Share This:
https://ntp.niehs.nih.gov/go/3420

TDMS Study 05037-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 06/23/97       
EXPERIMENT: 05037 TEST: 03                                                                                     TIME: 09:58:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NOI-ES-28024                              ROUTE: GAVAGE                                                  NTP C#: 56520        
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 1825-21-4       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 004    VEHICLE CONTROL                                                               
                                       INCLUDE 007    40 MG/KG                                                                      
                                       INCLUDE 010    40 MG/KG                                                                      
                                       INCLUDE 013    20 MG/KG                                                                      
                                       INCLUDE 016    20 MG/KG                                                                      
                                       INCLUDE 019    10 MG/KG                                                                      
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Southern Research Inst                                PENTACHLOROANISOLE                                  DATE: 06/23/97      
EXPERIMENT: 05037 TEST: 03                                                                                     TIME: 09:58:36      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NOI-ES-28024                              ROUTE: GAVAGE                                                  NTP C#: 56520       
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 1825-21-4      
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      213   507   527   568   594   605   611   617   624   649                 |
 |      651   653   683   683   684   689   701   702   703   703                 |
 |      704   705   705   705   718   726                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 4    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      435   437   488   520   521   529   535   568   570   577                 |
 |      578   598   604   613   626   627   634   649   649   667                 |
 |      684   687   689   709   724   726                                         |
 |  CENSORED DEATHS                                                               |
 |      572   625   640   678                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 5    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      486   493   507   509   568   578   628   633   654   683                 |
 |      684   687   697   701   703   704   704   705   718   718                 |
 |      719                                                                       |
 |  CENSORED DEATHS                                                               |
 |      185   185   185   185   185                                               |
 |                                                                                |
 ==================================================================================
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 40 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 4    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      60    66    66    66    67    67    96    96    96    96                  |
 |      96    97    97    108   108   108   109   109   109   110                 |
 |      206   206   488   514   548   635   636   684   697   697                 |
 |      702   709                                                                 |
 |  CENSORED DEATHS                                                               |
 |      185   185   592   696                                                     |
 |                                                                                |
 ==================================================================================
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0  98.0  98.0  98.0  98.0  94.0  88.0  76.0  48.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |10 MG/KG   |   100.0 100.0 100.0 100.0 100.0  96.0  86.0  73.8  61.1  45.3      |
 |           |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  91.1  86.7  80.0  53.3      |
 |           |                                                                    |
 |           |                                                                    |
 |40 MG/KG   |    88.0  60.0  55.7  55.7  55.7  55.7  51.4  49.3  44.8  33.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      10 MG/KG     20 MG/KG     40 MG/KG |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       48.0%        45.3%        53.3%        33.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.006      P=0.549      P=0.709N     P=0.009  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       639.6        601.7        641.9        267.2    |
 |NATURAL DEATHS (C)      |       (20.6)       (16.1)       (18.1)       (45.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       682.5        654.8        638.0        408.3    |
 |(STANDARD ERROR)        |       (12.4)       (12.1)       (23.6)       (42.0)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      213   353   444   477   522   526   579   579   589   590                 |
 |      596   616   620   640   669   683   684   687   705   705                 |
 |      718                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 20 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      330   345   541   589   611   625   647   667   673   687                 |
 |      689   695   702   718   724                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 40 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      517   570   628   712   715   723                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                PENTACHLOROANISOLE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0  98.0  96.0  96.0  92.0  88.0  78.0  72.0  58.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |20 MG/KG   |   100.0 100.0 100.0  96.0  96.0  96.0  94.0  92.0  86.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |40 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  94.0  88.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          20 MG/KG         40 MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.0%            70.0%            88.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.219N         P=0.001N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       580.7            616.2            644.2         |
 |NATURAL DEATHS (C)      |       (27.6)           (32.0)           (35.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       666.7            695.2            718.8         |
 |(STANDARD ERROR)        |       (15.5)           (11.9)           ( 5.6)        |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                         PENTACHLOROANISOLE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        10 MG/KG         = 2
                                                        20 MG/KG         = 3
                                                        40 MG/KG         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1         4                       1                                  2       3
      |           44                      1                                          33 1
      |                                                                      2       23 1  21     1
      |                                                                                           1   1
   90 +                                                                                 3  22     33  1 1
      |            4   4                                                                    22     3    11 3
P     |                                                                                      2    2      1113
E     |                                                                                           22       13 13
R  80 +                                                                                                        3    3
C     |                                                                                            2   2      11
E     |                4  4                                                                            222     1    13
N     |                                                                                                  2 2         33
T  70 +                                                                                                             1133
      |                                                                                                    22        1 1
S     |                                                                                                     2 2
U     |
R  60 +                   4              4                                                                    2   2 2  3 3
V     |                                                                                                             22
I     |                                  4                                           4
V     |                                                                              4   4     4                     2 121  3
A  50 +                                                                                        4            4           211
L     |                                                                                                                   1 1
      |                                                                                                     4       4     2 2
      |                                                                                                             4 4
   40 +
      |                                                                                                               44
      |                                                                                                                44
      |                                                                                                                 4   4
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.
                                                         PENTACHLOROANISOLE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        20 MG/KG         = 2
                                                        40 MG/KG         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                 1                  2                           3
      |
      |                                   1                  2 21                        3        3
      |                                                        21             1               2   3        3
   95 +
      |                                                                       1     1         2       2    3            3
      |                                                                             1      1          2  2              33
      |
   90 +                                                                                    11            2 2             33
      |
P     |                                                                                     1      1       2  2           3 3
E     |                                                                                                       2   2
R  85 +
C     |                                                                                            1  1           22
E     |                                                                                                            2 2
N     |
T  80 +                                                                                               11
      |
S     |                                                                                                1 1           22
U     |                                                                                                  11           22
R  75 +
V     |                                                                                                   1  1         2 2
I     |                                                                                                      1    1      22
V     |
A  70 +                                                                                                           1 1     2 2
L     |
      |
      |                                                                                                             11
   65 +
      |                                                                                                              1 1
      |
      |
   60 +                                                                                                                1 1
      |
      |                                                                                                                  1  1
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 2 obs hidden.