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https://ntp.niehs.nih.gov/go/1659

TDMS Study 05043-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE


NTP Experiment-Test: 05043-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 18:59:58




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          11           12           20                                                  
    Dead                                               5            7            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           31           28                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (10)         (45)                                                
      Serosa, Inflammation, Suppurative                3 (7%)       1 (10%)                                                         
   Intestine Small, Duodenum                          (48)         (48)         (48)                                                
      Lamina Propria, Congestion, Diffuse                                        1 (2%)                                             
      Lamina Propria, Pigmentation                                 44 (92%)     47 (98%)                                            
   Intestine Small, Jejunum                           (50)         (11)         (50)                                                
      Lamina Propria, Congestion, Diffuse                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Abscess, Single                                                            1 (2%)                                             
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 1 (2%)       3 (6%)                                                          
      Clear Cell Focus                                 1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change                                     1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 4 (8%)       5 (10%)      5 (10%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            9 (18%)      2 (4%)       8 (16%)                                            
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Kupffer Cell, Pigmentation                                   31 (62%)     50 (100%)                                           
      Serosa, Inflammation, Suppurative                2 (4%)       1 (2%)                                                          
      Serosa, Inflammation, Membranous                 1 (2%)                                                                       
   Mesentery                                          (7)          (4)          (4)                                                 
      Inflammation, Acute                              1 (14%)                                                                      
      Inflammation, Chronic                            3 (43%)                   1 (25%)                                            
      Inflammation, Chronic Active                                               1 (25%)                                            
      Inflammation, Suppurative                                     2 (50%)      1 (25%)                                            
      Fat, Necrosis                                    1 (14%)      1 (25%)      1 (25%)                                            
      Mesothelium, Inflammation, Membranous            1 (14%)                                                                      
   Pancreas                                           (50)         (14)         (49)                                                
      Atrophy                                                       1 (7%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)       2 (14%)      6 (12%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
      Acinus, Atrophy                                                            1 (2%)                                             
      Duct, Cyst                                                                 1 (2%)                                             
      Duct, Interlobular, Ectasia                                   1 (7%)                                                          
      Interlobular, Inflammation, Acute                                          1 (2%)                                             
      Serosa, Inflammation, Suppurative                1 (2%)                                                                       
      Serosa, Interlobular, Inflammation,                                                                                           
          Suppurative                                                            1 (2%)                                             
   Salivary Glands                                    (49)         (11)         (49)                                                
      Inflammation, Chronic                           23 (47%)      7 (64%)     18 (37%)                                            
      Artery, Inflammation, Chronic, Necrotizing                                 1 (2%)                                             
   Stomach                                            (49)         (20)         (50)                                                
      Serosa, Inflammation, Suppurative                1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (20)         (50)                                                
      Acanthosis                                      10 (20%)      9 (45%)     12 (24%)                                            
      Inflammation, Acute, Focal                       2 (4%)       1 (5%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                    3 (6%)                                             
      Ulcer                                            2 (4%)       5 (25%)      3 (6%)                                             
   Stomach, Glandular                                 (49)         (15)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Pigmentation                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (12)         (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Coronary Artery, Inflammation, Acute             1 (2%)                                                                       
      Myocardium, Inflammation, Acute                                            1 (2%)                                             
      Pericardium, Inflammation, Suppurative                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (14)         (50)                                                
      Capsule, Inflammation, Suppurative                            1 (7%)                                                          
      Capsule, Inflammation, Membranous                1 (2%)                                                                       
   Adrenal Gland, Cortex                              (49)         (13)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Capsule, Inflammation                                         1 (8%)                                                          
   Parathyroid Gland                                  (30)         (9)          (30)                                                
      Cyst                                             1 (3%)                                                                       
   Pituitary Gland                                    (46)         (13)         (44)                                                
      Pars Distalis, Hyperplasia                       3 (7%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                2 (4%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (13)         (50)                                                
      Inflammation, Chronic                            2 (4%)                                                                       
      Follicular Cell, Hyperplasia                     2 (4%)       1 (8%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Necrosis                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (25)         (44)                                                
      Cyst                                            14 (29%)      8 (32%)      6 (14%)                                            
      Cyst, Multiple                                   1 (2%)                                                                       
      Hyperplasia, Cystic, Papillary                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        6 (13%)      6 (24%)      5 (11%)                                            
      Bilateral, Inflammation, Suppurative             2 (4%)                    2 (5%)                                             
      Follicle, Cyst                                   5 (10%)                   1 (2%)                                             
      Periovarian Tissue, Inflammation, Chronic        2 (4%)       1 (4%)       3 (7%)                                             
      Periovarian Tissue, Inflammation, Suppurative                              1 (2%)                                             
      Periovarian Tissue, Necrosis                                               1 (2%)                                             
   Oviduct                                            (2)          (6)          (9)                                                 
      Inflammation, Suppurative                                     1 (17%)      1 (11%)                                            
   Uterus                                             (50)         (26)         (49)                                                
      Hydrometra                                                    1 (4%)       3 (6%)                                             
      Endometrium, Hemorrhage                                       1 (4%)                                                          
      Endometrium, Hyperplasia, Cystic                30 (60%)     15 (58%)     23 (47%)                                            
      Endometrium, Inflammation, Suppurative           8 (16%)      1 (4%)       9 (18%)                                            
      Muscularis, Inflammation, Suppurative                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (12)         (50)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)                    4 (8%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (8%)       3 (6%)                                             
   Lymph Node                                         (47)         (27)         (49)                                                
      Lumbar, Hematopoietic Cell Proliferation                      1 (4%)                                                          
      Lumbar, Hyperplasia, Lymphoid                                 1 (4%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                 2 (4%)                    2 (4%)                                             
      Mandibular, Hyperplasia, Plasma Cell                          1 (4%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hematopoietic Cell Proliferation                 1 (4%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell            2 (4%)       1 (4%)       1 (2%)                                             
      Mediastinal, Inflammation, Acute                 2 (4%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Pancreatic, Pigmentation                                                   5 (10%)                                            
      Renal, Hyperplasia, Lymphoid                     1 (2%)       2 (7%)       1 (2%)                                             
      Renal, Hyperplasia, Plasma Cell                  2 (4%)       2 (7%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (46)         (23)         (46)                                                
      Congestion                                                                 2 (4%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)       1 (4%)                                                          
      Inflammation, Suppurative                                     1 (4%)                                                          
      Pigmentation                                     1 (2%)       4 (17%)      8 (17%)                                            
      Serosa, Inflammation, Membranous                 1 (2%)                                                                       
   Spleen                                             (50)         (24)         (50)                                                
      Hematopoietic Cell Proliferation                 8 (16%)      9 (38%)     13 (26%)                                            
      Hyperplasia, Lymphoid                            4 (8%)       1 (4%)       3 (6%)                                             
      Metaplasia                                                                 1 (2%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)                                             
      Subcapsular, Inflammation, Acute                 1 (2%)                                                                       
   Thymus                                             (33)         (10)         (39)                                                
      Inflammation                                                  1 (10%)                                                         
      Thymocyte, Necrosis                                           1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (10)         (37)                                                
      Hyperplasia                                                   1 (10%)                                                         
      Hyperplasia, Cystic                              3 (8%)                                                                       
      Hyperplasia, Lymphoid                            1 (3%)                                                                       
      Inflammation, Chronic                            1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (12)         (50)                                                
      Joint, Tarsal, Hyperostosis                                                1 (2%)                                             
   Skeletal Muscle                                    (3)          (1)                                                              
      Abdominal, Inflammation, Suppurative                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (12)         (50)                                                
      Cerebellum, Abscess, Multiple                                              1 (2%)                                             
      Meninges, Inflammation, Acute                                              1 (2%)                                             
      Meninges, Inflammation, Chronic                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (50)                                                
      Congestion                                                    1 (5%)       1 (2%)                                             
      Edema                                                         1 (5%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Acute, Focal                                    1 (5%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (5%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (5%)                                                          
      Alveolus, Hyperplasia, Macrophage                1 (2%)                                                                       
      Lymphatic, Perivascular, Inflammation, Acute     1 (2%)                                                                       
      Mediastinum, Inflammation, Suppurative                                     1 (2%)                                             
      Peribronchiolar, Inflammation, Chronic           2 (4%)                                                                       
      Peribronchiolar, Perivascular, Inflammation,                                                                                  
           Chronic                                     2 (4%)                                                                       
      Perivascular, Inflammation, Acute                1 (2%)                                                                       
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
      Pleura, Inflammation, Chronic                                              1 (2%)                                             
      Pleura, Inflammation, Suppurative                             1 (5%)       1 (2%)                                             
   Nose                                               (45)         (11)         (46)                                                
      Inflammation, Suppurative                                     2 (18%)      1 (2%)                                             
      Mucosa, Inflammation, Chronic                                 1 (9%)       2 (4%)                                             
      Mucosa, Inflammation, Suppurative                                          5 (11%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                   1 (2%)                                             
      Turbinate, Inflammation, Chronic                              1 (9%)       1 (2%)                                             
      Turbinate, Inflammation, Suppurative                          1 (9%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (39)         (50)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           27 (54%)     10 (26%)     35 (70%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .019 G/      .038 /G                                                
                                                   72VF         KG 72LF      KG 72HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia                                                    3 (8%)       1 (2%)                                             
      Necrosis                                         2 (4%)       5 (13%)      8 (16%)                                            
      Cortex, Abscess, Single                                                    1 (2%)                                             
      Fat, Inflammation, Chronic                                    1 (3%)                                                          
      Papilla, Mineralization                                                    3 (6%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Dilatation                                      1 (3%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Mineralization                     1 (2%)                    1 (2%)                                             
      Renal Tubule, Necrosis                                                     1 (2%)                                             
      Renal Tubule, Pigmentation                                    4 (10%)     50 (100%)                                           
      Renal Tubule, Regeneration                      18 (36%)     24 (62%)     42 (84%)                                            
   Urinary Bladder                                    (47)         (10)         (47)                                                
      Artery, Serosa, Inflammation, Chronic                                      1 (2%)                                             
      Serosa, Inflammation, Suppurative                1 (2%)                                                                       
      Submucosa, Inflammation, Chronic                14 (30%)      1 (10%)     15 (32%)                                            
      Submucosa, Ulcer, Chronic                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           11           12                                                  
    Dead                                               6            6            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           33           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (14)         (44)                                                
      Serosa, Inflammation, Acute                                                1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (49)         (48)                                                
      Lamina Propria, Pigmentation                                 48 (98%)     47 (98%)                                            
   Intestine Small, Ileum                             (45)         (13)         (48)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Peyer's Patch, Hyperplasia, Neutrophil                        1 (8%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Fatty Change                                     2 (4%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       2 (4%)       3 (6%)                                             
      Mixed Cell Focus                                                           1 (2%)                                             
      Necrosis                                         4 (8%)                    3 (6%)                                             
      Kupffer Cell, Pigmentation                                   44 (88%)     47 (94%)                                            
   Mesentery                                          (3)          (3)                                                              
      Necrosis, Multifocal                                          1 (33%)                                                         
      Fat, Necrosis, Focal                             1 (33%)      1 (33%)                                                         
   Pancreas                                           (50)         (16)         (50)                                                
      Inflammation, Chronic                            3 (6%)       1 (6%)       2 (4%)                                             
      Acinus, Atrophy                                  2 (4%)                    2 (4%)                                             
      Acinus, Hypertrophy, Focal                                                 1 (2%)                                             
   Salivary Glands                                    (50)         (15)         (50)                                                
      Inflammation, Chronic                           26 (52%)      7 (47%)     31 (62%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
      Acinus, Atrophy, Focal                                                     1 (2%)                                             
   Stomach, Forestomach                               (50)         (23)         (50)                                                
      Acanthosis                                       4 (8%)      10 (43%)     13 (26%)                                            
      Cyst                                                          1 (4%)                                                          
      Inflammation, Acute                              1 (2%)                    5 (10%)                                            
      Inflammation, Chronic                            1 (2%)       3 (13%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Focal                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                         2 (9%)       5 (10%)                                            
   Stomach, Glandular                                 (50)         (22)         (50)                                                
      Pigmentation                                                               1 (2%)                                             
   Tooth                                              (1)                       (2)                                                 
      Peridontal Tissue, Inflammation, Chronic                                   1 (50%)                                            
      Peridontal Tissue, Inflammation, Suppurative     1 (100%)                                                                     
      Pulp, Inflammation, Necrotizing                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Artery, Inflammation, Chronic                                              1 (100%)                                           
   Heart                                              (50)         (15)         (50)                                                
      Coronary Artery, Inflammation, Chronic                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (15)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Hypertrophy                                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (15)         (49)                                                
      Hyperplasia                                      2 (4%)       1 (7%)                                                          
   Islets, Pancreatic                                 (50)         (15)         (50)                                                
      Hyperplasia                                                                3 (6%)                                             
   Parathyroid Gland                                  (33)         (8)          (33)                                                
      Cyst, Multiple                                                             1 (3%)                                             
   Pituitary Gland                                    (41)         (15)         (50)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Intermedia, Hyperplasia, Focal                                        1 (2%)                                             
   Thyroid Gland                                      (49)         (15)         (49)                                                
      Follicle, Hyperplasia                            1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                               3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (15)         (50)                                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Granulomatous                            1 (7%)                                                          
   Penis                                              (1)          (3)                                                              
      Inflammation, Chronic Active                                  1 (33%)                                                         
      Inflammation, Suppurative                        1 (100%)     1 (33%)                                                         
      Necrosis                                                      1 (33%)                                                         
   Preputial Gland                                    (4)          (8)          (6)                                                 
      Inflammation, Chronic                                         1 (13%)      2 (33%)                                            
      Inflammation, Suppurative                                     3 (38%)      2 (33%)                                            
      Duct, Ectasia                                    2 (50%)      3 (38%)      2 (33%)                                            
   Prostate                                           (50)         (15)         (46)                                                
      Inflammation, Acute                              1 (2%)       1 (7%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        5 (10%)      2 (13%)      1 (2%)                                             
   Seminal Vesicle                                    (49)         (19)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Testes                                             (50)         (16)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
      Interstitial Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)                                                                       
      Seminiferous Tubule, Degeneration                2 (4%)       1 (6%)                                                          
      Seminiferous Tubule, Mineralization              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (15)         (50)                                                
      Myelofibrosis                                    1 (2%)                    1 (2%)                                             
      Myeloid Cell, Hyperplasia                                     1 (7%)                                                          
   Lymph Node                                         (44)         (36)         (49)                                                
      Lumbar, Hyperplasia, Plasma Cell                 2 (5%)       1 (3%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (3%)                                                          
      Pancreatic, Pigmentation                                      1 (3%)       7 (14%)                                            
      Renal, Hyperplasia, Histiocytic                                            1 (2%)                                             
   Lymph Node, Mesenteric                             (44)         (32)         (49)                                                
      Congestion                                       6 (14%)     18 (56%)     16 (33%)                                            
      Hematopoietic Cell Proliferation                              2 (6%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Pigmentation                                                  5 (16%)     17 (35%)                                            
   Spleen                                             (50)         (19)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)       4 (21%)      5 (10%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       1 (5%)       1 (2%)                                             
      Pigmentation                                                               2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (29)         (11)         (31)                                                
      Necrosis                                         1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (29)         (50)                                                
      Inflammation, Chronic                            1 (2%)       1 (3%)                                                          
      Parakeratosis, Multifocal                                     1 (3%)                                                          
      Ulcer, Multiple                                               1 (3%)       1 (2%)                                             
      Dermis, Fibrosis                                              1 (3%)       2 (4%)                                             
      Dermis, Inflammation, Chronic                                 1 (3%)                                                          
      Dermis, Subcutaneous Tissue, Fibrosis            1 (2%)                                                                       
      Prepuce, Hyperkeratosis                          1 (2%)                                                                       
      Prepuce, Inflammation, Suppurative               2 (4%)       2 (7%)                                                          
      Prepuce, Necrosis, Focal                         1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (2%)                                             
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                             1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (19)         (50)                                                
      Hyperostosis                                                  1 (5%)       1 (2%)                                             
      Joint, Tarsal, Hyperostosis                      7 (14%)     14 (74%)     12 (24%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (50)                                                
      Congestion                                       2 (4%)       1 (5%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                                                       
      Peribronchiolar, Perivascular, Inflammation,                                                                                  
           Chronic                                                               1 (2%)                                             
      Perivascular, Inflammation, Chronic                           1 (5%)                                                          
   Nose                                               (42)         (11)         (39)                                                
      Mucosa, Inflammation, Suppurative                1 (2%)                                                                       
      Nasolacrimal Duct, Hyperplasia, Squamous                                   1 (3%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         2 (5%)       1 (9%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05043-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 18:59:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .019 G/      .038 G/                                                
                                                   72VM         KG 72LM      KG 72HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)                                                 
      Cataract                                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (50)                                                
      Inflammation, Chronic                           26 (52%)     16 (33%)     38 (76%)                                            
      Metaplasia                                                                 1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)                    1 (2%)                                             
      Necrosis                                                     12 (25%)     30 (60%)                                            
      Nephropathy                                      1 (2%)                                                                       
      Cortex, Inflammation, Suppurative                1 (2%)                                                                       
      Papilla, Necrosis                                1 (2%)                    1 (2%)                                             
      Pelvis, Inflammation, Acute                                   1 (2%)                                                          
      Renal Tubule, Calculus Micro Observation Only                 1 (2%)                                                          
      Renal Tubule, Dilatation                         1 (2%)      15 (31%)     46 (92%)                                            
      Renal Tubule, Hyperplasia                                                  3 (6%)                                             
      Renal Tubule, Mineralization                     2 (4%)                    8 (16%)                                            
      Renal Tubule, Pigmentation                                    8 (17%)     47 (94%)                                            
      Renal Tubule, Regeneration                      34 (68%)     34 (71%)     48 (96%)                                            
   Urethra                                            (1)                                                                           
      Mucosa, Lumen, Inflammation, Suppurative         1 (100%)                                                                     
   Urinary Bladder                                    (47)         (15)         (50)                                                
      Concretion                                                                 1 (2%)                                             
      Mucosa, Inflammation, Acute                      1 (2%)                                                                       
      Mucosa, Inflammation, Subacute                                1 (7%)                                                          
      Mucosa, Necrosis                                 1 (2%)       1 (7%)                                                          
      Serosa, Inflammation                                                       1 (2%)                                             
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Submucosa, Hemorrhage                            1 (2%)                                                                       
      Submucosa, Inflammation, Chronic                 3 (6%)                    6 (12%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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