National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3468

TDMS Study 05040-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: American Biogenics                                        DATE: 09/05/94   
EXP: 05040                      HYDROQUINONE                   TIME: 10:32:14   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55834B   
CONT:                                                          CAS: 000123319   
PATHOLOGIST: K. SMITH                        S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: American Biogenics                                        DATE: 09/05/94  
EXP: 05040                      HYDROQUINONE                   TIME: 10:32:14  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55834B  
CONT:                                                          CAS: 000123319  
PATHOLOGIST: K. SMITH                        S. EUSTIS                         

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 26     CENSORED DEATHS 12   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      367   381   459   483   515   546   560   567   593   596                 |
 |      602   602   616   637   646   654   665   676   681   683                 |
 |      702   713   715   729   730   730                                         |
 |  CENSORED DEATHS                                                               |
 |      273   459   459   459   459   459   459   459   459   459                 |
 |      459   710                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 32     CENSORED DEATHS 15   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      207   263   392   466   490   536   540   576   583   599                 |
 |      610   612   617   625   632   638   653   655   656   659                 |
 |      662   673   686   689   703   709   713   718   723   728                 |
 |      728   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      86    429   431   459   459   459   459   459   459   459                 |
 |      459   459   459   651   668                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 30     CENSORED DEATHS 17   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      501   522   554   556   562   581   597   598   606   606                 |
 |      612   612   631   637   638   651   659   672   672   672                 |
 |      676   686   689   700   702   710   711   718   718   720                 |
 |  CENSORED DEATHS                                                               |
 |      318   459   459   459   459   459   459   459   459   459                 |
 |      459   473   648   669   682   700   707                                   |
 |                                                                                |
 ==================================================================================

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  96.9  93.4  91.6  78.5  69.1  52.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |25 MG/KG   |   100.0 100.0  96.9  96.9  95.3  93.4  87.5  81.7  60.0  37.3      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  96.2  84.9  67.8  40.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          25 MG/KG         50 MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.0%            37.3%            40.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.371          P=0.217          P=0.427       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       609.5            608.4            639.0         |
 |NATURAL DEATHS (C)      |       (20.1)           (22.5)           (11.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       633.2            607.4            632.5         |
 |(STANDARD ERROR)        |       (15.3)           (17.9)           (13.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      372   476   500   501   553   575   646   647   658   674                 |
 |      685   686   702   710   722                                               |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 25     CENSORED DEATHS 13   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      373   444   487   492   560   576   595   624   625   625                 |
 |      633   654   655   655   661   667   668   672   672   708                 |
 |      709   710   719   721   724                                               |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      700   700   700                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 65     UNCENSORED DEATHS 20     CENSORED DEATHS 13   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      458   492   588   590   597   598   634   638   652   658                 |
 |      669   676   687   694   695   703   707   711   714   716                 |
 |  CENSORED DEATHS                                                               |
 |      343   458   458   458   458   458   458   458   458   458                 |
 |      458   658   658                                                           |
 |                                                                                |
 ==================================================================================

                                   HYDROQUINONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.5  96.6  93.0  89.3  83.9  72.9      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |25 MG/KG   |   100.0 100.0 100.0 100.0  98.5  96.9  93.3  87.8  73.1  53.9      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0 100.0 100.0 100.0  98.4  96.6  89.2  81.7  62.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          25 MG/KG         50 MG/KG      |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.9%            53.9%            62.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.350          P=0.067          P=0.380       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       607.1            625.2            643.9         |
 |NATURAL DEATHS (C)      |       (27.1)           (18.3)           (16.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       659.2            646.0            653.0         |
 |(STANDARD ERROR)        |       (13.8)           (13.5)           (13.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            HYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        25 MG/KG         = 2
                                                        50 MG/KG         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                2                        1                    3
      |                                  2        2               1  12          1     3   3
      |                                                               2          12 1      3    3
      |                                                                           2 12   1   21 33
   90 +                                                                                      21 13 3
      |                                                                                       2 11 2   3
P     |                                                                                          1 22 113
E     |                                                                                             2  2 2
R  80 +                                                                                                 33
C     |                                                                                                1 12 1
E     |                                                                                                   221 1
N     |                                                                                                     2211
T  70 +                                                                                                      231 1 1
      |                                                                                                          3311
S     |                                                                                                        2 2
U     |                                                                                                           331  11
R  60 +                                                                                                          2 23   11
V     |                                                                                                            223   1  1
I     |                                                                                                             2232
V     |                                                                                                               322   1
A  50 +
L     |                                                                                                                 22
      |                                                                                                                  22
      |
   40 +                                                                                                                  3  3
      |                                                                                                                   2 2
      |
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 34 obs hidden.

                                                            HYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        25 MG/KG         = 2
                                                        50 MG/KG         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                          1             3
      |                                                            1          2  3 1  3
      |                                                                       2      2
      |                                                                            1  31            3
   95 +                                                                              22             3 3
      |                                                                               2         2
      |                                                                                1       1      33
      |                                                                                        12  1
   90 +                                                                                            2  2
      |                                                                                            1   3    3 1
      |                                                                                               2    233
      |                                                                                                       11
P  85 +                                                                                                      3 3
E     |                                                                                                        1   1
R     |                                                                                                    22      11
C     |                                                                                                        3  3
E  80 +                                                                                                     2  2  33
N     |                                                                                                             1  1
T     |                                                                                                            3 3
      |                                                                                                              3311
S  75 +                                                                                                        2 2      1 1
U     |                                                                                                          22
R     |                                                                                                               33  1 1
V     |
I  70 +
V     |
A     |                                                                                                                33
L     |                                                                                                           2     2
   65 +
      |                                                                                                                 33
      |                                                                                                                  3  3
      |
   60 +                                                                                                                 22
      |
      |
      |                                                                                                                  22
   55 +
      |                                                                                                                   2 2
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 26801-26801/26801


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.