                       2  2                          3     2|     11  2.2|
      Mucosa, Hyperplasia                  |                               2                                          |      2  2.0|
      Olfactory Epithelium, Pigmentation   | 2  3  2  2  2  1  2  3  3  3  2  3  2  2  2  2  2  2  1  2  1  1  3  2  2|     50  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                  +           +  +  +|   8        |
      Cataract                             |    2                                                  2           4  2  2|      8  2.4|
      Cornea, Inflammation, Chronic Active |                                                                   1      |      1  1.0|
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Retina, Atrophy                      |    3                                                  3           4  3  3|      8  3.1|
      Sclera, Mineralization               |                                                       1                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    40 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                   4                    1  1                       2      |     10  1.6|
      Inflammation, Suppurative            |                   1                                                      |      1  1.0|
      Mineralization                       |          1  1        1     1     1  1  1     1     1  1                  |     15  1.1|
      Nephropathy                          | 1  1  1  1  1     4  1  1  1  1  1  1  2  1  1  1  2  1  1  1  2  2      |     42  1.3|
      Renal Tubule, Atrophy                |                   4                                                      |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           | 2  3  2  2  2     4  2  2  3  2  2  2  2  2  2  2  2     3  2  2  3  2  2|     45  2.2|
      Transitional Epithelium, Hyperplasia |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    20 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Basophilic Focus                     |             X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                                                         X|             
      Granuloma                            |                1  2     2        3                 2           1  3  1   |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hepatodiaphragmatic Nodule           |             X     X                       X     X           X            |             
      Hyperplasia, Focal                   |       2  3                             2  2     2                        |             
      Inflammation, Chronic                |                1  1  1                 1           1                     |             
      Mixed Cell Focus                     |                                                       4     X            |             
      Bile Duct, Hyperplasia               |       1     1        1  1                 1  1  1  1  1  1  1  1  1  1   |             
      Centrilobular, Atrophy               |          2                                                               |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Pigmentation             |                1     1  1     1     1  1        2        1               |             
      Hepatocyte, Vacuolization Cytoplasmic|                               2  2                                       |             
      Kupffer Cell, Pigmentation           |       2                                                                  |             
      Lobules, Necrosis                    |       1  2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                       +                              |             
      Fat, Necrosis                        |                   2                       4                              |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                             1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X     X     X                    X  X        X  X               |             
      Angiectasis                          | 1        2  1     2     2        2     1        3  1  1  2  2  1  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    20 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Clear Cell Focus                     |                            X                                             |             
      Degeneration, Fatty                  |                                        3                                 |             
      Hyperplasia, Focal                   |                   2     2     2     1     2                          2  1|             
      Hypertrophy, Focal                   |                                                          2               |             
      Necrosis                             |    4                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |          3     1     1           1                                1  1   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3     3  4                                         3           2   |             
      Pars Distalis, Cyst                  |       X  X           X  X  X        X  X  X     X  X  X        X  X  X   |             
      Pars Distalis, Hyperplasia           |                   1  2     2                                      3      |             
      Pars Distalis, Pigmentation          |          1  2  2     1     1                          1  2               |             
      Pars Intermedia, Angiectasis         |                                                          2               |             
      Pars Intermedia, Cyst                |             X                                                            |             
      Pars Intermedia, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                      +                                      +     +  +   |             
      Ectasia                              |                                                                   2      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +           +     +                       +               |             
      Cyst                                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |             3                                         3                  |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                2  1        1     1                          1  3         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +        +  +                    +                              |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Lymphatic, Dilatation        |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                      3                                                   |             
      Mediastinal, Pigmentation            |                      4                                                   |             
      Pancreatic, Hemorrhage               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    20 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Pigmentation                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +        +                                                      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +                             +     +                        |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |       2     3                                                            |             
      Necrosis                             |    3                                                                     |             
      Pigmentation, Hemosiderin            |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +  +        +           +           +                 +  +     +|             
      Hyperplasia, Cystic                  |          2  1        3           2           3                          1|             
      Hyperplasia, Lobular                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +                                      +              +                  |             
      Hemorrhage                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                     +                                    |             
      Calvarium, Osteopetrosis             |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                             +           +                           |             
      Compression                          |                                  X           X                           |             
      Hydrocephalus                        |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +                                +  +                             +|             
      Congestion                           |                                                                         4|             
      Infiltration Cellular, Histiocyte    | 1     1                                2                                 |             
      Inflammation, Chronic                |                                        1                                 |             
      Inflammation, Suppurative            |                                           3                              |             
      Alveolar Epithelium, Hyperplasia     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                            X  X                                         X|             
      Foreign Body                         |                            2  2                                          |             
      Fungus                               |                               X                                         X|             
      Inflammation, Chronic                |                3     3  3  3                                             |             
      Mucosa, Hyperplasia                  |                            2                                            2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    20 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                         2  2                                             |             
      Olfactory Epithelium, Pigmentation   |       1  2  1  1  2  2  2  1     1  2  2  1  1  2  2  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +           +               |             
      Cataract                             |                                              4           3               |             
      Phthisis Bulbi                       |                                                                          |             
      Retina, Atrophy                      |                                              4           3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                   2  2  2        3     3              2                  |             
      Inflammation, Suppurative            |                                  1                                       |             
      Mineralization                       | 1           2     1        1        1        1  1        2  1  2        1|             
      Nephropathy                          | 1        1  1  2  2  2  2  2  2  4  1  3  1  2  1  2  3  1  1  1  1  1  1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |       3  1  2  2  1  2  2        2  2  2  1  2  3  2  1  1  2  2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    20 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                2                    3                                   2|      4  2.3|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X|     44     |
      Clear Cell Focus                     | X                    X  X                                                |      3     |
      Developmental Malformation           |                                                                          |      1     |
      Granuloma                            |       1  1        1  1           1  1  1                 1  3  2  1      |     19  1.5|
      Hematopoietic Cell Proliferation     |                                              2  2                       2|      4  2.0|
      Hepatodiaphragmatic Nodule           |                                                             X  X         |      7     |
      Hyperplasia, Focal                   |                         2                                                |      6  2.2|
      Inflammation, Chronic                | 1        1                             1              1     3            |     10  1.2|
      Mixed Cell Focus                     |                                                    X        X            |      4  4.0|
      Bile Duct, Hyperplasia               |    2  1     1  1     1  1              1     1     1     1     1  1  1   |     27  1.0|
      Centrilobular, Atrophy               |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                 1                        |      1  1.0|
      Hepatocyte, Pigmentation             |    3        1        1  2  2     1     1                 1     1        1|     18  1.3|
      Hepatocyte, Vacuolization Cytoplasmic|    2                                                                     |      3  2.0|
      Kupffer Cell, Pigmentation           |                         2                                                |      2  2.0|
      Lobules, Necrosis                    |                                        1                                 |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Fat, Necrosis                        |          2                                                               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +                                          |   1        |
      Foreign Body                         |                               2                                          |      1  2.0|
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    20 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       X  X     X                             X     X           X         |     13     |
      Angiectasis                          | 1     2  2  1     1  2     2        2           1  1  2  2     2  1     1|     30  1.6|
      Clear Cell Focus                     |                                              X  X  X                     |      4     |
      Degeneration, Fatty                  |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |          2     2     1                    1           2  3               |     13  1.8|
      Hypertrophy, Focal                   |                2                                                     1   |      3  1.7|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  2                                       |      1  2.0|
      Hyperplasia                          |    1  2     1     2        3     2        1  1  1  2        1        2   |     18  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                               2                       1                  |      7  2.6|
      Pars Distalis, Cyst                  |       X  X  X     X           X     X  X  X        X     X  X  X     X   |     27     |
      Pars Distalis, Hyperplasia           |             1                 1        1                       1         |      8  1.5|
      Pars Distalis, Pigmentation          |    1     2                                               2               |     10  1.5|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |             X                                                            |      2     |
      Pars Intermedia, Pigmentation        |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                              +              +     +     +|   8        |
      Ectasia                              |                                                             2            |      2  2.0|
      Inflammation, Chronic                |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |   5        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                        3                                 |      1  3.0|
      Angiectasis                          |    3                                                                     |      1  3.0|
      Hemorrhage                           |    4                                                                     |      3  3.3|
      Hydrometra                           |          2                                                              3|      2  2.5|
      Hyperplasia, Cystic                  |    1  3        1                 1                    2           1     2|     13  1.5|
      Necrosis                             |    4                                                                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    20 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +     M              +              +                       +   |  11        |
      Inguinal, Hyperplasia, Plasma Cell   |                                              3                           |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                              3                           |      1  3.0|
      Lumbar, Lymphatic, Dilatation        |                                              4                           |      1  4.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      1  4.0|
      Pancreatic, Hemorrhage               |                               2                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                    +                                      +   |   3        |
      Hemorrhage                           |                               2                                          |      1  2.0|
      Hyperplasia, Lymphoid                |          2                                                               |      1  2.0|
      Hyperplasia, Plasma Cell             |          3                                                               |      1  3.0|
      Lymphatic, Dilatation                |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   3        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                         +                    +  +  +                     |  10        |
      Developmental Malformation           |                                                    X                     |      1     |
      Hematopoietic Cell Proliferation     |                                              4  4                        |      4  3.3|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                         3                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +        +  +     +           +  +  +        +           +|  21        |
      Hyperplasia, Cystic                  | 3              4        3        2           2  2  2        3           1|     15  2.3|
      Hyperplasia, Lobular                 |                                                             3            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   3        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                          +        +                 +        +         |   6        |
      Calvarium, Osteopetrosis             | 3                          2        3                 2        2         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                              +                           |   4        |
      Compression                          |                                              X                           |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    20 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                              +  +                        |   7        |
      Congestion                           |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                              2                           |      4  1.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                              4                           |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                      X                 X        X     X              X   |      8     |
      Foreign Body                         |                                        2                                 |      3  2.0|
      Fungus                               |                                        X        X                    X   |      5     |
      Inflammation, Chronic                |                         2  2           2        2           3  2  2  2  2|     13  2.4|
      Mucosa, Hyperplasia                  |                                        2              2              2   |      5  2.0|
      Mucosa, Metaplasia, Squamous         |                            2                                2            |      4  2.0|
      Olfactory Epithelium, Pigmentation   | 1  2  2  1  1     1  1  1  1  1  2  2  1  1  1  1  2  1  1  2  1  2  2  2|     46  1.4|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                       +         |   4        |
      Cataract                             |                                        3                                 |      3  3.3|
      Phthisis Bulbi                       |                                                                3         |      1  3.0|
      Retina, Atrophy                      |                                        3                                 |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            X                                             |      1     |
      Inflammation, Chronic                |    2  3        4                                            2        2   |     11  2.5|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       |    2        1  1     1  1              2  1  2  1        1  1  2        1|     24  1.3|
      Nephropathy                          | 1  3  3  2  2  4  1  1  1  3  1  1  1  1  1  2  1  1  2  1  1  1  1  3  1|     48  1.6|
      Renal Tubule, Dilatation             |    3                                                                     |      1  3.0|
      Renal Tubule, Pigmentation           |    2  2  1  2  2  2  2  3  3  1  2  3  1  2  3     2  2  1  2  2  2  2  2|     43  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                         +                                                |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|             
                                           | 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                            X                                             |             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X  X        X  X  X        X     X        X     X        X  X  X|             
      Clear Cell Focus                     |       X  X  X                             X        X  X           X  X  X|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                         X|             
      Granuloma                            |    1        2                 1           1        2  1              1  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   | 2                 3        2                 2                 2         |             
      Inflammation, Chronic                |    2                          1                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  2  2  2  1  2  3     2  2  2     1  2  3  1  2     1  1  2  2  2  2|             
      Centrilobular, Atrophy               |                   2                                            2         |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                       2        3  2                     |             
      Kupffer Cell, Hyperplasia            |                                                             3            |             
      Lobules, Necrosis                    |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +                 +        +                       +               |             
      Accessory Spleen                     |                                                                          |             
      Fat, Inflammation, Pyogranulomatous  |                                                                          |             
      Fat, Necrosis                        | 2     3                                                  4               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  1                    4     1           1  1        1      |             
      Fibrosis                             |                                                                3         |             
      Focal Cellular Change                |                                                       1                  |             
      Hyperplasia, Focal                   | 2     3     2     3  2  3                 3  3        3  2        1      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|             
                                           | 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                 4                        |             
      Erosion                              |                                  2                                       |             
      Inflammation, Chronic                |                            3                                             |             
      Ulcer                                |                         2                       4           3            |             
      Mucosa, Hyperplasia                  |          2                 2     3              3              2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                              1                           |             
      Mineralization                       |                      1                                                   |             
      Ulcer                                |                         2        2                          2            |             
      Mucosa, Hyperplasia                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                    +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Polyarteritis                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3  2     3  2     1     2           2  2  2  2  1     2        2  1  2|             
      Thrombosis                           |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Inflammation, Chronic    |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X  X        X              X  X        X              X        X|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                        X                                 |             
      Cyst                                 |          X                                                               |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hyperplasia, Focal                   |                                        1                 2           1   |             
      Vacuolization Cytoplasmic, Diffuse   |                                  3              1           3            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1  2     1              1        2  2  1  2           2        1  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia                          |                                     3  3  2                          3  2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                2     2                                      1        3   |             
      Pars Distalis, Pigmentation          |             2                                               2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|             
                                           | 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Angiectasis         |                                              2                           |             
      Pars Intermedia, Hyperplasia         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2              1  2  1                                                |             
      Follicle, Cyst                       |          X                                         X  X              X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +     +        +                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            3                             2               |             
      Foreign Body                         |    2                                                                     |             
      Inflammation, Chronic                | 2        2  3  1     2  2  3     2  2  3  2     3     2        2  2     2|             
      Inflammation, Suppurative            |    2     2     1                    1           3  1              3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                       3                  |             
      Inflammation, Chronic                | 1     1                    1                          2                  |             
      Inflammation, Suppurative            | 1     1        2  2        1  3     1        1  3     3  2  2  2  3  1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2  2  2     1  1  2     2           1  1  1  1                 2     3|             
      Interstitial Cell, Hyperplasia       |                                                 3        2               |             
      Seminiferous Tubule, Atrophy         |                         3                                2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                             4            |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Hypocellularity                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphatic, Dilatation      |                                                                         3|             
      Mediastinal, Hemorrhage              |                4     3  3                                                |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                   3      |             
      Pancreatic, Hyperplasia, Lymphoid    |                      2  2                                                |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|             
                                           | 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Lymphatic, Dilatation         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Hyperplasia, Lymphoid                |                         3                                                |             
      Hyperplasia, Plasma Cell             |    3  2  2  2     3  2              3        3  2     3                  |             
      Lymphatic, Dilatation                | 2                          2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                      2  4                                   4            |             
      Necrosis                             |                   4                                                      |             
      Pigmentation, Hemosiderin            |                               3                 3     3  3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Cyst                                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                   3  3        3  2  4  1     2  3        3        1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 4                        |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              |                                                 X                        |             
      Fibrosis                             |                                                 3                        |             
      Foreign Body                         |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X                 X     X  X               |             
      Hemorrhage                           |                   2                                                      |             
      Hydrocephalus                        |                                     2                                    |             
      Necrosis                             |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|             
                                           | 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Atelectasis                          |                                                                          |             
      Congestion                           |                3              3                                          |             
      Edema                                |                               2              2                           |             
      Hemorrhage                           |                                                                   2      |             
      Infiltration Cellular, Histiocyte    |       2        1     1  1  1        1  1        1  4  1  1  1  1  1  2  1|             
      Inflammation, Chronic                |    1                                   1           3                     |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   3     2              1                                 |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                X  X     X        X  X        X                           |             
      Foreign Body                         |                         2           2        3                           |             
      Fungus                               |                X        X        X  X        X                           |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Hyperplasia                  |                3        2           2                                    |             
      Mucosa, Metaplasia, Squamous         |                                  3                                       |             
      Nerve, Hypertrophy                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cataract                             |             3                                                            |             
      Retina, Atrophy                      |             3                                                            |             
      Sclera, Mineralization               |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |    1  2  2  3     2  2  3           3  3  2     3     3  4  3     4  4  4|             
      Inflammation, Suppurative            |       1                             1                                   1|             
      Mineralization                       |          1     2        3  1     1     1  1           1  1  1  1  1     1|             
      Nephropathy                          | 1  2  2  3  3  2  3  3  3  2  2  2  4  4  3  3  4  2  3  4  3  2  4  4  4|             
      Renal Tubule, Pigmentation           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Ectasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                 3                        |      1  3.0|
      Parasite Metazoan                    |                                                                   X      |      2     |
      Ulcer                                |                                                 4                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                    X           X                       X            |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                    X                                   X         |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X  X     X  X  X  X        X  X  X           X  X     X  X      |     27     |
      Clear Cell Focus                     |          X  X              X           X              X                  |     14     |
      Degeneration, Cystic                 |       3                                                        2         |      2  2.5|
      Eosinophilic Focus                   |                                                                      X  X|      3     |
      Granuloma                            |    2     3  2     1     1  1  3     1  3              2  1               |     19  1.6|
      Hematopoietic Cell Proliferation     |                      3           1           1                 2         |      4  1.8|
      Hyperplasia, Focal                   |             2                                                        2   |      7  2.1|
      Inflammation, Chronic                |                         2     3                    1  2                  |      6  1.8|
      Mixed Cell Focus                     |    X                                                                     |      1     |
      Bile Duct, Hyperplasia               | 2  2  3     1     2  1  2  2  2  1  1  1  2  2  1  3  2  2  1  2  2  3  1|     45  1.9|
      Centrilobular, Atrophy               |                                                                          |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|    3        2     2                                   3                  |      8  2.4|
      Kupffer Cell, Hyperplasia            | 2                    2                                                   |      3  2.3|
      Lobules, Necrosis                    |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +              +                                +     +         |  11        |
      Accessory Spleen                     |                                                          X               |      1     |
      Fat, Inflammation, Pyogranulomatous  |                         3                                                |      1  3.0|
      Fat, Necrosis                        |          3              3                                      3         |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       1           2        3           1  2        3                 3   |     14  1.9|
      Fibrosis                             |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |       2  4              3                 4  2           1           2  3|     19  2.5|
      Infiltration Cellular, Histiocyte    | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  4.0|
      Erosion                              |                                              2                           |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  3.0|
      Mucosa, Hyperplasia                  |                                              3                           |      6  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                      2                          1                        |      3  1.3|
      Mineralization                       |          1           2  1                                                |      4  1.3|
      Ulcer                                |                                                                          |      3  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                 +                             +               |   4        |
      Polyarteritis                        |          3                 3                             2               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  2  3  3     3  1  3  2  2  2     2  2  2  3  2  3           2      |     33  2.2|
      Thrombosis                           |          X                                                               |      1     |
      Epicardium, Inflammation, Chronic    |                      2                                                   |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                  1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |    X              X     X  X                 X                          X|     14     |
      Angiectasis                          |             2              2                                      2  2   |      4  2.0|
      Clear Cell Focus                     |    X        X                                                  X         |      4     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                      3                                                   |      2  2.5|
      Hyperplasia, Focal                   |                               2     1     1           2                  |      7  1.4|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2  1           1        2        1                 3     1     1|     23  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          | 3                                         3                 1            |      8  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                      3                                                   |      1  3.0|
      Pars Distalis, Cyst                  |             X        X              X                                   X|      5     |
      Pars Distalis, Hyperplasia           |                               2     1                          1  2     1|      9  1.7|
      Pars Distalis, Pigmentation          |                                                                          |      2  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Hyperplasia         |                      2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2  2                                2  3                                2|      9  1.9|
      Follicle, Cyst                       |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               3                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          3                                               3               |      4  2.8|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |    3  2  3              2     2        2  3     2        2  2        2  2|     28  2.2|
      Inflammation, Suppurative            | 2        3  4                                      1                     |     11  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  X                                       |      2     |
      Edema                                |                                                    4                     |      1  4.0|
      Fibrosis                             | 3                                                                        |      2  3.0|
      Inflammation, Chronic                | 3                          2        1                                    |      7  1.6|
      Inflammation, Suppurative            | 2  2              2  1           3           1  1  4  1                 1|     25  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    4                     |      1  4.0|
      Inflammation, Suppurative            |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       1  2        1        1     2  1  1              1  1  1  1  3  2   |     26  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                                                                          |      2  2.5|
      Seminiferous Tubule, Atrophy         |                                  1  4        4                           |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                                                         3|      2  3.5|
      Hyperplasia, Reticulum Cell          |                                        2                                 |      1  2.0|
      Hypocellularity                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Lymphatic, Dilatation      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                      3           3        3                       2     3|      8  3.0|
      Mediastinal, Pigmentation            | 3                    2           3                                2      |      4  2.5|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Renal, Hyperplasia, Lymphoid         |                                  3                                       |      1  3.0|
      Renal, Lymphatic, Dilatation         |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    2                                                                     |      2  2.5|
      Hyperplasia, Plasma Cell             |    2        3              2  3                    2        3     1  2  2|     19  2.4|
      Lymphatic, Dilatation                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                      3                                                   |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            3                                   1         |      2  2.0|
      Developmental Malformation           |                                  X                                       |      1     |
      Fibrosis                             |                   2                                                      |      2  2.5|
      Hematopoietic Cell Proliferation     | 2                    4           2  2        2                 2         |      9  2.7|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                      3   |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +|  46        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |    X                                                        X            |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Hyperplasia, Cystic                  |             1                 2           2        2  1        1        1|     17  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |       4                                                                  |      2  4.0|
      Cyst Epithelial Inclusion            |                                              X                           |      1     |
      Exudate                              |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Foreign Body                         |       4                                                                  |      1  4.0|
      Hyperkeratosis                       |       4                                                                  |      1  4.0|
      Inflammation, Granulomatous          |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                  X                 X                     |      6     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                      3                                                   |      1  3.0|
      Congestion                           |                                                                          |      2  3.0|
      Edema                                |                                              3                           |      3  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  2  1  1  2     1     1  3  1  1        1  3  1     1  1  3           1|     33  1.4|
      Inflammation, Chronic                |                   1        2                                3     1      |      7  1.7|
      Inflammation, Suppurative            |                                                 1                        |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             2              2                 3                           |      6  2.2|
      Mediastinum, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |          X  X  X  X  X  X        X                       X  X        X  X|     17     |
      Foreign Body                         |          3     2     1  3                                               2|      8  2.3|
      Fungus                               |          X  X  4  X  X  X        X                       X  X            |     14  4.0|
      Inflammation, Chronic                |             2     3                                                      |      2  2.5|
      Mucosa, Hyperplasia                  |          3  3        2           3                                      2|      8  2.5|
      Mucosa, Metaplasia, Squamous         |                   3  2  3                                2               |      5  2.6|
      Nerve, Hypertrophy                   |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2|            |
                                           | 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                   3                                                      |      2  3.0|
      Sclera, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         X                             X                  |      2     |
      Infarct                              |                                              2                           |      1  2.0|
      Inflammation, Chronic                | 3  2  2  4  2     3  1  4  2     2  1  2  3     2  3     4  1  2  3  3  4|     38  2.7|
      Inflammation, Suppurative            |          3        2     2                                1        1  1  1|     10  1.4|
      Mineralization                       |    1  1           1  2  1                    1                          1|     20  1.2|
      Nephropathy                          | 3  3  2  4  2     3  3  4  3  1  2  1  2  4  3  3  4  2  4  1  2  3  3  3|     49  2.8|
      Renal Tubule, Pigmentation           | 3                                                                        |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                 +        +               |   2        |
      Bulbourethral Gland, Ectasia         |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia                  |                                                    1                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|             
                                           | 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X  X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                                   X      |             
      Lymphatic, Dilatation                |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Basophilic Focus                     |             X                             X                       X      |             
      Clear Cell Focus                     |                                                                      X  X|             
      Congestion                           |    3              2     3  2        2  3     2  2     2                  |             
      Degeneration, Cystic                 |       2                          2                       1               |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |                                           1                             1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |       2     3                                                            |             
      Inflammation, Chronic                |                                        2                                2|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |    2  3  2  4                    2  1  2                 3  1     1  2  1|             
      Centrilobular, Necrosis              | 1              1  1  2     2     2  1        1  1  1        1            |             
      Hepatocyte, Pigmentation             |                                  1                                   1  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Lobules, Necrosis                    |                                                                          |             
      Periportal, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                             1            |             
      Portal, Necrosis                     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +  +  +  +                                            +|             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2     1                       1  2                                 |             
      Cytoplasmic Alteration               |                                                                          |             
      Edema                                |             3                                                            |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|             
                                           | 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +  +|             
      Polyarteritis                        |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cardiomyopathy                       |    1  2     1                       2  1  2              3        1  1   |             
      Myocardium, Inflammation, Chronic    |                      1     2  2                             1            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X  X                                   X                             X|             
      Angiectasis                          |                                        2                             3   |             
      Clear Cell Focus                     |          X                                                               |             
      Congestion                           |                                                             3  3         |             
      Hemorrhage                           |    3                       3                                             |             
      Hyperplasia, Focal                   |                                                          2               |             
      Vacuolization Cytoplasmic, Diffuse   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                                 |             
      Hyperplasia                          |          2                          3     1                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                          1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                         1|             
      Follicle, Cyst                       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|             
                                           | 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2  2                          2  2              2  2     2     2|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Suppurative            |    1     3                                1              2     2        1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                       2  2  1              1           1  2|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |    4        3                                                        4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2                                                                 3   |             
      Hyperplasia, Reticulum Cell          |                                           2                              |             
      Lymphatic, Dilatation                |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Hemorrhage                           |    2                                                                     |             
      Necrosis                             |                                           1                              |             
      Lymphatic, Dilatation                |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |             3                                                            |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Congestion                           |                3  2  3  3  3        4                       3  3         |             
      Cyst                                 |                                                                          |             
      Ectopic Parathyroid Gland            |                                     X                                    |             
      Hemorrhage                           | 3              3  2  3  3  3  4              3     4  2     3  3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|             
                                           | 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Cystic                  |          3                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                  X                                       |             
      Exudate                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Scrotum, Congestion                  |                                              2     2  2     2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Congestion                           | 3  2                          2     3        2  2  2  2     2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 4  3           3  3  3  3  3  4  3  4  3     3  3  2  2     3  3         |             
      Edema                                | 2                             2                    2                     |             
      Foreign Body                         |                                        3                                 |             
      Hemorrhage                           |                         3                                                |             
      Infiltration Cellular, Histiocyte    |       1  1                       1        1              2        2  2  1|             
      Inflammation, Chronic                |          1                                               2        1  2   |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |             1                                                            |             
      Metaplasia, Osseous                  |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     4                                    |             
      Exudate                              |       X                                                           X     X|             
      Foreign Body                         |       2                                                           2      |             
      Fungus                               |       X                                                           X     X|             
      Inflammation, Chronic                |       2                                                           3      |             
      Mucosa, Erosion                      |                                                                          |             
      Mucosa, Hyperplasia                  |       2                                                           2      |             
      Mucosa, Metaplasia, Squamous         |                                                                   3     3|             
      Olfactory Epithelium, Pigmentation   |    2  2  2  3                    2  1  1  2              2        2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|             
                                           | 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
      Sclera, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |       2  3  2                    3     2  2              3        3  4  2|             
      Inflammation, Suppurative            |          1                          1     1              2           2  1|             
      Mineralization                       |                                  1  1                                    |             
      Nephropathy                          |    2  3  2  3                    2  2  2  2              4     1  3  4  2|             
      Artery, Hypertrophy                  |                                                                   4      |             
      Renal Tubule, Pigmentation           |       2  2  2                       2     3              2           2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3|            |
                                           | 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    40 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                  X     X              X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |             3                                                            |      1  3.0|
      Parasite Metazoan                    |                                                 X     X                  |      3     |
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                                                                     |      2  1.5|
      Basophilic Focus                     |    X  X     X                          X                                X|      8     |
      Clear Cell Focus                     |    X        X                                                            |      4     |
      Congestion                           |                            2  3     2                          2         |     13  2.3|
      Degeneration, Cystic                 |                                           1        2                    1|      6  1.5|
      Eosinophilic Focus                   |                                                    X                     |      1     |
      Granuloma                            |       1  1  1                                         1              1  1|      8  1.0|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      1     |
      Hyperplasia, Focal                   |                                                                          |      2  2.5|
      Inflammation, Chronic                |       1                                            2                     |      4  1.8|
      Mixed Cell Focus                     |                                                       X                  |      1     |
      Bile Duct, Hyperplasia               |    3  2  1  3                    3  1  1  2        3  1  1        3  1  1|     26  1.9|
      Centrilobular, Necrosis              |                   1     2  2  3                 2                 3      |     17  1.6|
      Hepatocyte, Pigmentation             |                                                                      1   |      4  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                     2                 1                  |      2  1.5|
      Lobules, Necrosis                    |                                  1                                       |      1  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Portal, Necrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +  +              +               |   9        |
      Fat, Necrosis                        |                                           2              3               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2     3                                                     1  3     1|      9  1.8|
      Cytoplasmic Alteration               |                                  3                                       |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3|            |
                                           | 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    40 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                   1      |      1  1.0|
      Ulcer                                |                                  3              3                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                   +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +     +                                +                              |   5        |
      Polyarteritis                        |    3     3                                2                              |      5  2.4|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   3      |      1  3.0|
      Cardiomyopathy                       |    2        1                    2  1  3  2        2  2  2        3  1  3|     21  1.8|
      Myocardium, Inflammation, Chronic    |                   2     2                                   2            |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                    X  X                  |      6     |
      Angiectasis                          |       2  2                                                               |      4  2.3|
      Clear Cell Focus                     |             X                                         X                  |      3     |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                     2                       4  3         |      5  3.0|
      Hyperplasia, Focal                   |                                                          3               |      2  2.5|
      Vacuolization Cytoplasmic, Diffuse   |                                                                   3      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia                          |       1     2                             1        2  2                 1|      9  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          3               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       4     1                                                            |      2  2.5|
      Pars Distalis, Cyst                  |                                                       X                  |      2     |
      Pars Distalis, Hyperplasia           |    1        1                                                            |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3|            |
                                           | 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    40 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Angiectasis         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       2                                               2                 1|      4  1.5|
      Follicle, Cyst                       |             X                                                            |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |       2                                2                 2        2  2  3|     15  2.1|
      Inflammation, Suppurative            |       1                                   2                       2      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2        2                          1                                 |      4  1.8|
      Inflammation, Suppurative            |    2     1  2                    2  3     3        2              3  1   |     15  1.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2  1                                               1  3        1  1  1|     14  1.5|
      Interstitial Cell, Hyperplasia       |                                  1        2                              |      2  1.5|
      Seminiferous Tubule, Atrophy         |       4                                                           3      |      5  3.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Congestion              |                                                                2         |      1  2.0|
      Mediastinal, Hemorrhage              |                                     4                                    |      1  4.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                               3              3  2              2         |      5  2.4|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |          3                             3                 3               |      3  3.0|
      Hyperplasia, Plasma Cell             |          2                                4              2               |      5  2.6|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Lymphatic, Dilatation                |                                                          3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                      2   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3|            |
                                           | 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    40 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |    1                                                                     |      2  1.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                   3      |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                      2   |      2  2.0|
      Necrosis                             |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Congestion                           |                               3     4        3  3           3            |     13  3.1|
      Cyst                                 |       X                                                                  |      1     |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hemorrhage                           | 2              3  2  3  3  4                 3              3  3         |     21  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Cystic                  |       2                          3        1                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                  2                                       |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Exudate                              |                                  X                                       |      1     |
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
      Scrotum, Congestion                  |                2  2  2  2  2  3     3        2  2                        |     13  2.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X                          X                                       |      2     |
      Congestion                           | 2              2  3  2  2  3  2     3        3  2           2  2         |     21  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3              3  3  3  3  3  3     4        3  3  3        3  3         |     30  3.1|
      Edema                                |                                                 2  2                     |      5  2.0|
      Foreign Body                         |                                                    2                     |      2  2.5|
      Hemorrhage                           |                                                                   2      |      2  2.5|
      Infiltration Cellular, Histiocyte    |    1  1  1  1                    2  3  2  1  1     1  1  1        2  2  2|     23  1.4|
      Inflammation, Chronic                |    1     1                                                               |      6  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3|            |
                                           | 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    40 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                     3                                    |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                     3              4                     |      3  3.7|
      Exudate                              |          X  X                             X        X     X              X|      9     |
      Foreign Body                         |                                                                          |      2  2.0|
      Fungus                               |          X  X                                            X               |      6     |
      Inflammation, Chronic                |          2  3  2                                                         |      5  2.4|
      Mucosa, Erosion                      |                2                                                         |      1  2.0|
      Mucosa, Hyperplasia                  |                                                          3               |      3  2.3|
      Mucosa, Metaplasia, Squamous         |          2  3                                            3               |      5  2.8|
      Olfactory Epithelium, Pigmentation   |    2  2  1  2                    2     1  1        1  1  2        2  2  2|     25  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                    X                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                         +                  |   2        |
      Cataract                             |                                                       3                  |      1  3.0|
      Phthisis Bulbi                       |             3                                                            |      1  3.0|
      Retina, Atrophy                      |                                                       4                  |      1  4.0|
      Sclera, Mineralization               |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                     3                                    |      1  3.0|
      Cyst                                 |       X                                                                  |      1     |
      Inflammation, Chronic                |    3  2  2  2                    2     2  3           2  4              3|     20  2.6|
      Inflammation, Suppurative            |    3  3  2  1                    1                    1  2              2|     14  1.6|
      Mineralization                       |       2  1  1                             1           1                 1|      8  1.1|
      Nephropathy                          |    3  3  3  2                    3  1  3  3        1  3  4        1  1  4|     27  2.5|
      Artery, Hypertrophy                  |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |    2  2     2                    2        2        2              2     2|     16  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|             
                                           | 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |          X              X                                                |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X           X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Basophilic Focus                     |             X        X     X  X  X  X  X  X     X  X     X  X           X|             
      Clear Cell Focus                     |                                     X     X        X                     |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                  2              1           1  1     1   |             
      Eosinophilic Focus                   |                                                       X  X               |             
      Granuloma                            |                                  1                 2     3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |             1                          1           2     2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Hyperplasia               |             2  1  1  3  1  3  3  2  2  1  2  1  2  2  3  2  1  2  3  1  3|             
      Centrilobular, Atrophy               |                3  2                                                      |             
      Centrilobular, Necrosis              | 1  1     1                                                               |             
      Hepatocyte, Pigmentation             |                                                 1                        |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                3         |             
      Kupffer Cell, Hyperplasia            |                         2                          2                     |             
      Lobules, Necrosis                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3        3  1     1        1  3           1  3     1         |             
      Cytoplasmic Alteration               |                   3                                                      |             
      Focal Cellular Change                |             X                                                            |             
      Hyperplasia, Focal                   |                                     2  3  3                             3|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|             
                                           | 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                         3                                                |             
      Edema                                |                   2                                                      |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Ulcer                                |                                                                4         |             
      Mucosa, Hyperplasia                  |    2                                                           4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       1                  |             
      Erosion                              |                                                                2         |             
      Hemorrhage                           |                                                       1                  |             
      Mineralization                       |                                                                   2      |             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                         +                  |             
      Polyarteritis                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2        2  2     3  1  2  2  1        2  2  1  1  3  3     3     3|             
      Thrombosis                           |                                  X                                       |             
      Myocardium, Inflammation, Chronic    | 2        2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X  X  X                 X     X              X|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |             X                                                            |             
      Congestion                           |       2  2                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |             3                                                  2         |             
      Necrosis                             |                                                                   3      |             
      Vacuolization Cytoplasmic, Diffuse   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3              1  1           1           1  1     1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             1     1  2     1              2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|             
                                           | 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |    2                                                                     |             
      Pars Distalis, Cyst                  |                         X                                X               |             
      Pars Distalis, Hyperplasia           |                               2              1                           |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     1     3           2                  |             
      Follicle, Cyst                       |                                                    X                     |             
      Follicular Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Foreign Body                         |                                                 2                        |             
      Inflammation, Chronic                |             2  2        2        2  2                 3     2  2     2  1|             
      Inflammation, Suppurative            |                                                 2                       3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             
      Inflammation, Chronic                |                         1                                   1           1|             
      Inflammation, Suppurative            |                      2              1  1  3  2  1  1           3     3  1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1  3  2     1  1  2  2  2  2     1     2  2        2|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                     4     3              4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                              3              4            |             
      Hypocellularity                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hemorrhage              |                         2        2     2              3  3               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  3                                       |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Pigmentation            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2     2                                                               |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia, Lymphoid                |                      4                                3                  |             
      Hyperplasia, Plasma Cell             |             4     4  2        2  4     3  2     2     3     2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|             
                                           | 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |             3                                                            |             
      Lymphatic, Dilatation                |             3     3  2           2                    3     4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   4  3   |             
      Hyperplasia, Lymphoid                |                                                       4                  |             
      Hyperplasia, Reticulum Cell          |                                     2                                    |             
      Necrosis                             |                                     1                                    |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Fibrosis                             |                                                             3            |             
      Hematopoietic Cell Proliferation     |             3                                3              3  3         |             
      Hemorrhage                           |                               4                                          |             
      Hyperplasia, Mononuclear Cell        |                            3                                             |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Necrosis                             |                               3                                          |             
      Pigmentation, Hemosiderin            |                   3     2              3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +|             
      Congestion                           | 2  3  3  2                                                               |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           | 3  3  3  3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |             2           2              1  1                    2         |             
      Hyperplasia, Lobular                 |                                        2                    2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        4                                 |             
      Angiectasis                          |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                        4                                 |             
      Inflammation, Chronic                |                                        1                                 |             
      Ulcer                                |                                                                          |             
      Lip, Hemorrhage                      |                                                       2                  |             
      Scrotum, Congestion                  |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|             
                                           | 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Congestion                           | 2  2  2  2                                                               |             
      Degeneration, Focal                  |                                                                          |             
      Hemorrhage                           |                4                                                  3      |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3  3  3  3                                                               |             
      Edema                                |          2                                                               |             
      Hemorrhage                           |                               1                    1                     |             
      Infiltration Cellular, Histiocyte    |             1        1  1  1        1     1  1  1  2  1  1  1        1  1|             
      Inflammation, Chronic                |    1                    1  1        1                 1  1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             X           X     X  X     X        X     X                  |             
      Foreign Body                         |                               2  2     2              2                  |             
      Fungus                               |             X           X     X  X     X        X     X                  |             
      Inflammation, Chronic                |             4           3     2  2     3        2     3                  |             
      Mucosa, Hyperplasia                  |             3           3              2        2     3                  |             
      Mucosa, Metaplasia, Squamous         |             3                 2  2              2     4                  |             
      Olfactory Epithelium, Pigmentation   |             1     1  1     1  1  2  1  2  1     1  2  2  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                    +         |             
      Cataract                             |                                                                3         |             
      Retina, Atrophy                      |                                                                3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X        X            |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |             3        2  3  3     2  2  3  3     3  2  4  3  2  2     2  2|             
      Inflammation, Suppurative            |             1           2  2     1     2  2     1  1  2                 1|             
      Mineralization                       |                                        1     1     1  1  1  1           1|             
      Nephropathy                          | 1  1        3  1  1  2  4  3  2  2  2  3  4  1  3  3  3  3  2  3  2  3  3|             
      Renal Tubule, Pigmentation           |                               2  1     2     1        2  2              2|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |    3                                                                     |      1  3.0|
      Parasite Metazoan                    |                                                                   X      |      3     |
      Ulcer                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                           X                              |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                    X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     | X        X  X        X     X  X        X     X     X     X        X  X  X|     26     |
      Clear Cell Focus                     |       X                                X                 X               |      6     |
      Congestion                           |                                              3              3            |      2  3.0|
      Degeneration, Cystic                 |          1        3     2                                         2      |      9  1.6|
      Eosinophilic Focus                   |                         X  X        X  X  X        X     X               |      9     |
      Granuloma                            |       2  1  2                                                            |      6  1.8|
      Hematopoietic Cell Proliferation     |                               2     1                                    |      2  1.5|
      Hepatodiaphragmatic Nodule           |                      X                                X                  |      2     |
      Inflammation, Chronic                |          1           1     2                             2              2|      9  1.6|
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
      Bile Duct, Hyperplasia               | 2  3  1  2  1     3  2  2  1  1  2  2  2  2  2  2  3  3  2     1  3  4  3|     44  2.0|
      Centrilobular, Atrophy               |    2           2     2                                                   |      5  2.2|
      Centrilobular, Necrosis              |                   2              3                          1            |      6  1.5|
      Hepatocyte, Pigmentation             |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  3.0|
      Kupffer Cell, Hyperplasia            |                               2                                2         |      4  2.0|
      Lobules, Necrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +  +                 +  +  +   |   5        |
      Fat, Necrosis                        |                                           2  4                 3     3   |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |    1     1  3        1        2        1     1     2              1  2   |     19  1.7|
      Cytoplasmic Alteration               |                      3                                                   |      2  3.0|
      Focal Cellular Change                |    1                                                  X                  |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                      2                          1  2                    1|      8  2.1|
      Inflammation, Chronic                |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                              +                    +      |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      1  3.0|
      Edema                                | 3        2                                                     2         |      4  2.3|
      Erosion                              |                      3                                         2         |      2  2.5|
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                | 3                                                                        |      2  3.5|
      Mucosa, Hyperplasia                  |          3     3           1                                             |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  1.0|
      Erosion                              |                                  2                                       |      2  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +     M                                +                       +         |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                 +                          +                  |   5        |
      Polyarteritis                        |          2                 2                          3                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 3     3  2  3     2  3     3  3  2  2  2  3  2  2  3  2  3     2  3  3   |     36  2.3|
      Thrombosis                           |                                                                          |      1     |
      Myocardium, Inflammation, Chronic    |                                                             1            |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     X              X                     |      8     |
      Angiectasis                          |                                                       2  3               |      2  2.5|
      Clear Cell Focus                     |                            X     X                 X           X         |      5     |
      Congestion                           |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                       2                  |      1  2.0|
      Hyperplasia, Diffuse                 |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                            2  3                       2  2           1   |      7  2.1|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     1              3                 2     1        2  2           2  1|     16  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                           X                              |      1     |
      Hyperplasia                          |    2                                                              2  2   |      8  1.6|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |       X                                                              X   |      4     |
      Pars Distalis, Hyperplasia           |                            2                                   1     2   |      5  1.6|
      Pars Distalis, Pigmentation          |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |             3              3                                             |      5  2.4|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                | 3  2  3  2  2  2  2  3  2  3           2     3  3  2  2  2  2        2  2|     29  2.2|
      Inflammation, Suppurative            |       3  2  3        2     2                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1              1                                                |      5  1.0|
      Inflammation, Suppurative            | 3        1           3  1           2  1  1        1     1     3         |     20  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    1  1        1  1     1  2        3  2  1  1     3  2  2        1  2  2|     29  1.7|
      Interstitial Cell, Hyperplasia       | 1                    1                                                   |      2  1.0|
      Seminiferous Tubule, Atrophy         | 4  4              4                    4                                 |      7  3.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                   3           4        2                          3      |      6  3.2|
      Hypocellularity                      | 2                    3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Plasma Cell   |             2                                                            |      1  2.0|
      Mediastinal, Hemorrhage              |       4                 3                       2     3        3         |     10  2.7|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                2         |      1  2.0|
      Mediastinal, Pigmentation            |                                                                3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                3         |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Hyperplasia, Plasma Cell             | 3     2  3                 3     4     3     3                           |     17  2.9|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Lymphatic, Dilatation                | 3        3  3                                3                           |     10  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           | 2     3                 2                       1                        |      6  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Pigmentation                         |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             3            |      1  3.0|
      Degeneration, Fatty                  |                   4                                                      |      1  4.0|
      Fibrosis                             |                2                                         3               |      3  2.7|
      Hematopoietic Cell Proliferation     |                               3     2                             3      |      7  2.9|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Mononuclear Cell        |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                   4                                               3      |      2  3.5|
      Necrosis                             |                2                 1                                       |      3  2.0|
      Pigmentation, Hemosiderin            | 3        3           3                                         2  3      |      8  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Congestion                           |                                                                2         |      5  2.4|
      Cyst                                 |                                                       X                  |      1     |
      Hemorrhage                           |                                                             2            |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 3  1  2              3        4     2                                    |     11  2.1|
      Hyperplasia, Lobular                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  4.0|
      Angiectasis                          |                                                          2               |      1  2.0|
      Cyst Epithelial Inclusion            |    X                             X                                       |      2     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |    3                                                                     |      1  3.0|
      Lip, Hemorrhage                      |                                                                          |      1  2.0|
      Scrotum, Congestion                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X                    X        X                                          |      3     |
      Congestion                           |                                                                          |      4  2.0|
      Degeneration, Focal                  |                   2                                                      |      1  2.0|
      Hemorrhage                           |    4           2                                                         |      4  3.3|
      Hydrocephalus                        |                      2                                                   |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  2                                2      |      6  2.7|
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    | 1        1  1  3     1              1     1  1  1  2  1  1     1        1|     28  1.1|
      Inflammation, Chronic                | 1                                               1  2  1                  |     10  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |    X     X  X              X                                      X      |     12     |
      Foreign Body                         |    2                                                                     |      5  2.0|
      Fungus                               |    X     X  X                                                     X      |     11     |
      Inflammation, Chronic                |    3     3  3                                                     3      |     11  2.8|
      Mucosa, Hyperplasia                  |    3        3                                                            |      7  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3|            |
                                           | 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Metaplasia, Squamous         |    3     3  2                                                     3      |      9  2.7|
      Olfactory Epithelium, Pigmentation   | 1  1  1  1  1        1  1  1  2  1  2  2  1  1  2  1  1  2     1  1  1  1|     40  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           X                              |      3     |
      Hydronephrosis                       |                   4                                                      |      1  4.0|
      Infarct                              |    4                                                                     |      1  4.0|
      Inflammation, Chronic                | 3        3  2        2  2  3  2  4  3     4     1        3        3     3|     30  2.6|
      Inflammation, Suppurative            | 2        2  1        1     2  1     1  1                 1        2      |     20  1.5|
      Mineralization                       |          1           1  1  1  1                    1           1  1      |     15  1.0|
      Nephropathy                          | 3  3  2  3  3     1  3  2  3  3  4  4  2  4  2  2  2  2  3     2  3  2  2|     46  2.5|
      Renal Tubule, Pigmentation           | 2  2        2        2  2  2  2        1     2  2  2           1  2  2  2|     22  1.8|
      Transitional Epithelium, Hyperplasia |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|             
                                           | 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                             X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2              3                  |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X        X              X     X  X  X  X|             
      Clear Cell Focus                     |    X                 X                                   X        X     X|             
      Congestion                           |                                                                2         |             
      Degeneration, Cystic                 |             1                    1        2           2           1      |             
      Eosinophilic Focus                   |       X     X     X        X                             X               |             
      Granuloma                            |                         2                 3        1                 1   |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hepatodiaphragmatic Nodule           |                                           X                              |             
      Hyperplasia, Focal                   | 3                          2                    2     3                  |             
      Inflammation, Chronic                |       1                                2           2                     |             
      Mixed Cell Focus                     |    X                                      X                          X   |             
      Bile Duct, Hyperplasia               | 1  3  3  2  2  3  3  3  2  3  2  2  1  2  3     2  1  3  2  3  2  2  2  2|             
      Centrilobular, Necrosis              |                                              3                           |             
      Hepatocyte, Vacuolization Cytoplasmic| 2                                                                        |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |       1                                         3     1     1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +              +                          +        +         |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |             4              3                                   3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  1           1                    3     2                    1  2|             
      Cytoplasmic Alteration               |                2                                   4                     |             
      Hyperplasia, Focal                   |    2        3        2  2           3  1                             1  3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|             
                                           | 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                     1                                    |             
      Mucosa, Hyperplasia                  |             2  2                    2              1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                             3            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                        1  1                              |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  2     2  3  3        2  2  1     2  2  3        2     3  1  1  1|             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X     X        X           X                 X  X               |             
      Angiectasis                          |                      2                                   3               |             
      Clear Cell Focus                     |                                                          X               |             
      Hematopoietic Cell Proliferation     |                                  2                       2               |             
      Hyperplasia, Focal                   | 3     1  1        1     1        3                                       |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                 3           2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                           X                              |             
      Hyperplasia                          | 1     3        1                 1  1  2           1  2  3  1  1  1  3   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1  1                             2                 1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                         2|             
      Pars Distalis, Cyst                  |                                                    X                    X|             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  1           1              1                                      2|             
      Pars Distalis, Necrosis              |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|             
                                           | 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Nervosa, Cyst                   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  | 1                       2     1        1  2     1           1            |             
      Follicle, Cyst                       |             X                       X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
      Inflammation, Chronic                |             3     2  2        4        2  2  2     2  3  2  3     3  2  3|             
      Inflammation, Suppurative            |                1                          2        2  1           3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    1     3     1     1     2        3     1  3  4  1  2           2     1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2     2           1  1     2        3  1              1  1     3  2      |             
      Interstitial Cell, Hyperplasia       |                                                    1                     |             
      Seminiferous Tubule, Atrophy         |    4        3                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3                                       |             
      Hyperplasia, Reticulum Cell          |                                                       3                  |             
      Hypocellularity                      |                                                                          |             
      Myelofibrosis                        |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                               2                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                               2                                          |             
      Mediastinal, Hemorrhage              |       3           2                       3                              |             
      Mediastinal, Hyperplasia, Plasma Cell|                                           3     2                        |             
      Mediastinal, Pigmentation            | 3     3     3                             3           3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |          4     2     2                 3           3     3              3|             
      Lymphatic, Dilatation                |          3                                               3           4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                3                                                         |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|             
                                           | 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphatic, Dilatation                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  3                                       |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                     3     2        2                     |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X              X        X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |          2           1     1        2     1     2                        |             
      Hyperplasia, Lobular                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Basal Cell              |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                             3            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Congestion                           |                                              2                           |             
      Hemorrhage                           |                                                 3                        |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                 2         |             
      Edema                                |                            3                 2                           |             
      Foreign Body                         |             3                                                            |             
      Hemorrhage                           |                1                                      2                  |             
      Infiltration Cellular, Histiocyte    |    1     2  2        1  1  3     1     1              1  1     2  1      |             
      Inflammation, Chronic                |       1  1  2     1           1           1                              |             
      Inflammation, Suppurative            |                                                                          |             
      Leukocytosis                         |                                                                2         |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|             
                                           | 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X  X     X  X                          X        X  X        X            |             
      Foreign Body                         | 3  2     4                             2                                 |             
      Fungus                               | X  X     X                             X        X           X            |             
      Inflammation, Chronic                | 3  2     3                                                  4            |             
      Pigmentation                         |                                                             1            |             
      Mucosa, Hyperplasia                  | 3        3                             3                                 |             
      Mucosa, Metaplasia, Squamous         | 3  3                                   2                    4            |             
      Nerve, Hypertrophy                   |                                                                          |             
      Olfactory Epithelium, Pigmentation   |    1  1  1  1  1  1  1  1  1  1     1  1  1           1  1        1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                       +  +                     |             
      Cataract                             |                      3  3                          3                     |             
      Cornea, Hyperplasia                  |                         1                                                |             
      Retina, Atrophy                      |                      4  4                          4                     |             
      Sclera, Mineralization               |                         3                          1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |    2  3  4  3     2  2  2  2     2  3  4  3        1     2     3  3  2  2|             
      Inflammation, Suppurative            |       2              2  1        2     2  2              2        1     1|             
      Mineralization                       |          1        1                 1           1           1            |             
      Nephropathy                          | 2  3  3  4  3  2  2  3  2  3  1  2  4  4  3     2  2  2  3  1  3  3  3  2|             
      Renal Tubule, Pigmentation           | 1     1           1  1  2  1  1     1           1     1                  |             
      Transitional Epithelium, Hyperplasia |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                                                     X           X     X|      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        2                          2      |      4  2.3|
      Basophilic Focus                     |                      X  X  X     X        X              X     X  X  X  X|     27     |
      Clear Cell Focus                     |                         X  X                                             |      7     |
      Congestion                           |             3                                                            |      2  2.5|
      Degeneration, Cystic                 |                                                                          |      5  1.4|
      Eosinophilic Focus                   |    X                 X                                            X  X   |      9     |
      Granuloma                            | 1                       1  1              1           1     3            |     10  1.5|
      Hematopoietic Cell Proliferation     |                   2                                                      |      2  2.0|
      Hepatodiaphragmatic Nodule           |                                                    X                     |      2     |
      Hyperplasia, Focal                   |       2                                                                  |      5  2.4|
      Inflammation, Chronic                |                            1  1                    1           1        1|      8  1.3|
      Mixed Cell Focus                     |                                                                          |      3     |
      Bile Duct, Hyperplasia               | 1  2  3     3     2  3  3     1  3  2  2  2  1     2  1  2  1  3  3  2  1|     45  2.2|
      Centrilobular, Necrosis              |             3  3  4           1                 4                        |      6  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                     4                                    |      2  3.0|
      Kupffer Cell, Hyperplasia            |                                  3                                       |      1  3.0|
      Kupffer Cell, Pigmentation           |       3                                                                  |      1  3.0|
      Lobules, Necrosis                    |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                    +        +     +           +  +        +|  11        |
      Accessory Spleen                     |                                  X                                       |      1     |
      Fat, Necrosis                        |             3                                                           4|      5  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |    1     1           1  3  3        1                       1     1  3  2|     17  1.7|
      Cytoplasmic Alteration               |                                                       3                  |      3  3.0|
      Hyperplasia, Focal                   |    2                 2     3                       2     3     2  1  3  3|     17  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                       3                  |      2  2.5|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                     4        1        4                  |      4  2.5|
      Mucosa, Hyperplasia                  |                                  3  3                 4                  |      7  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                     2                                    |      1  2.0|
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                  3  3                                    |      2  3.0|
      Mineralization                       |                                  2                                       |      3  1.3|
      Ulcer                                |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                          +      |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                             +            |   1        |
      Developmental Malformation           |                                                             X            |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +              +  +                             +|   4        |
      Polyarteritis                        |                         2              3  3                             2|      4  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2     2     1     3  2  2  1  3     2  2     2  1  2  3  2  3  1  2  3|     37  2.0|
      Myocardium, Inflammation, Chronic    |       3              3           3                                       |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |             X        X                             X  X  X               |     11     |
      Angiectasis                          |                                                                          |      2  2.5|
      Clear Cell Focus                     | X  X                    X                                X               |      5     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |             1                          2           2                    2|     10  1.7|
      Necrosis                             |       3           4                                                      |      2  3.5|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    1  1              2  1           1     3        1  2  2     1  1  2  1|     26  1.5|
      Infiltration Cellular, Lymphocyte    |                                                          3               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                         1  4                                1            |      7  1.6|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hemorrhage            |                                  4                                       |      1  4.0|
      Pars Distalis, Hyperplasia           |                2     3                 1                                1|      9  1.6|
      Pars Distalis, Necrosis              |                                  4                                       |      1  4.0|
      Pars Intermedia, Angiectasis         |                                                                      3   |      1  3.0|
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                      X                                            X      |      3     |
      C-Cell, Hyperplasia                  |    2                    1                 1                          3  2|     12  1.5|
      Follicle, Cyst                       |                                  X     X              X                 X|      6     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Ectasia                              |                                                                          |      1  2.0|
      Inflammation, Chronic                | 2     2                 3        2        2                 2  3  2  2   |     23  2.4|
      Inflammation, Suppurative            |                                     2                                2   |      7  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |                                                                      1  1|      2  1.0|
      Inflammation, Suppurative            |       1     2  1  1           2     2        2  2  3  3  3  1     1      |     26  1.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       3  1              3  1     1     1           1           2     2  3|     21  1.8|
      Interstitial Cell, Hyperplasia       |                3                                                         |      2  2.0|
      Seminiferous Tubule, Atrophy         |                         4                       4                        |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                   2                             3                        |      3  2.7|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hypocellularity                      |                                              3                           |      1  3.0|
      Myelofibrosis                        |       4                                                                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |    2        4                                         2                  |      6  2.7|
      Mediastinal, Hyperplasia, Plasma Cell|                      2           2                 3                     |      5  2.4|
      Mediastinal, Pigmentation            |                   3        3                                   2         |      8  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                            3              3           3                 3|      4  3.0|
      Hyperplasia, Plasma Cell             |                      2     3     4     2  2        3  2  3     3  3     2|     18  2.7|
      Lymphatic, Dilatation                |                         2                 3                       3      |      6  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                  2                                       |      2  2.5|
      Hemorrhage                           |             4                                                            |      1  4.0|
      Lymphatic, Dilatation                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                             3           1|      2  2.0|
      Hematopoietic Cell Proliferation     |                3  4                             3  2           2         |      6  2.8|
      Hyperplasia, Re Cell                 |                                  3              3                        |      2  3.0|
      Necrosis                             |          4                                                               |      1  4.0|
      Pigmentation, Hemosiderin            |                               4              3     2  2                  |      7  2.6|
      Lymphoid Follicle, Atrophy           |                                                    3                     |      1  3.0|
      Red Pulp, Hyperplasia                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                            X                                             |      4     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |       3                       2                    2  4  1           2  1|     13  1.8|
      Hyperplasia, Lobular                 |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                          X               |      1     |
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                     X        X        X     X            |      4     |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                  2                                       |      2  2.5|
      Hydrocephalus                        |                               2     2        2        2                  |      4  2.0|
      Mineralization                       | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             3                                                            |      3  2.3|
      Edema                                |                                                                          |      2  2.5|
      Foreign Body                         |             3                                      2                     |      3  2.7|
      Hemorrhage                           |    2                                                                     |      3  1.7|
      Infiltration Cellular, Histiocyte    | 1  1           1  1        1  1  1  1  2  1  1  3  3  1     1  1  1  1   |     30  1.3|
      Inflammation, Chronic                | 1                    1     1              1  1     4     1        1      |     14  1.3|
      Inflammation, Suppurative            |    3                                               3                     |      2  3.0|
      Leukocytosis                         |                3  3                             3                        |      4  2.8|
      Alveolar Epithelium, Hyperplasia     |                         1        1                                       |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              | X     X  X                    X  X     X     X  X                       X|     17     |
      Foreign Body                         |                                  2              2                        |      6  2.5|
      Fungus                               | X     X  X                    X  X     X     X  X                       X|     15     |
      Inflammation, Chronic                | 2                                      3     2                           |      7  2.7|
      Pigmentation                         |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  | 2                             2        3     2                           |      7  2.6|
      Mucosa, Metaplasia, Squamous         |       3                       2  3                                      3|      8  2.9|
      Nerve, Hypertrophy                   |                                                             4            |      1  4.0|
      Olfactory Epithelium, Pigmentation   |    1  1              1  1  1  1     1     1              1     1  1  1  1|     29  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Hyperplasia                  |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +                                      +                              |   7        |
      Cataract                             | 2  3                                      2                              |      6  2.7|
      Cornea, Hyperplasia                  |                                                                          |      1  1.0|
      Retina, Atrophy                      | 4  4                                      3                              |      6  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05037-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PENTACHLOROANISOLE                                    Date: 06/23/97  
Route: GAVAGE                                                                                                     Time: 12:05:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3|            |
                                           | 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    10 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Sclera, Mineralization               | 1                                         2                              |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  X                                       |      1     |
      Inflammation, Chronic                | 2  3  3     2           2  2     4  3  2  3        3  3  3     2  3  1  2|     35  2.5|
      Inflammation, Suppurative            |       3                                1  1        1              1     2|     15  1.6|
      Mineralization                       |       1  1     1  1        1     3                    1              1   |     13  1.2|
      Nephropathy                          | 2  3  1  1  3  1  2  2  2  3  2  4  3  3  3  1  1  3  4  3  1  2  3  1  3|     49  2.4|
      Renal Tubule, Pigmentation           |                      1  1     2     2  1  2  1  1     2  2     2  1     1|     23  1.3|
      Transitional Epithelium, Hyperplasia |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
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