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TDMS Study 05040-02 Pathology Tables

NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97
Route: GAVAGE                                                                                                     Time: 10:15:11




       Facility:  American Biogenics Corp.

       Chemical CAS #:  000123319

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|             
                                           | 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +     A  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +     A  +  +  +  +     +  +  +  +  A  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                         X|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant                   |                                                          X  X            |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +     +                                +              +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Fat, Lymphoma Malignant              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Glandular, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|             
                                           | 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
      Epicardium, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Capsule, Lymphoma Malignant          |                                                                          |             
      Capsule, Lymphoma Malignant Mixed    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +     +  +  +  +  +     +  M  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                      X                                                   |             
      Pheochromocytoma Benign              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  A  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     +  +  +     +  +  M  +  +     +  +  M  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +     +  +  M  +  +     +  +  I  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X                                                              X     X   |             
      Pars Distalis, Carcinoma             |          X                                                               |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Follicular Cell, Adenoma             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma, Poorly Differentiated       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|             
                                           | 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Teratoma                             |                            X                                             |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |       X                                                                 X|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant                        |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                             X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Serosa, Lymphoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                          X               |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |       X                                                                  |             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                          X               |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |       X                                                                  |             
      Inguinal, Lymphoma Malignant Mixed   |                                  X                                       |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                          X  X            |             
      Lumbar, Lymphoma Malignant Mixed     |                                  X                                       |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Mediastinal, Lymphoma Malignant      |                                                          X               |             
      Mediastinal, Lymphoma Malignant Mixed|                                  X                                       |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Pancreatic, Lymphoma Malignant       |                                                          X               |             
      Pancreatic, Lymphoma Malignant Mixed |                                  X                                       |             
      Renal, Lymphoma Malignant Lymphocytic|       X                                                                  |             
      Renal, Lymphoma Malignant            |                                                             X            |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +     M  +  +     +  +  +  +  +     +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|             
                                           | 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                         X              X         |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X  X              X                          X              X        X|             
      Lymphoma Malignant                   |                                                          X  X            |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X  X           X                             X              X         |             
      Lymphoma Malignant                   |                                                          X  X            |             
      Lymphoma Malignant Mixed             |                X                 X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +     M  +  +  +  +     +  +  +  +  M  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                                         X                       X|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant                        |                                                          X               |             
      Tail, Neurofibrosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Extension, Metastatic,    |                                                                          |             
           Pituitary Gland                 |          X                                                               |             
      Cerebrum, Oligodendroglioma Malignant|                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |             
      Basal Cell Carcinoma, Metastatic     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                         X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|             
                                           | 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                          X  X            |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Pleura, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, External Ear, Squamous Cell   |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +              +                                +      |             
      Adenoma                              |                   X                                               X      |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Fat, Lymphoma Malignant Mixed        |                                                                          |             
      Renal Tubule, Adenoma                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                 X                       X|             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                          X  X            |             
      Lymphoma Malignant Lymphocytic       |    X  X           X  X           X              X              X        X|             
      Lymphoma Malignant Mixed             |                X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|             
                                           | 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +        M  +  +  +  +     +  +  +     A  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     A  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +        A  +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     A  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +        A  +  +  +  +     +  +  +     +  +  +  +  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Hemangioma                           |                                                                   X      |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                      X   |             
      Hepatocellular Adenoma               | X                             X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                       +     +        +     +           +  +     +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Fat, Lymphoma Malignant              |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +        M  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +        +  +  +  +  +     +  +  +     M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +        +  +  +  +  +     +  +  +        +  +  +  +  +|             
      Glandular, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +        +  +  +  +  +     +  +  +        +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|             
                                           | 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Epicardium, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Capsule, Lymphoma Malignant          |                                                                         X|             
      Capsule, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  M  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +        M  +  +  +  +     +  +  +     M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     M  +  +        M  +  M  M  +     +  M  +     +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X                 X                 X                     |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Intermedia, Adenoma             |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma, Poorly Differentiated       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|             
                                           | 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Teratoma                             |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant                        |                                                                         X|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +        +  M  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Serosa, Lymphoma Malignant           |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant                   |                                                                         X|             
      Axillary, Lymphoma Malignant         |                                                                          |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant Mixed  |                                                 X                        |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                   X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                 X                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                 X                        |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +        M  +  +  +  +     +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|             
                                           | 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     M  +  +        +  +  +  +  +     M  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |       X                                         X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X                          X                             X            |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |       X                                         X                 X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     A  M  +        M  +  +  +  +     +  +  +     +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     M  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Adenocarcinoma                       |                            X           X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                              X                           |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant                        |                                                                          |             
      Tail, Neurofibrosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Carcinoma, Extension, Metastatic,    |                                                                          |             
           Pituitary Gland                 |                                                                          |             
      Cerebrum, Oligodendroglioma Malignant|                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                X        X|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Basal Cell Carcinoma, Metastatic     |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|             
                                           | 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pleura, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     A  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, External Ear, Squamous Cell   |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Fat, Lymphoma Malignant Mixed        |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     M  +  +        +  M  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +        +  +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |    X                          X                             X            |             
      Lymphoma Malignant Mixed             |       X                                         X                 X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +     +  +  +  +                                 |  50        |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  52        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M     +  +  +  +                                 |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  52        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  52        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          3 |
      Lymphoma Malignant                   |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                  X  X                                    |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                    +        +  +                                    |  19        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Fat, Lymphoma Malignant              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +     +  +  +  +                                 |  54        |
      Lymphoma Malignant Lymphocytic       |                         X     X                                          |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
      Glandular, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +        +  +  +                                 |  53        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Epicardium, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                         X                                                |          1 |
      Capsule, Lymphoma Malignant          |                                                                          |          1 |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +     M  +  +  +                                 |  51        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M     +  +  +  +                                 |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  M  +     +  +  +  M                                 |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I     +  +  +  +                                 |  52        |
      Pars Distalis, Adenoma               |          X  X  X              X                                          |         11 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Follicular Cell, Adenoma             |             X                                                            |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   1        |
      Sarcoma, Poorly Differentiated       |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Teratoma                             |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                         X                                                |          3 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Serosa, Lymphoma Malignant           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |          1 |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                     X                                    |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Lymphoma Malignant           |                                                                          |          2 |
      Lumbar, Lymphoma Malignant Mixed     |                                     X                                    |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                               X                                          |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                  X  X                                    |          4 |
      Renal, Lymphoma Malignant Lymphocytic|                         X                                                |          2 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
      Thoracic, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  +  +  +                                 |  50        |
      Lymphoma Malignant Lymphocytic       |                         X     X                                          |          6 |
      Lymphoma Malignant                   |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +     +  +  +  +                                 |  52        |
      Lymphoma Malignant Lymphocytic       |    X                    X     X                                          |         11 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                  X  X                                    |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant Lymphocytic       |                         X     X                                          |         10 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                  X  X                                    |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  M     +  +  M  M                                 |  44        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                  X                                       |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +     +  +  +  +                                 |  52        |
      Adenocarcinoma                       |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Tail, Neurofibrosarcoma              |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Carcinoma, Extension, Metastatic,    |                                                                          |            |
           Pituitary Gland                 |                                                                          |          1 |
      Cerebrum, Oligodendroglioma Malignant|                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                 +              +                                 |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Basal Cell Carcinoma, Metastatic     |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X     X                                          |          4 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
      Pleura, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  54        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   1        |
      Canal, External Ear, Squamous Cell   |                                                                          |            |
          Carcinoma                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4|                             |            |
                             DAY ON TEST   | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5|                             |            |
                                           | 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                             |     A      |
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |    X                    X                                                |          4 |
      Lymphoma Malignant                   |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                     X                                    |          2 |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Fat, Lymphoma Malignant Mixed        |                                  X                                       |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  53        |
      Lymphoma Malignant Lymphocytic       |                         X     X                                          |          4 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +                                 |  55        |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |    X                    X     X                                          |         14 |
      Lymphoma Malignant Mixed             |                                  X  X                                    |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|             
                                           | 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +                 +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                 +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             M                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                 +           +           +                  |             
      Serosa, Fibrosarcoma, Metastatic,    |                                                                          |             
           Mesentery                       |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                 +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Jejunum, Lymphoma Malignant Mixed    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Cholangiocarcinoma, Metastatic       |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X                       X              X     X     X        X  X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +     +  +                          +      |             
      Cholangiocarcinoma, Metastatic       |                                                                          |             
      Fibrosarcoma                         |                               X                                          |             
      Fibrosarcoma, Multiple               |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +     +           +           +           +                  |             
      Fibrosarcoma, Early Invasion,        |                                                                          |             
          Metastatic, Mesentery            |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                 +           +           +                  |             
      Serosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                 +           +           +                  |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|             
                                           | 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                 +           +           +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                 +           +        +  +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                 +           +           +                  |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                                                                          |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                 +           +           +                  |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +     +  +        +  +  +  +  +        +  +     +  +  +      |             
      Pars Distalis, Adenoma               | X                 X  X        X     X              X        X  X  X      |             
      Pars Distalis, Carcinoma             |                                  X                    X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +     +     +     +     +     +     +     +           +      |             
      Hemangioma                           |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +           +           +           +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|             
                                           | 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant Mixed  |             X                                                            |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |             X                                                            |             
      Lumbar, Osteosarcoma, Metastatic,    |                                                                          |             
           Bone                            |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|             X                                                            |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                 +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +     +           +           +           M           +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Renal, Cholangiocarcinoma, Metastatic|                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +                 +           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                 M           +           +           M      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|             
                                           | 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +  +              +  +        +           +                  |             
      Adenocarcinoma                       | X              X                 X                                       |             
      Cholangiocarcinoma, Multiple,        |                                                                          |             
          Metastatic                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |             
           Metastatic, Liver               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                 +           +           +                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hepatocellular  |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                 +           +           +                  |             
      Lumbar, Vertebra, Osteosarcoma       |                                           X                              |             
      Vertebra, Cholangiocarcinoma,        |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Abdominal, Fibrosarcoma, Early       |                                                                          |             
          Invasion, Metastatic, Mesentery  |                               X                                          |             
      Abdominal, Diaphragm,                |                                                                          |             
          Cholangiocarcinoma, Metastatic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                 +           +           +                  |             
      Carcinoma, Extension, Metastatic,    |                                                                          |             
           Pituitary Gland                 |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Perivascular, Lymphoma Malignant     |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Perivascular, Lymphoma Malignant     |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                    X        X            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|             
                                           | 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                 +           +           +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                 +           +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +     +                                                   |             
      Adenoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +                 +           +           +                  |             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Osteosarcoma, Metastatic, Bone       |                                           X                              |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                 +           +           +                  |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +           +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    50 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  A  +           M              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  A  +           +              M  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +           +              +  +              +               |             
      Serosa, Fibrosarcoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       | X           X                                                            |             
      Jejunum, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma, Metastatic       |                         X                                                |             
      Hemangioma                           |                                                                   X      |             
      Hepatocellular Carcinoma             |                         X                                X               |             
      Hepatocellular Adenoma               |          X     X     X                                                   |             
      Hepatocellular Adenoma, Multiple     | X                       X        X                                       |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                            X           X   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                      X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +     +        +                                 |             
      Cholangiocarcinoma, Metastatic       |                         X                                                |             
      Fibrosarcoma                         |                                                                          |             
      Fibrosarcoma, Multiple               |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +           +              +  +              +               |             
      Fibrosarcoma, Early Invasion,        |                                                                          |             
          Metastatic, Mesentery            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +           +              +  +              +               |             
      Serosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +           +              +  +              +               |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    50 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +           +              +  +              M               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +           +              M  +              M               |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                         X                                                |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +           +                 +                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +           +                 +                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M  +           +              M  M              +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +           M     +        M  +           +  +  M           +|             
      Pars Distalis, Adenoma               | X                             X           X           X                 X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Follicular Cell, Adenoma             |                X                                X        X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           M                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |             X                             X                          X   |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +     +        +     +  +  +  +        +  +            |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +           +     +        +  +              +           +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    50 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                           X                              |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                           X                              |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |             X                                            X               |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                           X                              |             
      Lumbar, Osteosarcoma, Metastatic,    |                                                                          |             
           Bone                            |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                      X   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                           X                              |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |             X                                            X               |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |             X                                            X               |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                      X                              |             
      Renal, Cholangiocarcinoma, Metastatic|                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  M  +           +        +     +  +           +  +  +        +   |             
      Lymphoma Malignant Lymphocytic       | X           X                             X           X  X           X   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                        X            |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Lymphocytic       |             X                                            X               |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    50 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M           +              +  +              +              +|             
      Adenocarcinoma                       | X                                                                       X|             
      Cholangiocarcinoma, Multiple,        |                                                                          |             
          Metastatic                       |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Lymphoma Malignant                   |                                                                          |             
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |             
           Metastatic, Liver               |                         X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +              +  +              +               |             
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |             
      Subcutaneous Tissue, Hepatocellular  |                                                                          |             
          Carcinoma, Metastatic, Liver     |                         X                                                |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +           +              +  +              +               |             
      Lumbar, Vertebra, Osteosarcoma       |                                                                          |             
      Vertebra, Cholangiocarcinoma,        |                                                                          |             
          Metastatic                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Abdominal, Fibrosarcoma, Early       |                                                                          |             
          Invasion, Metastatic, Mesentery  |                                                                          |             
      Abdominal, Diaphragm,                |                                                                          |             
          Cholangiocarcinoma, Metastatic   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +           +              +  +              +               |             
      Carcinoma, Extension, Metastatic,    |                                                                          |             
           Pituitary Gland                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Perivascular, Lymphoma Malignant     |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Perivascular, Lymphoma Malignant     |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                           X     X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    50 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +           +              +  +              +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +           +              +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +           +              +  +              +               |             
      Hepatocellular Carcinoma, Metastatic |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Capsule, Cholangiocarcinoma,         |                                                                          |             
          Metastatic                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +           +              +  +              +               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                             X                              |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X           X                             X           X  X           X   |             
      Lymphoma Malignant Mixed             |    X                                      X                 X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +        +  +                 +                              |  16        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +     +        A  M                 +                              |  12        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +     +        A  +                 +                              |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     +           +                 +                              |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +                             +                              |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     +           +                 +                              |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +     +        A  +                 +                              |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +           +                 +                              |  15        |
      Serosa, Fibrosarcoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     A                             +                              |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Jejunum, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     A                             +                              |  12        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +  +  +                              |  55        |
      Cholangiocarcinoma, Metastatic       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                     X                                    |         11 |
      Hepatocellular Adenoma, Multiple     |                                  X                                       |          4 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          4 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +     +           +                              |  12        |
      Cholangiocarcinoma, Metastatic       |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Fibrosarcoma, Multiple               |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +     +        A  +                 +                              |  16        |
      Fibrosarcoma, Early Invasion,        |                                                                          |            |
          Metastatic, Mesentery            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +  +  M                              |  54        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +     +        A  +        +     +  +                              |  17        |
      Serosa, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +     +           +        +     +  +                              |  17        |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +     +           +        +     +  +                              |  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +        +  +                 +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +     +        +  M                 +                              |  13        |
      Capsule, Cholangiocarcinoma,         |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +     +        +                    +                              |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +     +        M                    M                              |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +        A  +                 +                              |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +     +        +  +                 +                              |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +        +  +        +        M                              |  29        |
      Pars Distalis, Adenoma               |                                                                          |         14 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Follicular Cell, Adenoma             |                                  X                                       |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  M  +  M     +  +  +  +  +                              |  53        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +     +     +  +  +                 +                              |  29        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +        +  +                 +                              |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +        +  +                 +                              |  22        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                                           X                              |          1 |
      Iliac, Lymphoma Malignant            |                      X                                                   |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                           X                              |          3 |
      Lumbar, Lymphoma Malignant           |                      X                                                   |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Lumbar, Osteosarcoma, Metastatic,    |                                                                          |            |
           Bone                            |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                           X                              |          2 |
      Mediastinal, Lymphoma Malignant      |                      X                                                   |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Popliteal, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +        +  +                 +                              |  16        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       M     +        +  +                 +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Renal, Cholangiocarcinoma, Metastatic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +        +  +              +  +                              |  22        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          7 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                        X                                 |          4 |
      Capsule, Cholangiocarcinoma,         |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     M        +  M                 +                              |  13        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     +        +  +                 +                              |  20        |
      Adenocarcinoma                       |                                                                          |          5 |
      Cholangiocarcinoma, Multiple,        |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Thoracic, Hepatocellular Carcinoma,  |                                                                          |            |
           Metastatic, Liver               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +        +  +                 +                              |  16        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hepatocellular  |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +        +  +                 +                              |  16        |
      Lumbar, Vertebra, Osteosarcoma       |                                                                          |          1 |
      Vertebra, Cholangiocarcinoma,        |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Abdominal, Fibrosarcoma, Early       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
          Invasion, Metastatic, Mesentery  |                                                                          |          1 |
      Abdominal, Diaphragm,                |                                                                          |            |
          Cholangiocarcinoma, Metastatic   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +        +  +                 +                              |  16        |
      Carcinoma, Extension, Metastatic,    |                                                                          |            |
           Pituitary Gland                 |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Perivascular, Lymphoma Malignant     |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Perivascular, Lymphoma Malignant     |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +  +  +                              |  55        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          6 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +        +  +                 +                              |  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +        +  +                 +                              |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Adenoma                              |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +        +  +                 +                              |  16        |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Capsule, Cholangiocarcinoma,         |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +     +        +  M                 +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6|                             |            |
                             DAY ON TEST   | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4|                             |            |
                                           | 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |     A      |
    50 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant                   |                      X                                                   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          7 |
      Lymphoma Malignant Mixed             |                                        X                                 |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|             
                                           | 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  M  +  +  A     +  +  +  +  M  +  +  +  M     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  A     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  A     +  +  +  +  +  +  +  +  A     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +        +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                     X           X                        |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |          X                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|             
                                           | 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  +  +  M     +  +  +  M  +  +  +  +  +     +  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Pars Distalis, Adenoma               |                X     X        X  X        X  X                 X         |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Follicular Cell, Adenoma             |                   X                          X                    X      |             
      Follicular Cell, Carcinoma           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant                   |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant                        |                         X                                                |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
      Lymphoma Malignant                   |                         X                                                |             
      Axillary, Lymphoma Malignant         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|             
                                           | 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Histiocytic                      |                      X                                                   |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant         |          X              X                             X                  |             
      Iliac, Lymphoma Malignant            |                         X                             X                  |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                       X                  |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                      X                                                   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                         X                             X                  |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                       X                  |             
      Pancreatic, Histiocytic Sarcoma      | X                                                                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                      X                                                   |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Pancreatic, Lymphoma Malignant       |                         X                                                |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Popliteal, Lymphoma Malignant        |                                                       X                  |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +     M  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant                   |                         X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     M  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                    X           X         |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|             
                                           | 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                    X           X         |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  A     +  +  +  M  +  +  +  +  A     M  +  +      |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Adenocarcinoma                       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant                        |                                                       X                  |             
      Thoracic, Subcutaneous Tissue,       |                                                                          |             
          Hemangiosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Lymphoma Malignant                   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Carcinoma, Metastatic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|             
                                           | 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +      |             
      Lymphoma Malignant                   |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant                   |          X              X                             X                  |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |          X                                         X           X         |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|             
                                           | 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  M  M  M  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A      |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Adenoma               | X           X  X                          X     X  X              X      |             
      Hepatocellular Adenoma, Multiple     |                                                             X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                               X  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                             +         |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|             
                                           | 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +     M  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +      |             
      Pars Distalis, Adenoma               |       X                       X                                          |             
      Pars Intermedia, Adenoma             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Follicular Cell, Adenoma             |                X                 X                                       |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |       X                                                                  |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant                        |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                               X                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|             
                                           | 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                               X                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                               X                                          |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     M  +  M  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X              X      |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X              X      |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                               X  X  X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|             
                                           | 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X              X      |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                               X  X  X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  M      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X                     |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Adenocarcinoma                       |                                           X                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant                        |                                                                          |             
      Thoracic, Subcutaneous Tissue,       |                                                                          |             
          Hemangiosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Carcinoma, Metastatic                |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|             
                                           | 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                          +              +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +                          +              +                     |             
      Adenoma                              | X        X                                                               |             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X                     |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                               X  X                                       |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal Tubule, Adenoma                | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                            X              X      |             
      Lymphoma Malignant Mixed             |                               X  X  X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  M  +     +  +  +     +                              |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +     +                              |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  53        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +     +                              |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +     +                              |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +     +                              |  51        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          3 |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  52        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +     +                              |  52        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Hepatocellular Carcinoma             |                      X                                                   |          2 |
      Hepatocellular Adenoma               |    X                             X                                       |         11 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   4        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +     +                              |  53        |
      Lymphoma Malignant Lymphocytic       |                                  X  X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +     +                              |  54        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Pericardium, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M     +  +  +  +     +  +  +     +                              |  52        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  M  +     +                              |  52        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M     +  +  +  +     M  +  +     +                              |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  M  +     +  +  +     +                              |  52        |
      Pars Distalis, Adenoma               |                               X  X                                       |         11 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Follicular Cell, Adenoma             |                               X                                          |          6 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +     +                              |  54        |
      Cystadenoma                          |                                     X                                    |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                  X  X                                    |          3 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Undifferentiated Cell  |                                                                          |            |
          Type                             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +     +                              |  54        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +     +                              |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |          3 |
      Iliac, Lymphoma Malignant            |                                                                          |          2 |
      Iliac, Lymphoma Malignant Mixed      |          X                                                               |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |          2 |
      Lumbar, Lymphoma Malignant Mixed     |          X                                                               |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                  X  X                                    |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Popliteal, Lymphoma Malignant        |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X  X                                    |          6 |
      Lymphoma Malignant                   |                                                                          |          2 |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  52        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X  X                                    |          7 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X        X                                                               |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X  X                                    |          7 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +     +  +  +     M                              |  47        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X  X                                    |          4 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +     +  +  +     +                              |  53        |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Thoracic, Subcutaneous Tissue,       |                                                                          |            |
          Hemangiosarcoma                  |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                           +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +     +                              |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   7        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |       +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          4 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3|                             |            |
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8|                             |            |
                                           | 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +     +                              |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +     +                              |  55        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X  X  X                                    |          9 |
      Lymphoma Malignant Mixed             | X        X                                                               |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|             
                                           | 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +     A  +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +     A  +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +        +  +  +  +  A  +  M  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +     A  +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
      Adenocarcinoma                       |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangioma, Marked                   |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |       X              X              X     X     X  X                     |             
      Hepatocellular Carcinoma, Multiple   |                                                       X                  |             
      Hepatocellular Adenoma               |                X                    X  X     X                           |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +        +  +                                 |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +        +                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|             
                                           | 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  M  +     +  M  +  +  +  +  +  +  M  +  +  +  M  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Follicular Cell, Adenoma             |                                  X     X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +              +           +                                   +        +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Interstitial Cell, Adenoma           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  M  +     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|             
                                           | 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +     +  +  +  M  +  M  +  M  +  M  M  +  M  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M     M     M  M  M  M  M  M  M  M  M  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Fibroma                              |                      X                                                   |             
      Fibrosarcoma                         |       X                                                                  |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                      X                                                   |             
      Subcutaneous Tissue, Neurofibroma    |                X                                                         |             
      Subcutaneous Tissue, Sarcoma         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Osteosarcoma                         |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Intercostal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +                    +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                             X                       X            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                      X                          X  X  X                  |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|             
                                           | 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                      +                           |             
      Adenoma                              |       X                                      X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|             
                                           | 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A     +  +  A        +  +  +        +  +  +  +     +  +  +  M   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A     +  +  A        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +           +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +           +  +  +        +  +  +  +     +  +  +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +           +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangioma, Marked                   |                                                                          |             
      Hemangiosarcoma                      |                                                                   X      |             
      Hepatocellular Carcinoma             |                   X                                   X                  |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |       X                                                     X            |             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                              +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Squamous Cell Papilloma              |                                                       X     X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                 +                          +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|             
                                           | 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +        +  M  +        +  +  +  +     +  +  +  +   |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +        +  +  +        M  M  +  +     +  +  M  M   |             
      Pars Distalis, Adenoma               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +           +              +  +                 +                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Iliac, Lymphoma Malignant Histiocytic|          X                                                               |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                   X      |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |          X                                                               |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|             
                                           | 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M     +  +  M        M  +  M        +  +  +  +     +  M  +  M   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M        M  M  M        M  M  M  +     M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Squamous Cell Papilloma              |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                    X  X              X   |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Intercostal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                X                                X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                                     X                                    |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|             
                                           | 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Adenoma                              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +        +  +  +        +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3|                             |            |
                             DAY ON TEST   | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3|                             |            |
                                           | 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +     M  +  +  +  M  +  +  +  A  A                              |  44        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  A     +  +  +  +  +  +  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +  +  +  +  +  +  +  +  A  +                              |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +  +  +  +  +  +  +  +  +  +                              |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +  +  +  +  +  +  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +     +  +  +  +  +  +  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +  +  +  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     A     +  +  +  +  +  +  +  +  A  +                              |  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +  +  +  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |          1 |
      Hemangioma, Marked                   |                                        X                                 |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             | X                       X  X           X                                 |         12 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               | X              X     X                                                   |          9 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   6        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +     +  +  +  +  +  +  +  +  +  +                              |  54        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3|                             |            |
                             DAY ON TEST   | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3|                             |            |
                                           | 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  54        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +     +  +  +  +  +  +  M  +  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     M  +  M  +  +  +  M  +  +  +                              |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  M                              |  50        |
      Pars Distalis, Adenoma               |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  M  +  +  +  +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +                                    |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3|                             |            |
                             DAY ON TEST   | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3|                             |            |
                                           | 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Histiocytic                      |    X                                                                     |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                X                                                         |          2 |
      Renal, Lymphoma Malignant Histiocytic|    X                                                                     |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  52        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     M  +  +  +  +  +  +  +  +  +                              |  54        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M     +  +  +  +  M  +  +  +  M  +                              |  39        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M     M  M  M  M  M  M  M  M  M  M                              |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Fibroma                              |                                                                          |          1 |
      Fibrosarcoma                         |          X                                                               |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |          5 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  54        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   3        |
      Intercostal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3|                             |            |
                             DAY ON TEST   | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3|                             |            |
                                           | 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                             |     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Alveolar/Bronchiolar Adenoma         | X              X                                                         |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |    X  X              X        X                                          |          8 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          5 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +     +                                                                  |   5        |
      Adenoma                              | X     X                                                                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  54        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +                              |  55        |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Lymphocytic       |                X                          X                              |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|             
                                           | 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +                             +        +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +                             +        +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +                             A        +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +                                      +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +                                      +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +                                      +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +                             A        +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +                                      +     +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +                                      +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +                                      +     +               |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X                       X                                X              X|             
      Hepatocellular Adenoma               | X              X  X              X                 X     X        X      |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Sinusoid, Sarcoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +                             A        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +                             +        +     +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +                             A        +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +                                      +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +                                      +  +  +               |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +                             +        +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                               X                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +                             A        +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +        +                             +        +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|             
                                           | 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +                             +        +  M  +               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                                    +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +        +                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +                             +        +  +  +              +|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +                             +        +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +                 +  +        +        +  +  +  +           +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                               X                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |    X                          X                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                               X                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                               X                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        M                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |    X                                                  X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +        +                 +  +        M        +  +  +  +           +|             
      Lymphoma Malignant Lymphocytic       |    X                          X                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +  +  +     +  +        A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                  X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|             
                                           | 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M        +                             +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M                                         M        M  M  M               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +           +                 +        +  +  +  +     +      |             
      Fibroma                              | X                                                                        |             
      Fibrosarcoma                         | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                               X              X      |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +        +        +           +     +  +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +                 +           +        +  +  +  +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |    X                                                           X         |             
      Alveolar/Bronchiolar Carcinoma       | X                                                           X  X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +                             +        +  +  +               |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +                             A        +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                           |             
      Pinna, Histiocytic Sarcoma           |                                              X                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +                             +        +  +  +               |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +                             A        +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +        +  +  +  +  +     +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|             
                                           | 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                          X                       X                  |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|             
                             DAY ON TEST   | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|             
                                           | 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          M  A  +     +     A              +                    M  A      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +        +     A              +                    +  A      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +        +     +              +                    +  A      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  A        +     +              +        +  +        +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                 +              +                    +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                 A              +        +           +  A      |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +           +     A              +           +        +  A      |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemangiosarcoma                      |                                                          X               |             
      Hepatocellular Carcinoma             |          X  X     X  X                 X                 X     X         |             
      Hepatocellular Adenoma               |                      X           X           X              X            |             
      Hepatocellular Adenoma, Multiple     |       X                                               X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sinusoid, Sarcoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                        +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +        +     +              +                    +  M      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +        +     +              +                    +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pheochromocytoma Benign              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +        +     +              +                    +  M      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  +        +     +              M                    +  M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|             
                             DAY ON TEST   | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|             
                                           | 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +        +     +              M                    +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Carcinoma                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +                                            +               |             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +        +     +              +                    +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +        +     +     +        +        +  +  +     +  +      |             
      Axillary, Lymphoma Malignant Mixed   |                                  X                                       |             
      Inguinal, Lymphoma Malignant Mixed   |                                  X                                       |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                  X                                       |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                       X                  |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                  X                                       |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +        +     +     +        +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +        +     +     +        +        +           +  A      |             
      Lymphoma Malignant Lymphocytic       |                      X                             X                     |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A      |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|             
                             DAY ON TEST   | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|             
                                           | 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +        M     M     +        M                    M  M      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M        M     M              M                    M  M      |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +  +     +  +     +     +  +  +     +  +  +  +  +      |             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                X                                                         |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                       X                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                X              X           X                              |             
      Subcutaneous Tissue, Sarcoma         |       X                             X                       X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +  +     +  +  +  +  +  +        +  +        +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +     +  +     +        +  +  +  +     +           +  +      |             
      Alveolar/Bronchiolar Adenoma         |       X           X                    X     X     X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +        +     +              +                    +  +      |             
      Mucosa, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +        +     +              +                    +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Histiocytic Sarcoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +        +     +              +                    +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +           +     +              +                    +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|             
                             DAY ON TEST   | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|             
                                           | 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                    X                             X  X                  |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5|                             |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9|                             |            |
                                           | 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                             +     +                              |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                     +     A                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                             A     +                              |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                                   +                              |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                                   +                              |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                                   +                              |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +           +                 A     +                              |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                           +                              |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                           M                              |  10        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +           +                       +                              |  13        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +     +  +  +  +  +                              |  54        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |         11 |
      Hepatocellular Adenoma               |                         X        X  X  X                                 |         15 |
      Hepatocellular Adenoma, Multiple     | X                 X  X                                                   |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sinusoid, Sarcoma                    |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                             +     +                              |  15        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                             +     +                              |  16        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                             A     +                              |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                                   +                              |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                                   +                              |  15        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                             +     +                              |  17        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +  +                              |  53        |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +  +                              |  52        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5|                             |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9|                             |            |
                                           | 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                X                       X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +  +                              |  52        |
      Pheochromocytoma Benign              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                             +     +                              |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                             +     +                              |  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       M                             +     +                              |  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +     +                              |  53        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +  +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +                             +     +                              |  18        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                             +     +                              |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +           +  +  +           +     +                              |  29        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5|                             |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9|                             |            |
                                           | 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Thoracic, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +              +  +           +     +                              |  23        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +  +                              |  52        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                             +     +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M                             M     M                              |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +              +              +     +                              |  33        |
      Fibroma                              |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    | X                                         X                              |          8 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                          +  +     +                              |  32        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +        +     +     +     +                              |  31        |
      Alveolar/Bronchiolar Adenoma         | X              X                                                         |          9 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                             +     +                              |  17        |
      Mucosa, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                             +     +                              |  16        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5|                             |            |
                             DAY ON TEST   | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9|                             |            |
                                           | 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    50 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Histiocytic Sarcoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   2        |
      Adenoma                              |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                             +     +                              |  17        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                             +     +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +  +     +  +  +  +  +                              |  54        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X     X                                                                  |          9 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|             
                                           | 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  A     +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  A     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
      Serosa, Carcinoid Tumor Benign       |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  A     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Jejunum, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A     +  +  +  +     +  +  +  A     +  +  +  +     +  +  A     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X                             X        X        X           X            |             
      Hepatocellular Adenoma               |                                     X        X  X                        |             
      Hepatocellular Adenoma, Multiple     |                                                                X         |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +                          +                    +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +              +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|             
                                           | 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  M  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     +  +  +  M     +  M  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +     +  +  M  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Interstitial Cell, Adenoma           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Iliac, Lymphoma Malignant Mixed      |                                  X                                       |             
      Renal, Lymphoma Malignant Lymphocytic|                                           X                              |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +        +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  M  +        +  M  +  M  +  +  +  M  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                           X     X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  A  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +     +  +  +  M  +  +  +  +  +     +  +  M     M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M     M  M  M  M  M  M  M  M  M     M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|             
                                           | 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                   +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |          X     X                                   X              X      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                           X            |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +                 +                                                   |             
      Adenoma                              |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
      Renal Tubule, Carcinoma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|             
                                           | 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X     X                        |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|             
                                           | 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  M  +        +  +  +  +     +  +  +  M  M  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  A        +  +  +  +     +  +  +  A  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  A        +  +  +  +     +  +  +  A  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Serosa, Carcinoid Tumor Benign       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  A        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  A        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  A        +  +  +  +     +  +  +  A  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Jejunum, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  A        +  +  +  +     +  +  +  A  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Hemangioma                           |             X                                                            |             
      Hemangiosarcoma                      |                                                       X                  |             
      Hepatocellular Carcinoma             |                      X                                                   |             
      Hepatocellular Adenoma               | X  X     X                       X                 X                     |             
      Hepatocellular Adenoma, Multiple     |                                              X              X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Pericardium, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|             
                                           | 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +        +  +  +  M     +  +  +  M  +  +  M  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  M  +      |             
      Follicular Cell, Adenoma             |             X                                X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                 +           +            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                +     +        +     +            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Interstitial Cell, Adenoma           |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Thoracic, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +        M  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  M        +  +  +  M     +  +  +  +  +  +  M  +      |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M        M  +  M  M     M  M  M  M  M  M  M  M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|             
                                           | 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                 +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |    X     X                                                               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                 +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                 +      |             
      Adenoma                              |                                                 X                 X      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|             
                                           | 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4|                             |            |
                             DAY ON TEST   | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8|                             |            |
                                           | 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M     +  +  +  M  +                              |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  49        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  52        |
      Serosa, Carcinoid Tumor Benign       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +     +  +  +  +  M                              |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Jejunum, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  M  +     +  +  +  +  A                              |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                        X                                 |          2 |
      Hepatocellular Carcinoma             |                                     X                                    |          7 |
      Hepatocellular Adenoma               |       X  X  X        X  X     X     X                                    |         15 |
      Hepatocellular Adenoma, Multiple     |    X                                   X                                 |          5 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  53        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     M  +  +  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Pericardium, Lymphoma Malignant      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4|                             |            |
                             DAY ON TEST   | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8|                             |            |
                                           | 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     M  +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +        +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +        +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +     +  +  +  +  +                              |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +     M  +  +  M  +                              |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +     M  +  +  +  +                              |  50        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  54        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  54        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |   7        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Interstitial Cell, Adenoma           | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Thoracic, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  51        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  50        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4|                             |            |
                             DAY ON TEST   | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8|                             |            |
                                           | 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  54        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +     +  +  M  M  M                              |  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M     M  M  M  M  M                              |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Fibrosarcoma                         |             X                                                            |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                  X     X                                 |          2 |
      Subcutaneous Tissue, Hemangiosarcoma |                                     X                                    |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +           +                                                   |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |          6 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                     X                                    |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05040-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HYDROQUINONE                                       Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 10:15:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4|                             |            |
                             DAY ON TEST   | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8|                             |            |
                                           | 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     A      |
    100MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +                                          |   7        |
      Adenoma                              | X                             X                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +                              |  55        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
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